LOCUS       NM_001164072            2019 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus TRAF family member-associated Nf-kappa B activator
            (Tank), transcript variant 2, mRNA.
ACCESSION   NM_001164072
VERSION     NM_001164072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Wakabayashi,A., Yoshinaga,M. and Takeuchi,O.
  TITLE     TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by
            suppressing DNA-cGAS aggregation
  JOURNAL   Life Sci Alliance 5 (2), e202101067 (2021)
   PUBMED   34819357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Pang,Y., Ma,M., Wang,D., Li,X. and Jiang,L.
  TITLE     TANK Promotes Pressure Overload Induced Cardiac Hypertrophy via
            Activating AKT Signaling Pathway
  JOURNAL   Front Cardiovasc Med 8, 687540 (2021)
   PUBMED   34540911
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Zhu,L., Li,Y., Xie,X., Zhou,X., Gu,M., Jie,Z., Ko,C.J., Gao,T.,
            Hernandez,B.E., Cheng,X. and Sun,S.C.
  TITLE     TBKBP1 and TBK1 form a growth factor signalling axis mediating
            immunosuppression and tumourigenesis
  JOURNAL   Nat Cell Biol 21 (12), 1604-1614 (2019)
   PUBMED   31792381
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Muller,C.P., Chu,C., Qin,L., Liu,C., Xu,B., Gao,H., Ruggeri,B.,
            Hieber,S., Schneider,J., Jia,T., Tay,N., Akira,S., Satoh,T.,
            Banaschewski,T., Bokde,A.L.W., Bromberg,U., Buchel,C.,
            Quinlan,E.B., Flor,H., Frouin,V., Garavan,H., Gowland,P., Heinz,A.,
            Ittermann,B., Martinot,J.L., Martinot,M.P., Artiges,E.,
            Lemaitre,H., Nees,F., Papadopoulos Orfanos,D., Paus,T., Poustka,L.,
            Millenet,S., Frohner,J.H., Smolka,M.N., Walter,H., Whelan,R.,
            Bakalkin,G., Liu,Y., Desrivieres,S., Elliott,P., Eulenburg,V.,
            Levy,D., Crews,F. and Schumann,G.
  TITLE     The Cortical Neuroimmune Regulator TANK Affects Emotional
            Processing and Enhances Alcohol Drinking: A Translational Study
  JOURNAL   Cereb Cortex 29 (4), 1736-1751 (2019)
   PUBMED   30721969
  REMARK    GeneRIF: Findings suggest that the cortical neuroimmune regulator
            TANK is involved in cortical aversive emotion processing and
            related control of alcohol drinking behavior. A tank knock out
            mouse model suggests a role of TANK in alcohol drinking,
            anxiety-related behavior, as well as alcohol exposure induced
            activation of insular cortex NF-kappaB.
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Bakshi,S., Taylor,J., Strickson,S., McCartney,T. and Cohen,P.
  TITLE     Identification of TBK1 complexes required for the phosphorylation
            of IRF3 and the production of interferon beta
  JOURNAL   Biochem J 474 (7), 1163-1174 (2017)
   PUBMED   28159912
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Pomerantz,J.L. and Baltimore,D.
  TITLE     NF-kappaB activation by a signaling complex containing TRAF2, TANK
            and TBK1, a novel IKK-related kinase
  JOURNAL   EMBO J 18 (23), 6694-6704 (1999)
   PUBMED   10581243
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Rothe,M., Xiong,J., Shu,H.B., Williamson,K., Goddard,A. and
            Goeddel,D.V.
  TITLE     I-TRAF is a novel TRAF-interacting protein that regulates
            TRAF-mediated signal transduction
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8241-8246 (1996)
   PUBMED   8710854
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Cheng,G. and Baltimore,D.
  TITLE     TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB
            activation
  JOURNAL   Genes Dev 10 (8), 963-973 (1996)
   PUBMED   8608943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB660164.1, AK165420.1, AK147727.1 and AL845291.5.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR and uses an alternate in-frame splice site in the central
            coding region, compared to variant 1. The resulting isoform (2)
            lacks one internal residue, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026148.1, U51907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BB660164.1         2-46
            46-560              AK165420.1         2-516
            561-1389            AK147727.1         715-1543
            1390-2019           AL845291.5         28006-28635
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.56 cM"
     gene            1..2019
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /note="TRAF family member-associated Nf-kappa B activator"
                     /db_xref="GeneID:21353"
                     /db_xref="MGI:MGI:107676"
     exon            1..112
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     exon            113..260
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1403
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /note="isoform 2 is encoded by transcript variant 2; TRAF
                     family member-associated NF-kappa-B activator;
                     TRAF-interacting protein"
                     /codon_start=1
                     /product="TRAF family member-associated NF-kappa-B
                     activator isoform 2"
                     /protein_id="NP_001157544.1"
                     /db_xref="CCDS:CCDS50593.1"
                     /db_xref="GeneID:21353"
                     /db_xref="MGI:MGI:107676"
                     /translation="MDKNIGEQLNRAYEAFRQACMDRDSAVRELQQKTENYEQRIREQ
                     QEQLSFQQNLIDRLKSQLLLVDSSRDNSYGYVPLLEDSDRRKNNLTLDEPHDKVKLGT
                     LRDKQSKVRRQEVSSGKESAKGLNIPLHHERDNIEKTFWDLKEEFHRICLLAKAQKDH
                     LSKLNIPDIATDTQCSVPIQCTDKTEKQEALFKPQAKDDINRGMSCVTAVTPRGLGRD
                     EEDTSFESLSKFNVKFPPMDNDSIFLHSTPEAPSILAPATPETVCQDRFNMEVRDNPG
                     NFVKTEETLFEIQGIDPITSAIQNLKTTDKTNPSNLRATCLPAGDHNVFYVNTFPLQD
                     PPDAPFPSLDSPGKAVRGPQQPFWKPFLNQDTDLVVPSDSDSELLKPLVCEFCQELFP
                     PSITSRGDFLRHLNTHFNGET"
     exon            261..369
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     exon            370..488
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     exon            489..559
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     exon            560..675
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1226
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..2019
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /note="hexamer: ATTAAA"
     polyA_site      1938
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /note="major polyA site"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="Tank"
                     /gene_synonym="E430026L09Rik; I-TRAF"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcagt cgctgccctc tgaactggaa cggaaagcta cttccggttg cagtcattct
       61 gccgggcacc ggcgacctgt ggcgtgagcg agcacagccg gaaccctcca ctagctggca
      121 ttcctaccat cctttatagt gatgctacag gacaaagagg aatggataaa aacattggtg
      181 agcaactcaa tagagcatat gaagccttcc gacaggcatg catggataga gattcagcag
      241 taagagagct acagcaaaag actgagaact atgaacaaag aatacgcgag caacaggaac
      301 agctgtcatt tcaacaaaac ctaattgaca ggctgaaatc acagctactt ctcgtggatt
      361 ctagtcgaga taacagttat ggctatgtac ctttgcttga agacagtgac agaaggaaga
      421 ataatttgac ccttgatgaa ccacatgata aagtgaaact aggaacactg agagataagc
      481 aatcaaaggt gagacgacaa gaagtttctt ctggaaaaga atccgccaag ggtctcaaca
      541 tccctctgca tcacgaaagg gataatatag agaagacttt ctgggacctt aaagaagaat
      601 ttcataggat ttgcttgcta gcaaaagcac agaaagatca cttaagcaaa cttaatatac
      661 cagatattgc aactgacaca cagtgttctg tgcctataca gtgtactgat aaaacagaga
      721 aacaagaagc gctgtttaag ccccaggcta aagatgatat aaatagaggt atgtcgtgcg
      781 tcacagctgt cacaccaaga ggactgggcc gggatgagga agatacctct tttgaatcac
      841 tttctaaatt caatgtcaag tttccgccta tggacaatga ctctattttt ctacatagca
      901 ctccagaggc cccgagcatc cttgctcctg ccacacctga gacagtgtgc caggaccgat
      961 ttaatatgga agtcagagac aacccaggaa actttgttaa aacagaagaa actttatttg
     1021 aaattcaggg aattgacccc ataacttcag ctatacaaaa ccttaaaaca actgacaaaa
     1081 caaacccctc aaatcttaga gcgacgtgtt tgccagctgg agaccacaat gtgttctatg
     1141 taaatacgtt cccacttcaa gacccgcctg acgcaccttt tccctcactg gattccccag
     1201 gaaaggctgt ccgaggacca cagcagccct tttggaagcc ttttcttaac caagacactg
     1261 acttagtggt accaagtgat tcagactcag agctccttaa acctctagtg tgtgaattct
     1321 gtcaagagct tttcccacca tccattacat ccagagggga tttcctccgg catcttaata
     1381 cacactttaa tggggagact taaatcacgt ttgaaaacag acatatcatg ttctctgtgg
     1441 tggttttgga tttgtaacgc tagagaacgc tttctcgtga gccaaatgta agattgatta
     1501 taaagttgtt actttatctt ttaagagatc attttgtata gaactataac tcattatatt
     1561 attcatgttt atacctataa tttctacatt tcaaaattac acatgtgact tacagagtta
     1621 ttcagtcata atttatgttt caaatagcta agtttattgt ttgactattg tgagatctat
     1681 taaatttagt aatagcaaat gtttatagga tattcaaatt tcatttgaat ttttaattat
     1741 ttttgctaca ggtaatattc ctttaaaata cgtatataac gtacagagaa taacagacaa
     1801 tatgatctaa gtaaatgtcg aatcaatcat tagttgccca gggaaattta aacattatag
     1861 atcattttta aataatacac atagttttaa tttttactgt gtgtatagat gcatgattaa
     1921 atgacttaaa tattaaaagt gacttacgtc gtgcttatta aaagtgttct ttgtttctga
     1981 gataaataaa taaatcgcat ttggggaggg ttcataaaa
//
