LOCUS       NM_001359109            1589 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus transport and golgi organization 2 (Tango2),
            transcript variant 3, mRNA.
ACCESSION   NM_001359109 XM_006522228
VERSION     NM_001359109.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1589)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1589)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1589)
  AUTHORS   Kremer,L.S., Distelmaier,F., Alhaddad,B., Hempel,M., Iuso,A.,
            Kupper,C., Muhlhausen,C., Kovacs-Nagy,R., Satanovskij,R., Graf,E.,
            Berutti,R., Eckstein,G., Durbin,R., Sauer,S., Hoffmann,G.F.,
            Strom,T.M., Santer,R., Meitinger,T., Klopstock,T., Prokisch,H. and
            Haack,T.B.
  TITLE     Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset
            Recurrent Metabolic Crises with Encephalocardiomyopathy
  JOURNAL   Am J Hum Genet 98 (2), 358-362 (2016)
   PUBMED   26805782
  REMARK    GeneRIF: Our study suggests TANGO2 deficiency as a differential
            diagnosis in cases of episodic encephalopathy and/or myopathy in
            infancy and childhood of unknown cause, especially in individuals
            with cardiac arrhythmias.
REFERENCE   4  (bases 1 to 1589)
  AUTHORS   Paronett,E.M., Meechan,D.W., Karpinski,B.A., LaMantia,A.S. and
            Maynard,T.M.
  TITLE     Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a
            Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical
            Projection Neuron Generation
  JOURNAL   Cereb Cortex 25 (10), 3977-3993 (2015)
   PUBMED   25452572
REFERENCE   5  (bases 1 to 1589)
  AUTHORS   Karpinski,B.A., Maynard,T.M., Fralish,M.S., Nuwayhid,S., Zohn,I.E.,
            Moody,S.A. and LaMantia,A.S.
  TITLE     Dysphagia and disrupted cranial nerve development in a mouse model
            of DiGeorge (22q11) deletion syndrome
  JOURNAL   Dis Model Mech 7 (2), 245-257 (2014)
   PUBMED   24357327
REFERENCE   6  (bases 1 to 1589)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   7  (bases 1 to 1589)
  AUTHORS   Sutherland,H.F., Kim,U.J. and Scambler,P.J.
  TITLE     Cloning and comparative mapping of the DiGeorge syndrome critical
            region in the mouse
  JOURNAL   Genomics 52 (1), 37-43 (1998)
   PUBMED   9740669
REFERENCE   8  (bases 1 to 1589)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   9  (bases 1 to 1589)
  AUTHORS   McKie,J.M., Sutherland,H.F., Harvey,E., Kim,U.J. and Scambler,P.J.
  TITLE     A human gene similar to Drosophila melanogaster peanut maps to the
            DiGeorge syndrome region of 22q11
  JOURNAL   Hum Genet 101 (1), 6-12 (1997)
   PUBMED   9385360
REFERENCE   10 (bases 1 to 1589)
  AUTHORS   Halford,S., Wilson,D.I., Daw,S.C., Roberts,C., Wadey,R., Kamath,S.,
            Wickremasinghe,A., Burn,J., Goodship,J., Mattei,M.G. et al.
  TITLE     Isolation of a gene expressed during early embryogenesis from the
            region of 22q11 commonly deleted in DiGeorge syndrome
  JOURNAL   Hum Mol Genet 2 (10), 1577-1582 (1993)
   PUBMED   8268909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084822.36.
            
            On Dec 21, 2017 this sequence version replaced XM_006522228.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3554391.1,
                                           SRR7652917.109249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC084822.36        143240-143352       c
            114-207             AC084822.36        123799-123892       c
            208-296             AC084822.36        116088-116176       c
            297-416             AC084822.36        112081-112200       c
            417-531             AC084822.36        110311-110425       c
            532-602             AC084822.36        107412-107482       c
            603-756             AC084822.36        103125-103278       c
            757-861             AC084822.36        102128-102232       c
            862-1589            AC084822.36        100267-100994       c
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.34 cM"
     gene            1..1589
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /note="transport and golgi organization 2"
                     /db_xref="GeneID:27883"
                     /db_xref="MGI:MGI:101825"
     exon            1..113
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            114..207
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..982
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /note="isoform 1 is encoded by transcript variant 3;
                     ser/Thr-rich protein T10 in DGCR region; transport and
                     golgi organization 2 homolog"
                     /codon_start=1
                     /product="transport and Golgi organization 2 homolog
                     isoform 1"
                     /protein_id="NP_001346038.1"
                     /db_xref="CCDS:CCDS28019.1"
                     /db_xref="GeneID:27883"
                     /db_xref="MGI:MGI:101825"
                     /translation="MCIIFFKFDPRPVSKNAYRLILAANRDEFYNRPSKLADFWGNNS
                     EILSGLDMEEGKAGGTWLGISTRGKLGALTNYLQPRQEPDARGRGELVSHFLTSDMDS
                     LSYLKKVSTEGHLYNGFNIIAADLSTSKGDVVCYYGNRGEPEPIVLTPGTYGLSNALL
                     ETPWKKLCFGKQLFMEAVEQSEALPKDVLVTQLLDVLNNEEAQLPDPAIEDQGQEYVQ
                     PILNKYAAVCVRCATYGTRTNTIILVDANGHVTFTERSMLDKDTSRWETNTYEFTLQS
                     "
     exon            208..296
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            297..416
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            417..531
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            532..602
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            603..756
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            757..861
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1589
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /note="hexamer: AATAAA"
     polyA_site      1589
                     /gene="Tango2"
                     /gene_synonym="D16H22S680E; T10"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gaggcggtga gtgtgcagcg ggtggctggg gctagcgggc tgcgctcctg
       61 gcggggctga cccaaggtcg ggcgccgggc tcctggaacg cggtctggat cagaccttgt
      121 gaccgtgtga gcaaagccac ccttgcaacc catgtgcatc atcttcttta agtttgatcc
      181 tcgtcctgtt tccaaaaatg catacaggct catcttggca gccaacagag atgaattcta
      241 taacaggccg tccaagttgg cagacttctg ggggaacaac agtgagatcc tcagtgggct
      301 cgacatggag gaaggcaagg caggaggaac atggctgggc atcagcacac gtgggaagct
      361 gggggcactc accaactacc tacagccccg gcaagagcca gacgcccgtg gtagaggtga
      421 acttgtgtct cactttctga ccagtgacat ggacagcctg tcctacctga agaaggtctc
      481 tacagagggc cacctgtata acggctttaa catcatagca gctgacctga gcacgtcaaa
      541 aggagatgtt gtttgctact atggaaaccg gggggagcct gagcctattg tcttgacacc
      601 aggaacctat gggctaagca atgccctgct ggagacgccc tggaagaagc tgtgctttgg
      661 caaacaactc ttcatggaag cagtggagca gagcgaagca ctccctaagg acgtccttgt
      721 cactcagctc ctagatgtcc tcaacaatga ggaggcacag ctgccagacc cagccattga
      781 ggaccagggc caggagtatg tacagccaat tctgaacaag tatgcagctg tgtgtgtccg
      841 ctgtgccacc tatggcacca gaaccaacac catcatcctt gtggatgcaa atggccacgt
      901 gaccttcact gaacggagca tgctggacaa agacacctct cgctgggaga ccaacaccta
      961 tgagttcaca ctacagagtt agcccctgcc aggttccaag gatgctgttc ctgaagggcc
     1021 agcgtggaca ggaacctttc acggccactc tgcaggtctg tggctcagcc agcaccccta
     1081 ggaccaggtt gttctgattt gtgtcctcat actcagctca gggtctctct ttgtaccaat
     1141 ggagaacgac agagttaaat actaggcgtg agtcaggcct gggtatgccg tatgtgaaca
     1201 cacagacctg tttgttgctc aaccccactg ccactgtgtg cacctgactg atgagtagga
     1261 tcatgcctct cacctcacac gtttgggcag tgggtctcat ccatggacgg gtaacaaaag
     1321 cagactcttt acagaaactg gagatcctgt atttgtttgt gttcatatgt gttcggtggt
     1381 tcttcatata cgaggaccct gtgtgcattt tctcagtcct gtagtgtgga ccctgggatc
     1441 tcttagaccc ctgcttgccc aggattgtgg gttctgagca agacatcttc aaccagtccc
     1501 gtccatctcc cattgccctt gttatggtat acaccatagg aatgtgaact tgaatgtgca
     1561 cagttgataa taaatctttg aagttgtaa
//
