LOCUS       NM_181071              11864 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tetratricopeptide repeat, ankyrin repeat and
            coiled-coil containing 2 (Tanc2), mRNA.
ACCESSION   NM_181071 XM_001000829 XM_001000860 XM_001000873 XM_001000886
            XM_001000900 XM_001000913 XM_001000922 XM_001004226 XM_001004229
            XM_001004235 XM_001004240 XM_903099 XM_903101 XM_903102 XM_911892
            XM_922187 XM_922195 XM_922205 XM_922212 XM_922217 XM_922223
            XM_984944
VERSION     NM_181071.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11864)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11864)
  AUTHORS   Yang,Q., Liu,H., Zhong,D., Li,Z., Li,J., Xiao,K. and Liu,W.
  TITLE     Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes
            liquid-liquid phase separation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119650 (2024)
   PUBMED   38092135
  REMARK    GeneRIF: Tanc1/2 TPR domain interacts with Myo18a C-terminus and
            undergoes liquid-liquid phase separation.
REFERENCE   3  (bases 1 to 11864)
  AUTHORS   Garrett,L., Da Silva-Buttkus,P., Rathkolb,B., Gerlini,R.,
            Becker,L., Sanz-Moreno,A., Seisenberger,C., Zimprich,A.,
            Aguilar-Pimentel,A., Amarie,O.V., Cho,Y.L., Kraiger,M.,
            Spielmann,N., Calzada-Wack,J., Marschall,S., Busch,D.,
            Schmitt-Weber,C., Wolf,E., Wurst,W., Fuchs,H., Gailus-Durner,V.,
            Holter,S.M. and Hrabe de Angelis,M.
  TITLE     Post-synaptic scaffold protein TANC2 in psychiatric and somatic
            disease risk
  JOURNAL   Dis Model Mech 15 (3) (2022)
   PUBMED   34964047
  REMARK    GeneRIF: Post-synaptic scaffold protein TANC2 in psychiatric and
            somatic disease risk.
REFERENCE   4  (bases 1 to 11864)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11864)
  AUTHORS   Kim,S.G., Lee,S., Kim,Y., Park,J., Woo,D., Kim,D., Li,Y., Shin,W.,
            Kang,H., Yook,C., Lee,M., Kim,K., Roh,J.D., Ryu,J., Jung,H.,
            Um,S.M., Yang,E., Kim,H., Han,J., Heo,W.D. and Kim,E.
  TITLE     Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the
            developing mouse brain and human neurons
  JOURNAL   Nat Commun 12 (1), 2695 (2021)
   PUBMED   33976205
  REMARK    GeneRIF: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling
            in the developing mouse brain and human neurons.
            Erratum:[Nat Commun. 2022 Nov 1;13(1):6544. doi:
            10.1038/s41467-022-33972-9.. PMID: 36319630]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11864)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 11864)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 11864)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 11864)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 11864)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP766228.1, AK051973.1, AK173111.1, AL596246.10 and AI413677.1.
            
            On or before Feb 3, 2007 this sequence version replaced
            XM_001004235.1, XM_001004240.1, XM_001004226.1, XM_001004229.1,
            XM_903101.2, XM_903099.2, XM_903102.2, XM_922223.2, XM_911892.2,
            XM_984944.1, XM_922217.2, XM_922195.2, XM_922205.2, XM_922187.2,
            XM_922212.2, XM_001000913.1, XM_001000922.1, XM_001000900.1,
            XM_001000886.1, XM_001000860.1, XM_001000873.1, XM_001000829.1,
            NM_181071.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               BP766228.1         28-291
            265-1866            AK051973.1         261-1862
            1867-3963           AK173111.1         337-2433
            3964-6897           AK173111.1         2464-5397
            6898-11608          AL596246.10        84592-89302
            11609-11864         AI413677.1         1-256               c
FEATURES             Location/Qualifiers
     source          1..11864
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.73 cM"
     gene            1..11864
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /note="tetratricopeptide repeat, ankyrin repeat and
                     coiled-coil containing 2"
                     /db_xref="GeneID:77097"
                     /db_xref="MGI:MGI:2444121"
     exon            1..264
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            265..354
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..6272
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /note="tetratricopeptide repeat, ankyrin repeat and
                     coiled-coil domain-containing protein 2"
                     /codon_start=1
                     /product="protein TANC2"
                     /protein_id="NP_851416.2"
                     /db_xref="CCDS:CCDS36357.1"
                     /db_xref="GeneID:77097"
                     /db_xref="MGI:MGI:2444121"
                     /translation="MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRS
                     GQGGISTESDCAFEPDYAVPPLPVSEGDVEQELGPPPSVDEAANTLMTRLGFLLGEKV
                     TEVQPSDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTNAAAK
                     DCSYGAVTSPTSTLESRDSGIIATLTNYSENMERTKYVGEGSKELGSGGNLKPWQSQK
                     SSMDSCLYRVDENMAASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAH
                     LEDLAYLDEQRHTPLRTSLRMPRQSLSGARTQQDLRVRFAPYRPPDISLKPLLFEVPS
                     ITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTR
                     MRQIASDSPHASPKHVDANRELPLTQAPSAHSSITSGSCPGTPEMRRRQEEAMRRLAS
                     QVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCV
                     QDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMI
                     GNFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEI
                     QNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVS
                     LSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWED
                     FQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFS
                     RQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLR
                     NLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAS
                     SESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ
                     CDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFD
                     SLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT
                     HGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHL
                     SVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLD
                     RAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKE
                     AAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALEL
                     KPKSYEAYYARARAKRSSRQFAAALEDLKEAIKLCPNNREIQRLLMRVEEECRQMQQQ
                     QQQQPPPPPQQPPQELPEEETEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEAR
                     PSQGLPVIQSPPSSPAHRDSAYISSSPLGSHQVFDFRSNSSVGSPTRQGYQSTSPALS
                     PTHQNSHYRPSPPHTSPAHQGASYRFSPPPVGGQSKEYPSPPPSPLRRGPQYRASPPA
                     ESMSVYRSQSGSPVRYQQETNVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQ
                     PAKAQIVRSNQPSSAVHSSTVIPTGAYGQVAHSMASKYQSSQGDMGVSQSRLVYQGSI
                     GGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAYRGGMRYSQTPQIGRSQS
                     ASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGL
                     RFSPSSNSISSTSNLTPTFRPSSSIQQMEIPLKPAYDRSCDELSPVSPTQGGYPSEPT
                     RSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSS
                     ISNIAFYNKTNNAQNGHLLEDDYYSPHGMLANGSRGDLLERVSQASSYPDVKVARTLP
                     VAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV"
     exon            355..426
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..498
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..647
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            648..834
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1098
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1224
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1506
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1640
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1872
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2039
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2647
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2756
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2879
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3116
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3302
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3396
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3530
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3654
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3830
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..3963
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4055
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..4202
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4303
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..11860
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11836..11841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /note="hexamer: TATAAA"
     polyA_site      11860
                     /gene="Tanc2"
                     /gene_synonym="3526402J09Rik; 5730590C14Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgctcacctc ccggctgtgc cgcgcgcgag gcggagcgag gcgcccgccg ccgccgcggt
       61 gctgaggggc gagcctgtcc cccccgcgcc gccgctgaca ggaggaccgc agcgggctgc
      121 cagcgctcgc cggccgcgag gccccgccga gcccgactga ggtgcggatc ctccgtgggg
      181 cgtccgcggg cggcgcggtc ctcaccggag accactggca cgcgggcttg accccgaggt
      241 gcgccgcgcc ccttagaacg gcagttttat attaaaggag cacaaccatg tttcggaata
      301 gtctcaagat gcttcttact ggtgggaagt caagtcggaa aaacaggtca agtgatggag
      361 gaagcgagga accaccggat cgaagacagt cgagtgtaga ttctcgccaa agccgctctg
      421 ggcaaggtgg catctccaca gaaagcgatt gtgcttttga gccagactat gctgttccac
      481 cacttccagt gagtgaaggt gatgttgaac aagaacttgg cccacctcca tctgtagatg
      541 aggcagcaaa cacactcatg actcgtctgg gtttcctcct tggagagaaa gtcacagaag
      601 tacaaccaag tgaccaatat agcatggagg tacaggatga aaatcagact tcagcaatca
      661 cccagagaat aagtccctgc tccaccttga ctagcagcac tgcctctcca ccagccagca
      721 gcccctgctc tacgctccca ccagtcagta caaatgcagc tgccaaggac tgtagctatg
      781 gggctgtcac cagccccacc tccactctag aaagcagaga cagtggcatc attgcaacat
      841 taacaaatta ttctgaaaac atggagcgaa caaaatatgt tggagaaggc agtaaagaat
      901 taggatctgg aggaaaccta aaaccatggc agtctcaaaa atccagcatg gactcttgtc
      961 tgtaccgagt ggatgaaaac atggctgcat ccacatacag tctgaacaag atcccggagc
     1021 gaaatctgga aacagtttta tcgcaatcag tacagtctat tccgttgtat ctcatgcctc
     1081 ggccaaattc tgtagcagcc accagctctg cccacttgga ggatcttgct tacctggatg
     1141 agcagagaca cactcctttg aggacatccc ttagaatgcc aagacagagc ctgagtggtg
     1201 ctcgaacaca gcaggatctc agagttcgct ttgcacctta cagacctcca gacatctcct
     1261 tgaagcccct actcttcgaa gtgcccagca ttaccacgga gtcagtgttt gttggtcgag
     1321 attgggtatt ccatgagatt gatgctcagc ttcagagttc taatgccagc gtgaaccaag
     1381 gagtagtgat tgtgggaaac attgggttcg gcaaaactgc catcatctcc agactggtgg
     1441 ccctcagctg ccatggtaca cggatgagac agatcgcctc tgacagccca cacgcctccc
     1501 ccaaacatgt ggacgccaac agagagctac cactcaccca agcaccttca gctcactcat
     1561 ctattaccag tggaagctgc ccaggaactc cagaaatgcg caggcggcaa gaggaagcca
     1621 tgcgaagact tgcctcacag gtggttgcct atcactattg ccaggcagat aatgcctaca
     1681 cctgcctggt accagaattc gtccacaatg ttgctgccct gctctgccgc tcacctcagc
     1741 tgacagctta ccgggaacag cttcttcggg agcctcacct gcagagcatg ctaagcctcc
     1801 ggtcctgtgt tcaagatccc atggcctcct tccggagagg agtcctagag cccttggaga
     1861 acctccacaa agagagaaaa atcccagatg aagatttcat cattttaatt gatggattaa
     1921 atgaagcaga atttcacaaa ccggattatg gggatacaat tgtatcattt ctaagtaaaa
     1981 tgattggaaa ttttccttct tggctcaaac taattgtaac agttaggacc agtttacagg
     2041 aaattaccaa gttgctgcct ttccatagga tttttttgga tcgactagaa gagaatgaag
     2101 ccatagacca ggacctgcag gcttacatcc tgcaccggat tcacagcagc tcagagatcc
     2161 agaataacat ctcacttaat ggcaagatgg acaatactac atttggcaaa ctcagttctc
     2221 acctcaagac cctcagtcaa gggtcatatc tatacctgaa actcacattt gacctcatag
     2281 agaaaggcta cctagtgcta aagagttcta gctacaaagt cgttcctgtt tcgctctctg
     2341 aggtttattt actccagtgc aatatgaagt tcccaactca gtcttccttt gaccgggtga
     2401 tgcctctcct gaatgtggca gtagcctctc tccacccact tacggatgaa catattttcc
     2461 aggccatcaa tgctgggagc attgaaggca cactagaatg ggaagacttt caacaaagaa
     2521 tggagaacct ctccatgttc ctcatcaagc gcagagacat gactcggatg tttgtgcatc
     2581 cttcttttcg agaatggctt atctggagag aagaaggaga gaaaaccaaa tttctctgtg
     2641 atcccaggag tggccacaca ttacttgcct tctggttctc ccgccaagag ggaaaactaa
     2701 accgacagca gactattgaa ctaggacatc acatcctcaa agcacacatc tttaagggtt
     2761 tgagtaaaaa ggttggtgta tcgtcctcca tcctccaagg cctctggatc tcctacagca
     2821 cagaaggtct ttccatggca ttggcctctt tacgaaatct ctacactcca aatataaagg
     2881 tcagcagact gctgattctg ggaggtgcca atattaatta ccggacagag gttctaaata
     2941 atgctcctat cctatgtgtc cagtctcacc ttggatacac agaaatggtg gccctgcttt
     3001 tggagtttgg ggctaatgtg gatgcctctt ctgagagtgg cctgactccc ctggggtatg
     3061 ctgcagcagc agggttcctg agcatcgtgg tgttgctgtg caagaaacgg gccaaggtgg
     3121 atcacttgga taagaatgga cagtgtgctt tggttcatgc tgctctgcga ggtcatctag
     3181 aggttgtcaa gtttctgatt cagtgtgact ggacaatggc tggccagcag caaggagtgt
     3241 ttaagaagag ccacgccatc cagcaggccc tcattgctgc agccagcatg ggttacactg
     3301 agattgtctc ctacctactt gatcttccag aaaaagatga agaggaagtg gagcgagcac
     3361 aaatcaacag ttttgacagt ctctggggag agacagccct gacagccgca gccggaaggg
     3421 gcaaactgga tgtgtgccgt ctgcttttgg agcaaggggc agcagtggcc cagccaaacc
     3481 gcagaggagc agtgcctcta ttcagcactg ttcgccaggg ccattggcag attgttgatc
     3541 ttttactgac ccatggagct gatgtcaaca tggcagacaa gcagggtcgt actcccctga
     3601 tgatggctgc ttctgaaggc catctaggaa ccgtggactt cctactagca caaggtgcct
     3661 ccattgccct gatggacaaa gaaggactaa cagcccttag ctgggcttgt ctgaagggcc
     3721 atctctcagt agtacgctct ctggtggata acggggctgc tacagaccat gcagacaaga
     3781 atggccgtac cccactggac ctagcagctt tctacggtga tgctgaggtg gtccagttcc
     3841 tggtagatca tggggccatg attgagcatg ttgactacag tggaatgcgt cctttggata
     3901 gggcagtggg ttgccggaac acgtctgttg tagtaactct actgaaaaaa ggagccaaaa
     3961 taggtccagc cacatgggcg atggccacct ccaaaccaga catcatgatc atcctgttga
     4021 gcaagctgat ggaagagggg gacatgtttt ataagaaagg gaaagtaaag gaggctgccc
     4081 agcgctacca gtatgctctg aagaaattcc ctagagaagg gtttggtgag gacctgaaaa
     4141 ccttccggga gctaaaagtg tctctcctcc tcaacctctc tcgatgtcgc aggaaaatga
     4201 acgattttgg aatggcggag gaatttgcta ctaaagccct ggagctgaaa ccgaaatctt
     4261 atgaagcata ctatgcgaga gcaagggcaa aacgcagcag cagacagttt gcagcagccc
     4321 tagaggacct gaaagaggcc atcaagctat gtcccaacaa ccgtgagatc cagaggcttc
     4381 tgatgcgagt ggaggaagag tgcagacaga tgcagcagca gcagcagcag cagccaccac
     4441 ccccacccca gcagcctccg caggagttgc cagaggaaga aacagagcct gagccccagc
     4501 atgaagatat atactctgta caggacatat ttgaggagga atacttggaa caagatgttg
     4561 aaaatgtttc tattggcctc cagacagagg ctcgccccag tcaggggctc ccagtaatcc
     4621 agagcccacc ctcctctcca gcccatcggg actcggccta catctctagc tcacctcttg
     4681 gctctcatca ggtttttgac ttccggtcca atagttctgt aggttccccc actagacaag
     4741 gttatcagtc cacttcgcct gctctttctc caactcacca gaactctcat tacaggccta
     4801 gcccaccaca tacttctcca gctcatcagg gtgcatctta ccggttcagc ccacctcctg
     4861 tgggagggca aagcaaggaa taccctagcc ctcccccttc ccctctccgt agaggccctc
     4921 agtatagggc cagtcctcca gctgagagca tgagtgtcta tagatcccag tctggctcac
     4981 ctgtacgcta tcagcaagaa acaaatgtga gtcagcttcc tggcagacca aaatctccac
     5041 tatccaaaat ggcccagcgg ccctaccaga tgcctcagct tccagtggca gttccccagc
     5101 aaggtctcag gctacagcct gccaaggccc agattgtaag aagtaaccag cctagctcag
     5161 cagttcattc aagcactgta atcccaacag gagcctatgg ccaagtagcc cattcaatgg
     5221 ccagtaaata ccagtcttca caaggagaca tgggagtaag tcagagccga ttggtttatc
     5281 agggatcaat aggggggatt gtaggagatg ggagacctgt acagcatgtc caagccagtc
     5341 tgagtgctgg tgccatctgt cagcatggag gattgaccaa agaagacctg ccacagcgac
     5401 cctcctctgc ctatcgaggt ggtatgaggt acagccagac accacagatt gggcgtagcc
     5461 aatcagcgtc atattatcca gtctgtcact caaaactaga tctggagcgt tcctccagcc
     5521 agctgggttc ccccgatgtg tcacatttaa tcagaagacc tatcagtgtc aaccctaatg
     5581 aaatcaagcc ccacccacca actcccaggc cgctgctgca ctcacagagt gtgggcctgc
     5641 gcttttctcc atccagcaat agcatctcat ccacctccaa cctgactccc accttccggc
     5701 cttcttcttc aattcagcaa atggagatcc cactaaaacc ggcatatgat aggtcatgtg
     5761 atgagctatc accagtatct cccactcagg gaggttatcc tagtgagcct acccgatcca
     5821 ggaccacacc attcatgggg atcatagata aaacagcccg gactcaacag tacccccacc
     5881 ttcaccagca gaatcggacc tgggcagtct catcagtgga tacggttctc agtcccacgt
     5941 ctccaggcaa cctgcctcag cctgaatcct tcagtccacc atcatccatc agcaacattg
     6001 ccttttataa caaaaccaac aatgcacaga atggccattt gctggaggac gattattaca
     6061 gcccccatgg gatgctggct aatgggtctc gtggagacct cttggaaaga gtcagccagg
     6121 cctcctctta tcctgatgtg aaggtggcac ggaccctacc agtggctcag gcataccagg
     6181 acaacctgta caggcaattg tctcgggact ctcgacaagg gcagacatcg cccatcaaac
     6241 caaagagacc atttgtggag tctaatgttt aagagacatt tgttggagtg agacccatat
     6301 gttttcactg cacattttca ggcttggttt ccacatctga ggtagttctc tggcttaatt
     6361 tctcatgtag tttctgtgtg gtgttcagag gtgacagccc acatgttgaa atcctttgca
     6421 tgcagctgac tgggaagctg gcctctggtg agccaggact tcagtttctc gggtctgtgc
     6481 cccagccaca tgctctctcc ctctcttcca ataccaacga ggagatttcg tgccgtgagc
     6541 tttaaccagg gagatcagac atactggtcg gctttttcca ggagacaatc gctttcactg
     6601 atgttcttgt tgtgtgaatg tctttttcct ttttaaaaaa gtaagatgtt cttgtttgtt
     6661 ttcttctaga agcgttagga cacgtgtgat gcctttctgt ccttgcatcc ttcctcagtg
     6721 ttcacatggc cagccccagt gcatcgctgt gccatggtct tctccccaga ctccagctcc
     6781 ctgcaggcgt cagctctaga atcttcattt cctttattgc tggtccttct ctgggacaaa
     6841 ggggtctagg gagagtgaga gagaaagagt aagagaggaa gaaagaaaga aagaaagaaa
     6901 gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa
     6961 gaaaaagaaa gaaagaaacg ctaaattgat tggaagaaaa gcccactata attatctgaa
     7021 atgttactat gttggttttc caagaagtgt ttggggaact tttaataaac atccagccct
     7081 gattagccaa ggaaattcca ggagaactgt tggtattttt aaagtactca ccaagaggta
     7141 ttctctaggc tttaactaac agctactaaa ggctgctgat tttccacggc tagagaaggg
     7201 aataagtatg gagaaaggag gagaaagggg gaaagattgt tcttgcttct caccaagaga
     7261 aagctgtgtc aagtctgcat tttagatcac aaaaaaaaac cctgaacaac ctctgaggtc
     7321 tggctgctgt agtaacccga ctcgatgcac tttcacctgg agccaggctt cgctcagctc
     7381 cattgtctca aaaccaagat gatagtgtaa agagtttctt ccagaacctg cttaggttct
     7441 cttgggactg taaggcccat cccagggttt ccacccaggc cactacattc cgtgttggct
     7501 gttatctaat tccattttaa gacctctgat ttcattattc tctgttaaag gaattgtctc
     7561 ttttatctaa gagtgttaaa tggtaatctt tgaaaatcag aaacagccaa aagtgttaca
     7621 gattgctctg agcactgggt aggggcatga gattgatagt aggccttttc ctccctccgt
     7681 ttccattcgt cttgtggctg tttgctaacc tgattttttg aaaagctgag acaactgtga
     7741 gataggcatc aaggacacag gaaccaaagc tgtagcacag taccatctct gggaacacgt
     7801 cagttctcaa aaccaagcca caggtccagc aaagtaacca tgttgcttgt tgctaccatg
     7861 ttcttaggga gcatttctca ttagtgaagg gctgcaggaa ggacaatttc ctgaacaaaa
     7921 cccagctgtg atctgtttgg aatgcagttc tctgatagga tctgaagtca tgcagagcat
     7981 gacactgcaa tcagaaacct ttcatcactg atttagattc tgccagtaga tggaccccag
     8041 gccccccaag cctaaaacag atcagaattc atctctgtaa gcaggactgc ttttactctg
     8101 atatagaact gccccatcct cctagactag gataggcact ggtcatttct ccctacctga
     8161 ccatccacct gtctttatct tcatctctcc catctggaag aagcttatag ctgtggggtc
     8221 agcctatagc tgggagcagc agcctctcca gtccccttgt ggcctggaca cagctctgtt
     8281 ggtctctgca tcacattgta tcttacctga accacctctg agggagctcc tacagtccat
     8341 taataaagtg ctcccgcctg tttggaaagc cacccttacc accttacctg cccaagtggg
     8401 ttagaatgcc atgcagacct aaaaatacac cacagctgcc actattaccc atggtccctc
     8461 attttcccag gaaaattaag agagttagcg tctctacccc cacctgaaat agcagtgtca
     8521 aaccacaatt atttcctatc cattataaga gagagtgcat gccactactg gagcaagtgg
     8581 tttttgactt aagaacacca atgggagctt cctgaggcag gagacaagca tcttccctgg
     8641 atgcagactg cctgccctgc tttgctactt cactgccatg gttgatctta gtactgtatt
     8701 ttaaatgtgc ccctcccttc ccaacaatga acatttgcct ggcttcagga tggaagacaa
     8761 atcttaaatg aaactggcaa attcttatca ctcaattcac atcaccctta agtagagaca
     8821 ggtgacaaac ttcagcttgt aggtttctca cccaaacatg ttcctttgcc caaaattctt
     8881 gcactggtgg gtttccatca catcatgtct ataaatgggt gcactttact gtttgaattt
     8941 gtaactctga taaatactgg atatttaagt gtgagtaatg tcttcattag aaattagagt
     9001 cactcttgtc tctagtgtgt tttttcaaga aaaaaagata caaggaaaga aatcaagcag
     9061 tgggccacag catttatagc acagaaataa cgttgtatat aagcctcaaa gagtaaggat
     9121 ttttaaacac aagaaaacat ttgcagtgat tttaaagtgc ttttccagca attttcttag
     9181 ggactcctga gacatggttc atttatttac tggatcagta aggcacacaa gtaacaatta
     9241 aaattattgt ttatttacaa agtaaaggga aaacctctgt aacatgagaa ttcggcatgg
     9301 acaaatggag atcattttgt atctgctgtt gtgtctgtcc aggttgcagt cgtgcactat
     9361 tagtcccgag ttaatagagc acaaccccct ctcgttccag gtgccccttt ctagatgtgt
     9421 ttaacttaaa cttgatggct caggaaaatt ccactcatta gaattgtgta cagtatccca
     9481 ggttgttgcc cagatatcca agtttgctga ttttagttaa gcctggatta tcacttttcc
     9541 taaattatta taaacagaac agcttagaga aaggtgttct cctcccttat attgtatagt
     9601 agtttatgat tccctctaaa tattggtatt tttatatttc agagatatac ccaatagaaa
     9661 aattttaaac cagtatctaa tttaatatcc ataagtattt ttccttagag tttagtcata
     9721 tgcagtggga tatgtggatg tcacttgtgc ttcaccgtac tctaccacta ggtgtcactg
     9781 tgaccctgca tcatacttac ctggttacaa agaatggctt cgtggagctg ctgccagtgc
     9841 agctggcaag ggggccctac agactagagg ttcaggaaga agggaacaca agcctgaggg
     9901 ggcttcctgc agccatgccc ctgtagcaag gcagactctg gacaccacgt ttgcgaggtt
     9961 acattgcgct ccctttctcc ccgttagaaa ccgttcctct cagttcactc agcctccggc
    10021 ttttataact ccagaagaat cacagttggg tggttgatta aagatggtta tttttctact
    10081 gcagaaatgc cttggacaaa accagttgct cactgaatct ttgccacaca atggaacagg
    10141 ctccccaggt ggcaggatat gctgcctctg tgcccatctc ttgttgaggc tctgagcgct
    10201 cagcagcccc acccacccta cctgtctgcc ctcaggctgc ccagttctca agaaggggtc
    10261 tgctaccgcc tttactctga gggccatact gccctgcctc gtgcttgttg agaggtgtga
    10321 cttctccttt tcctctggga attccagact gaccatctac catgactaac aatgaacaaa
    10381 gggcttaggg taagagctac ctacaaagac gcgtcatgga aaccttcacc atgcaatgcc
    10441 ttgaactcag ctctggctgc tcccaagaaa aggcagctgg ctaggggcct ggacacaagc
    10501 acaacggggc tggtggagcc actgtgcaga gctacttgaa tattcactgg gtcttcatca
    10561 actctttttg taatacagac cactcaaggg ctgaagtgtt ggtaaccttc atttcggtgt
    10621 ccaatgcctc acagcagctg agccaccctg agatgcttgt ggccacgtga tggccacagt
    10681 cagagctttg aaagtcagta ccaaatgaac gtataattgg acaccaaaaa tcaagtgtta
    10741 ctctcatgtt tcctcaccct gtcatctcat ttcttcctgc tgactatcgt gatccctaca
    10801 ctaagctgac cagtcaggct acagctggct gcacgcagat gccagccagc accatctcct
    10861 ggtttcagat agacctactc cgtgggaaga acgtggccta gctgctttgt ttctgtagca
    10921 cttgatggct ggattttttc ctttgctaat cactaaccag aaaatctggc taggactcaa
    10981 ctcactccct tcaatcccca ggaccagaca gagagttaat tctggaaaat tccgtacttg
    11041 aatgtacctg ccttactgtg tacccattca ctgggggagg ggggattaga gatgttggct
    11101 ctagatatcc acttcattca aagttatttt ggaaatcctg taagttctac ttcctgtcct
    11161 gctttgcttt cctttgcttt gctttgcttt gctttgcttt gctttgcttt gctttgcttt
    11221 gctttgcttt gcttgtttgt tttgttcctg acatttgact gattcctgct gagttgggcc
    11281 gttccctgtg gggcccaggg caggtgccat tctcaggcat ggcctccctt ccatctagca
    11341 cagcatctgt ccctctgttc tgtctcctcc aacccaagac gattttaatt agtacagaca
    11401 tgtacagtct acaattaaag agtgatttgt actaatatga ttttgattat tcctctttgc
    11461 tgtcctttca agacacttgc tggaaaaagc tttaatgcac ttagttttcc tttaggtttt
    11521 ctataactca gatgtaaagg actttctctg tacagtatat tatccaatgc atgtttgttc
    11581 tctatcctga tatatcaaac accacacggt cgtgaactcg tgcagtgggg atggcccaca
    11641 cccagcggag gcctccagcc ccgtgaataa ggaagacatt ttctctactg tacttgcttg
    11701 aacagtttta ttgtctgtac atgtgagctg tgtgagatag atgtgaaaag ttcaaatgaa
    11761 tgcattttcc tgccccatgt atacagagcg tcatctgtac aatgaactgt atgtatgaaa
    11821 gcaaatgtac gtatttataa atggtcaaca cttggagaaa aaaa
//
