LOCUS       NM_019518               2025 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus trafficking regulator and scaffold protein tamalin
            (Tamalin), mRNA.
ACCESSION   NM_019518
VERSION     NM_019518.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Martinez-Garcia,M., Naharro,P.R., Skinner,M.W., Baran,K.A.,
            Lascarez-Lagunas,L.I., Nadarajan,S., Shin,N., Silva-Garcia,C.G.,
            Saito,T.T., Beese-Sims,S., Diaz-Pacheco,B.N., Berson,E.,
            Castaner,A.B., Pacheco,S., Martinez-Perez,E., Jordan,P.W. and
            Colaiacovo,M.P.
  TITLE     GRAS-1 is a novel regulator of early meiotic chromosome dynamics in
            C. elegans
  JOURNAL   PLoS Genet 19 (2), e1010666 (2023)
   PUBMED   36809245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Seo,Y., Mo,S., Kim,S., Kim,H. and Park,H.C.
  TITLE     Tamalin Function Is Required for the Survival of Neurons and
            Oligodendrocytes in the CNS
  JOURNAL   Int J Mol Sci 23 (21), 13395 (2022)
   PUBMED   36362204
  REMARK    GeneRIF: Tamalin Function Is Required for the Survival of Neurons
            and Oligodendrocytes in the CNS.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Pandey,S., Ramsakha,N., Sharma,R., Gulia,R., Ojha,P., Lu,W. and
            Bhattacharyya,S.
  TITLE     The post-synaptic scaffolding protein tamalin regulates
            ligand-mediated trafficking of metabotropic glutamate receptors
  JOURNAL   J Biol Chem 295 (25), 8575-8588 (2020)
   PUBMED   32376687
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Chiu,S.L., Diering,G.H., Ye,B., Takamiya,K., Chen,C.M., Jiang,Y.,
            Niranjan,T., Schwartz,C.E., Wang,T. and Huganir,R.L.
  TITLE     GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal
            Recycling of AMPA Receptors
  JOURNAL   Neuron 93 (6), 1405-1419 (2017)
   PUBMED   28285821
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Seldin,L., Muroyama,A. and Lechler,T.
  TITLE     NuMA-microtubule interactions are critical for spindle orientation
            and the morphogenesis of diverse epidermal structures
  JOURNAL   Elife 5, e12504 (2016)
   PUBMED   26765568
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Ogawa,M., Miyakawa,T., Nakamura,K., Kitano,J., Furushima,K.,
            Kiyonari,H., Nakayama,R., Nakao,K., Moriyoshi,K. and Nakanishi,S.
  TITLE     Altered sensitivities to morphine and cocaine in scaffold protein
            tamalin knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14789-14794 (2007)
   PUBMED   17766434
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Hirose,M., Kitano,J., Nakajima,Y., Moriyoshi,K., Yanagi,S.,
            Yamamura,H., Muto,T., Jingami,H. and Nakanishi,S.
  TITLE     Phosphorylation and recruitment of Syk by immunoreceptor
            tyrosine-based activation motif-based phosphorylation of tamalin
  JOURNAL   J Biol Chem 279 (31), 32308-32315 (2004)
   PUBMED   15173175
  REMARK    GeneRIF: tamalin is a novel signaling molecule that possesses a PDZ
            domain and a PDZ binding motif and mediates Syk signaling in an
            ITAM-based fashion
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Kitano,J., Kimura,K., Yamazaki,Y., Soda,T., Shigemoto,R.,
            Nakajima,Y. and Nakanishi,S.
  TITLE     Tamalin, a PDZ domain-containing protein, links a protein complex
            formation of group 1 metabotropic glutamate receptors and the
            guanine nucleotide exchange factor cytohesins
  JOURNAL   J Neurosci 22 (4), 1280-1289 (2002)
   PUBMED   11850456
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Ye,B., Sugo,N., Hurn,P.D. and Huganir,R.L.
  TITLE     Physiological and pathological caspase cleavage of the neuronal
            RasGEF GRASP-1 as detected using a cleavage site-specific antibody
  JOURNAL   Neuroscience 114 (1), 217-227 (2002)
   PUBMED   12207967
  REMARK    GeneRIF: Caspase cleavage of GRASP-1 occurs in specific brain
            regions in a time-dependent manner during development and ischemia.
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY730445.1 and BC046307.1.
            
            On May 27, 2006 this sequence version replaced NM_019518.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041603.1, BC046307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY730445.1         20-51
            33-2025             BC046307.1         1-1993
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.57 cM"
     gene            1..2025
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /note="trafficking regulator and scaffold protein tamalin"
                     /db_xref="GeneID:56149"
                     /db_xref="MGI:MGI:1860303"
     exon            1..338
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1274
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /note="GRP1-associated scaffold protein; GRP1 (general
                     receptor for phosphoinositides 1)-associated scaffold
                     protein"
                     /codon_start=1
                     /product="general receptor for phosphoinositides
                     1-associated scaffold protein"
                     /protein_id="NP_062391.3"
                     /db_xref="CCDS:CCDS27847.1"
                     /db_xref="GeneID:56149"
                     /db_xref="MGI:MGI:1860303"
                     /translation="MTLRRLRKLQQKEEATAAPDPAGRAPDSEAARAAPLPSGPPAAA
                     APPGAPGEELYAALEDYHPAELYRALAVSGGTLPRRKGSGFRWKNFTQSPEQQRKVLT
                     LEKGDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGL
                     NVEGIRHREIVDIIKASGNVLRLETLYGTSIRKAELEARLQYLKQTLYEKWGEYRSLM
                     VQEQRLVHGLVVKDPSIYDTLESVRSCLYGAGLLPGSLPFGPLLAAPGSARGGARRAK
                     GDTDDAVYHTCFFGGAEPQALPPPPPPARALGPSSAETPASVLFPAPRSTLSRSASVR
                     CAGPGGGGGAPGALWTEAREQALCGAGLRKTKYRSFRRRLLKFIPGLNRSLEEEESQL
                     "
     exon            339..388
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            389..443
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            444..546
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            547..640
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            641..707
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            708..774
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            775..2014
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /note="hexamer: TATAAA"
     polyA_site      2014
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /note="major polyA site"
ORIGIN      
        1 ctacacgcgg cccgctgggc tggcgtccca aagccgtccc taacaccatc aagcagagag
       61 agcgcggcct ctgaggggcg ccggacgccg gagccatgac cctccgccga ctcaggaagc
      121 tgcagcagaa ggaggaggcg actgccgcgc cggaccccgc tggccgggct cccgactccg
      181 aagccgctcg cgccgccccg ctaccctccg gccctccggc tgccgccgct ccgcccggag
      241 cccccgggga ggagctgtac gcagcactgg aggactatca ccctgccgag ctgtaccgcg
      301 cgctcgccgt gtccgggggt accctgcctc gccgaaaggg ctcaggattc cgttggaaga
      361 atttcactca gagtcctgaa cagcaacgga aggttctaac tttggagaaa ggggacaacc
      421 agacctttgg cttcgagatc cagacatatg gccttcacca ccgagaggag cagcgtgtag
      481 agatggtgac cttcgtctgc cgagttcatg aatccagccc tgcccagctg gctgggctca
      541 cgccagggga cactattgcc agcgtcaacg gtctcaacgt ggaaggcatc cggcaccggg
      601 agattgtcga tatcatcaag gcgtctggca acgttctcag gctggaaact ctgtacggga
      661 cgtccattcg gaaggcagaa ctggaggcgc gcctgcagta ccttaagcaa accctgtacg
      721 agaagtgggg agaatacagg tcacttatgg tacaggagca gcggctagta catggcctgg
      781 tggtgaaaga cccaagcatc tatgacacac tggagtccgt gcgctcctgc ctctacggcg
      841 caggcttgct tcccgggtcg ctgccctttg ggcctctgct cgccgcgcct gggagtgccc
      901 gcgggggtgc gcggcgggcc aaaggggaca cagacgacgc cgtgtaccac acgtgcttct
      961 ttgggggcgc cgagccgcag gcactgccac ccccgccacc ccccgcgcgc gcgttaggcc
     1021 cgagctccgc ggagaccccc gcgtccgtgc tgtttcccgc acctcgctcc acgctcagcc
     1081 gcagcgccag tgtgcggtgc gcgggcccgg gcggcggcgg gggcgcgccg ggcgcactct
     1141 ggactgaggc ccgcgagcag gccctgtgtg gcgccggcct acgcaagacc aagtaccgca
     1201 gcttccgcag acggctgctc aagttcatcc ccggactcaa ccgctccctg gaggaagagg
     1261 agagccagct gtaggggcgc gggtgggcag gtgggaagta tttatttatt tattcatcgt
     1321 aacagcctgt gcaaaaagta ggggcggtag tgtcggtcca aggaccccgg gagcccaaag
     1381 ctgcgggaga gggtccttgc tagctctggt ctttctggtc ggttcattgg cttgtctgct
     1441 gaacaaaaaa aaaagggggg gggggctagt tgctttctgc cctcccctaa accacagcag
     1501 gagctctaca gggggagaat agacactggg aattgggaga aatctggggg accaaagagg
     1561 gctgtaccag gctaaagtct gggtcagtcg tgccttgtgg gggtcctgtc ccaagaaacc
     1621 ctctcctcag atatactggc tccccagccc ttccttagcc ttggggagag gagatccacg
     1681 atggatcatt ccccacccta cagagacaga cagacagata cacacacaca cacacacaca
     1741 cacacacaca cacacacatc aatggaccag tgggccccaa gggggcaagg tgctggtccc
     1801 ctccctccaa ccttgacccc taagggctta acccctgtcc aggggcctat aactaagtgg
     1861 ggtcctgcca ggccggggtc ctgggttctg tgctccttgg ggaacaagaa tgagttcatt
     1921 caggtggggt ggggcagcct ggactgttcc accgttttct gcatatgttg cttctgaacc
     1981 acaaactgta taaaattgat gggttttttt tgcaaaaaaa aaaaa
//
