LOCUS       NM_011528               1276 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transaldolase 1 (Taldo1), mRNA.
ACCESSION   NM_011528
VERSION     NM_011528.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1276)
  AUTHORS   Li,C., Song,Z., Gao,P., Duan,W., Liu,X., Liang,S., Gong,Q. and
            Guo,J.
  TITLE     Transaldolase inhibits CD36 expression by modulating
            glutathione-p38 signaling, exerting protective effects against
            macrophage foam cell formation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (9), 1496-1505 (2023)
   PUBMED   37528662
  REMARK    GeneRIF: Transaldolase inhibits CD36 expression by modulating
            glutathione-p38 signaling, exerting protective effects against
            macrophage foam cell formation.
REFERENCE   2  (bases 1 to 1276)
  AUTHORS   Oaks,Z., Patel,A., Huang,N., Choudhary,G., Winans,T., Faludi,T.,
            Krakko,D., Duarte,M., Lewis,J., Beckford,M., Blair,S., Kelly,R.,
            Landas,S.K., Middleton,F.A., Asara,J.M., Chung,S.K.,
            Fernandez,D.R., Banki,K. and Perl,A.
  TITLE     Cytosolic aldose metabolism contributes to progression from
            cirrhosis to hepatocarcinogenesis
  JOURNAL   Nat Metab 5 (1), 41-60 (2023)
   PUBMED   36658399
  REMARK    Erratum:[Nat Metab. 2023 Feb;5(2):349. doi:
            10.1038/s42255-023-00752-8.. PMID: 36755183]
REFERENCE   3  (bases 1 to 1276)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   4  (bases 1 to 1276)
  AUTHORS   Moriyama,T., Tanaka,S., Nakayama,Y., Fukumoto,M., Tsujimura,K.,
            Yamada,K., Bamba,T., Yoneda,Y., Fukusaki,E. and Oka,M.
  TITLE     Two isoforms of TALDO1 generated by alternative translational
            initiation show differential nucleocytoplasmic distribution to
            regulate the global metabolic network
  JOURNAL   Sci Rep 6, 34648 (2016)
   PUBMED   27703206
  REMARK    GeneRIF: These results demonstrate that the nucleocytoplasmic
            distribution of TALDO1, modulated via alternative translational
            initiation and dimer formation, plays an important role in a wide
            range of metabolic networks
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1276)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1276)
  AUTHORS   Hanczko,R., Fernandez,D.R., Doherty,E., Qian,Y., Vas,G., Niland,B.,
            Telarico,T., Garba,A., Banerjee,S., Middleton,F.A., Barrett,D.,
            Barcza,M., Banki,K., Landas,S.K. and Perl,A.
  TITLE     Prevention of hepatocarcinogenesis and increased susceptibility to
            acetaminophen-induced liver failure in transaldolase-deficient mice
            by N-acetylcysteine
  JOURNAL   J Clin Invest 119 (6), 1546-1557 (2009)
   PUBMED   19436114
  REMARK    GeneRIF: Reduced beta-catenin phosphorylation and enhanced c-Jun
            expression in Taldo1-/- livers reflected adaptation to oxidative
            stress
REFERENCE   7  (bases 1 to 1276)
  AUTHORS   Perl,A., Qian,Y., Chohan,K.R., Shirley,C.R., Amidon,W.,
            Banerjee,S., Middleton,F.A., Conkrite,K.L., Barcza,M.,
            Gonchoroff,N., Suarez,S.S. and Banki,K.
  TITLE     Transaldolase is essential for maintenance of the mitochondrial
            transmembrane potential and fertility of spermatozoa
  JOURNAL   Proc Natl Acad Sci U S A 103 (40), 14813-14818 (2006)
   PUBMED   17003133
  REMARK    GeneRIF: These data reveal an essential role of transaldolase in
            sperm-cell mitochondrial function and, thus, male fertility.
REFERENCE   8  (bases 1 to 1276)
  AUTHORS   Kusuda,J., Hirai,M., Toyoda,A., Tanuma,R., Nomura-Kitabayashi,A.
            and Hashimoto,K.
  TITLE     Cloning and chromosomal localization of a paralog and a mouse
            homolog of the human transaldolase gene
  JOURNAL   Gene 209 (1-2), 13-21 (1998)
   PUBMED   9524206
REFERENCE   9  (bases 1 to 1276)
  AUTHORS   Gumaa,K.A. and McLean,P.
  TITLE     The pentose phosphate pathway of glucose metabolism. Enzyme
            profiles and transient and steady-state content of intermediates of
            alternative pathways of glucose metabolism in Krebs ascites cells
  JOURNAL   Biochem J 115 (5), 1009-1029 (1969)
   PUBMED   5360673
REFERENCE   10 (bases 1 to 1276)
  AUTHORS   HIATT,H.H.
  TITLE     Glycogen formation via the pentose phosphate pathway in mice in
            vivo
  JOURNAL   J Biol Chem 224 (2), 851-859 (1957)
   PUBMED   13405914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163434.5.
            
            On Mar 20, 2010 this sequence version replaced NM_011528.3.
            
            Summary: This gene encodes a key enzyme of the nonoxidative pentose
            phosphate pathway that provides ribose-5-phosphate for nucleic acid
            synthesis and nicotinamide adenine dinucleotide phosphate (NADPH)
            for lipid biosynthesis. The encoded protein is important for
            maintaining structure and function of mitochondria. Studies in
            knockout mice identify that deficiency of this gene product is a
            cause of sperm dysmotility and male infertility. Deficiency of this
            protein has also been identified as a cause of hepatocarcinogenesis
            in mice. Two related pseudogenes have been identified on chromosome
            10. [provided by RefSeq, Mar 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094277.1, U67611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC163434.5         188391-188549
            160-283             AC163434.5         192280-192403
            284-391             AC163434.5         194726-194833
            392-523             AC163434.5         196519-196650
            524-699             AC163434.5         197812-197987
            700-897             AC163434.5         198103-198300
            898-1043            AC163434.5         198415-198560
            1044-1276           AC163434.5         198975-199207
FEATURES             Location/Qualifiers
     source          1..1276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.73 cM"
     gene            1..1276
                     /gene="Taldo1"
                     /note="transaldolase 1"
                     /db_xref="GeneID:21351"
                     /db_xref="MGI:MGI:1274789"
     exon            1..159
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1076
                     /gene="Taldo1"
                     /EC_number="2.2.1.2"
                     /codon_start=1
                     /product="transaldolase"
                     /protein_id="NP_035658.1"
                     /db_xref="CCDS:CCDS22011.1"
                     /db_xref="GeneID:21351"
                     /db_xref="MGI:MGI:1274789"
                     /translation="MSGSPVKRQRMESALDQLKQFTTVVADTGDFNAIDEYKPQDATT
                     NPSLILAAAQMPAYQELVEEAIAYGKKLGGPQEEQIKNAIDKLFVLFGAEILKKIPGR
                     VSTEVDARLSFDKDAMVARARRLIELYKEAGVGKDRILIKLSSTWEGIQAGKELEEQH
                     GIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPQEDPGVKSVT
                     KIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLKDNSKLAPALSV
                     KAAQTSDSEKIHLDEKAFRWLHNEDQMAVEKLSDGIRKFAADAIKLERMLTERMFSAE
                     NGK"
     exon            160..283
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..391
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..523
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..699
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..897
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1043
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1276
                     /gene="Taldo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1247..1252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taldo1"
                     /note="hexamer: ATTAAA"
     polyA_site      1268
                     /gene="Taldo1"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgcggg gcattgtggg ttagcacgca ccggctaccg cctcagctgt tcgcgtttcg
       61 ccatgtcggg gtccccggta aagcgccaga ggatggagtc cgccttggac cagctcaagc
      121 agttcaccac cgtggtggcc gacacgggtg atttcaatgc catcgatgaa tacaagcccc
      181 aagatgccac caccaaccca tccctgatcc tggctgcagc ccagatgcct gcctaccaag
      241 agctggtaga ggaggccatt gcctacggca agaagctggg tgggcctcaa gaggagcaga
      301 ttaaaaatgc cattgacaaa ctttttgtgc tgtttggagc agaaatatta aagaagattc
      361 caggccgtgt atccacagaa gttgatgcaa ggctttcctt tgataaggat gccatggtgg
      421 cccgagccag gcgcctcatc gagctttaca aagaagctgg ggtcggcaag gacagaattc
      481 tcatcaagtt atcatcaacc tgggagggga ttcaggctgg aaaggagctg gaggaacagc
      541 atggcatcca ctgcaacatg acactgcttt tctccttcgc ccaggctgtg gcctgtgctg
      601 aggcgggcgt gacgctcatc tctccctttg tggggcgcat ccttgattgg catgtggcaa
      661 acacagacaa gaaatcctat gaaccccagg aggaccctgg ggtcaagagt gtcaccaaaa
      721 tctacaacta ctacaagaag ttcggctaca agaccattgt catgggcgcc tccttccgca
      781 acacgggcga gatcaaagca ctggcgggct gtgacttcct caccatctcc ccgaagctcc
      841 tgggggagct gctcaaggat aacagcaagc tggcgcctgc gctctctgtc aaggcggccc
      901 agaccagtga ctcggagaag atacatctgg acgagaaggc cttccgttgg ctgcacaacg
      961 aagaccaaat ggccgtggag aagctctccg acggcatccg caaatttgct gctgatgcca
     1021 taaagttgga gcggatgctc acggaacgaa tgttcagcgc tgagaacggg aagtagtgca
     1081 acacccgagg ccccagtcct gcaccgaggc tgaccccaga cctgcactgc ctttgagctg
     1141 ggtcctaatt gcacatggct tgtgacgaat gaatcttgca ttttttagtg atcggagaag
     1201 ggatggatca taggattctg attttatgtg aaattttgtc taattcatta aagcagttgc
     1261 ttttcctatg ctgttt
//
