LOCUS       NM_009317               2975 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus T cell acute lymphocytic leukemia 2 (Tal2), mRNA.
ACCESSION   NM_009317
VERSION     NM_009317.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2975)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2975)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2975)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2975)
  AUTHORS   Kirjavainen,A., Singh,P., Lahti,L., Seja,P., Lelkes,Z.,
            Makkonen,A., Kilpinen,S., Ono,Y., Salminen,M., Aitta-Aho,T.,
            Stenberg,T., Molchanova,S., Achim,K. and Partanen,J.
  TITLE     Gata2, Nkx2-2 and Skor2 form a transcription factor network
            regulating development of a midbrain GABAergic neuron subtype with
            characteristics of REM-sleep regulatory neurons
  JOURNAL   Development 149 (14) (2022)
   PUBMED   35815619
REFERENCE   5  (bases 1 to 2975)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   6  (bases 1 to 2975)
  AUTHORS   Zhang,S., Ramsay,E.S. and Mock,B.A.
  TITLE     Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and
            p19ARF, is a candidate for the plasmacytoma susceptibility locus,
            Pctr1
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2429-2434 (1998)
   PUBMED   9482902
REFERENCE   7  (bases 1 to 2975)
  AUTHORS   Yasui,K., Zhang,S.C., Uemura,M., Aizawa,S. and Ueki,T.
  TITLE     Expression of a twist-related gene, Bbtwist, during the development
            of a lancelet species and its relation to cephalochordate anterior
            structures
  JOURNAL   Dev Biol 195 (1), 49-59 (1998)
   PUBMED   9520323
REFERENCE   8  (bases 1 to 2975)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   9  (bases 1 to 2975)
  AUTHORS   Baer,R.
  TITLE     TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins
            implicated in T cell acute leukaemia
  JOURNAL   Semin Cancer Biol 4 (6), 341-347 (1993)
   PUBMED   8142619
  REMARK    Review article
REFERENCE   10 (bases 1 to 2975)
  AUTHORS   Xia,Y., Brown,L., Yang,C.Y., Tsan,J.T., Siciliano,M.J., Espinosa,R.
            3rd, Le Beau,M.M. and Baer,R.J.
  TITLE     TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32)
            translocation in human T-cell leukemia
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 11416-11420 (1991)
   PUBMED   1763056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844585.11.
            
            On Jan 31, 2019 this sequence version replaced NM_009317.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018448.1, BC110625.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL844585.11        25508-25580
            74-2975             AL844585.11        31618-34519
FEATURES             Location/Qualifiers
     source          1..2975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 28.75 cM"
     gene            1..2975
                     /gene="Tal2"
                     /gene_synonym="bHLHa19"
                     /note="T cell acute lymphocytic leukemia 2"
                     /db_xref="GeneID:21350"
                     /db_xref="MGI:MGI:99540"
     exon            1..73
                     /gene="Tal2"
                     /gene_synonym="bHLHa19"
                     /inference="alignment:Splign:2.1.0"
     exon            74..2975
                     /gene="Tal2"
                     /gene_synonym="bHLHa19"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..410
                     /gene="Tal2"
                     /gene_synonym="bHLHa19"
                     /note="TAL-2"
                     /codon_start=1
                     /product="T-cell acute lymphocytic leukemia protein 2
                     homolog"
                     /protein_id="NP_033343.1"
                     /db_xref="CCDS:CCDS18192.1"
                     /db_xref="GeneID:21350"
                     /db_xref="MGI:MGI:99540"
                     /translation="MTRKIFTNTRERWRQQSVNNAFAKLRKLIPTHPPDKKLSKNETL
                     RLAMRYINFLVKVLGEQSLHQTGVAAQGNILGLFPPKTRLPDEDDRTLLNDYRVPSPG
                     PSHGAP"
     regulatory      1131..1136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tal2"
                     /gene_synonym="bHLHa19"
                     /note="hexamer: AATAAT"
     polyA_site      1150
                     /gene="Tal2"
                     /gene_synonym="bHLHa19"
                     /note="major polyA site"
ORIGIN      
        1 aggcgagggc gcacacagac tggcgctgcg acagctacct tgactgcgcc ggttcccagc
       61 tcctagcaag aaggaacctg gacatgacca gaaagatctt cacaaatacc agggagcggt
      121 ggaggcagca gagtgtcaac aatgcctttg ccaagctgag gaaacttatc cctactcacc
      181 ctccagacaa gaagctgagc aagaacgaga cgcttcgctt ggcaatgagg tatatcaact
      241 tcttggtcaa ggtcttggga gagcaaagcc tgcatcaaac aggagtcgct gctcagggaa
      301 acattctggg gctctttccc ccaaagaccc gcctgccaga tgaggatgac agaactctac
      361 tgaatgacta ccgagttcct tcccctggcc caagccacgg ggctccctaa ggtggtggtg
      421 acagtcagcc cccagggcag cactggttga agagtcacgt gatttcatgc tgtggcgagg
      481 tatgacaccg gaagtgacaa agtgatgaac agcagctgag agctgaaagg agacttgagc
      541 aatattgctc gagccctatt accctagaac ttcaggtggg gaaaaaaacc agcaaaacaa
      601 aacagccgta agtttaaaac tgctgtttcg ctcatgacat cagtaatgag gacttcctta
      661 gactggatct cagatgaaag aacaatgctt gttgccctct gaatatatta aaacgtttat
      721 tttgagaaag gagacgcgtt tgatgggagg caaatacatg ttaagactga tgagtgaaga
      781 gttagccact gtggaaacca acccgggaga gccatggggc cggccctccc tggagggatg
      841 cccctctgga gcagagcagt gaggattatg tgtgtggaaa gcctcctttg acctctgtgg
      901 aatcatgata ttcgacttca gttgagcctc tgatacatat actatctctg agaacaaata
      961 gcaggtttca tccatctaag gaaaagtctt gctaacttat gaactggact gcatggtttt
     1021 cttataaacc ttagctaaaa tgagcccgag cacaccctta gtttgacaca cttggtactg
     1081 actcttttaa ttcagcccaa attcatgctg acttaagtcc tgtaaaatta aataattacg
     1141 aaaatccgaa tattgccatt ttatgattca ttgagagtaa acaatagaac tagaatacca
     1201 gatgctaatg tacgagtgct ttagacttgg tcttcctgcc tcccacagag catttcctca
     1261 tccttaagct ggggcagagt agcacccagt aaatcagtag cacactgtgg atcttgcagt
     1321 catcaccaca aaccaacctg gtcctgatgg tgcctggact caaagataag tccagtagta
     1381 gctgagcccc agttgcagaa aatgcctatc tctggagcat tttatttccc caaagttcgt
     1441 ttggctttat aatcttttga attacaggtg ggcagtctat ggattgtggt tataaatttt
     1501 cgatagctac actatagaga aatttaagct tctttgtctc tctagaaagt attttcttta
     1561 tatgtaacaa ggtgactgtc attaaggtca attcagccga tgcacttata gcacaccggg
     1621 tttccctcta agtcctttat ttaccctgca cttgattaat ctccccacag aaacagtata
     1681 gattatagag acaagtgagc acagaggcca ggagattact tccgtccacc ccaagtgtgc
     1741 atatcattct tagcagcctg gggagagtca gacactggga catttcaatg tctttgtgta
     1801 atgccagcct ctcacctggc attagataaa aacagcacat ttggcattgc tttgctttta
     1861 cttagcttct ttgaatgtga ggaaggcaga gaggacctct gtccctaaat gcaggacttt
     1921 tgtgccatac acagaatgct cttttccctg cttgctgggc ctttcgtctg tgctcagaga
     1981 gggccttccc tgaagtgctc caaggacacc aaatgaaatg aggaggttga gctgtaatta
     2041 cactgaatga ggggggtgat aatttcaaga acccctagag gaaatccttt caaagatgaa
     2101 taaatctttg caatattatt ataggtgatg tacttcttaa aatatttatt caccttaaaa
     2161 tttctatacc aagttgtatt aaattaacat cagaagaagg aggaggagga ggaggaggag
     2221 gaggaggagg aggaggagga ggaggaggag aagaagaaga aggagaagga gaaagaagga
     2281 gagttgttat tacatcaggc ccaaatagtc acggtatgta tgggactaga aactaattca
     2341 aaactctctg tatgtttttc actggtatct tcatgccagg catggtggtc ctagcagtaa
     2401 gaattcatag ttcagatgca tcatagtcta ccagatgcta catctgttta tgggtcattt
     2461 gagtctaaca gaagagttaa gccacatttt ctaactatgc tcctctcttc cttgaactaa
     2521 agtgagtgtc tggtcttctt tggactgtaa tggaaatgct tagcaaccac atccaagttt
     2581 tatacagact ctgcttggtt actccacttc acagagaaga aaaaaggtcc agggagtttc
     2641 agaatggctt tccaaaggtc tcggggcatc cgcagaggtc taggacacag atgcctgttt
     2701 cttgcttgac cctttccagc ttttccttac tgctgatcag tcaacgtgta tctggggttg
     2761 aaaacaaaca aaagcgcctt acattaacct cttcctgaaa gcatttagtg atctatgctt
     2821 tttgtgacac aaaattatca tgctttgtag aatgtgagta gatgtgtcaa ccaaagattt
     2881 ttaaaaatct gttagtatgt tttgtgagtt cttgaccatt aattataatt tgctatttaa
     2941 ctgttaattt attacaaata aattatttaa gaaaa
//
