LOCUS       NM_001287388            4254 bp    mRNA    linear   ROD 18-AUG-2023
DEFINITION  Mus musculus T cell acute lymphocytic leukemia 1 (Tal1), transcript
            variant 2, mRNA.
ACCESSION   NM_001287388 XM_006502911
VERSION     NM_001287388.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4254)
  AUTHORS   Sharma A, Mistriel-Zerbib S, Najar RA, Engal E, Bentata M, Taqatqa
            N, Dahan S, Cohen K, Jaffe-Herman S, Geminder O, Baker M, Nevo Y,
            Plaschkes I, Kay G, Drier Y, Berger M and Salton M.
  TITLE     Isoforms of the TAL1 transcription factor have different roles in
            hematopoiesis and cell growth
  JOURNAL   PLoS Biol 21 (6), e3002175 (2023)
   PUBMED   37379322
  REMARK    GeneRIF: Isoforms of the TAL1 transcription factor have different
            roles in hematopoiesis and cell growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4254)
  AUTHORS   Puelles L and Hidalgo-Sanchez M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4254)
  AUTHORS   Chuang CK, Chen SF, Su YH, Chen WH, Lin WM, Wang IC and Shyue SK.
  TITLE     The Role of SCL Isoforms in Embryonic Hematopoiesis
  JOURNAL   Int J Mol Sci 24 (7), 6427 (2023)
   PUBMED   37047400
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4254)
  AUTHORS   Serina Secanechia YN, Bergiers I, Rogon M, Arnold C, Descostes N,
            Le S, Lopez-Anguita N, Ganter K, Kapsali C, Bouilleau L, Gut A,
            Uzuotaite A, Aliyeva A, Zaugg JB and Lancrin C.
  TITLE     Identifying a novel role for the master regulator Tal1 in the
            Endothelial to Hematopoietic Transition
  JOURNAL   Sci Rep 12 (1), 16974 (2022)
   PUBMED   36217016
  REMARK    GeneRIF: Identifying a novel role for the master regulator Tal1 in
            the Endothelial to Hematopoietic Transition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4254)
  AUTHORS   Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H,
            Sakai T, Yoshimura T, Miyasaka M and Hayasaka H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4254)
  AUTHORS   Hanley-Hyde J, Mushinski JF, Sadofsky M, Huppi K, Krall M, Kozak CA
            and Mock B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
REFERENCE   7  (bases 1 to 4254)
  AUTHORS   Shultz LD, Lane PW, Coman DR, Taylor S, Hall E, Lyons B, Wood BG
            and Schlager G.
  TITLE     Hairpatches, a single gene mutation characterized by progressive
            renal disease and alopecia in the mouse. A potential model for a
            newly described heritable human disorder
  JOURNAL   Lab Invest 65 (5), 588-600 (1991)
   PUBMED   1836514
REFERENCE   8  (bases 1 to 4254)
  AUTHORS   Begley CG, Visvader J, Green AR, Aplan PD, Metcalf D, Kirsch IR and
            Gough NM.
  TITLE     Molecular cloning and chromosomal localization of the murine
            homolog of the human helix-loop-helix gene SCL
  JOURNAL   Proc Natl Acad Sci U S A 88 (3), 869-873 (1991)
   PUBMED   1704135
REFERENCE   9  (bases 1 to 4254)
  AUTHORS   Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J
            and Kirsch IR.
  TITLE     The SCL gene is formed from a transcriptionally complex locus
  JOURNAL   Mol Cell Biol 10 (12), 6426-6435 (1990)
   PUBMED   2247063
REFERENCE   10 (bases 1 to 4254)
  AUTHORS   Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A,
            Crist W, Ozanne B, Siciliano MJ and Baer R.
  TITLE     The tal gene undergoes chromosome translocation in T cell leukemia
            and potentially encodes a helix-loop-helix protein
  JOURNAL   EMBO J 9 (2), 415-424 (1990)
   PUBMED   2303035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157852.1 and BC063060.1.
            
            [WARNING] On Nov 27, 2023 this sequence was replaced by
            NM_001287388.2.
            
            On Jan 5, 2014 this sequence version replaced XM_006502911.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157852.1, SRR7345562.3052651.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3703              AK157852.1         2-3704
            3704-4254           BC063060.1         3687-4237
FEATURES             Location/Qualifiers
     source          1..4254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.73 cM"
     gene            1..4254
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
                     /note="T cell acute lymphocytic leukemia 1"
                     /db_xref="GeneID:21349"
                     /db_xref="MGI:MGI:98480"
     exon            1..61
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..209
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..656
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..751
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..4230
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4211..4216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
     polyA_site      4230
                     /gene="Tal1"
                     /gene_synonym="bHLHa17; Hpt; Scl; SCL/tal-1; tal-1"
ORIGIN      
        1 gtcttcccgc ccgcagcgcc aggcctggat tcgcgctgcc cctgggtttc gcctatttct
       61 gaccgcgcag gacctcacgg caagctaagt aactgctggt ctctcagcga gagccgggaa
      121 acccagcttc ggggtcctac ctcgacccct ctccagcgga ggagtggagg tcctaaccag
      181 ccgagtaggt ctctctaaat atgccccagg atgacggagc ggccgccgag cgaggcggca
      241 cgcagtgacc cgcaactaga gggacaggac gcggccgagg cccgcatggc ccccccgcac
      301 ctagtcctgc tcaacggcgt cgccaaggag acgagccgcg cagccccggc tgagcccccc
      361 gtcatcgagc taggagcgcg cagcggcgcg gggggcggcc ctgccagtgg gggcggtgcc
      421 gcgagggact taaagggccg cgacgcagta gcagccgaag ctcgccttcg ggtgcccacc
      481 accgagctgt gcagacctcc cggacccgcc ccggcgcccg cgcccgcctc ggctcctgca
      541 gagctgcctg gagacggccg catggtgcag ctgagcccgc ccgcgctggc agcccctgcc
      601 ggccccggcc gagcgctgct ctatagcctt agccagccgc tcgcctcact aggcagtggg
      661 ttctttgggg aaccggatgc cttccccatg ttcaccaaca acaaccgggt gaagaggagg
      721 ccctccccat atgagatgga gatttctgat ggtcctcaca ccaaagtagt gcggcgcatc
      781 ttcaccaaca gccgggaacg atggcggcag cagaatgtga atggggcatt tgctgagctc
      841 agaaagctga tccccaccca cccaccagac aagaaactaa gcaagaatga gatcctccgc
      901 cttgccatga agtacatcaa tttcctggcc aagttactca atgaccagga ggaggaaggc
      961 acccagcgtg ccaagcctgg caaggacccc gtggtgggag ctggtggggg tggggcaggg
     1021 ggtggcatcc cccctgaaga ccttctacag gacgtgcttt cccccaactc cagctgtggc
     1081 agctctctgg atggggcagc cagcccggac agttacacag aggagccaac acccaagcac
     1141 acttcccgca gcctccatcc tgccctgctg cctgccgctg atggggctgg cccccggtga
     1201 tgcgtctggg gctgcccagg gccagcaggc aggggccttt aggcccctgg gttgctgggc
     1261 ttcagggcag gtgggatgag aagcaggtca atggacttat gtgaacttcc cttacagttt
     1321 gaactttggg aagtcccaac tgaccctagg ctggcatttc tgtttcctgc atggaaacag
     1381 aagaggcaaa cagagtgaag tagtaggtac tttttctgaa gatggcacgg tcttctccct
     1441 ttcccaagcc caaagatttc cccaatgatg aggctcaagt gtctagtttt ggtctagagt
     1501 ttgtgagcct tgttttggac aagatctggg gttgtcacct gttacctgag gcatccaatt
     1561 ggcctctgcc ttgcctttct cccatcccga gctggctggg tggcttttgt ggcagcttct
     1621 gttcaaatac ttaggtaccc aagagctgac catttcttga gccccatctt cacccaggtc
     1681 catgttgatc catccagctt gccagctgct gtggagagtc aagctttgag gtgccttctt
     1741 cagggcctgg ttggaaaaga tggccagtaa acagacaacc tgctctcaac tagctggggc
     1801 agaaaaccca acagcccctt ttgctccagg gaatcagagc tctctccctc actgagactt
     1861 gccttcctat cctgtggctg tgaggaccaa gtcagcagcc ttgagcatgc tttgttgggc
     1921 tgtgtgcagg cacagaaagg gaaagtgaca ttagggcaag caaagcaaga gtgtttgggg
     1981 cactgggttt caactccagc gcatccctgt ttgtgcagga gagcaaagga tagagtgctg
     2041 gtgcattgca tgttggtgct ggggctgtgc agcccatagg cttccccagg aagcccgaag
     2101 gaagcttccc attgcaagat gtctgttggc tgatggtctg gatgtccaaa tggaggacaa
     2161 actgtcctgt acatactcta tttgggattc tgcctgacca gttgttggtt ggcaactcta
     2221 ggccatgata ccacccaaga tgcagcctga tgctaaggca aggagtccag tcagaggcaa
     2281 ggccctggct gagacctggg catgcacctt tgctcagctt aactttaagt actctcccct
     2341 cacacaactg caggccctac gtgtgtgcat ggtaggttgg cttaacatga aacgagtgcc
     2401 ccctctaaaa cttgtacatg aaagttttgt aaagcagacc cttctcctcc atcttttaaa
     2461 gacacaaccc ctgcaagtca ttttgtaaag tggagaatcc ttttgtagta tggacaaata
     2521 ccccattgtt tctcccctgt gtcaatccag gtggtgggac cgatctatcc taaagctagg
     2581 cctgcctata atgaagttca agctcatgaa acaaagtgcg cagaagtcct gtgtatctgt
     2641 cattgtattg gtgtcactca gttctcactc tctccagggt ttgcctttga gctagagaga
     2701 aaatatccaa aggccccatc atgtaacgta tgagcccatc acttttctgt tggagtttca
     2761 gcatgatgtt tcagttcaca ccatgatgga gcctgagtat agacttaggc agacagagac
     2821 tgatcctgtt cctgctcccc tccccttctt attaagtact gagggccccc aggtaatggg
     2881 acaatgtggt cagctactaa ggcattgtga ttctttgtct cctatcacat tctgctatca
     2941 catgaacatt aaggctggtt ctttcccatt gcgtgggagt tagttcaagg ggtctgaccc
     3001 atgaggaaat gggtccaaag ctgtgtttgc ttcttagtgg aatgagttgg gaatgaaaac
     3061 tgtggctctg taggtggatt ctatgagagg gatcacactt ttgttgggag cctaagctgc
     3121 agttccctac atcagctttg cagcttcact gggataaaca cgctaggcgg tggacggact
     3181 gtgatcataa cattggaagt ccattgggtc cgtaaagact gctctggagc acagagggcc
     3241 ggtgcatcgc gggggggggg ggggcgggga ttgcacacac ggggttctgt gttctacacc
     3301 cagcacaggc acaaaagaag cttcataacc cttagtactg accgtgccgt gaggttccag
     3361 ccagagttca ggcctgggca gttgatgtgt ttgtgtcatt tggattataa aatattttcc
     3421 attgagttat gtagatgcta atttctcaag attaatctta atttctcccc gattccaagg
     3481 caagaaacag gagtgagaag gggtgagaga tttcgaaagt ttctaaaggg gctgggcagg
     3541 gaagagccag ggttttggtc tttgtaagat ctaaggaaga ccctgaattc tgttctcata
     3601 ctccataccc catatctttc ttcctctgtg tcttccttgc ccttaaagaa attgcagcat
     3661 tccaagaaca atatctgtac aaagggggaa atgtaagcat gagaaaacat taaaaaaaaa
     3721 aaacagtgat gaacataacc acagagagaa tcccaccctt caagaataat tcatgtttat
     3781 ttgtggtggc aaataacaaa atggtacaac ctttatcctt ttccagaaac aaaaaccaag
     3841 ggcacagcaa ctagagtgag ctgacagcta ttttggcctt tttggtgggt ctagccgtac
     3901 ttgggatccc agtggtacat gaccctctgc cgaaggcttg cctcagtctg tgtacatagc
     3961 acgccatgtc tgtgggcaag cccagcactt tgcgtcagtg tcgtactgta tgtaatgaac
     4021 tgtgttggtc tctgtgtttt ttttttctga agaagaggag taactactcc gggtaccttg
     4081 atatttgtac agcctatagg ccaacactgc gggcgtgtga ctctttattg aaaaacaaaa
     4141 acaaaaaaat accagtgtgg tgatgatagt gtgtgtatat atatataagg ttatatgggg
     4201 aagatttcta aataaaagtt ttacaaaggg aaaaaaaaaa aaaaaaaaaa aaaa
//
