LOCUS       NM_178598               1382 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transgelin 2 (Tagln2), mRNA.
ACCESSION   NM_178598
VERSION     NM_178598.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Li,Z., Ye,Z., Ma,J., Gu,Q., Teng,J. and Gong,X.
  TITLE     MicroRNA-133b alleviates doxorubicin-induced cardiomyocyte
            apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   33982775
  REMARK    GeneRIF: MicroRNA133b alleviates doxorubicininduced cardiomyocyte
            apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   Gu,W.K., Li,X.M., Edderkaoui,B., Strong,D.D., Lau,K.H.,
            Beamer,W.G., Donahue,L.R., Mohan,S. and Baylink,D.J.
  TITLE     Construction of a BAC contig for a 3 cM biologically significant
            region of mouse chromosome 1
  JOURNAL   Genetica 114 (1), 1-9 (2002)
   PUBMED   11990753
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   10 (bases 1 to 1382)
  AUTHORS   Stanier,P., Abu-Hayyeh,S., Murdoch,J.N., Eddleston,J. and Copp,A.J.
  TITLE     Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and
            9: further evidence for a paralogous relationship
  JOURNAL   Genomics 51 (1), 144-147 (1998)
   PUBMED   9693045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151576.1.
            
            On Jul 15, 2006 this sequence version replaced NM_178598.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151576.1, BC049861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.89 cM"
     gene            1..1382
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="transgelin 2"
                     /db_xref="GeneID:21346"
                     /db_xref="MGI:MGI:1312985"
     exon            1..87
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     exon            88..295
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..715
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative; transgelin 2 (MGD|MGI:1312985
                     GB|BC049861, evidence: BLASTN, 99%, match=1379);
                     SM22-beta"
                     /codon_start=1
                     /product="transgelin-2"
                     /protein_id="NP_848713.1"
                     /db_xref="CCDS:CCDS35784.1"
                     /db_xref="GeneID:21346"
                     /db_xref="MGI:MGI:1312985"
                     /translation="MANRGPSYGLSREVQQKIEKQYDADLEQILIQWITTQCREDVGQ
                     PQPGRENFQKWLKDGTVLCKLINSLYPEGQAPVKKIQASSMAFKQMEQISQFLQAAER
                     YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPR
                     NFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL"
     exon            296..470
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     exon            471..573
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1382
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative"
     polyA_site      1382
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /note="putative"
ORIGIN      
        1 gaaaactcca agcccggccg ggtcttgagc tccactcgcc gctgcagccc ctgtcgtgcg
       61 tgcgctctca tccagccctc ttggacgctc tttgccatca ccacagctgc tcagaatggc
      121 caacagggga ccttcctacg gcctgagccg agaggtgcag cagaagattg agaagcagta
      181 cgacgcggat ctggagcaga tcctcatcca gtggatcacc actcagtgcc gtgaggacgt
      241 gggccagccc cagcctggcc gtgagaactt ccagaagtgg ctcaaggacg gcacggttct
      301 gtgcaagctt attaattcac tgtatcctga ggggcaggcc ccagtaaaga agatccaggc
      361 ctcttcgatg gccttcaagc agatggagca gatctcccag ttcctgcagg cagccgagcg
      421 ctatggcatt aacaccacgg acatcttcca gactgtggat ctctgggaag gaaagaacat
      481 ggcttgtgtg cagcggacac taatgaacct gggtgggctg gcagtagcca gggacgatgg
      541 gctcttctct ggggatccca actggtttcc taagaaatcc aaggagaacc ctcggaactt
      601 ctcggacaac cagttgcaag agggcaagaa cgtgattggg ttgcagatgg gcaccaaccg
      661 tggagcatct caggccggca tgaccggcta tgggatgcca cggcagatcc tctgatcata
      721 ctctctctcc ttcccctgcc ctccatgaat ggttaatata tatgtatata tatgttttag
      781 cagacattcc ctgagagccc ctggattgct gaactcccct ctgccagggt ccaggccagc
      841 ctatcttgtc accactggca gggcctgata attgcctctc tctctctctc tctttctctc
      901 tctctctctc tctctctctc tctctctctc tctctgggct tactaatgca ttccttcccc
      961 cacaaccatc aaaactggac caacaaaaac cctgggacca aagttgcctc cccacagcat
     1021 ctttcctgct ttcctgatct cttcttttag tccatccctt ggctaggagt cagagattct
     1081 gccccatggc ctgatgctgc accgaccctt ccttctacaa ggaggcctct cctacagctg
     1141 tggctgcagg gacttaattt atagggaggg gcctgtggct gtcactccag ccacagctgg
     1201 gctgtactta ccacacgtct gggcagcttt ccctagcaga ggctctttgg cttctttctt
     1261 tccattcctc tctcactgtg gctaaggggt ggagcagagg taggacggct gcccaccatg
     1321 ctctggggct tgacgaacac gagtttgctg attttaaata aaaagatctc attttgtttt
     1381 gc
//
