LOCUS       NP_848713                199 aa            linear   ROD 30-APR-2024
DEFINITION  transgelin-2 [Mus musculus].
ACCESSION   NP_848713
VERSION     NP_848713.1
DBSOURCE    REFSEQ: accession NM_178598.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 199)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 199)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (residues 1 to 199)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 199)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 199)
  AUTHORS   Li,Z., Ye,Z., Ma,J., Gu,Q., Teng,J. and Gong,X.
  TITLE     MicroRNA-133b alleviates doxorubicin-induced cardiomyocyte
            apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   33982775
  REMARK    GeneRIF: MicroRNA133b alleviates doxorubicininduced cardiomyocyte
            apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
REFERENCE   6  (residues 1 to 199)
  AUTHORS   Gu,W.K., Li,X.M., Edderkaoui,B., Strong,D.D., Lau,K.H.,
            Beamer,W.G., Donahue,L.R., Mohan,S. and Baylink,D.J.
  TITLE     Construction of a BAC contig for a 3 cM biologically significant
            region of mouse chromosome 1
  JOURNAL   Genetica 114 (1), 1-9 (2002)
   PUBMED   11990753
REFERENCE   7  (residues 1 to 199)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   8  (residues 1 to 199)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   9  (residues 1 to 199)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   10 (residues 1 to 199)
  AUTHORS   Stanier,P., Abu-Hayyeh,S., Murdoch,J.N., Eddleston,J. and Copp,A.J.
  TITLE     Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and
            9: further evidence for a paralogous relationship
  JOURNAL   Genomics 51 (1), 144-147 (1998)
   PUBMED   9693045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151576.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151576.1, BC049861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.89 cM"
     Protein         1..199
                     /product="transgelin-2"
                     /note="SM22-beta"
                     /calculated_mol_wt=22264
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Site            17
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Region          18..154
                     /region_name="CH_TAGLN2"
                     /note="calponin homology (CH) domain found in
                     transgelin-2; cd21280"
                     /db_xref="CDD:409129"
     Site            20
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Site            order(26,30,88,90..91,94..95,97,107..115,121,123..124,
                     126..127,130..131,134)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409129"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Region          174..199
                     /region_name="Calponin-like"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Region          174..198
                     /region_name="Calponin"
                     /note="Calponin family repeat; pfam00402"
                     /db_xref="CDD:459803"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Site            182
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     Site            196
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P37802; propagated from
                     UniProtKB/Swiss-Prot (Q9WVA4.4)"
     CDS             1..199
                     /gene="Tagln2"
                     /gene_synonym="2700094C18Rik; Sm22a; Sm22B; SM22beta"
                     /coded_by="NM_178598.2:116..715"
                     /note="putative; transgelin 2 (MGD|MGI:1312985
                     GB|BC049861, evidence: BLASTN, 99%, match=1379)"
                     /db_xref="CCDS:CCDS35784.1"
                     /db_xref="GeneID:21346"
                     /db_xref="MGI:MGI:1312985"
ORIGIN      
        1 manrgpsygl srevqqkiek qydadleqil iqwittqcre dvgqpqpgre nfqkwlkdgt
       61 vlcklinsly pegqapvkki qassmafkqm eqisqflqaa eryginttdi fqtvdlwegk
      121 nmacvqrtlm nlgglavard dglfsgdpnw fpkkskenpr nfsdnqlqeg knviglqmgt
      181 nrgasqagmt gygmprqil
//
