LOCUS       NM_011526               1586 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transgelin (Tagln), mRNA.
ACCESSION   NM_011526
VERSION     NM_011526.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Carolina,E., Kuse,Y., Okumura,A., Aoshima,K., Tadokoro,T.,
            Matsumoto,S., Kanai,E., Okumura,T., Kasai,T., Yamabe,S.,
            Nishikawa,Y., Yamaguchi,K., Furukawa,Y., Tanimizu,N. and
            Taniguchi,H.
  TITLE     Generation of human iPSC-derived 3D bile duct within liver organoid
            by incorporating human iPSC-derived blood vessel
  JOURNAL   Nat Commun 15 (1), 7424 (2024)
   PUBMED   39198465
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1586)
  AUTHORS   Tan,Z., Chen,P., Dong,X., Guo,S., Leung,V.Y.L., Cheung,J.P.Y.,
            Chan,D., Richardson,S.M., Hoyland,J.A., To,M.K.T. and Cheah,K.S.E.
  TITLE     Progenitor-like cells contributing to cellular heterogeneity in the
            nucleus pulposus are lost in intervertebral disc degeneration
  JOURNAL   Cell Rep 43 (6), 114342 (2024)
   PUBMED   38865240
REFERENCE   4  (bases 1 to 1586)
  AUTHORS   Wang,L., He,X., Hu,G., Liu,J., Kang,X., Yu,L., Dong,K., Zhao,J.,
            Zhang,A., Zhang,W., Brands,M.W., Su,H., Zheng,Z. and Zhou,J.
  TITLE     A novel mouse model carrying a gene trap insertion into the Hmgxb4
            gene locus to examine Hmgxb4 expression in vivo
  JOURNAL   Physiol Rep 12 (8), e16014 (2024)
   PUBMED   38644513
REFERENCE   5  (bases 1 to 1586)
  AUTHORS   Stokes,G., Li,Z., Talaba,N., Genthe,W., Brix,M.B., Pham,B.,
            Wienhold,M.D., Sandok,G., Hernan,R., Wynn,J., Tang,H., Tabima,D.M.,
            Rodgers,A., Hacker,T.A., Chesler,N.C., Zhang,P., Murad,R.,
            Yuan,J.X., Shen,Y., Chung,W.K. and McCulley,D.J.
  TITLE     Rescuing lung development through embryonic inhibition of histone
            acetylation
  JOURNAL   Sci Transl Med 16 (732), eadc8930 (2024)
   PUBMED   38295182
REFERENCE   6  (bases 1 to 1586)
  AUTHORS   Assinder,S.J., Stanton,J.A. and Prasad,P.D.
  TITLE     Transgelin: an actin-binding protein and tumour suppressor
  JOURNAL   Int J Biochem Cell Biol 41 (3), 482-486 (2009)
   PUBMED   18378184
  REMARK    GeneRIF: involved in calcium-independent smooth muscle contraction
            Review article
REFERENCE   7  (bases 1 to 1586)
  AUTHORS   Moessler,H., Mericskay,M., Li,Z., Nagl,S., Paulin,D. and Small,J.V.
  TITLE     The SM 22 promoter directs tissue-specific expression in arterial
            but not in venous or visceral smooth muscle cells in transgenic
            mice
  JOURNAL   Development 122 (8), 2415-2425 (1996)
   PUBMED   8756287
REFERENCE   8  (bases 1 to 1586)
  AUTHORS   Li,L., Miano,J.M., Cserjesi,P. and Olson,E.N.
  TITLE     SM22 alpha, a marker of adult smooth muscle, is expressed in
            multiple myogenic lineages during embryogenesis
  JOURNAL   Circ Res 78 (2), 188-195 (1996)
   PUBMED   8575061
REFERENCE   9  (bases 1 to 1586)
  AUTHORS   Solway,J., Seltzer,J., Samaha,F.F., Kim,S., Alger,L.E., Niu,Q.,
            Morrisey,E.E., Ip,H.S. and Parmacek,M.S.
  TITLE     Structure and expression of a smooth muscle cell-specific gene,
            SM22 alpha
  JOURNAL   J Biol Chem 270 (22), 13460-13469 (1995)
   PUBMED   7768949
REFERENCE   10 (bases 1 to 1586)
  AUTHORS   Almendral,J.M., Santaren,J.F., Perera,J., Zerial,M. and Bravo,R.
  TITLE     Expression, cloning and cDNA sequence of a fibroblast
            serum-regulated gene encoding a putative actin-associated protein
            (p27)
  JOURNAL   Exp Cell Res 181 (2), 518-530 (1989)
   PUBMED   2924801
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122273.4 and AK077235.1.
            
            On Mar 13, 2010 this sequence version replaced NM_011526.4.
            
            Summary: This gene encodes a smooth muscle cell-specific
            cytoskeletal protein. The encoded protein is structurally similar
            to calponin, an actin-binding protein. In mouse models of
            atherosclerosis the gene product may be involved in plaque cell and
            atherosclerotic lesion formation during atherogenesis. [provided by
            RefSeq, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077235.1, BC003795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC122273.4         144959-145118
            161-884             AK077235.1         2-725
            885-1075            AC122273.4         150688-150878
            1076-1586           AK077235.1         919-1429
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.36 cM"
     gene            1..1586
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /note="transgelin"
                     /db_xref="GeneID:21345"
                     /db_xref="MGI:MGI:106012"
     exon            1..225
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /inference="alignment:Splign:2.1.0"
     exon            226..417
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..843
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /note="Sm22alpha; actin-associated protein p27; smooth
                     muscle protein 22-alpha; SM22-alpha"
                     /codon_start=1
                     /product="transgelin"
                     /protein_id="NP_035656.1"
                     /db_xref="CCDS:CCDS23137.1"
                     /db_xref="GeneID:21345"
                     /db_xref="MGI:MGI:106012"
                     /translation="MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIVVQCGPDVGR
                     PDRGRLGFQVWLKNGVILSKLVNSLYPEGSKPVKVPENPPSMVFKQMEQVAQFLKAAE
                     DYGVIKTDMFQTVDLYEGKDMAAVQRTLMALGSLAVTKNDGNYRGDPNWFMKKAQEHK
                     RDFTDSQLQEGKHVIGLQMGSNRGASQAGMTGYGRPRQIIS"
     exon            418..595
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /inference="alignment:Splign:2.1.0"
     exon            596..698
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1586
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1209
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /note="major polyA site"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /note="hexamer: AATATA"
     polyA_site      1257
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /note="major polyA site"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
                     /note="hexamer: AACAAA"
     polyA_site      1573
                     /gene="Tagln"
                     /gene_synonym="Sm22; Sm22a; Ws310"
ORIGIN      
        1 ggtgtctttc cccaaatatg gagcctgtgt ggagtgagtg gggcggcccg gggtggtgag
       61 ccaagcagac ttccatgggc agggaggggc gccagcgggc ggcagagggg tgacatcact
      121 gcctaggcgg cctttaaacc cctcacccag ccggcgcccc ggcccgtctg ccccagccca
      181 gacaccgaag ctactctcct tccagtccac aaacgaccaa gccttctctg cctcaacatg
      241 gccaacaagg gtccatccta cggcatgagc cgagaagtgc agtccaaaat tgagaagaag
      301 tatgacgagg agctggagga gcgactagtg gagtggattg tagtgcagtg tggccctgat
      361 gtaggccgcc cagatcgtgg gcgcctgggc ttccaggtgt ggctgaagaa tggtgtgatt
      421 ctgagcaaat tggtgaacag cctgtatcct gagggatcga agccagtgaa ggtgcctgag
      481 aacccaccct ccatggtctt taagcagatg gaacaggtgg ctcaattctt gaaggcagct
      541 gaagattatg gagtcatcaa gactgacatg ttccagactg ttgacctcta tgaaggtaag
      601 gatatggcag cagtgcagag gactctaatg gctttgggca gtttggctgt gaccaaaaac
      661 gatggaaact accgtggaga tcccaactgg tttatgaaga aagcccagga gcataagagg
      721 gacttcacag acagccaact gcaggagggg aagcacgtca ttggccttca aatgggcagc
      781 aacagaggag cctcgcaggc tggcatgaca ggctatgggc gaccccggca gatcatcagt
      841 tagaaaggga aggccagccc tgagctgcag catcctgctt agcctgcctc acaaatgcct
      901 atgtaggttc ttagccctga cagctctgag gtgtcactgg gcaaagatga ctgcacatgg
      961 gcagctccca cctatcctta gcctcagccc agcatcttac cccagagcca ccactgccct
     1021 ggcccctgtt cccagctgta cccccacctc tactgttcct ctcatcctgg agtaagcagg
     1081 gagaagtggg ctggggtagc ctggctgtag gccagcccac tgtccttgat atcgaatgtc
     1141 ctttgaagga gacccagccc agcctctaca tcttttcctg gaatatgttt ttgggttgaa
     1201 attcaaaaag gaaaaaagaa aaatatataa atatatatat atatacatgt atctccatct
     1261 tttctccggc ctggctggca gtttggtttg tcactcctgt tagcattcca ggaaccctga
     1321 gggtggaagc atgttgggct cacacgttcc tggccgatgg cttctggatg actcctctgg
     1381 ccccacaggc tcagagcttc agaggaagca ggctatggag aagaagagtg acctgcatct
     1441 gcatagctct ggtttggcag aaggagagaa tactgggagt ggtggacttg tttgggtttt
     1501 tatacttctg ctttttattt tggaaagctg tgcagaaaaa aattcaacaa aatgttgctt
     1561 tgaaaagtaa aaatcaaatc ttaagc
//
