LOCUS       NM_145968               3076 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus T cell activation Rho GTPase activating protein
            (Tagap), mRNA.
ACCESSION   NM_145968 XM_001471952
VERSION     NM_145968.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3076)
  AUTHORS   Xu,Z., Zheng,T., Zheng,Z., Jiang,W., Huang,L., Deng,K., Yuan,L.,
            Qin,F., Sun,Y., Qin,J. and Li,S.
  TITLE     TAGAP expression influences CD4+ T cell differentiation, immune
            infiltration, and cytotoxicity in LUAD through the STAT pathway:
            implications for immunotherapy
  JOURNAL   Front Immunol 14, 1224340 (2023)
   PUBMED   37744350
  REMARK    GeneRIF: TAGAP expression influences CD4+ T cell differentiation,
            immune infiltration, and cytotoxicity in LUAD through the STAT
            pathway: implications for immunotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3076)
  AUTHORS   Chen,J., He,R., Sun,W., Gao,R., Peng,Q., Zhu,L., Du,Y., Ma,X.,
            Guo,X., Zhang,H., Tan,C., Wang,J., Zhang,W., Weng,X., Man,J.,
            Bauer,H., Wang,Q.K., Martin,B.N., Zhang,C.J., Li,X. and Wang,C.
  TITLE     TAGAP instructs Th17 differentiation by bridging Dectin activation
            to EPHB2 signaling in innate antifungal response
  JOURNAL   Nat Commun 11 (1), 1913 (2020)
   PUBMED   32312989
  REMARK    GeneRIF: TAGAP instructs Th17 differentiation by bridging Dectin
            activation to EPHB2 signaling in innate antifungal response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3076)
  AUTHORS   Duke-Cohan,J.S., Ishikawa,Y., Yoshizawa,A., Choi,Y.I., Lee,C.N.,
            Acuto,O., Kissler,S. and Reinherz,E.L.
  TITLE     Regulation of thymocyte trafficking by Tagap, a GAP domain protein
            linked to human autoimmunity
  JOURNAL   Sci Signal 11 (534) (2018)
   PUBMED   29895617
  REMARK    GeneRIF: Loss of Tagap in mice suppressed the sema3E- and
            plexin-D1-mediated release of thymocytes that adhered within the
            cortex through beta1-containing integrins. This suppression led to
            the impaired translocation of thymocytes from the cortex to the
            medulla and resulted in the formation of ectopic medullary
            structures within the thymic cortex leading to autoimmune
            disorders.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3076)
  AUTHORS   Arshad,M., Bhatti,A., John,P., Jalil,F., Borghese,F.,
            Kawalkowska,J.Z., Williams,R.O. and Clanchy,F.I.L.
  TITLE     T cell activation Rho GTPase activating protein (TAGAP) is
            upregulated in clinical and experimental arthritis
  JOURNAL   Cytokine 104, 130-135 (2018)
   PUBMED   29017772
  REMARK    GeneRIF: These findings indicate that increased TAGAP expression is
            a distinguishing feature of inflammatory disease and further
            highlight the role of TAGAP in rheumatoid arthritis susceptibility.
REFERENCE   5  (bases 1 to 3076)
  AUTHORS   Tamehiro,N., Nishida,K., Yanobu-Takanashi,R., Goto,M., Okamura,T.
            and Suzuki,H.
  TITLE     T-cell activation RhoGTPase-activating protein plays an important
            role in TH17-cell differentiation
  JOURNAL   Immunol Cell Biol 95 (8), 729-735 (2017)
   PUBMED   28462950
  REMARK    GeneRIF: these studies demonstrated that TAGAP was required for
            TH17 differentiation in vitro and that the loss of TAGAP in mice
            ameliorated the clinical features of experimental autoimmune
            encephalomyelitis, indicating that TAGAP is critical for disease
            progression
REFERENCE   6  (bases 1 to 3076)
  AUTHORS   Schimenti,J.
  TITLE     Segregation distortion of mouse t haplotypes the molecular basis
            emerges
  JOURNAL   Trends Genet 16 (6), 240-243 (2000)
   PUBMED   10827448
  REMARK    Review article
REFERENCE   7  (bases 1 to 3076)
  AUTHORS   Willison,K.R.
  TITLE     Distorting sex ratios
  JOURNAL   Nature 402 (6758), 131-132 (1999)
   PUBMED   10647000
REFERENCE   8  (bases 1 to 3076)
  AUTHORS   Ott,M.O., Rey-Campos,J., Cereghini,S. and Yaniv,M.
  TITLE     vHNF1 is expressed in epithelial cells of distinct embryonic origin
            during development and precedes HNF1 expression
  JOURNAL   Mech Dev 36 (1-2), 47-58 (1991)
   PUBMED   1685890
REFERENCE   9  (bases 1 to 3076)
  AUTHORS   Lyon,M.F.
  TITLE     Male sterility of the mouse t-complex is due to homozygosity of the
            distorter genes
  JOURNAL   Cell 44 (2), 357-363 (1986)
   PUBMED   3943128
REFERENCE   10 (bases 1 to 3076)
  AUTHORS   Lyon,M.F.
  TITLE     Transmission ratio distortion in mouse t-haplotypes is due to
            multiple distorter genes acting on a responder locus
  JOURNAL   Cell 37 (2), 621-628 (1984)
   PUBMED   6722884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY117429.1, BC150728.1 and AC164314.5.
            
            On or before Jul 26, 2011 this sequence version replaced
            XM_001471952.2, NM_145968.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030886.1, BC150728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BY117429.1         2-56
            56-1197             BC150728.1         1-1142
            1198-3076           AC164314.5         13062-14940
FEATURES             Location/Qualifiers
     source          1..3076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.82 cM"
     gene            1..3076
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /note="T cell activation Rho GTPase activating protein"
                     /db_xref="GeneID:72536"
                     /db_xref="MGI:MGI:3615484"
     exon            1..109
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            110..190
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2308
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /note="T-cell activation GTPase-activating protein 1;
                     t-complex distorter 1A"
                     /codon_start=1
                     /product="T-cell activation Rho GTPase-activating protein"
                     /protein_id="NP_666080.1"
                     /db_xref="CCDS:CCDS28379.1"
                     /db_xref="GeneID:72536"
                     /db_xref="MGI:MGI:3615484"
                     /translation="MKLISSLDGSKTLNANNMETLIECQSEGDIKVPPLLTSCESEDS
                     ICQLTEIKKRKKVLSWPSLMRKLSPSSDFSGSLEPELKVSLFDQPLSIICGENDTLPR
                     PIQDILTILCLKGPSTEGIFRKAASEKARKELKEGLNCGVSVNLKQLPVHLLAVVFKD
                     FLRGIPLKLLSCDLFEDWMGALEKPTEEDRIEALKQVAGGLPRPNLLLLRHLLYVLHL
                     ISKNAEVNKMDSSNLAICIGPNMLTLKNDQSLSFQAQKDLNNKVKILVEFLIDNCFEI
                     FGENIRTRSRITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVEPTSGAASPNRQLEGPT
                     PTMAGLDTRGQRDTCESSSESSVSMVVRLKSSIVQQDRRFSEPNMSPSRECLVGPTSK
                     QKLARSEDSFTLSQDASCSEGDEAEDPFTEEVFPAVDSKPKRPVDLKIKNWTQGLASP
                     QGHITKAFSRSSPGESLGSSPVPSPSCPKRNFFTRHQSFTTKTDKTKPQREIRKHSMS
                     FSFASHKKVLPRTSSIGSEKSKDFSRDQLQKDLRKESQLSGRIVQENESEIQSQTSLG
                     FSLSGTWALSVDNTFQLVDMRKPGSPPSYEEAIYYQTSGLTAYGGQTVGSMRSRMFKP
                     STAVPPVPSHHGGDLSEGTPGGHRLSSVTEHWTHSQTVHVSIETQGRSELHQLRTVSE
                     SMQKAKLDCLGPQHSHLVFEADQLCCARESYI"
     exon            191..244
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            245..311
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            312..478
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            479..640
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            641..750
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            751..946
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1061
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..3076
                     /gene="Tagap"
                     /gene_synonym="2610315E15Rik; Tcd-1; Tcd1; Tcd1a; tcs-1;
                     tcs1; TRD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgccttgt ctctgtgggt ggactcctag ggtcagagtg tcatgttgtg tctcccgttt
       61 tccacagttc gccagaggta aaaagagctc tggctgaaga ccgttgctgg atcaaagcct
      121 cgaggtagtg gacccccctc ttggactgtc agtctccatt ccaatgaagc tgataagcag
      181 tctcgatggt tcaaaaacac ttaatgctaa caacatggag acattaattg aatgtcagtc
      241 agagggtgat atcaaagtgc ctcccctgct gacatcatgt gagagtgaag acagcatttg
      301 ccagctaact gaaattaaga agagaaagaa agtgctgtcc tggccatctc tcatgagaaa
      361 gctctctcct tcatccgact tctctgggtc attggaacca gagctgaaag tgtcgctgtt
      421 tgaccaaccc ttgtcgatca tctgtgggga gaacgacaca cttcccagac ccatccagga
      481 catcctcacc atcctctgcc ttaaaggtcc ttcaacggaa gggatattca ggaaagctgc
      541 cagcgagaaa gcccgcaagg agctgaagga ggggcttaac tgtggggtct ccgtgaatct
      601 gaagcagctc cctgtgcacc tcctagctgt ggtcttcaag gacttcctcc gagggatacc
      661 cctgaagcta ctctcctgtg atctctttga ggactggatg ggcgccctgg agaagcccac
      721 cgaggaggac agaatcgagg ccctgaagca ggttgctggt ggcctccccc ggcccaacct
      781 tctcctgctc aggcacttgc tctacgtgct ccacctcatc agcaagaacg ctgaggtcaa
      841 caagatggac tccagcaacc tcgccatctg catcgggcct aacatgctca ctctgaagaa
      901 cgaccagagc ctgtccttcc aggcccagaa ggacctgaac aataaggtta agatcttggt
      961 ggaattcctc atcgacaact gctttgagat atttggggag aacattcgga cgcgttcccg
     1021 catcacttct gacgactccc tggaacacac tgacagttca gacgtgtcaa ctctgcagaa
     1081 tgactcggcc tatgacagca atgacccaga tgtggagccc acaagtggcg cagcctctcc
     1141 caacaggcaa ctggagggtc ccactcccac aatggctggt ctggataccc ggggccaacg
     1201 ggacacctgt gagtcaagct cagagtccag cgttagcatg gtagtcaggc tgaaaagctc
     1261 cattgtccaa caagacaggc ggttctctga acccaacatg tcaccctcac gagagtgcct
     1321 cgtgggccca acatccaagc aaaagctagc aaggagtgag gacagcttca ctctgtccca
     1381 ggacgcctcc tgttctgaag gcgatgaagc tgaagatccc tttacagagg aagtcttccc
     1441 agcagtggac agcaaaccca agagacctgt ggatttgaaa ataaagaatt ggacccaagg
     1501 tttagcatct ccacagggac acataaccaa agctttctcc agatcctccc caggcgaatc
     1561 tttgggcagc tcacctgtgc cttctccatc ctgccccaag agaaacttct tcaccagaca
     1621 ccagagtttc acaacaaaga cagacaaaac caaaccccag agagaaatta gaaagcactc
     1681 catgtcgttt tcctttgcgt ctcacaagaa agtgctgccc cgaacctcca gcattgggtc
     1741 tgagaaatcc aaagactttt ctagagacca actccagaag gacttgagga aagagagcca
     1801 actttctggc agaatcgtcc aggaaaatga gtcagaaatc caaagccaaa catctctggg
     1861 cttcagcttg tctggcacct gggccctctc agtcgacaac acgttccagt tagtggatat
     1921 gaggaaacca ggaagcccac catcttacga agaggccatt tattaccaga catcaggact
     1981 cacagcctac ggtggccaga cagttgggag tatgaggtca agaatgttca agccaagcac
     2041 agcagtgccc cctgtgcctt ctcaccatgg aggtgacctc agtgaaggga cacctggtgg
     2101 acacagattg tcttctgtga ctgagcactg gacacacagt cagactgtcc atgtctctat
     2161 agaaactcag gggagatctg agctacacca gttgaggaca gtgtccgagt ccatgcagaa
     2221 ggctaagctg gactgtcttg ggccacaaca cagccactta gtctttgagg ctgaccaact
     2281 ctgctgtgct agagaatcct acatttaaga aagccttgta ccatggctaa cttgtgtgtg
     2341 aagatgcgac tgcagagaac tgtctgttga gtcacagata agctcattca gaactcagtg
     2401 tgcggctctc ctctgtgagg atggctcaca cggtgacacc aaattttgcc tgtgtgtaac
     2461 cgggtttgtg caatatgtag taaatgtata aaatgtatta ttatatgcaa ggtattagat
     2521 gcaaagggtg tctgcgtaca tcccttcatg cattcacttc tgtatgttgt ttttttgtcc
     2581 tcaggcactt gtttctatta agtagaaaga gtttttactt ttcttaatgt tacagcaaat
     2641 gccatgcctg tgttcacatt agccgccagc tgcatgtagg tggaaatgtc tgagcctctg
     2701 atgcatcttc tcctaagcag gcttgagacg agtcagcatc atagaaggga acagactgga
     2761 agacactgta cttggtgtgt gacccatcag ccgcactggg agaaggtctt tcagtcatct
     2821 aatggaatgt gggtggcgtg gtggaaatgc attctgttag tagtaactca cgcagagtac
     2881 tttgagcctc tgcagctcag tcatgtcttg tgcagctgtg tagtggtaag cactgttgta
     2941 tgcattgggg agtcttgtat aagacttcag tagagtttat ttattagtca caataaactg
     3001 ccctcctcct ttagacagtt tattacttgc tgatgttata tcctttgcct caaataaaaa
     3061 tccgccaaga acatta
//
