LOCUS       NM_001252310            2665 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus TAFA chemokine like family member 5 (Tafa5),
            transcript variant 1, mRNA.
ACCESSION   NM_001252310
VERSION     NM_001252310.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Kwak,H., Cho,E.H., Cho,E.B., Lee,Y.N., Shahapal,A., Yong,H.J.,
            Reyes-Alcaraz,A., Jeong,Y., Lee,Y., Lee,M., Ha,N., Oh,S., Lee,J.K.,
            Lee,W.S., Kim,W.K., Yoo,S., Kwon,S.G., Hwang,J.I. and Seong,J.Y.
  TITLE     Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5
            knockout, and LacZ knockin mice
  JOURNAL   Mol Cells 47 (12), 100125 (2024)
   PUBMED   39426682
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Park,S., Shahapal,A., Yoo,S., Kwak,H., Lee,M., Lee,S.M., Hwang,J.I.
            and Seong,J.Y.
  TITLE     FAM19A5 Deficiency Mitigates the Abeta Plaque Burden and Improves
            Cognition in Mouse Models of Alzheimer's Disease
  JOURNAL   Exp Neurobiol 33 (4), 193-201 (2024)
   PUBMED   39266475
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Huang,S., Zheng,C., Xie,G., Song,Z., Wang,P., Bai,Y., Chen,D.,
            Zhang,Y., Lv,P., Liang,W., She,S., Li,Q., Liu,Z., Wang,Y.,
            Xing,G.G. and Wang,Y.
  TITLE     FAM19A5/TAFA5, a novel neurokine, plays a crucial role in
            depressive-like and spatial memory-related behaviors in mice
  JOURNAL   Mol Psychiatry 26 (6), 2363-2379 (2021)
   PUBMED   32317715
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Vidal,V.P., Jian-Motamedi,F., Rekima,S., Gregoire,E.P.,
            Szenker-Ravi,E., Leushacke,M., Reversade,B., Chaboissier,M.C. and
            Schedl,A.
  TITLE     R-spondin signalling is essential for the maintenance and
            differentiation of mouse nephron progenitors
  JOURNAL   Elife 9, e53895 (2020)
   PUBMED   32324134
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Kang,D., Kim,H.R., Kim,K.K., Kim,D.H., Jeong,B., Jin,S., Park,J.W.,
            Seong,J.Y. and Lee,B.J.
  TITLE     Brain-specific chemokine FAM19A5 induces hypothalamic inflammation
  JOURNAL   Biochem Biophys Res Commun 523 (4), 829-834 (2020)
   PUBMED   31954515
  REMARK    GeneRIF: Brain-specific chemokine FAM19A5 induces hypothalamic
            inflammation.
REFERENCE   6  (bases 1 to 2665)
  AUTHORS   Das,A., Tanigawa,S., Karner,C.M., Xin,M., Lum,L., Chen,C.,
            Olson,E.N., Perantoni,A.O. and Carroll,T.J.
  TITLE     Stromal-epithelial crosstalk regulates kidney progenitor cell
            differentiation
  JOURNAL   Nat Cell Biol 15 (9), 1035-1044 (2013)
   PUBMED   23974041
  REMARK    Erratum:[Nat Cell Biol. 2013 Oct;15(10):1260]
REFERENCE   7  (bases 1 to 2665)
  AUTHORS   Karner,C.M., Das,A., Ma,Z., Self,M., Chen,C., Lum,L., Oliver,G. and
            Carroll,T.J.
  TITLE     Canonical Wnt9b signaling balances progenitor cell expansion and
            differentiation during kidney development
  JOURNAL   Development 138 (7), 1247-1257 (2011)
   PUBMED   21350016
REFERENCE   8  (bases 1 to 2665)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   9  (bases 1 to 2665)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
REFERENCE   10 (bases 1 to 2665)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY733542.1, BU057253.1,
            AK090194.1, AC123925.4 and BE945208.1.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090307.1, AK090194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY733542.1         2-45
            45-175              BU057253.1         1-131
            176-1306            AK090194.1         2-1132
            1307-2522           AC123925.4         41910-43125
            2523-2665           BE945208.1         2-144               c
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 42.1 cM"
     gene            1..2665
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="TAFA chemokine like family member 5"
                     /db_xref="GeneID:106014"
                     /db_xref="MGI:MGI:2146182"
     exon            1..305
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..592
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; chemokine-like protein TAFA-5; protein FAM19A5;
                     family with sequence similarity 19, member A5"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-5 isoform 1
                     precursor"
                     /protein_id="NP_001239239.1"
                     /db_xref="CCDS:CCDS88823.1"
                     /db_xref="GeneID:106014"
                     /db_xref="MGI:MGI:2146182"
                     /translation="MAPSPRTSSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGT
                     CEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPC
                     LEGEGCDLLINRSGWTCTQPGGRIKTTTVS"
     exon            306..455
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..583
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /inference="alignment:Splign:2.1.0"
     exon            584..2651
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="hexamer: ATTAAA"
     polyA_site      1518
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="hexamer: ATTAAA"
     polyA_site      1563
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="major polyA site"
     regulatory      2626..2631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="hexamer: AATAAA"
     regulatory      2630..2635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
                     /note="hexamer: AAGAAA"
     polyA_site      2648
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
     polyA_site      2651
                     /gene="Tafa5"
                     /gene_synonym="Fam19a5; Tafa-5; Tara-5"
ORIGIN      
        1 agtgggccgg ggcccgggcg cggcggcggc ggcggagaag gaggaggagg aggaggacga
       61 ggaagaggag gaggaggagg acgaggagga ggatggcacg cgcggggccc gcacgtggag
      121 gccggcgcgg gggcgcgggc agggccggct gctgagaagc gctgctgccc cccgcgcggg
      181 caccgcggct tcaatggcgc catcgcccag gaccagcagc cggcaagatg cgaccgccct
      241 gcccagcatg tcctcaactt tttgggcatt catgatcctg gccagcctgc tcatcgccta
      301 ctgcagtcag ctggccgctg gaacctgtga gattgtgacc ctagaccggg acagcagcca
      361 gccacggagg acgatcgccc ggcagacagc acgctgtgca tgcagaaagg ggcagatagc
      421 aggcaccact cgagcccggc ctgcttgtgt ggacgctcga attatcaaga caaagcagtg
      481 gtgtgacatg cttccttgcc tggaggggga aggctgtgac ttgttaatca accggtcagg
      541 ctggacttgc acacagcccg gagggcggat aaagaccacc acggtctcct gacaatcgca
      601 gcccctgcgg tgccccctgg gagtggctgt ggctccctgg aaattctaca cctcagccac
      661 agtcctgcat cctatgtgga caccgctcat tctcccccat ccacccactg tttcccagag
      721 gcctaacaaa gacagcccaa ttcctcggag ctctgagctc aagtctgtcc agctgaaccc
      781 aggaggctgg gactcagaca cacatgtcaa gggtggtacc tggaatcagc aatacctggt
      841 gtgtggagcc tggctgcatc catcctcact agccgcttgc tccctggagt tggaggaccg
      901 gaacaaggaa attgtggccc ggccagctgg gccacaacgc aaggtccggg gactgtcagg
      961 tgcagaagcc accaccccct ctgtcccaga ctgtctgaat cgcttttatt ttcttatact
     1021 ttcagtatac tcaatagacc aaagagcaaa tctattttaa cgtggacaca tccctgctgc
     1081 caagagttcc ctgggtttga ttgtggggca ggggagggcg cagtggcaga catgctggtg
     1141 gcccaggcag catggagagg gcatctgagg ccaagacccc cgccccacga acactgcagc
     1201 gtgccctaag aggatggctt tgcccagaag gacaccaccg tggtgcacct gcaggaccca
     1261 gcaggggcat ggccggcgac ggcccccagc ggacagcaag ggccccggac acagaccctt
     1321 tgcccctgtg cttagaccaa ctctatcgta ctaaaatcac tttctgtttt aaccagttag
     1381 acatgcctct tccacagctc catttttgat agttggataa tccaccattt gccaagagca
     1441 tgctgggtct cctgtgactg ctatctcatc tgatacacca tttagctcca gaaagcaaat
     1501 taaagaaaac tgaagtaacc ctgtttgaaa gagatcatta aatgtatttt gcaaaagcct
     1561 aaagttatat atttaacagt ttttatatgt tgtatatttg tagaaaatcc tatttaacat
     1621 ttgacggcag gtctgaccat cctgagagtt gtggccaggc ctccctgtga tcctggagac
     1681 tctggggtgg ccatggagga cctcagagca gacatggacg ggcagagctg tgggtgaggt
     1741 gcagaggacc ctgcccattc taggaagctc tgtctctctt tgctttggtt tggtctgata
     1801 gttcacatcc ccctgtgagt ctgtgtgttg gtaaacattg cgtatacaat attttggtca
     1861 tggattttgg tccctctctc tcttaacccc ttttgccatc catagatctt gagtccatgt
     1921 acggccaact tgcccttccc aggtgaatga cccccttcgt cttcaaaggt ccttgttctc
     1981 cacattggga ggcaaagaca gcagggatgg agggggtgga gaagctgggg agcagagtca
     2041 ctgtccttgc ttgccctaca ctgtggggtc agaggctatc agataaggga cacagtcccc
     2101 attcattttc ctgagttctg ctaccagcat actacctaca tgtccaatta acatgactat
     2161 catgctagta atatactact aaaggcaaac atttaaaaaa atgtatttaa ctccagtata
     2221 tagatgccgt tccagcaacc ataggctaaa gataggaaag aaagtccatt tctgtgagac
     2281 ccattccggt acccatgtgt cctcccttca ctcatgcaga gattagtatc ctgggcaggg
     2341 agatgaagct gacatgaggg gctctcatca aaggaggtgg tcaaacaagg ccactgtctc
     2401 cgaagtgtca ggctccagtg gcctgtgttg cagggggtca acagggcagg aggtctcatt
     2461 tcaccactga acctcaacat ccgccccacc tccccttggc tgtttctttt gaaagctagc
     2521 atagagacct ccgagggcag agaccaggag acttaagatg ttacagcata tttccccctt
     2581 gttttacagt atccaatttt tgtgttgatt cagctaaatt atgaaaataa agaaaaaaag
     2641 tcctttgata aaaaaaaaaa aaaaa
//
