LOCUS       NM_177233               2182 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus TAFA chemokine like family member 4 (Tafa4), mRNA.
ACCESSION   NM_177233
VERSION     NM_177233.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Zhou,C., Li,M., Liu,Y., Wang,X., Zhang,S., Guan,L., Hong,J.,
            Zhou,W., Wu,G., Diao,W., Huang,Q. and Yang,P.
  TITLE     Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by
            modulating the expression of FcepsilonRI in mast cells
  JOURNAL   Clin Exp Immunol 211 (1), 15-22 (2023)
   PUBMED   36368013
  REMARK    GeneRIF: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal
            allergy by modulating the expression of FcepsilonRI in mast cells.
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Yoo,S., Santos,C., Reynders,A., Marics,I., Malapert,P.,
            Gaillard,S., Charron,A., Ugolini,S., Rossignol,R., El Khallouqi,A.,
            Springael,J.Y., Parmentier,M., Saurin,A.J., Goaillard,J.M.,
            Castets,F., Clerc,N. and Moqrich,A.
  TITLE     TAFA4 relieves injury-induced mechanical hypersensitivity through
            LDL receptors and modulation of spinal A-type K+ current
  JOURNAL   Cell Rep 37 (4), 109884 (2021)
   PUBMED   34706225
  REMARK    GeneRIF: TAFA4 relieves injury-induced mechanical hypersensitivity
            through LDL receptors and modulation of spinal A-type K(+) current.
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Li,H., Kurtzeborn,K., Kupari,J., Gui,Y., Siefker,E., Lu,B.,
            Matlik,K., Olfat,S., Montano-Rodriguez,A.R., Huh,S.H.,
            Costantini,F., Andressoo,J.O. and Kuure,S.
  TITLE     Postnatal prolongation of mammalian nephrogenesis by excess fetal
            GDNF
  JOURNAL   Development 148 (10) (2021)
   PUBMED   34032268
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Wang,W., Li,T., Wang,X., Yuan,W., Cheng,Y., Zhang,H., Xu,E.,
            Zhang,Y., Shi,S., Ma,D. and Han,W.
  TITLE     FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1
            (FPR1) and is able to promote the migration and phagocytosis of
            macrophages
  JOURNAL   Cell Mol Immunol 12 (5), 615-624 (2015)
   PUBMED   25109685
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Lou,S., Pan,X., Huang,T., Duan,B., Yang,F.C., Yang,J., Xiong,M.,
            Liu,Y. and Ma,Q.
  TITLE     Incoherent feed-forward regulatory loops control segregation of
            C-mechanoreceptors, nociceptors, and pruriceptors
  JOURNAL   J Neurosci 35 (13), 5317-5329 (2015)
   PUBMED   25834056
REFERENCE   9  (bases 1 to 2182)
  AUTHORS   Delfini,M.C., Mantilleri,A., Gaillard,S., Hao,J., Reynders,A.,
            Malapert,P., Alonso,S., Francois,A., Barrere,C., Seal,R.,
            Landry,M., Eschallier,A., Alloui,A., Bourinet,E., Delmas,P., Le
            Feuvre,Y. and Moqrich,A.
  TITLE     TAFA4, a chemokine-like protein, modulates injury-induced
            mechanical and chemical pain hypersensitivity in mice
  JOURNAL   Cell Rep 5 (2), 378-388 (2013)
   PUBMED   24139797
  REMARK    GeneRIF: TAFA4 is required to maintain the normal threshold of
            injury-induced mechanical and chemical pain hypersensitivity and
            strongly support a potential role of TAFA4 as a potent analgesic in
            the settings of inflammation and neuropathy.
REFERENCE   10 (bases 1 to 2182)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160399.6 and AC133086.4.
            
            On Nov 17, 2006 this sequence version replaced NM_177233.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089490.1, AK149355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AC160399.6         178029-178309       c
            282-421             AC160399.6         137813-137952       c
            422-537             AC160399.6         132270-132385       c
            538-693             AC133086.4         88922-89077
            694-818             AC133086.4         108962-109086
            819-2182            AC133086.4         120265-121628
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.8 cM"
     gene            1..2182
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /note="TAFA chemokine like family member 4"
                     /db_xref="GeneID:320701"
                     /db_xref="MGI:MGI:2444563"
     exon            1..281
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..421
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /inference="alignment:Splign:2.1.0"
     exon            422..537
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..830
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /note="family with sequence similarity 19 (chemokine (C-C
                     motif)-like), member A4; chemokine-like protein TAFA-4;
                     protein FAM19A4; family with sequence similarity 19,
                     member A4"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-4 precursor"
                     /protein_id="NP_796207.2"
                     /db_xref="CCDS:CCDS51858.1"
                     /db_xref="GeneID:320701"
                     /db_xref="MGI:MGI:2444563"
                     /translation="MRVCAKWVLLSRWLVLTYVLMVCCKLMSASSQHLRGHAGHHLIK
                     PGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEAAIVIEKWWCHM
                     NPCLEGEDCKVLPDSSGWSCSSGNKVKTTKVTR"
     exon            538..693
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /inference="alignment:Splign:2.1.0"
     exon            694..818
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /inference="alignment:Splign:2.1.0"
     exon            819..2182
                     /gene="Tafa4"
                     /gene_synonym="C130034I18Rik; Fam19a4; Fam19a4 Tafa-4;
                     Tafa-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctagcctg gagccaccct ggacggggcg cacttgctgg gcgcgcaggg ctgtctgcac
       61 cctctgggat ctggctggga caatgtttct tctttaagac acggcgcttc ccacggtagc
      121 tttggcttct ctttgcagca gcaccggaac tttccccact ttcggccgta ctaagagggt
      181 gatgggcgca agtcgccagc tgagcatcct ttggtttcag tgctgtgatc ggcgcttcac
      241 tctggactcc cggatctgac tcggctgctc tttctagtct aacaggtcct ccaagcccaa
      301 gaagttttgg ggggctgcag agatgattgg tcccagttac aaagggacat tcacggtcac
      361 tctccaggac cttcttgagt aacagtgttt gactggaacc atatactgtg aactctccaa
      421 ggatgagagt ctgtgctaag tgggtgctgc tgtcacgctg gctggttctg acctatgtgt
      481 taatggtctg ctgtaagctg atgtccgcct cgagccagca cctccgggga catgcaggtc
      541 accacctgat caagccaggt acctgcgagg tggtcgccgt gcaccgctgc tgcaataaga
      601 accgcataga ggagcgctct cagacggtca aatgttcctg cttcccaggc caggtggctg
      661 gcacaactcg ggcacagcct tcttgtgttg aagctgccat tgtgattgag aagtggtggt
      721 gccacatgaa tccttgcttg gaaggagagg actgtaaagt gcttccagac tcttcgggtt
      781 ggtcctgtag cagtggcaat aaagtcaaaa ccaccaaggt gacccggtag cagacacaaa
      841 agtgttttga ccccgagggg catcgggacg cagagctgtg ctgtgtggat taccagacta
      901 gtgagaactc actcaccttg gaacttgctc agaagttcat agccaaaata tgtgcagtgt
      961 ggaaggtggc atttacgtgg ctgttcccgt ttgtctgctt tgtgatctca tcacactgaa
     1021 ctacagctta ggtggccact caactgaggt gttacctgga tctcaaaagg agcctgccta
     1081 gcacaagaaa tgctggagag gacatcggag gtgctaatgt ggatggagca gcgctgggag
     1141 aacctggatc ttcttgttct ccttttccca aggaacatgg acagaagtac aaaaggaccc
     1201 aggccgatcc tcttttaaat gtgtccctta gccattatac agaaggcatg aaagcagtct
     1261 aagtgacaga agatttggct catatacgtg tgttctagat taaagaattt gaattatctg
     1321 gtgcaagaaa ttaactttat gaaccttgga gaatggaagg actcattggg ttactatgtg
     1381 cacatttgta ttttttactt ttgataattt gacatgttta tcttcttagt tccattccta
     1441 cgttagcaga gatgtagcag aagctttgta atcctggtac actggtggct gagttctatg
     1501 gaaagcagag tagcaccaga ggtttacaac caaagctttc tcatggcata ttcacaaaag
     1561 atcatgtacc tgttgggact tttatggctt ggggttaatg agataggaga atcatttaag
     1621 acagaggaca gtctctgttt agaggaaggg tgatttctta gatctacttt atgggaatat
     1681 ttttattatc tccgagaaga agtctttaaa tgctaactat tcacatgaca gttgacgcaa
     1741 gcctaacaga gtcccttctg tacccgtttg ttcggtttct tacttcttta aatgttaagt
     1801 aaaacctcag tcatcttgcc tccaatttca gtgatttcac agacactgcc atgcagaaac
     1861 ataagaaaca aagagacact ggcccaggtt tgaaatgatg ttattcatgt acacacatct
     1921 gtaatgtggg attgattgta tgtattaaga aatgttgaca gtatacttgc tgcgccaact
     1981 gtctgtcctt ttgcaattac aaagaaacat aggttctatt atgttgtcta cagtgctatc
     2041 aattatttga ttttcttgca gaagaagtgg gaatgggtgc tacctgttta taggttaaac
     2101 tttggtttga acttggctga ctgggtgtct actggaatag ttattctcat atgactaagt
     2161 aaaatatcac tctgttgatg ac
//
