LOCUS       NM_183224               4317 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TAFA chemokine like family member 3 (Tafa3), mRNA.
ACCESSION   NM_183224 XM_982351
VERSION     NM_183224.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4317)
  AUTHORS   Kim,S., Lee,B., Choi,J.H., Kim,J.H., Kim,C.H. and Shin,H.S.
  TITLE     Deficiency of a brain-specific chemokine-like molecule, SAM3,
            induces cardinal phenotypes of autism spectrum disorders in mice
  JOURNAL   Sci Rep 7 (1), 16503 (2017)
   PUBMED   29184127
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4317)
  AUTHORS   Park,K.U., Randazzo,G., Jones,K.L. and Brzezinski,J.A. 4th.
  TITLE     Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar
            Interneurons in the Mouse Retina
  JOURNAL   Invest Ophthalmol Vis Sci 58 (2), 1137-1150 (2017)
   PUBMED   28199486
REFERENCE   4  (bases 1 to 4317)
  AUTHORS   Shao,Y., Deng,T., Zhang,T., Li,P. and Wang,Y.
  TITLE     FAM19A3, a novel secreted protein, modulates the
            microglia/macrophage polarization dynamics and ameliorates cerebral
            ischemia
  JOURNAL   FEBS Lett 589 (4), 467-475 (2015)
   PUBMED   25595455
REFERENCE   5  (bases 1 to 4317)
  AUTHORS   Fischer,C., Christ,E., Korf,H.W. and von Gall,C.
  TITLE     Tafa-3 encoding for a secretory peptide is expressed in the mouse
            pars tuberalis and is affected by melatonin 1 receptor deficiency
  JOURNAL   Gen Comp Endocrinol 177 (1), 98-103 (2012)
   PUBMED   22426341
  REMARK    GeneRIF: The data suggest that TAFA-3 is a signaling molecule from
            the hypophysial pars tuberalis.
REFERENCE   6  (bases 1 to 4317)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK078681.1 and AC171110.2.
            
            On Nov 10, 2011 this sequence version replaced NM_183224.2.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078681.1, BC118531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               AK078681.1         1-384
            385-440             AC171110.2         119346-119401
            441-509             AK078681.1         441-509
            510-1126            AK078681.1         511-1127
            1127-4317           AC171110.2         124834-128024
FEATURES             Location/Qualifiers
     source          1..4317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.84 cM"
     gene            1..4317
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /note="TAFA chemokine like family member 3"
                     /db_xref="GeneID:329731"
                     /db_xref="MGI:MGI:3046463"
     exon            1..371
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            372..496
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..585
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            586..701
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..988
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /note="chemokine-like protein TAFA-3; protein FAM19A3;
                     family with sequence similarity 19, member A3"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-3 precursor"
                     /protein_id="NP_899047.1"
                     /db_xref="CCDS:CCDS51032.1"
                     /db_xref="GeneID:329731"
                     /db_xref="MGI:MGI:3046463"
                     /translation="MERPTSNWSAGSWVLALCLAWLWTCPASASLQPPTSAVLVKQGT
                     CEVIAAHRCCNRNRIEERSQTVKCSCLSGQVAGTTRAKPSCVDASIVLQKWWCQMEPC
                     LLGEECKVLPDLSGWSCSSGHKVKTTKVTR"
     exon            702..851
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            852..976
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..4317
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4296..4301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /note="hexamer: AATAAA"
     polyA_site      4317
                     /gene="Tafa3"
                     /gene_synonym="7530404M11Rik; Fam19a3; Sam3; Tafa-3"
                     /note="major polyA site"
ORIGIN      
        1 acacagtttc gaagaagccg gcggtgcccg caaaggctgg agtagcgaga acgactccca
       61 gtctagcggc tgcgcgctcc tcaacctgca gaccgaaagc tcgggaggac ccggcctagc
      121 cccgcagaac tggtgggtgc tggaccagag catctaggtg ctctaagccg gagactccag
      181 cttagccaga gcccctgctc tcctcgggcg caacaacttt gacgatctat cgcggacaga
      241 gctcaaaacc agacaacacc taagctggcc actccctcga agagcccgat ttggagagtc
      301 tagatgccaa gctcagaagc agcgaggacc tcaggccaga aagttgaacc cgggccactg
      361 ctgtgaagca gcttcctctt agcccctcca ggggtctggt ctctctccat tctgaacaac
      421 cgccatattg ttcatcagat ggaacaagtc tgagaccagc agatgaacag gcagaggcct
      481 gaagacccca ggaacagctc tgccttcctg ttccttgatc cctctctgtc aatcatcata
      541 tcctacagtg acatcccgcc ccaccgaaag ctgcctggag acaagaccga tggagaggcc
      601 caccagcaac tggagcgcag gcagctgggt gcttgcactg tgcctcgcct ggctgtggac
      661 gtgtccggcc tctgcttcct tgcagcctcc aacatccgca gtcctagtga agcagggcac
      721 ctgcgaggtg attgctgcac atcgctgctg caaccggaac cgcattgagg agcgctccca
      781 gacggtcaaa tgctcctgcc tgtccggcca ggtggctggc accaccagag caaagccctc
      841 ctgcgtggac gcctccatcg tcctgcagaa gtggtggtgt cagatggagc cctgcctgct
      901 gggagaggag tgtaaggtgc tcccggacct gtcagggtgg agctgcagca gtggacacaa
      961 ggtcaaaacc accaaggtca cacggtaact ctcggaggtc atggcttagg taggacagcc
     1021 ttgactgagc tcgggactga agaaaggcct ggtcaccaga cagcagataa gaggacttac
     1081 ctggacatgt gcccatgtca agtgtaacat agaccggcca gggccctggg cagcactctg
     1141 ttcagctaaa atgcttggat ctttggccac acacttgaga gacctgtgct ctcctatgaa
     1201 caaagtcaac acacaaacct atccttaagg aatatcttgt caagttaagg agtggatgac
     1261 aggcaatttc aacagtttaa agtgtttggt accgtggctt ctgagcgacc tgcagtgggt
     1321 gtggtggggt ggggcggatg gaatttacac agatcttcag ccacccgatc ccaggacaca
     1381 aagttatgag ggccacacca gtatcttccc atcttggcct tcccatcaaa cctgcatccc
     1441 cagcaagatg ctaagatgtg agaggaaaac actgccccct ggtgccaagc cagtgggatc
     1501 tcttttggac agcactggaa agtagagatg aagggcttct tccgcacacc tctgcagagg
     1561 cagggcgggg cgcacatccc atgctgtcca tggatggaca ggacctcagt cagaatcacc
     1621 cctccacctt gaacttcggg tgtttggttg ctgttttaaa ggacgaggaa accgagtcac
     1681 agaggatgag atggatttgc ccaggatctc acagcttggc cttccaaaaa cacggatgtt
     1741 aggactccag cctaggcctt ccgtggcagt tttatctaga cagtgagacc ccgcaaacac
     1801 tgtctggata gcaccaacat gattcttggg agatgggact ttgaccactg gaattttggt
     1861 tgaggccact gatctcccat caaacaaaca aacaaacaaa ccctagaata tacacacaca
     1921 cacacacaca cagcagagtg gagctccttc tcagtccccc aaggccaaac aggccccgtg
     1981 acagcccaga ggtcgctcag cccagcggca gcagaagcag tgtgagcagt taggtatccc
     2041 atcacccact ctgcttctct atcaggagct tcagccagcc ccctacatag gtacctgcca
     2101 ggaggcagag gggcaggcca gaggacttca taaccaggct ggcctcctag atggcttggg
     2161 agtagcaagc tggcttactt ttattaccaa ggccttaagt gttagagtga gtgttagaga
     2221 ccagcctgga tgatggttcc ctgagaaggt aaatcagcca tagtttacac tggaatcttg
     2281 gtgcccttct ccttgcctgt gtcccaatgc atttgactaa gactctggta tcaccccacc
     2341 tcagggcatg ttttgggttt ggcaaaatga gatgaacagt aacgttatct ttcaaaggca
     2401 ggcctctgtc agtctctgct tgtagcacgg tgacaggcca gggtcaccaa gggtcaatgg
     2461 cagtcatggt ctccttcagt actgaggagt ggaggccaga gggtgtgtta agtctccgtg
     2521 acatattctt tgttttgttg ttttgcttct ttttgtcttt aaaaacatta tagacttgcc
     2581 aatgccatct ttagctctag ggagggaagg aacacattgt tgcccatgtc aggtctgtga
     2641 cccttcccag gggacgtcga aggcctggga tggcctccca gcctcttggc tcaccctctg
     2701 taccatggaa acctgagcgc agggctgggg ctgggtttgt tttcctcctg atgctcagag
     2761 agagatgtgt gagtgaatta tttaggttac ggcttcagca gagccagaca gtgaaagcct
     2821 gctttcctgg aggccagaag gtaggtcctg tcggtgggtg tggagctcca tagactctct
     2881 gctcactctg tcctggacac tgtcacccaa cggtcggctc ccctgccgtg ccccacctgt
     2941 gttgtccaca cgaactgggt tagagtggag agttcagaga tgacgcgtca caagctcccg
     3001 agagctgcca gtctcctcca gctccccccc accccccgct gcctcggggt cctgattctg
     3061 taccttctct gacccccact aaagttgcta attccttgtt aagtctccct ccctgcctcc
     3121 tgacctagcc atgcatttag tgggtgaact ctgagctgag tgggtatctg tagatttcca
     3181 gggaagcccc acacaaaaag ctctggcaaa gaaaagatcc agacccccac ctccaactcc
     3241 accccccccc aaaatttgta tccagctgaa tccaaacctg tgtaggtttt gtagctatgc
     3301 aaagaacagt ctagaaataa atggagggtt ttttggtttg gttttggggg ggggtttaga
     3361 gcataggggt tcctccagtc atttgacttc ctctgccctc cttgacgaga acatctcatc
     3421 atctgaggtt tgctggaacc ccatctcttc agctatgcgg gctctaggaa agccagcaac
     3481 tactaaatca tgtgactgat ttctgctaac ctcctggcag ttgtactgag tctgtgagtg
     3541 acatcctgat taatgatccc agacagctcc acaacattga cttgcacatt gagacgacag
     3601 ctccctaaac ccagaattat agttgcaaga gggtttagaa gccagctctt tgatttgcca
     3661 gcctgggaga gggtagctca gaaaggttaa gtaatttgcc cgaagtcaca cagcaagctg
     3721 gtggcatgtc cttgctcagt gactcagcat agagttcttt ccactattgt acatcccatt
     3781 gtaccccaga gcagatgaga acttggaagg agaacagggt tcttaactgt gagagtctca
     3841 ttctggaatc gcccaacact gtgagagcaa gggccagagg gaagaagagc aggaaacaca
     3901 tagtgatcac atacacatag ggaagcaaga aggggagggg tggatgccca gaatttcaaa
     3961 ctacagagtc aaaccgaaca ggacaaatgc cacacgaagg agaactggtg cctgtccttt
     4021 cctgaggagg caacatggag tgttgtcagt ccttggcaaa ctgggtgtgg gggtgcatgc
     4081 ctatatccca ggtactcagg aagcaataag gaggatggca agatggaggc caggctggac
     4141 ctaacagaga ccctgtcaaa agaggaacaa caataacaac agaaaaagaa tggaaaccct
     4201 tgcagaacct tgatgctgtc ttgatcaccc caggttcttt ttgtcctatg cagaggattg
     4261 caaactaaag cacataggtt actttttttt taacaaataa agttttattg aaacata
//
