LOCUS       NM_001252387            4152 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TAFA chemokine like family member 2 (Tafa2),
            transcript variant 2, mRNA.
ACCESSION   NM_001252387
VERSION     NM_001252387.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Liang,H., Tang,L.Y., Ge,H.Y., Chen,M.M., Lu,S.Y., Zhang,H.X.,
            Shen,C.L., Shen,Y., Fei,J. and Wang,Z.G.
  TITLE     Neuronal survival factor TAFA2 suppresses apoptosis through binding
            to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway
  JOURNAL   Life Sci 334, 122241 (2023)
   PUBMED   37944639
  REMARK    GeneRIF: Neuronal survival factor TAFA2 suppresses apoptosis
            through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2
            signaling pathway.
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Munz,M., Bharioke,A., Kosche,G., Moreno-Juan,V., Brignall,A.,
            Rodrigues,T.M., Graff-Meyer,A., Ulmer,T., Haeuselmann,S.,
            Pavlinic,D., Ledergerber,N., Gross-Scherf,B., Rozsa,B., Krol,J.,
            Picelli,S., Cowan,C.S. and Roska,B.
  TITLE     Pyramidal neurons form active, transient, multilayered circuits
            perturbed by autism-associated mutations at the inception of
            neocortex
  JOURNAL   Cell 186 (9), 1930-1949 (2023)
   PUBMED   37071993
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Di Bella,D.J., Habibi,E., Stickels,R.R., Scalia,G., Brown,J.,
            Yadollahpour,P., Yang,S.M., Abbate,C., Biancalani,T., Macosko,E.Z.,
            Chen,F., Regev,A. and Arlotta,P.
  TITLE     Molecular logic of cellular diversification in the mouse cerebral
            cortex
  JOURNAL   Nature 595 (7868), 554-559 (2021)
   PUBMED   34163074
  REMARK    Erratum:[Nature. 2021 Aug;596(7873):E11. doi:
            10.1038/s41586-021-03797-5.. PMID: 34341543]
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Wang,X., Shen,C., Chen,X., Wang,J., Cui,X., Wang,Y., Zhang,H.,
            Tang,L., Lu,S., Fei,J. and Wang,Z.
  TITLE     Tafa-2 plays an essential role in neuronal survival and
            neurobiological function in mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 50 (10), 984-995 (2018)
   PUBMED   30137205
  REMARK    GeneRIF: chemokine-like protein TAFA-2
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Choi,J.H., Jeong,Y.M., Kim,S., Lee,B., Ariyasiri,K., Kim,H.T.,
            Jung,S.H., Hwang,K.S., Choi,T.I., Park,C.O., Huh,W.K., Carl,M.,
            Rosenfeld,J.A., Raskin,S., Ma,A., Gecz,J., Kim,H.G., Kim,J.S.,
            Shin,H.C., Park,D.S., Gerlai,R., Jamieson,B.B., Kim,J.S.,
            Iremonger,K.J., Lee,S.H., Shin,H.S. and Kim,C.H.
  TITLE     Targeted knockout of a chemokine-like gene increases anxiety and
            fear responses
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), E1041-E1050 (2018)
   PUBMED   29339520
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 4152)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD350359.1, BC027082.1,
            AK164201.1 and AK140763.1.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines that act as
            regulators of immune and nervous cells. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) lacks an exon and uses a
            downstream, in-frame start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus, compared to isoform
            1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.67487.1,
                                           SRR1660815.187961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               CD350359.1         1-114
            115-909             BC027082.1         1-795
            910-3895            AK164201.1         2-2987
            3896-4152           AK140763.1         4107-4363
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 72.31 cM"
     gene            1..4152
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="TAFA chemokine like family member 2"
                     /db_xref="GeneID:268354"
                     /db_xref="MGI:MGI:2143691"
     exon            1..1466
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1573
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1468..1863
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; chemokine-like protein TAFA-2; protein FAM19A2;
                     family with sequence similarity 19, member A2"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-2 isoform 2
                     precursor"
                     /protein_id="NP_001239316.1"
                     /db_xref="CCDS:CCDS88096.1"
                     /db_xref="GeneID:268354"
                     /db_xref="MGI:MGI:2143691"
                     /translation="MNKRYLQKATQGKLLIIIFIVTLWGKAVSSANHHKAHHVRTGTC
                     EVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCL
                     EGEECKVLPDRKGWSCSSGNKVKTTRVTH"
     exon            1574..1726
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1851
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..4152
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3882..3887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="hexamer: AATACA"
     regulatory      3896..3901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="hexamer: AATAGA"
     polyA_site      3911
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="major polyA site"
     polyA_site      3916
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
     regulatory      3980..3985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="hexamer: AATAAA"
     polyA_site      4003
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
     regulatory      4129..4134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
                     /note="hexamer: AATAAA"
     polyA_site      4152
                     /gene="Tafa2"
                     /gene_synonym="6330575M02; Fam19a2; FAM19A2 TAFA-2; Sam2;
                     Tafa-2"
ORIGIN      
        1 agacagaggg agtcaaagcc tcccggtcca gccgtcccat tttactgctt aactcagcct
       61 ggagtgtcag aacccatctt tgcctgcctt ctctgtgctt tgtacagtgg ggccagtcgc
      121 tcccaacggc cagcccgctg agtggaacag gggtctaggg tggactagca gggctctgcc
      181 cgttggggtg actttcgaac attatcttta gtgtatttta acagtacaga gcttgtggtg
      241 ggactcagag agggagaagc tttgattgct ttttaaaatt attttatttt attttatttt
      301 ttggcttttt tttttttttt cttctggtga tctggatttg tttcctcggg cccctcccct
      361 tgttccgttc tttctcactc ccgcctttgg cgaagtgaca caggcgacac ctgctcgctt
      421 gtgtctgctg ctggaactcg cacctccaag gtggtgaagg tgccggcgcg ctcgtgactt
      481 ggggggacag cagaggggtt ccctcccttg gagcacacga tgcggagagt ggcggcgggt
      541 gggatgcgag gagctctacc ggctgcactt ggaggcgcga tcgaggggct gcagctggcc
      601 gggagttgct gctaagtgga cgcgactcga cggcgcccag gtgtccgaga gggcacccgc
      661 gggacccgag tgcgagctgc gggaacgcag gcgtctcccg gggaggacgc cggccgagcg
      721 cacagcccgc gagcctgctc agaaccgctc cacaccggga gcctgcagac ctgggagagc
      781 cggggaactc gaggagtgtg ctcggcggcg gaggctgctc tgctgaaggt gaatcaccgc
      841 gtccaattgc ctttccctag agaacccggg ggagggcggg agagggggaa cgtgtgagcg
      901 cgcgcgtttg tgtgcaaggg agagccgacg cggggcgaga ggaaaagtcc tcgctcgccg
      961 ctcaaagcaa acaaaccgga gatggaataa gagcggcggt ggctggagcc cgcctggatc
     1021 ctcgcagtcg cgggagccga gcgcaccacc gcgcgcagcg catcgccggg gacagcgggc
     1081 gaccgcgggc gccgccgggg gctgcggaga ctttggctct ccccctcggt cgacgaccct
     1141 tccgattact ttgacactgt gggataaaga gcagagcccg gggaccgacc tcgcgcgctg
     1201 caccttcctt ttgcttcggg gaagggggac cccagcttgt aggtgaagac gctgccgagc
     1261 ccccctttag ccttcggagg aggcagcact cacactcgct cgccctctgc gaacacacac
     1321 cggcggactt gaggtcccta tgcccctgga tggtgccagc ggaccggcat ctcggaagcg
     1381 atgcaggagc ggtgaggctg gcgtcggccc gcggaagcta ccggaccatc gctaggtgct
     1441 gccgcccccg ggacgcccgg ctgcaggatg aataagagat acttgcagaa agcaacacaa
     1501 ggaaagcttc tgataattat ttttatagtg accttgtggg ggaaagccgt ttccagcgcc
     1561 aaccatcaca aagctcacca tgttagaact gggacttgcg aggttgtggc gctgcacaga
     1621 tgctgtaata agaacaagat agaagaacgg tcccaaacgg tcaagtgctc ctgcttccct
     1681 gggcaggtgg caggcactac ccgagctgct ccgtcttgtg tggatgcatc catagtggaa
     1741 caaaagtggt ggtgtcatat gcagccatgc ctggagggag aggaatgtaa agtccttcca
     1801 gatcgcaaag gatggagctg ttcctctgga aacaaagtaa aaacaactag ggtaacccat
     1861 taaccactcc taaatcaaat aatactgatg gctgggttca tggagacaca agaatagaaa
     1921 ctggactcct gccgtgacct tgaagatttt tatactgctt agaagagaca tttaaaatcc
     1981 atttccaagg aattctatgg cttttcatct acttcttagt gaaactaaga ctttacagaa
     2041 gtctacagtg aacgttgggt cctgaagact tcatccgctg tgaactaacg cttggctcac
     2101 aacacttctg agggaagggg gcgcagttct ccacggagct gggatagagt tggttttctg
     2161 gggtgacacc agagactgtc acctttaagg ttccttgctt cagctgtgac tgttcttgtg
     2221 tctgaagctg cttcccaagc tgactgtcct gtcattgatg tgttcctggc tcttttgctc
     2281 cttgtctagt aggactatgc acagctttga tgacgttccc tttgtaaact cttccagcat
     2341 ggcgtagaca ggggcaattt tattggtatt ctaaccttga aactctgaaa gcctacatgt
     2401 tgtaatgtct tactcttgcc tctgtgaaag gaatagaagt atttacccat cgataatgat
     2461 aatcattggc aaatcacaat gatctgagta tatccctcat ataacaatgt gtaggcgacc
     2521 tgacacgttt ccccaaggct aacacgtgac tgcagctctc tgacggttga acagatagca
     2581 gttaggattg gattccaatt cccattacac agtgctctgt gcctctagtg cacccttcct
     2641 tccagggttg gttggttttt tttgtttttg tttttgtttt ttttaagtgt actttccttt
     2701 tactttattt cacagaactc atcagtatac agtcaagtta gcagagagct tttgatttaa
     2761 aataataaaa taaaataaaa cccgccaggg atgcatgtgc ttctctgatt tctcatcact
     2821 tacatttttc tttctgtctc attttaaggt cgtctcttgc tcgatcccaa tgactgcttg
     2881 aatgcttatg tatttgttca gtctgtggct agaaaaaaac aaaacctgtt gattttcctt
     2941 gaccacaaag gtctaaatac tcacttacgg ttgttccatt caaacaattc ttggccagta
     3001 ttttgtccat attttctcac cctaaaactt gtgattttta gttcttcgtg gtttttctta
     3061 caaatattta aaggccttaa acgttgattt acctttttct aagttattac agaatgtata
     3121 attttgtacg gcgtttattt tgtttcactt gtgatgtggg ggaagggaac agtgggtact
     3181 gagttgccac cctataataa taataccatg taaacttata gtttgaaggc atataaaagc
     3241 aagggttttc catgtcttaa ttattttagc ttgatcaaaa gatgtttcac agatcatcct
     3301 attagggggt ccatcatttt agtaaaagag tgaagatgtg tgggacttct tgtatttcta
     3361 ggactcactg acaaagccag ttaaccttag gttggtttct aggatggagg ttcatatatt
     3421 ctagaggaga atttgtacct gttagtctgt aacaatactc aaagggtcgc acagtaacta
     3481 ggacctttgg tgggaagaac agctaaaagt gcaaaaatct gttaaaaaat taaattggaa
     3541 aacgacactt ttaatattga ttgaaagtca actgcctcat gaaactgtgg gacaaagtga
     3601 ttcctgactc acttttaatt gcataaaacc aactgggtgg ttctacgtgg gttttgttat
     3661 ggatcagttc tacacagagt caaaatgtaa ggagtaacag ttatgttgga ctttctctgt
     3721 caaacaaatt atcactactt tctttggttc aaaatgaaaa actatcattt tggatattat
     3781 gagtttatcc taggttggtt tgaaattatg gatcatgctt ctcattgcga aatctatgtc
     3841 atttaaaaca acactggaaa ttctgtatta tataaaagtg taatacatgc gtatcaatag
     3901 aaaaaaataa atgaaatttc aaatatatga acaagaatat tcccagtaga ttaatgttgt
     3961 gactattctg aaaaaaataa ataaaattgg aatataaaat agacactcct ttcacaagta
     4021 caatttggaa aatctgattt cttgtatctt atttttaaag taccctagtt agtaaccagt
     4081 acaactctga atttagatgg aaactgacaa atttttaaat cctcttttaa taaaattctg
     4141 tgcttaacgt tc
//
