LOCUS       NM_182808               3252 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus TAFA chemokine like family member 1 (Tafa1), mRNA.
ACCESSION   NM_182808
VERSION     NM_182808.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Yong,H.J., Hwang,J.I. and Seong,J.Y.
  TITLE     Alterations in Dendritic Spine Maturation and Neurite Development
            Mediated by FAM19A1
  JOURNAL   Cells 10 (8), 1868 (2021)
   PUBMED   34440636
  REMARK    GeneRIF: Alterations in Dendritic Spine Maturation and Neurite
            Development Mediated by FAM19A1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Di Bella,D.J., Habibi,E., Stickels,R.R., Scalia,G., Brown,J.,
            Yadollahpour,P., Yang,S.M., Abbate,C., Biancalani,T., Macosko,E.Z.,
            Chen,F., Regev,A. and Arlotta,P.
  TITLE     Molecular logic of cellular diversification in the mouse cerebral
            cortex
  JOURNAL   Nature 595 (7868), 554-559 (2021)
   PUBMED   34163074
  REMARK    Erratum:[Nature. 2021 Aug;596(7873):E11. doi:
            10.1038/s41586-021-03797-5. PMID: 34341543]
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Khalaj,A.J., Sterky,F.H., Sclip,A., Schwenk,J., Brunger,A.T.,
            Fakler,B. and Sudhof,T.C.
  TITLE     Deorphanizing FAM19A proteins as pan-neurexin ligands with an
            unusual biosynthetic binding mechanism
  JOURNAL   J Cell Biol 219 (9) (2020)
   PUBMED   32706374
  REMARK    GeneRIF: Deorphanizing FAM19A proteins as pan-neurexin ligands with
            an unusual biosynthetic binding mechanism.
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Yong,H.J., Ha,N., Cho,E.B., Yun,S., Kim,H., Hwang,J.I. and
            Seong,J.Y.
  TITLE     The unique expression profile of FAM19A1 in the mouse brain and its
            association with hyperactivity, long-term memory and fear
            acquisition
  JOURNAL   Sci Rep 10 (1), 3969 (2020)
   PUBMED   32123192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Lei,X., Liu,L., Terrillion,C.E., Karuppagounder,S.S., Cisternas,P.,
            Lay,M., Martinelli,D.C., Aja,S., Dong,X., Pletnikov,M.V. and
            Wong,G.W.
  TITLE     FAM19A1, a brain-enriched and metabolically responsive neurokine,
            regulates food intake patterns and mouse behaviors
  JOURNAL   FASEB J 33 (12), 14734-14747 (2019)
   PUBMED   31689372
  REMARK    GeneRIF: In male mice, FAM19A1 deficiency alters food intake
            patterns during the light and dark cycle. Fam19a1 KO mice are
            hyperactive, and locomotor hyperactivity is more pronounced in
            female KO mice.
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Zheng,C., Chen,D., Zhang,Y., Bai,Y., Huang,S., Zheng,D., Liang,W.,
            She,S., Peng,X., Wang,P., Mo,X., Song,Q., Lv,P., Huang,J., Ye,R.D.
            and Wang,Y.
  TITLE     FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell
            proliferation and differentiation
  JOURNAL   FASEB J, fj201800020RRR (2018) In press
   PUBMED   29799787
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050001.1, AY325120.1, AK049880.1 and AC158674.10.
            
            On Oct 8, 2011 this sequence version replaced NM_182808.2.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines that act as
            regulators of immune and nervous cells. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050001.1, ERR3363660.1151630.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AK050001.1         2-200
            200-1000            AY325120.1         1-801
            1001-2521           AK049880.1         892-2412
            2522-3252           AC158674.10        116036-116766       c
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.67 cM"
     gene            1..3252
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /note="TAFA chemokine like family member 1"
                     /db_xref="GeneID:320265"
                     /db_xref="MGI:MGI:2443695"
     exon            1..433
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..554
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..695
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..820
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..3252
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1944
                     /gene="Tafa1"
                     /gene_synonym="C630007B19Rik; Fam19a1; FAM19A1 TAFA-1;
                     Tafa-1"
                     /note="major polyA site"
ORIGIN      
        1 atttcgctgc ctaactctgt cctgaatgta ctggagtagg gatggtctgt ccgtggctat
       61 aaactgcttc tcatcaggaa actacattag ctcaccatca cttcaaaggt ctcgtcagac
      121 agaggtgacg ccaggggatg atttaaaggt gaacatgaca aggtttccac ccctcaaacc
      181 ttgcttcctt ttctgacaat acagtgaacg agcccaacgt cttcacaact gtggaaacgg
      241 gactggaaga gaaaagcttg cctttttttc ttttcttttc ttttcttttt tttttttcaa
      301 ttcttaataa agaattgctg ggaagcattc tctttgaaaa atctcagaac tgtggcacag
      361 atggatttta aaaagtgtta gctctttcca atgagcacta ggagggttcc ctgctcttgg
      421 ctggattttt cagagaatgg caatggtctc tgcaatgtcc tgggccctgt acttgtggat
      481 aagtgcttgt gcgatgctgc tctgccatgg gtcactccaa cacaccttcc agcagcatca
      541 cctgcaccgg ccagaaggag ggacctgtga agtgatcgcg gcccacaggt gttgtaacaa
      601 gaaccgcatc gaggagcggt cacaaacagt gaagtgttcc tgtttacctg ggaaagtggc
      661 tgggacaaca agaaaccgac cttcctgtgt ggatgcctcc atagtaattg ggaaatggtg
      721 gtgtgagatg gagccctgcc tagaaggaga agaatgtaag acactccctg acaattctgg
      781 atggatgtgt gctacaggca acaagattaa gactacacga attcacccaa gaacctaaca
      841 gaagcatttg ttatataaat aggaaaaaga acaacctgtg gaatatacgt tgtgaggatt
      901 taaaacatct tccatagttg caagccaagt ggatctctta tctgcacttt ggttaccaga
      961 taaccacagt gcacttactc tgatacacag tatcccaaaa gaagaagact cgggattttc
     1021 tggcaacatc aaggaaaatg gcttttaaaa aaaaatgagt tttctctgtg aaatttggag
     1081 gatcatgaag aacgatcaac tgtcttctaa tttggaacta acattacttt gtaccatttg
     1141 aaatatatat gtatatataa tattttgaaa tattatatat tctcttcaag aaatgaacag
     1201 taccacaatg tgaggtggct ggtgtatccc tttcagtttt ggatgtttgg tcggttttgt
     1261 tttgtttgcc attccttttt ctctcggtaa ggaagataca tgcccatgtg aaaatccaac
     1321 atggcactct ccctggaagg ccagctgcaa gccgactcct ggaagctgag gcatcctaac
     1381 agtactgagt caagagcttc cccctgtttc tacctggtga cccaaggaag ctccttgtct
     1441 tgatttattg ctttctatcc tgtgcaatat tagcatgcaa gcttggctta cataatcata
     1501 ctttatattc gattgatata taataaccgt tctaacctct tccaggaaaa tatttttaga
     1561 actactagct tttccacaga taagcaaatg gggattcttg agggagctgc tccaccgtgc
     1621 tattaagact ctggcaggat ggtaggatgt agatccctat attaataagt cctgtaaata
     1681 cagtgtctta gggctttgta tagctgtcct agactacaga agtgtcctct gattaaatcc
     1741 aaagtctgcc attgttaact ccatagtgct gtagcgacac gttttatcat ggcgcctctt
     1801 tctatgtttg ctttgctttt tcctagagtg ttcatctctc ctctgatgag ataggaaagc
     1861 tatggaagca attaggtttc ccaatgatct atgtgaccaa gtgttggaca gccctattaa
     1921 agtggtaaat aacttctttc ttaacccact cgtcctcttt gtctgccatt tagttttata
     1981 gactctcttt taactaaacc gagagatcac gagactacgg aggctattat ttccaacaat
     2041 aatatttttg aaacttagaa actcattaat atgattgtag taaaatatcc aattacaatt
     2101 tctgggattc catgtgggtc actctgataa tatatatggg gctcacacac acacacacac
     2161 acacacacac acacacacac caatgagagg taaaaaacaa caaaaaccta aaatccatta
     2221 tccctgtctt tttcgagtta ctgagctgag aggtaagagg taaacaccta cttaaggtct
     2281 agttttcctg gggaaaattt taatgggatt ttacactccg atgtcatctc acaactgcag
     2341 ggtttttttt ttcttcccaa attattctct gtcatctgtg tttttagagc ctcttagtaa
     2401 atcacagcac tgtagtccct aagtctgtac tttttaggat caaacttcaa gtaaaactca
     2461 agattacctc ttattatacc cagaaagcct gaagtttaat tgaatgtgtg aagttctaac
     2521 caaaaaaaaa aaattttttt tttgattctg tattgtgaag gcctgtaaaa tgaatgcatc
     2581 tagagataga aatagaatcc gtactgtaaa attgagactt ccaaatgctt tggtggatat
     2641 ttgctaaaag ataacaaaat ctataccagt atccatgtgt ggtggcaagt gatagctagg
     2701 catcatttga gatcccagta cttgaaacat ggaggtagga agattgcaag ttcaaagtca
     2761 gcctgggata caaagcaaga cccctgcccc aaaacaaaga aaaccatttg tgacagcact
     2821 catttcttag ttacagcact gattcaaggg ccaagcaata tgctggtaaa aacaaccttt
     2881 catatgtcaa cttcagatta aaattaaaac catgaactct cagaattata cacttgagga
     2941 aaaattaaaa tagaaatatt tgccacagaa tttagtagaa cctttagtat acccaaagat
     3001 ggtatcacat caaggaagat tagaacaaga gagcctggtt caaaacaaaa acaagtaagt
     3061 aaatcaggat tccagcatgg cggggcatca ttgtgatcaa taggggatca tgtgaaatgg
     3121 gagcctacag aaatttactt ctaggtgaat ttaccataac cacattgcca tatcttcaga
     3181 tttttgggaa atgcagaaat caagagcttt gcataaaagt ccctaacagt cctaataaat
     3241 aagccaagtt ca
//
