LOCUS       NM_001410187            6304 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 8 (Taf8),
            transcript variant 4, mRNA.
ACCESSION   NM_001410187 XM_036160732
VERSION     NM_001410187.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6304)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
  REMARK    GeneRIF: Loss of TAF8 causes TFIID dysfunction and p53-mediated
            apoptotic neuronal cell death.
REFERENCE   3  (bases 1 to 6304)
  AUTHORS   Scheer,E., Luo,J., Bernardini,A., Ruffenach,F., Garnier,J.M.,
            Kolb-Cheynel,I., Gupta,K., Berger,I., Ranish,J. and Tora,L.
  TITLE     TAF8 regions important for TFIID lobe B assembly or for TAF2
            interactions are required for embryonic stem cell survival
  JOURNAL   J Biol Chem 297 (5), 101288 (2021)
   PUBMED   34634302
  REMARK    GeneRIF: TAF8 regions important for TFIID lobe B assembly or for
            TAF2 interactions are required for embryonic stem cell survival.
REFERENCE   4  (bases 1 to 6304)
  AUTHORS   Kamenova,I., Mukherjee,P., Conic,S., Mueller,F., El-Saafin,F.,
            Bardot,P., Garnier,J.M., Dembele,D., Capponi,S., Timmers,H.T.M.,
            Vincent,S.D. and Tora,L.
  TITLE     Co-translational assembly of mammalian nuclear multisubunit
            complexes
  JOURNAL   Nat Commun 10 (1), 1740 (2019)
   PUBMED   30988355
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6304)
  AUTHORS   El-Saafin,F., Curry,C., Ye,T., Garnier,J.M., Kolb-Cheynel,I.,
            Stierle,M., Downer,N.L., Dixon,M.P., Negroni,L., Berger,I.,
            Thomas,T., Voss,A.K., Dobyns,W., Devys,D. and Tora,L.
  TITLE     Homozygous TAF8 mutation in a patient with intellectual disability
            results in undetectable TAF8 protein, but preserved RNA polymerase
            II transcription
  JOURNAL   Hum Mol Genet 27 (12), 2171-2186 (2018)
   PUBMED   29648665
  REMARK    GeneRIF: In contrast, loss of TAF8 in mouse embryonic stem cells
            and blastocysts leads to cell death and to a global decrease in Pol
            II transcription
REFERENCE   6  (bases 1 to 6304)
  AUTHORS   Guermah,M., Ge,K., Chiang,C.M. and Roeder,R.G.
  TITLE     The TBN protein, which is essential for early embryonic mouse
            development, is an inducible TAFII implicated in adipogenesis
  JOURNAL   Mol Cell 12 (4), 991-1001 (2003)
   PUBMED   14580349
REFERENCE   7  (bases 1 to 6304)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6304)
  AUTHORS   White-Cooper,H., Leroy,D., MacQueen,A. and Fuller,M.T.
  TITLE     Transcription of meiotic cell cycle and terminal differentiation
            genes depends on a conserved chromatin associated protein, whose
            nuclear localisation is regulated
  JOURNAL   Development 127 (24), 5463-5473 (2000)
   PUBMED   11076766
REFERENCE   9  (bases 1 to 6304)
  AUTHORS   Voss,A.K., Thomas,T., Petrou,P., Anastassiadis,K., Scholer,H. and
            Gruss,P.
  TITLE     Taube nuss is a novel gene essential for the survival of
            pluripotent cells of early mouse embryos
  JOURNAL   Development 127 (24), 5449-5461 (2000)
   PUBMED   11076765
REFERENCE   10 (bases 1 to 6304)
  AUTHORS   Voss,A.K., Thomas,T. and Gruss,P.
  TITLE     Efficiency assessment of the gene trap approach
  JOURNAL   Dev Dyn 212 (2), 171-180 (1998)
   PUBMED   9626493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139214.12.
            
            On Jul 29, 2022 this sequence version replaced XM_036160732.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.21215.1,
                                           SRR9219380.11830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC139214.12        92607-92663         c
            58-214              AC139214.12        91660-91816         c
            215-313             AC139214.12        88916-89014         c
            314-376             AC139214.12        88554-88616         c
            377-501             AC139214.12        86954-87078         c
            502-649             AC139214.12        84718-84865         c
            650-6304            AC139214.12        78426-84080         c
FEATURES             Location/Qualifiers
     source          1..6304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.33 cM"
     gene            1..6304
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="TATA-box binding protein associated factor 8"
                     /db_xref="GeneID:63856"
                     /db_xref="MGI:MGI:1926879"
     exon            1..57
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..987
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="isoform 4 is encoded by transcript variant 4;
                     transcription initiation factor TFIID subunit 8; protein
                     taube nuss; TBP-associated factor 8"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 8
                     isoform 4"
                     /protein_id="NP_001397116.1"
                     /db_xref="GeneID:63856"
                     /db_xref="MGI:MGI:1926879"
                     /translation="MADTAAGPGGSGTRPGSKQSTNPADNYHLARRRTLQVVVSSLLT
                     EAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNV
                     DTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKT
                     PTYREPVSDYQILREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFT
                     IPYLTALLPSELEIQQMEETDSSEQEEQTDTENNALHISTVGPPLLPASQQSQNSLSH
                     ILPLPLGTEQGLPQVSGWLLQACMMGCVSSLHHETHLLGSHTFSRW"
     exon            58..214
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     exon            215..313
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     exon            314..376
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     exon            377..501
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     exon            502..649
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     exon            650..6304
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="hexamer: AATAAA"
     polyA_site      1305
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="major polyA site"
     regulatory      6037..6042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="hexamer: AATAAA"
     regulatory      6050..6055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="hexamer: AATAAA"
     polyA_site      6057
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="major polyA site"
     polyA_site      6075
                     /gene="Taf8"
                     /gene_synonym="Tbn"
     regulatory      6100..6105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf8"
                     /gene_synonym="Tbn"
                     /note="hexamer: AATGAA"
     polyA_site      6113
                     /gene="Taf8"
                     /gene_synonym="Tbn"
     polyA_site      6120
                     /gene="Taf8"
                     /gene_synonym="Tbn"
     polyA_site      6304
                     /gene="Taf8"
                     /gene_synonym="Tbn"
ORIGIN      
        1 acactacgca agagcaagat ggctgacacg gcggccgggc ctggtggctc cggaacgaga
       61 ccgggaagta agcaatccac taaccctgct gataactacc atctggcccg gaggaggacc
      121 ctgcaagtgg ttgtgagctc cttgctgaca gaggcgggat ttgagagtgc cgagaaagcg
      181 tctgtggaga cactgacaga gatgctgcag agctacatct cagaaatcgg gagaagtgct
      241 aagtcatact gtgagcacac agccaggacc cagcccacac tgtcggacat cgtggtcaca
      301 ttggttgaaa tgggcttcaa tgttgacact ctacctgcct atgcaaaacg gtctcagagg
      361 atggtcatca ctgcacctcc agtgaccaat cagccagtga cccccaaggc cctcactgca
      421 gggcagaacc ggccccaccc gccacacatc cccagccatt ttcctgagtt tccggatccc
      481 cacacctaca tcaaaactcc gacataccgt gagccagtgt ctgactacca gatccttcgg
      541 gagaaggccg catctcagag acgagacgtg gagcgagcac tcacccgctt catggccaag
      601 acaggcgaga cccagagtct tttcaaggat gatgtcagca cttttccttt gatcgctgcc
      661 agaccgttca ccatccccta cctcacggcc ttgcttcctt ctgagctgga gatacagcag
      721 atggaagaga ccgactcctc ggagcaggag gagcaaacag atacagagaa caacgctctt
      781 catatcagca cggtgggtcc tccccttctg cctgcctcac agcaatccca aaacagcctg
      841 tcccacatcc tgcccctgcc cctaggaact gaacagggcc ttccccaggt ctctggctgg
      901 ctgttacaag cttgcatgat gggctgtgtg tccagtctcc atcatgagac acacctcctg
      961 gggagtcaca cattcagcag atggtgaacg agcactgtaa ggtccagacc ctggtcctgg
     1021 tctgaggaac tagtgtggag caagacagat aaagccccgc cttcaggaac taaagagact
     1081 agagatggag ctgtggaggt ggtgggggat tacaggtgac atttgggtaa agacctgaag
     1141 agactaacgc ctgccctgct catctctgga gtttccaggc aggggacaga gcacatgcag
     1201 ggccagcctg aggtagaggg agctaactcc tggtacctcc ttctgtgtta gactgcagac
     1261 tcacacttcc atactacaaa gtacaataaa agactgttac tggcacttgt tactattctg
     1321 gtagcctgca aaatgtaatc gtgttagaat cctggtcctg cctctgcctg ctctgtgctg
     1381 ggattataac ccagtcacat ctcactctga ccagtttaaa ctgccccctt gtgtcctgat
     1441 gtgaggtgtc tctcacgccc ttgagcgtaa ggagcgaggt gtttagagcc agtgctgttc
     1501 tgttctgttc tcttctgtcg tgtgaactgg ctctcgtgca ggcagcctag aagtttaacc
     1561 ttttcctctc ttatgagaaa tcttagcaat catgtactca gtaaacatgg gttggcagtg
     1621 agcatgtgtc tgcccgggat acagcagtga ccccagtata taaaacctct gccccccctt
     1681 gaaaaacctt aaaaaaaaaa caaacaaaac aagcaaaaac aaaaaacccc tctgctcccg
     1741 agagcctgtg aaatcatccc ttacacgtaa ctcaagacga aacggttcgc ggtgaggatg
     1801 gagcctttgc ttccgataac agcacaccca gggaggacca agcagaggct tgaaggagag
     1861 aggagagccg aaccatcact gccgtcaagg gccagagcaa catcagtggt tgggatggaa
     1921 agacagggaa gggaagagga agggagggct gctgggatgg gcccgctgct tcaggagctg
     1981 ggagcagagt tgcagaggag caccgagcca gggagggaca cttgccaact tctgcaagca
     2041 tcgttgatgg ctacgatgac ggtgggcccc agtcacaggg atgtaggcca gggacaagtg
     2101 tgggtccctc tcctcaggtg gccacagcag aggcagtgca aatgctctct ttgtatcgat
     2161 aagtaaagcc aagaggatga cctagcagat gggagatgtg gcagaaaaga aacaagtgtg
     2221 gctgcagaac tcatcagctc caggcgcctg aagggtggtg gcttgtcccc acagcaggaa
     2281 gagtcaggta gggcacccaa ggaaagctga cgcacgttga tgtgcggtgc ctgtgagatg
     2341 cttgtacaaa gcatttgatc tgggaactgg tggtggcaca gacaggttgc agttggagtc
     2401 ctcagtgtgg aagcggaagc catagctggg ggacagatag ggttgttggt gcctccacgc
     2461 cggccctggc ttgaggctac ctgtgtctga aggggcaaat cgtagcagta gcgtttctac
     2521 aagctgtact ccatagagag acacaacatc taaattgtgg gccctccatg tcgctctcac
     2581 cgattgtttg aggtacaatt gaggcagcct ttgagtaact ttggggtttg gatgtggaag
     2641 ggtggtggac tgaggacatg gtaggcagtc ctctgttagg cccataagaa cacaggatgg
     2701 ctgcttgttt tgttttgttt tgtttttaag atttatttat ttgttatatg taagtacact
     2761 gaggcggtct tcagacacac cagaagaggg catcagatct cattacagat ggttgtgagc
     2821 caccatgtgt ttgctgggat ttgaacacag gacttcccag agagctgtca gtgctcttaa
     2881 ctgctgagcc atctgagcgg gggtcagata ggcctttccc atacctgaca catcagcgtg
     2941 gttgctctta tagagacagg cctggagtgg ggagtcagcg gaccttcccc atacctggtg
     3001 caacagtgtg gttgctctta ggctctggtt ttgaagaggg actctgcggt ggttttagtg
     3061 tggaggactc gagcacatta ctgaatgggg atggctttgc agggagatga cagttaatga
     3121 atagtgagga gatgttgcaa aacctagaag ccatacagag tgttacggcc cagtaagccg
     3181 gagactggtg tctgtacccc agcccaactg tcccttgaga taaagcctct attcatactt
     3241 tttttttgcc atctggtcac gtatgaaggt gtcctggttg gggtctgagg cctcctttaa
     3301 actctcagtt cctccagggc acccgtggtg tgtcactggg aggcgctgca ggtcagcttt
     3361 tggtcacggc gtgcacagcc tggtcaggct ctgggtgtgg tggtccatgc cctggctctg
     3421 ctaccactgc tcaataaaga agtacagaaa caaagctgga agccagagtg tgggggctgg
     3481 ggagagcata cacatgataa ggaaagggga gtcagtcacc caggcgtcca gcagtgtttc
     3541 taatgaagcc atggactcgg ctttgccttg tcaagctcca cttcaggatt ccagaaagtt
     3601 cttgaatatg ctgaaatatg gtcattggct ctttgttcca agtgccagaa atgagagatt
     3661 tgggggagat gtattagacc tatgttagtt ggggcctagg agacagacaa cctgtgcact
     3721 gaatgtcctg gccctcctgt gtcccttata ccaagatacc catggttacg ccctttcctc
     3781 atcccagtgc attagacttc ctccctgaag catgtaaatt ctaacctcct aggtctccat
     3841 tctttatgtc cccaccttct gaagatgtca aagaccctgg agtgtatcac tttgtcagag
     3901 ttcacagttt cactgtccag gtctcatcga ggcaggcaga tatggcagca ctgggaaggc
     3961 ggtgctcttg tctcctcata tctcattaga caccagagtg gctcttgtcc cgggcacagt
     4021 ctccttcctc acgccactgg tattctgctt tattccggct tttgcccaaa ggacgattcc
     4081 ggagctgaga aggagagcgc ttctgttctg cagcagagct cctccttgtc cggcagccgg
     4141 aatggcgagg agagcgtcat cgataacccc tatctgcggc ccgtgaagaa gcccaagatc
     4201 cgtaggaaga agtgagtggg ggctggctcc agcccgctcc agcctgcttg tctgctcctt
     4261 ggtaggaata ggctgcccag tgggtgcagc ttgctgggca ctgctcgggc aagaggaagg
     4321 cttcctctgc ttctcttcct tggctcccac gcgtacccgc ttctctctag tggctgtgtc
     4381 ctgccagctg taggctgctc gtgcctggga gaacaggagg ggcccacagc agcctctgtg
     4441 gttcttcttc tttctaggtc cctctcgtga cccgagaagg aagctgccct gtaaaggaga
     4501 gaacacgctt ccctggggag tgaaatcacg gagggaagag gagggtggcg tccttctggc
     4561 ctgggccagg ctgtgtcatt ttagtagcag ctttgtgtga agacagcctg ttgtgcttga
     4621 ctgtgaatgg aggaaatgtg gtgcggtaaa ggacggttcc gtccccttgg ccgtgctgct
     4681 gcaactgtgc cggggactgc tggtgactcc attgatcaat catgggactt gattcgtttg
     4741 gaacctggag ggccagggaa gaggcagaac gacgcctatg gctctgtgcc ctgccgagaa
     4801 ggcggccatg tgtaccttcc agccctcttg gatccctctc gctgatataa atgcagagag
     4861 gtctcacttc tcacctggac cccaaggttc ctgctgagtg gattgaaaat gactatgtat
     4921 ctcattgtgt tggaaacagg cccacagccc accttggatc tagggctgcc aggagctagg
     4981 aacaaaggtg tcaggatcaa tcaatgacag tggccatggg gtagccttga tctctgacca
     5041 gcatttgatt aaagctgacc acagtggagt caaaccaatc ctgtggcttc aaaaggagcc
     5101 atggacttaa agcaccgtga agagtactta gcaggtagga gaggactaag cctagctgtg
     5161 aaatgcagct ctggtagaaa gctacgtgcc cacctgctgg acggaggggg tgagaagacc
     5221 ctgctgagac cctccacccc accccacact tccccctaat catgaatctt cgtgcctcta
     5281 aggaaggatg acagggacac atggaaattg acacaacgtg gataagttgt ccttgggttg
     5341 gaatgcctcc tccatcctga cggctgctgc tgcttctgct actgcagtct tgctcatttt
     5401 ctctccccac ccctcctgtt tcagagatag gctctctctg tagtccaggc tatcccagaa
     5461 ttcagtgtgt atcccaggct cagtgccttc ctgccacctg ctgcaggtat aggtgcaggc
     5521 caccatgctt ggcttccagg cagctggtag aggctccacc ttccccgctg attctctgga
     5581 gggaaagagc tctgtgtctg gaattggagg acaagaaatg tcgagaaagt gagcttcctc
     5641 agctccggac caaacaggac tatttccgtc gtgactcaga acttccagga cctgtgtggc
     5701 tcccgagagc ttgtggtaga cttggctact ctgggcgagt cagctgaaat ccagtcaagg
     5761 tcagacagga gcgatcacac cttgctgttc ccgatgtgac tagcgagcac atctgtaatt
     5821 ccagcaccat tgtcactggc gttgggaaca gtgtgcaagg tgggggtggg aggggctctt
     5881 gcctgtgacc tcagaactgc ggtgcagtct ctctctagga agagagattt tgtgttaaag
     5941 catataattc tcaatgtgta tttatatatt tctatttttt ataatggggg agacttattg
     6001 gaaggagaaa tgaagtgtga tttatgggag gcctgtaata aaaattcata ataaaaactt
     6061 tgtaaatgac tcagacatag ggcctctcaa atggtaggca atgaagcact gtacccagct
     6121 tttcctgtga cttgctttaa acacgttttc tgcatgctga gtggtggtag cacatacctg
     6181 caatcccagt atttgggata ctgagttcaa gaccagcctg gattatatag taagtaagcc
     6241 ccagcctcaa acccagaaca agttgttagt gttcatttgt ttgtttttaa gaattttaaa
     6301 tttt
//
