LOCUS       NM_146092               2203 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 6 like
            (Taf6l), transcript variant 1, mRNA.
ACCESSION   NM_146092
VERSION     NM_146092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Seruggia,D., Oti,M., Tripathi,P., Canver,M.C., LeBlanc,L., Di
            Giammartino,D.C., Bullen,M.J., Nefzger,C.M., Sun,Y.B.Y.,
            Farouni,R., Polo,J.M., Pinello,L., Apostolou,E., Kim,J., Orkin,S.H.
            and Das,P.P.
  TITLE     TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via
            the MYC Regulatory Network
  JOURNAL   Mol Cell 74 (6), 1148-1163 (2019)
   PUBMED   31005419
  REMARK    GeneRIF: TAF5L and TAF6L maintain self-renewal of embryonic stem
            cells via the MYC regulatory network.
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Bardot,P., Vincent,S.D., Fournier,M., Hubaud,A., Joint,M., Tora,L.
            and Pourquie,O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Chen,J., An,B.S., Cheng,L., Hammond,G.L. and Leung,P.C.
  TITLE     Gonadotropin-releasing hormone-mediated phosphorylation of estrogen
            receptor-alpha contributes to fosB expression in mouse gonadotrophs
  JOURNAL   Endocrinology 150 (10), 4583-4593 (2009)
   PUBMED   19574399
  REMARK    GeneRIF: Gonadotropin-releasing hormone-mediated phosphorylation of
            ERalpha in LbetaT2 pituitary cells results in its rapid association
            with p300-CBP-associated factor and the transcriptional activation
            of fosB.
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Nagy,Z. and Tora,L.
  TITLE     Distinct GCN5/PCAF-containing complexes function as co-activators
            and are involved in transcription factor and global histone
            acetylation
  JOURNAL   Oncogene 26 (37), 5341-5357 (2007)
   PUBMED   17694077
  REMARK    Review article
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Floyd,J.A., Gold,D.A., Concepcion,D., Poon,T.H., Wang,X.,
            Keithley,E., Chen,D., Ward,E.J., Chinn,S.B., Friedman,R.A.,
            Yu,H.T., Moriwaki,K., Shiroishi,T. and Hamilton,B.A.
  TITLE     A natural allele of Nxf1 suppresses retrovirus insertional
            mutations
  JOURNAL   Nat Genet 35 (3), 221-228 (2003)
   PUBMED   14517553
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY295292.1, BC028647.1 and AC025794.9.
            
            On Apr 28, 2010 this sequence version replaced NM_146092.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020299.1, SRR7652917.534086.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY295292.1         2-54
            54-2065             BC028647.1         1-2012
            2066-2203           AC025794.9         237125-237262       c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.56 cM"
     gene            1..2203
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /note="TATA-box binding protein associated factor 6 like"
                     /db_xref="GeneID:225895"
                     /db_xref="MGI:MGI:2444957"
     exon            1..107
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            108..164
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2028
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TAF6-like RNA polymerase II p300/CBP-associated
                     factor-associated factor 65 kDa subunit 6L; PAF65-alpha;
                     PCAF-associated factor 65-alpha; TAF6-like RNA polymerase
                     II, p300/CBP-associated factor (PCAF)-associated factor"
                     /codon_start=1
                     /product="TAF6-like RNA polymerase II p300/CBP-associated
                     factor-associated factor 65 kDa subunit 6L isoform 1"
                     /protein_id="NP_666204.2"
                     /db_xref="CCDS:CCDS29546.2"
                     /db_xref="GeneID:225895"
                     /db_xref="MGI:MGI:2444957"
                     /translation="MQSSTGAMSEREERRFVEIPRESVRLMAESTGLELSDEVAALLA
                     EDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPLRPAR
                     EGDLYFPEDREVSLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSL
                     TDDLLKYYQQVTRAVLGDDPQLMKVALQDLQTNSKIAALLPYFVYVVSGVKSVSHDLE
                     QLHRLLQVARSLIRNPHLCLGPYVRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAAL
                     LLSHIFWTHGDLVSGLYQQILLSLQKVLTDPVRPLCSHYGAVVGLHALGWKAVERVLY
                     PHLPTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGLG
                     GRGYRPAEDLPWDSLLLQESPPGGSSETGFGSGLPPPSGVAGPEDPSSLTLADIYREL
                     YSFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPDSVRKMPQLTASAVVSPQGDESP
                     CGGTLATATAASESRPLPRVHRARGAPRQQGPGAGTRDVFQKSRFAPRGAPHFRFIIA
                     GRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPMIGRTGRPARRWALSDYSLYLPL"
     exon            165..324
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            325..411
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            412..562
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            563..613
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            614..708
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            709..783
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1004
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1137
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1266
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..2203
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /note="hexamer: AATAAA"
     polyA_site      2065
                     /gene="Taf6l"
                     /gene_synonym="2810417N14Rik; C530024J06Rik; Paf65a"
                     /note="major polyA site"
ORIGIN      
        1 atatggaggg cggagcctgg gcgcggagag agggaattac cgtgagccgg tgagtggaag
       61 cagccgtccc tccccagcag gcgccctccc aaccccggag tctgcagcaa gtgttaatga
      121 gggtatagta tgtgctgacc ctgctggagg cctgggatgc aaagttccac cggggccatg
      181 tcagaacgag aggagaggag gtttgtggag atccctcggg agtcggtccg gctcatggca
      241 gagagcacag gtctagagct gagtgacgag gtggccgctc tgctcgctga agatgtgtgc
      301 taccgtctcc gagaggccac acagaatagc tctcaattca tgaaacacac caaacgaagg
      361 aagctgacgg tggaggactt caacagggct ctcaggtgga gcagcgtgga ggctgtgtgt
      421 ggctatgggt cccaggaggc attgcccttg cgccctgcaa gggagggtga tctctacttc
      481 ccggaggatc gagaagtgag cctggtggag ctggcactag ccaccaacat ccccaagggc
      541 tgtgcagaga cagctgtcag agttcatgtc tcctatctgg atggcaaagg aaacctggca
      601 cctcagggat cagtgcccag tgcagtgtct tcactgacag atgacctgct caaatactac
      661 cagcaagtga cacgggctgt actgggagat gacccacagc tgatgaaggt tgccctccag
      721 gacctccaga caaactccaa gattgcagca ctcctgcctt actttgttta tgtggtcagt
      781 ggggtaaaat ctgtaagcca cgacctggaa caactgcacc gactactgca ggtggcaagg
      841 agcctgatac ggaacccaca cctgtgcttg ggaccctatg tccgatcctt ggtgggcagc
      901 gtgctttact gtgtcttgga gccactggcc gcctccatca accctttgaa tgaccactgg
      961 actctgcgag atggggctgc ccttctactc agtcacatat tctggacgca tggagacctt
     1021 gtaagtggcc tgtatcagca gattctgctg tccctgcaga aggtcctgac agaccctgtt
     1081 cggcctctct gttctcacta tggggcagtg gtggggctgc atgctctagg ctggaaggca
     1141 gtggagcgag tcctctaccc acatctgccc acttactgga caaacttgca ggctgtgctg
     1201 gatgactatt ccgtatctaa tgcccaggtc aaagcggacg ggcacaaagt gtatggagcc
     1261 attctggtgg ccgtagaacg actattgaag atgaaagctc aggcagcaga gcccaaccgc
     1321 ggtggccttg gcgggagagg gtaccgtcct gcggaggacc tgccttggga cagccttctc
     1381 ctacaagaat ctccccccgg gggcagctcc gaaacaggtt ttgggtctgg tctcccgcca
     1441 ccatcagggg ttgcgggacc agaggaccct tcttccttga ccctggcaga catctaccgt
     1501 gagctatact ccttctttgg tgacagcttg gccactcgct ttggcactgg ccagcctgct
     1561 cccacggccc cgcgaccacc cggagacaag aaggagcctg cggctgcccc ggattcggtg
     1621 cggaaaatgc cgcagctgac tgccagcgcc gtggtcagcc ctcagggtga cgaaagcccg
     1681 tgcggtggga ctctcgccac cgccaccgcc gcctcggaga gcaggccgct accgcgcgta
     1741 caccgggcgc ggggtgctcc tcgtcagcag ggccccggcg cgggaacgcg agacgtcttc
     1801 cagaagagcc gcttcgcgcc ccgtggcgcc ccacacttcc ggtttataat cgcagggcgt
     1861 caggccgggc ggcgctgccg cgggcgcctc tttcaaactg cctttcctgc cccatatggg
     1921 cccagccccg cgtcccgcta cgtgcagaag ctgcccatga tcggccgtac cggccgcccg
     1981 gcccgccgct gggcgctctc cgactactcg ctgtacctgc cgctgtgagg ttgcggcgcc
     2041 tcggagaata aagccacacc cggaagtgac gtgtctatgc tcgtgggcgg ggcttgggtg
     2101 gttgtcttcc tggtagcctg ggcgccatgg cgctgccctg gttgcagcga gttgagctct
     2161 tgctcttcac tgccgccttc ctgtgcgggg ctttggcggc cgc
//
