LOCUS       NM_009315               2304 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 6 (Taf6),
            transcript variant 2, mRNA.
ACCESSION   NM_009315
VERSION     NM_009315.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Bardot,P., Vincent,S.D., Fournier,M., Hubaud,A., Joint,M., Tora,L.
            and Pourquie,O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Langer,D., Martianov,I., Alpern,D., Rhinn,M., Keime,C., Dolle,P.,
            Mengus,G. and Davidson,I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Kurakin,A.V., Wu,S. and Bredesen,D.E.
  TITLE     Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains
            revealed by target-assisted iterative screening
  JOURNAL   J Biol Chem 278 (36), 34102-34109 (2003)
   PUBMED   12829691
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Pointud,J.C., Mengus,G., Brancorsini,S., Monaco,L., Parvinen,M.,
            Sassone-Corsi,P. and Davidson,I.
  TITLE     The intracellular localisation of TAF7L, a paralogue of
            transcription factor TFIID subunit TAF7, is developmentally
            regulated during male germ-cell differentiation
  JOURNAL   J Cell Sci 116 (Pt 9), 1847-1858 (2003)
   PUBMED   12665565
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Umehara,T., Kida,S. and Horikoshi,M.
  TITLE     Isolation of a cDNA encoding a mouse TFIID subunit containing
            histone H4 homology
  JOURNAL   Gene 161 (2), 301-302 (1995)
   PUBMED   7665100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151719.3.
            
            [WARNING] On Mar 13, 2025 this sequence was replaced by
            NM_009315.5.
            
            On Oct 12, 2017 this sequence version replaced NM_009315.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All four transcripts encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058583.1, SRR7652917.1003888.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC151719.3         217342-217398       c
            58-273              AC151719.3         214504-214719       c
            274-360             AC151719.3         214011-214097       c
            361-514             AC151719.3         213740-213893       c
            515-571             AC151719.3         213486-213542       c
            572-691             AC151719.3         213267-213386       c
            692-837             AC151719.3         212770-212915       c
            838-915             AC151719.3         212586-212663       c
            916-1017            AC151719.3         212373-212474       c
            1018-1200           AC151719.3         212080-212262       c
            1201-1275           AC151719.3         211290-211364       c
            1276-1401           AC151719.3         211063-211188       c
            1402-1575           AC151719.3         209952-210125       c
            1576-1773           AC151719.3         209585-209782       c
            1774-2304           AC151719.3         208789-209319       c
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.98 cM"
     gene            1..2304
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /note="TATA-box binding protein associated factor 6"
                     /db_xref="GeneID:21343"
                     /db_xref="MGI:MGI:109129"
     exon            1..57
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            58..273
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2154
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /note="TAF6 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 80 kDa; TAFII80; TAFII-70;
                     TAFII-80; TAF(II)70; transcription initiation factor TFIID
                     70 kDa subunit; transcription initiation factor TFIID 80
                     kDa subunit; TATA box binding protein (Tbp)-associated
                     factor, RNA polymerase II, E"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 6"
                     /protein_id="NP_033341.1"
                     /db_xref="CCDS:CCDS19795.1"
                     /db_xref="GeneID:21343"
                     /db_xref="MGI:MGI:109129"
                     /translation="MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVS
                     YRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGR
                     ELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAE
                     ATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSV
                     EQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNL
                     ALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAA
                     RLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLI
                     LPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRG
                     EFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLK
                     VPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGST
                     TTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGSGSVQKYIVVSLPPTGEGKGGPPSH
                     PSPVPPSSSSPSPLGGSTLCGGKQEAGDSPPPAPGTPKANGSQPTGPGSPQPAL"
     exon            274..360
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            361..514
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            515..571
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            572..691
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            692..837
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            838..915
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1017
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1200
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1275
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1401
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1575
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1773
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2304
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="Taf6"
                     /gene_synonym="80kDa; p80; TAF(II)80; Taf2e; TAFII70"
                     /note="major polyA site"
ORIGIN      
        1 gtcagggggc ggggccaaga tggcgccgag cgccgggtga gcggcgcttt ggcagcggat
       61 ctccatcttt ccatcctggg gaggcatcct tccagggaca ggagctggaa ttccagcatg
      121 gccgaggaga agaaactgaa actcagcaat actgtgttgc cctctgagtc catgaaggtg
      181 gtggcagaat ctatgggcat tgctcagatt caggaggaga cttgccagct actgacagat
      241 gaggtcagct accgcatcaa ggagattgcc caggatgccc tgaagttcat gcacatgggg
      301 aaacgacaga agctcactac cagtgacatt gactatgcat tgaagttaaa gaatgtggag
      361 ccactgtatg gcttccatgc tcaggagttc atccctttcc ggtttgcctc tggcgggggc
      421 cgggagctgt acttctatga agagaaggaa gtggacctga gtgacatcat caacacccct
      481 ctgcctcggg tgcctctgga tgtctgcctc aaagctcatt ggctaagcat cgaaggctgc
      541 cagccagcta taccagagaa tccaccccca gctcccaaag agcagcagaa ggctgaggcc
      601 acagaacccc tgaaatcagc aaagccaggc caagaagaag atggacccct gaaaggcaaa
      661 ggtcaagggg cagctgcagc tgatggcaaa ggaaaagaga agaaggcacc tcccttgctg
      721 gagggggccc ctttccgcct gaagccccgc agcatccatg agctgtctgt ggagcagcag
      781 ctgtattaca aggagatcac ggaagcctgt gtgggatcct gtgaggccaa gagagcggaa
      841 gctctgcaga gcattgccac ggacccaggg ctctatcaga tgctaccacg gttcagtacc
      901 ttcatctcag agggggtccg tgtgaatgta gttcagaata acctggcctt gcttatctac
      961 ctgatgcgta tggtgaaggc cctgatggac aaccccacac tgtatctaga gaaatatgtg
     1021 catgagctca ttccagcagt aatgacctgc attgtgagta gacagctgtg cttgcggcca
     1081 gatgtggaca atcactgggc actccgggat tttgctgccc gtctagtggc ccaaatctgt
     1141 aagcatttca gcacaaccac caacaacatc caatcccgaa tcactaagac ctttaccaag
     1201 agctgggtcg acgagaagac tccatggaca actcgatatg gctccattgc aggcctagca
     1261 gagctgggac atgatgtgat taagacgcta attctgccaa ggctgcagca ggaaggggaa
     1321 cggatccgca gtgtcttgga tgggcctgtg ctgagcaaca tcgaccgtat tggagcagac
     1381 catgtgcaga gccttctcct gaaacactgt gccccagtac tggccaagct gcgccctcca
     1441 cctgacaatc aggatgccta ccggggagaa tttgggtccc ttgggcccct tctctgttcc
     1501 catgtggtga aggccagggc ccaggctgct ctacaagctc agcaggtcaa caggaccaca
     1561 ctcaccatca cacagcctcg gcccacactg accctttcac aggcccctca gccaggccct
     1621 cgcacgcctg gcttattgaa ggtccctggc tccattgcct tgcctgttca gacactggtg
     1681 tctgcgagag ctgctgctcc tcctcagcct tctcctcctc caaccaagtt tattgtaatg
     1741 tcctcatctt ccagtgcctc atcaacccag caggttctgt ccctcagcac ctcagctcct
     1801 ggctcaggct ctactactac ctctcctgtc accaccacgg ttcccagcgt gcagcccatc
     1861 gtcaagctgg tctccactgc taccactgca cccccaagca cagcccctgc tggttctggc
     1921 agtgttcaga aatacattgt ggtctctctt cccccaacag gggaaggcaa aggaggccct
     1981 ccttctcatc cttctccagt ccccccttca tcttcttcac catccccact tgggggaagt
     2041 accctctgtg gggggaagca ggaagctggg gacagccccc ctccagctcc agggactcca
     2101 aaggctaatg gctcgcagcc tactggacct ggctctcccc agcctgctct gtgatgtgtc
     2161 acatgtgctg acctcctctc ttgtgcagat tcctacacac tcaaacaacc tgtgagggag
     2221 gaaggaggaa aggttttccc cagtgacttt ctttttagat attgtacagt aagttcctca
     2281 gaataaaagt tggatttgta agtt
//
