LOCUS       NM_177342               3258 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 5 (Taf5),
            mRNA.
ACCESSION   NM_177342
VERSION     NM_177342.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   He,X.D., Phillips,S., Hioki,K., Majhi,P.D., Babbitt,C.,
            Tremblay,K.D., Pobezinsky,L.A. and Mager,J.
  TITLE     TATA-binding associated factors have distinct roles during early
            mammalian development
  JOURNAL   Dev Biol 511, 53-62 (2024)
   PUBMED   38593904
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Bardot,P., Vincent,S.D., Fournier,M., Hubaud,A., Joint,M., Tora,L.
            and Pourquie,O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Langer,D., Martianov,I., Alpern,D., Rhinn,M., Keime,C., Dolle,P.,
            Mengus,G. and Davidson,I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Guermah,M., Ge,K., Chiang,C.M. and Roeder,R.G.
  TITLE     The TBN protein, which is essential for early embryonic mouse
            development, is an inducible TAFII implicated in adipogenesis
  JOURNAL   Mol Cell 12 (4), 991-1001 (2003)
   PUBMED   14580349
REFERENCE   8  (bases 1 to 3258)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   10 (bases 1 to 3258)
  AUTHORS   Le Douarin,B., Zechel,C., Garnier,J.M., Lutz,Y., Tora,L.,
            Pierrat,P., Heery,D., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     The N-terminal part of TIF1, a putative mediator of the
            ligand-dependent activation function (AF-2) of nuclear receptors,
            is fused to B-raf in the oncogenic protein T18
  JOURNAL   EMBO J 14 (9), 2020-2033 (1995)
   PUBMED   7744009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031985.1, BU057827.1, BQ714348.1 and AC124724.4.
            
            On Jul 25, 2006 this sequence version replaced NM_177342.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088953.1, AK169453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               AK031985.1         5-952
            949-1652            BU057827.1         47-750
            1653-2332           BQ714348.1         145-824
            2333-3258           AC124724.4         81201-82126         c
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.19 cM"
     gene            1..3258
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /note="TATA-box binding protein associated factor 5"
                     /db_xref="GeneID:226182"
                     /db_xref="MGI:MGI:2442144"
     exon            1..579
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2423
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /note="Tbp-associated factor 5; TAFII100; TAFII-100;
                     TAF(II)100; transcription initiation factor TFIID 100 kDa
                     subunit; TAF5 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 100kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 5"
                     /protein_id="NP_796316.2"
                     /db_xref="CCDS:CCDS29886.1"
                     /db_xref="GeneID:226182"
                     /db_xref="MGI:MGI:2442144"
                     /translation="MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTPNNGP
                     NGGGGGNVAVAAAAGGDGGTPKPGVAVSAAAPAGAAPVPAAPAEAGAPHDRQTLLAVL
                     QFLRQSNLREAEEALRREARLLEEAVAGSGAPGELDGAGAEAASALLSRVTASVPGSA
                     APEPPGTGASVTSVFSGSASGPAAPGKVASVAVEDQPDVSAVLSAYNQQGDPTMYEEY
                     YSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYY
                     QDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIV
                     QEHLYIDIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPEIEVPLDDEDE
                     EGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTK
                     RVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV
                     KQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG
                     TVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF
                     AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG
                     RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD
                     AVKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY
                     SPQ"
     exon            580..817
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1133
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1297
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1433
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1554
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1684
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1849
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2027
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2205
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..3258
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3258
                     /gene="Taf5"
                     /gene_synonym="6330528C20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtggctcag ccgcaagatg gcggcgctgg cggaggagca gacggaggtg gcggtcaagc
       61 tagagcctga gggaccgccg acgctgctac ctccgcaggc tggcgacggc gcaggcgagg
      121 ggagcggcgg cactcccaac aacggcccca acggcggcgg cggcgggaat gtggcagtgg
      181 cagcggcggc cggcggggac ggcgggaccc ccaagcctgg ggtggctgtc tccgccgctg
      241 ccccggcggg ggcggccccg gtgcccgccg ctccggcgga ggccggcgct ccccacgacc
      301 gacagaccct cctggccgtg ctgcaattcc tccggcagag caacctccgc gaggccgaag
      361 aggcgctgcg ccgggaggcc cggctgctgg aggaggcggt ggcgggctcc ggagctccgg
      421 gagagttgga cggggccggc gcggaggcgg ccagcgcgct tctcagccgg gtcaccgctt
      481 cagttcccgg ctctgcggcc cccgagcctc cggggacggg cgcctcggtg acctcggtgt
      541 tctcgggttc agcctcaggt cctgcggctc cgggaaaggt tgcaagtgta gctgtggaag
      601 accagccaga cgtcagtgct gtcttgtcgg cctacaacca acaaggagac cctacaatgt
      661 atgaagaata ctacagtgga ctgaaacact tcattgaatg ttctctggac tgccatcgag
      721 cagagttatc ccaactcttt tatcctctgt ttgtacatat gtacttggag ctagtttata
      781 atcaacatga aaatgaagca aaatcattct ttgagaagtt ccatggagat caggaatgtt
      841 actaccagga tgacctacga gtgttatcta gtcttaccaa aaaggagcac atgaaaggga
      901 acgagaccat gctggacttt cggacgagta aattcgttct ccgcatttcc cgggactcgt
      961 accagctctt gaagcggcat ctccaggaga agcagaacaa tcagatctgg aacatcgtgc
     1021 aggagcacct ctacatcgac atcttcgacg ggatgcctcg cagtaagcaa cagatcgacg
     1081 ccatggtggg cagcctggca ggagaggcga aacgagaggc gaacaaatcg aaggtatttt
     1141 ttggtttact aaaagaacca gaaattgagg tgcctttgga tgatgaggac gaagaaggag
     1201 aaaatgaaga aggaaaacct aaaaagaaga agcctaagaa ggatagtatt ggctctaaaa
     1261 gcaaaaaaca agatcccaat gccccgcctc aaaacagaat tcctcttcct gagttaaaag
     1321 attcagacaa actggacaaa ataatgaata tgaaagaaac taccaaacga gtgcgcctcg
     1381 ggccagactg tttaccctcc atttgtttct atacattcct taatgcttac cagggcctca
     1441 ctgcagtgga tgtcactgat gactctagtc tgattgctgg aggttttgct gattcaactg
     1501 tcagagtgtg gtctgtgacc cctaaaaagc ttcgtagtgt caaacaagca tcagatctta
     1561 gtcttataga caaagaatca gatgatgtct tagagagaat catggatgag aaaactgcaa
     1621 gtgagttgaa gattttgtat ggtcacagtg ggcctgtcta tggagccagc ttcagtccgg
     1681 ataggaacta cctactctcc tcttcagagg atggaactgt tagactctgg agccttcaga
     1741 ctttcacttg cttggttggg tataaaggac acaactaccc agtatgggac acacagtttt
     1801 ctccatacgg atattatttc gtgtcaggag gccatgaccg agtagctcgg ctttgggcta
     1861 ccgatcacta tcagcctttg aggatatttg ctggccatct tgctgatgtg aattgcacta
     1921 gatttcatcc aaattcgaac tatgttgcta cgggctctgc agacagaact gtgcggctct
     1981 gggatgtcct caatggtaac tgtgtaagaa tcttcactgg gcacaaggga ccaattcatt
     2041 ccttgacatt ttctcccaat gggagattcc tggctacagg agcaacagat ggcagagtac
     2101 ttctttggga tattggacac ggcttgatgg ttggagaatt aaaaggccac actgatacag
     2161 tgtgttcact taggtttagt agagatggtg aaattttggc atcaggttca atggataata
     2221 cagtccggtt atgggacgcc gtcaaagcgt ttgaagactt agagactgat gactttacta
     2281 cagccaccgg gcatataaac ctacctgaga attcccagga gttgttattg ggtacatata
     2341 tgaccaaatc aacaccagtt gtacacctac attttacaag aagaaacttg gttctagctg
     2401 caggagctta cagtccgcaa taagccaacg gtattagaga ccttttggaa gctactgttt
     2461 ggaaaaggga gactaaaagc aaatacctca gtgattagta tttaagctac aaagaatgtt
     2521 tttgtctaca tggatctgga agtatgctgc ttggaaaatc tgaacaagac agttccacgt
     2581 ttctatagca accacattta actaatttcc gttagttgaa taagaggtat tatgttcgtg
     2641 gaggggacat ttatggtgct ttggattgtg tggaaactat gcattttttt tttgttgttc
     2701 aaatgctatt ttaatttatt gtgtttagaa aaaaatcaat ttgatttaaa caattcattc
     2761 tgcttcaaga ttcaagttaa gaaatatagt accaccttga gtagctgaag agttctatga
     2821 acgtgtgtgt gctgtaatga ggttattgta cggcactcaa gcagcgtgtt cagtgaccca
     2881 ctaacatgct tcccttcacc caccattagt ggactgtatg gaactgagta gggaccacac
     2941 ttcctaagtc tacatgtaca gccatccacc aacatctcag ttcctaccat gtaagtttgg
     3001 cgtgcaatca aacacttaca aagcaggtga ggagatttag attccacact ctacttcagc
     3061 taacatggct acatatgacc tagtacactt gaagtcagac agacatttca gttgcttacc
     3121 tccaatactg agccttgctt tggaaaacta agagattcag accaagtcac tgccagtttt
     3181 tgcctttgtt gcattttgta cagttttata tttttgatat cttgtaaata aagacaacca
     3241 gcttttccag gttcataa
//
