LOCUS       NM_001369357            6878 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 4b (Taf4b),
            transcript variant 2, mRNA.
ACCESSION   NM_001369357 XM_006526281
VERSION     NM_001369357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6878)
  AUTHORS   Gura,M.A., Bartholomew,M.A., Abt,K.M., Relovska,S., Seymour,K.A.
            and Freiman,R.N.
  TITLE     Transcription and chromatin regulation by TAF4b during cellular
            quiescence of developing prospermatogonia
  JOURNAL   Front Cell Dev Biol 11, 1270408 (2023)
   PUBMED   37900284
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6878)
  AUTHORS   Gura,M.A., Relovska,S., Abt,K.M., Seymour,K.A., Wu,T., Kaya,H.,
            Turner,J.M.A., Fazzio,T.G. and Freiman,R.N.
  TITLE     TAF4b transcription networks regulating early oocyte
            differentiation
  JOURNAL   Development 149 (3) (2022)
   PUBMED   35043944
  REMARK    GeneRIF: TAF4b transcription networks regulating early oocyte
            differentiation.
REFERENCE   3  (bases 1 to 6878)
  AUTHORS   Gustafson,E.A., Seymour,K.A., Sigrist,K., Rooij,D.G.D.E. and
            Freiman,R.N.
  TITLE     ZFP628 Is a TAF4b-Interacting Transcription Factor Required for
            Mouse Spermiogenesis
  JOURNAL   Mol Cell Biol 40 (7), e00228-19 (2020)
   PUBMED   31932482
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6878)
  AUTHORS   Gura,M.A., Mikedis,M.M., Seymour,K.A., de Rooij,D.G., Page,D.C. and
            Freiman,R.N.
  TITLE     Dynamic and regulated TAF gene expression during mouse embryonic
            germ cell development
  JOURNAL   PLoS Genet 16 (1), e1008515 (2020)
   PUBMED   31914128
  REMARK    GeneRIF: Taf4b mRNA and protein expression is differentially
            regulated during embryonic germ cell development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6878)
  AUTHORS   Xia,X., Zhou,X., Quan,Y., Hu,Y., Xing,F., Li,Z., Xu,B., Xu,C. and
            Zhang,A.
  TITLE     Germline deletion of Cdyl causes teratozoospermia and progressive
            infertility in male mice
  JOURNAL   Cell Death Dis 10 (3), 229 (2019)
   PUBMED   30850578
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6878)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 6878)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6878)
  AUTHORS   Freiman,R.N., Albright,S.R., Chu,L.E., Zheng,S., Liang,H.E.,
            Sha,W.C. and Tjian,R.
  TITLE     Redundant role of tissue-selective TAF(II)105 in B lymphocytes
  JOURNAL   Mol Cell Biol 22 (18), 6564-6572 (2002)
   PUBMED   12192054
  REMARK    GeneRIF: role of TAF(II)105 in B lymphocytes
REFERENCE   9  (bases 1 to 6878)
  AUTHORS   Silkov,A., Wolstein,O., Shachar,I. and Dikstein,R.
  TITLE     Enhanced apoptosis of B and T lymphocytes in TAFII105
            dominant-negative transgenic mice is linked to nuclear factor-kappa
            B
  JOURNAL   J Biol Chem 277 (20), 17821-17829 (2002)
   PUBMED   11856754
  REMARK    GeneRIF: has a pro-survival role in B and T lymphocytes, where the
            native protein is expressed; important for T cell maturation and
            for production of certain antibody isotypes.
REFERENCE   10 (bases 1 to 6878)
  AUTHORS   Freiman,R.N., Albright,S.R., Zheng,S., Sha,W.C., Hammer,R.E. and
            Tjian,R.
  TITLE     Requirement of tissue-selective TBP-associated factor TAFII105 in
            ovarian development
  JOURNAL   Science 293 (5537), 2084-2087 (2001)
   PUBMED   11557891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102692.6, AC133172.4 and AC125091.3.
            
            On Apr 5, 2019 this sequence version replaced XM_006526281.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.3235754.1,
                                           SRR11927938.4167140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-690               AC102692.6         28754-29443         c
            691-836             AC102692.6         15630-15775         c
            837-944             AC102692.6         13502-13609         c
            945-1106            AC102692.6         8061-8222           c
            1107-1229           AC102692.6         7849-7971           c
            1230-1319           AC102692.6         5254-5343           c
            1320-1919           AC133172.4         64745-65344         c
            1920-2037           AC133172.4         56880-56997         c
            2038-2149           AC133172.4         56230-56341         c
            2150-2319           AC133172.4         48247-48416         c
            2320-2450           AC133172.4         42513-42643         c
            2451-2576           AC133172.4         36405-36530         c
            2577-2633           AC133172.4         33965-34021         c
            2634-2738           AC133172.4         19159-19263         c
            2739-6878           AC125091.3         137690-141829       c
FEATURES             Location/Qualifiers
     source          1..6878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 8.28 cM"
     gene            1..6878
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /note="TATA-box binding protein associated factor 4b"
                     /db_xref="GeneID:72504"
                     /db_xref="MGI:MGI:2152345"
     exon            1..690
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2903
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /note="isoform 2 is encoded by transcript variant 2; TATA
                     box binding protein (TBP)-associated factor, RNA
                     polymerase II, C2, 105kD; TAF4B RNA polymerase II, TATA
                     box binding protein (TBP)-associated factor, 105 kDa;
                     TAF(II)105; transcription initiation factor TFIID 105 kDa
                     subunit; transcription initiation factor TFIID subunit 4B"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 4B
                     isoform 2"
                     /protein_id="NP_001356286.1"
                     /db_xref="CCDS:CCDS89195.1"
                     /db_xref="GeneID:72504"
                     /db_xref="MGI:MGI:2152345"
                     /translation="MPAGLTEPAGAAAPVVSSASGAVTMAPVAALPVRVEGTPVALGP
                     VTKAPVSVCVESVAPQPLPAPVGTLVTKVVPVTALPKLGSPRLPAPQIVTVKTPGTTT
                     IQLPANLQLPPGTVLIKSNSGQLMLVSPQQAVTGAKTTSNITPRPAVPANTQTVKICT
                     VPNSSSQLMKKVTVAPVKNLTQIGTTVATTASSTSSGQPVALPSSVITVTPAKLVNTV
                     STLKSSSLGVLSTPSNDARLKAETSVAAQTALPPTVLENVKKCKNFLSMLIKLACSGS
                     QSPEMGQNVKRLVEQLLDAEIEAEEFTRKLYIELKSAPQPHLVPFLKKSVVALRQLLP
                     NSQSFIENCVKEVSGDVVISSCTMTTATSPVVTSTVSPVLVSGATAPRTLSVQQTLNP
                     LAGPGVANTGVVTLHSVAPAAATGGTTAATVLLQTSKPLTTSVPNTVAAVSLQPENPV
                     VSGAAVTLAIPSATFGEASATPLCLPSAKPAITSAGTKADKPAIGTPVQIVTQPSTLL
                     PQAAGIPQTAKVKQLVVQQPSGSSVNHVTSISHSSPLSTQNCGQKTPVNAVMPTTSII
                     KQITLPGNKLLSLQAQRSSIQSNKIKENGPTCFRGEDDINDVTFMAEVNLDEENACIL
                     AAHSDFVGTLIQSCKEEPFLVIGALQKRILDIGKKHDITELNSDAVNLISHATQERLR
                     GLLEKLTTIAQHRMTIYKGSENYILSTDTRSQLKFLEKLDQLEKQRKDLEEREMLLKA
                     AKSRSNKEDPEQLRLKQKAKELQQLELAQIQYRDANLTALAAIGPRKKRPLESGNESF
                     KDNPSTSGTSSLTATKPFRPRITRICLRDLIFCMEQEREMKYSRALYLALLK"
     exon            691..836
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            837..944
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1106
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1229
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1319
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1919
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2037
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2149
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2319
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2450
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2576
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2633
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2738
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..6878
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4394..4399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /note="hexamer: ATTAAA"
     polyA_site      4419
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /note="major polyA site"
     regulatory      6858..6863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
                     /note="hexamer: AATAAA"
     polyA_site      6878
                     /gene="Taf4b"
                     /gene_synonym="105kDa; 2610524B04Rik; 4932409F03Rik;
                     Taf2c2; TAFII-105; TAFII105"
ORIGIN      
        1 ggggtttgtg cggagcgcgt gtgggtcgcc tgcggactct gcgggtctgt aggattttga
       61 atttctggcg cggaagctcc gagttaaagc tccccgggtg ggaactgaag tgacgccctg
      121 agggagctgc cggtccgggc gcttctgccg cgggacccgg gctgagcgcg cacgtgtgag
      181 cgccgctgag ggagtgcccg gcggtgtcgc cgccagccgg gcccggagcg cgcgtgtgct
      241 ccgcgatgct gcggcgcccg gactgcaccc gagtctcctg ccgctcgccc cggctcgcct
      301 cgcttcagtt ccgggaaggg cagcgtcgct gccgctgagc ctccgagggc atgccggcgg
      361 gcctcacgga gccggccggc gccgctgctc ctgtagtctc gagcgcgtcg ggggccgtga
      421 ccatggctcc ggtcgccgcg ctgcccgtcc gggtggaggg caccccggtg gccctgggcc
      481 ctgtgactaa ggctcctgtc agtgtttgcg tggagtctgt ggcgccccag cccttgccag
      541 ccccagtggg gactctagtg accaaagtgg ttcctgtcac tgcccttcct aaactcggca
      601 gccctaggct gcccgctcct cagatagtca ccgtgaaaac gccgggcacc acgacaatcc
      661 aactaccggc taatttgcag cttcctccag gaacagtttt gatcaaaagt aacagtggtc
      721 agttgatgct ggtatcgcct cagcaagctg taacaggagc caagaccaca agtaacataa
      781 ctccaagacc agcagtacca gcaaacactc aaacagtaaa gatctgtaca gtgccgaatt
      841 ctagctcaca attaatgaag aaagtaacag tggcgcctgt taaaaatttg acacagatag
      901 gaactactgt ggcaaccact gcctccagta cttcctcagg acaacctgtg gctctaccaa
      961 gcagtgtcat cacagttact cctgcaaagc tggtgaatac tgtatccacc ctgaagtcat
     1021 caagtttggg agtgttatct accccctcaa atgacgcacg tctcaaagct gagacttcag
     1081 tagctgctca gactgctctt cctccgacag tgctagaaaa tgtgaaaaaa tgtaaaaact
     1141 tcctttcaat gttaataaaa ctagcatgta gtggatcaca gtctccagaa atggggcaga
     1201 atgtgaagag gctggtggag cagcttttgg atgcagaaat tgaagcagaa gagtttacta
     1261 ggaaactgta tattgaactc aagtctgcac ctcagccgca cctcgtccct tttcttaaga
     1321 agagtgtggt tgccctaaga cagcttcttc caaattccca gagcttcatt gagaactgtg
     1381 tgaaggaagt ttctggtgat gtggtcattt cctcctgtac catgacaaca gcaacgtctc
     1441 ctgtggtgac aagtacagtt tccccagtcc ttgtgtctgg agcaacagca cccagaactc
     1501 tgtctgttca gcagaccctg aatccacttg ctggtccagg agtagcaaac actggagttg
     1561 tgacactgca ttctgttgcc ccagctgctg caacaggagg tacgacagct gcaactgttt
     1621 tgcttcaaac ttcaaaacca ctaacaacat cagtaccaaa tacagtggca gcagtgtccc
     1681 ttcagcctga gaatccagtt gtgtctgggg cagcagtaac actggctatt ccatcagcaa
     1741 cttttggaga agcgtccgct acacctcttt gtcttccatc tgcgaagcct gccattacct
     1801 ctgctgggac caaagctgat aaacctgcca ttggcactcc agtccagatc gttacacaac
     1861 cgagcaccct ccttccacag gcggctggca ttccacagac agccaaagtc aagcaactag
     1921 ttgtacagca gccttcagga agcagtgtga atcatgtgac ctccatttcc cattcctcac
     1981 cattgagcac tcagaactgt gggcagaaga caccagtaaa tgctgtgatg cctactactt
     2041 ccatcataaa gcaaattact ctgcctggaa ataaactttt gtcgcttcaa gctcaaagat
     2101 cttctattca gagcaataaa ataaaagaga atggaccaac atgcttcaga ggtgaagatg
     2161 acatcaatga tgtgactttc atggcagagg tcaaccttga tgaagaaaat gcctgcatct
     2221 tagcagcaca ttctgacttt gttggcacac ttattcagtc atgtaaagaa gaaccattcc
     2281 ttgtcattgg agctctacag aagagaattt tagacattgg taaaaagcat gacattacag
     2341 aacttaactc tgatgctgtg aacttgatct cccatgcaac acaggagaga ttacgaggcc
     2401 ttctagagaa actaactaca attgctcagc atcgaatgac tatttacaag ggaagtgaaa
     2461 attatatctt gtctactgat accagatcac agctcaaatt tcttgaaaag ctcgatcagt
     2521 tggagaaaca gaggaaggat ttagaagaaa gagagatgtt actaaaggca gccaagagtc
     2581 gctccaataa agaagatcca gagcagctga gattaaaaca aaaagccaaa gagttgcagc
     2641 agttggagct tgcccagatc cagtacagag atgctaatct cacagctctt gcagctattg
     2701 gaccaaggaa gaagagacca ctagaatcag gaaatgagag cttcaaagat aacccttcta
     2761 cttctgggac ttccagccta acagccacca aaccatttcg tccaagaatc acaagaatct
     2821 gcctcaggga tttgatattc tgtatggaac aggaaagaga gatgaagtat tctcgagccc
     2881 tataccttgc ccttcttaag tgatgactcc atccatccag acgcacactg tttactgcca
     2941 aagacgacac tgagcgcact gttgcactgt tctgaaccct cccttggagt atggaagacc
     3001 actgcttaca ctgacaagct tttgctacgt cttgtctttg tggcctgtgg gttcatgccg
     3061 ctgagaattc agatgctttc tgaaactcag tgtatgtata ctttatgagg aagtatcacc
     3121 tactgacctg catttaaaat tacaatagct agggattagc ttttgccacc ttcatttatt
     3181 ttgttgtttc cactcagtag caatgaggtg ccttcctctg atacaggctg tatctagatg
     3241 tgggataaag aaggagtcaa aatatatcct gtgctgagcc tgtctcctag tgttagattt
     3301 tatggtctgc agttagaggt tacttagctc atggtgacag ttaccttctg tagttgaagt
     3361 gtgacaagct acagagtaga ggcaaagtca acttgaatta gttgagccag aattacatag
     3421 ctgataatta tacagtgagg ttgctgactc tctggcttcc tacacagcag tgtttctgat
     3481 acctagtgag ggccatcctt ttcagctaag taaaatcgct actgctatac ctcactgaaa
     3541 tgtggaaaag gtagaaagta ctggaaaaaa tataaggcct tgcattcaaa ttgacaaagg
     3601 atgagaatgc tatcttgaaa tagatgtggc tgctcaggga atgccaaagc tggtccttgt
     3661 tttagtgata ggggaaaaaa aaaagaaaaa atcataggtc aaccaaagaa gaaatctggc
     3721 acacatttag ttacagtatt tcaaaaggat gatttgtttt tgtattattt taattcccaa
     3781 gaaggagttc tttcttttat aaagaatctc ccagttaccc tatgttttaa gcatctagtg
     3841 cttttcaaat ttctaactgc tggtaagaac atttaagcag taggattccc tttgaattgt
     3901 gtacttaaga ggtgctgtca tgtgtcttgc tcttaggggg tggctctaaa cgtgagcaac
     3961 acactatgta cctctctctg aggaggaagc tgatattcaa agtacctcct ctctcccttt
     4021 gaaatctact tgtgtacatt atagctgaca gaaataatgg ggaaactgaa atcacatacc
     4081 gaaagaatgc caaactctcc tggggaaaca tttcaagtat gtcactctct gtcctgttct
     4141 tcccataggg actgttatgg ccacattcta tactgttgta agagtttaac tggccacaat
     4201 ttttgtttta gtaagttatg taaaatgccg taaattatgt atatgcttta aaaagtacct
     4261 tactaagaga tgtataccca aagttgtata tttaaatgct tagctttatt ttttgtaaag
     4321 tccagcatac tcccacattt gtgtaatctt attgatctga tgtttaaaat tatttcaaat
     4381 acattatttt atgattaaaa acaaacaaaa ctttgctcag tcactgtctt tgcagcagtt
     4441 tctattagca gccagtccct ggaggatgca gatctgcctg gcagtgagtc tattatttat
     4501 ttgcatttgg gttctgtgaa catttgggtt ctggaattgc acttagatct aagtttctat
     4561 atcacttcct ttgaaatagt tgtaattttg ccaactattt gactcaaaaa gaaagctaga
     4621 catagtcatt atggaagatt ttcttggtcc attgagtttt tcttaccaag atattcttgt
     4681 tcaaaatgtg taatgtaagc cttttgtata tacatatgtg tggtgtatgt atggtgccat
     4741 ctcctctcac ctctatctta agtttgtaga caggcactga gtctggagct tactcttggc
     4801 tagagaggct gcccagcagc ccctgtgcat cttcccgtct ctgcctttga gctctacgag
     4861 ttcaggagtg taccaccatg gctaacattg tacatgggta ctggggatcc gaacctgggt
     4921 ccttaagctc accacagcag gcactttacc cactgagcca gtccctaagt tccttaatgt
     4981 acattttgaa acttgggttg tacaggtttc aaaacctctt atacagagaa aaacaaatgt
     5041 gtgtatccga gatatacaca ggtagttggc aaaatggaga ctttggggta gatttgctcg
     5101 ccagatacat tgtttttaaa tacacagtaa taacaagcct tttttgttgt cagtggtggt
     5161 gttttgtttt gttttgttac gtgaatgctg tggattcagc tcaggctctc acgtctgtac
     5221 accagagaca ctcctactca ctgtcacctc cctagctcca ctaatcttct tctttttaaa
     5281 gaagcattgg aaattttaaa atatttattg tctgtgtgtc tgatttatag gcatgcacgt
     5341 gtagagatca ggggacagct tacaggagtt ggttctcttt attgtggaga tcaaatttga
     5401 cctggagatc aaatcagacc agatcgtcag gcttggcaac aagtgtcctt aacctgctga
     5461 gccatttcac tgtcccaaca aacattttaa aacctataaa attcttcaaa attatatgtg
     5521 gcaaaagttc tgtttcatta gaattttgtc aagagaaatg tacttagaat taagacttca
     5581 tactagtgat gccattcttc cagcagaaaa cacagaaatg ttatggcata atttttagga
     5641 aagtaacagg accaaggtac atgctgactt gaacttttca ctttgtatgt tgtagaatga
     5701 atccgttcag tgtgtgtaca aatttgacct taaaagttcc aattacattg tgcagggata
     5761 agcatattgt gtcacatgtc tgaggataac ctggtagaca gtgtttactt tgtaccattc
     5821 ttcttgtgat actctatctc agttgtcaac ttggtgtgct ctagaatcac attagagaca
     5881 ggtttctggg aatgcctctg ggaattcttt aggtttattg actaatctat agcatacaca
     5941 cagcatctct cattatgtca ggcttgttcc actgtacagc aaatccttgg tggtcatcca
     6001 gcggtactgg catctccaaa atgctggagt ctctgcaact gggctgtacc tttgccactg
     6061 gcctctcctg ggctctcttc aaggactctg tccctgacat atggtgccaa gcctcaacat
     6121 ctctccatga gcccttctat cctggatctt ctactgcagc taagtctata ccttcaccaa
     6181 tggcctctcc tcaggaactg cagcactacc acacagtaca aagactcagc tgctctctgt
     6241 gaaccctgca cacctttaaa acagtactac ctgagtgact cttacactaa caactttagt
     6301 tatcagcaca tgatacatct ctggatgctt caagaataca ggttctatgt gctgaccctg
     6361 aggaagcact tcccagaaga tgaccctgag gaagcacttc cccagtgatg ccagtctctt
     6421 cttaatcacc actaatttct cagctgcagt tgactgttat caattgtcac aacaaaacaa
     6481 aggttttact ttagcagctc tggtctccta ttaatcacag ccaattctgc tgactagttc
     6541 tgtgtgaatt tgacagaagc tagagtcctt ttagaagagg gaacccaaat tcagaaaatg
     6601 ccccgaccag gttcatctgt gggtaagcct gtggtgtaat ttattcattg atgattgata
     6661 tggaacagtt tggctctctg tgggtggtgc caccactgca ctggtagccc tgagtactat
     6721 aagaaagcat gctgaacgag tcagtaaaca acactcctcc atcatggcct ctgcttcagc
     6781 tcctgcctct aggtttctgt cctgttcctg cctttacttc ccccagtgat ggactgtaat
     6841 gtggaactgt gaactgaaat aaaccctttc ctcctcaa
//
