LOCUS       NM_001081092            4472 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus TATA-box binding protein associated factor 4 (Taf4),
            mRNA.
ACCESSION   NM_001081092 XM_130764
VERSION     NM_001081092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4472)
  AUTHORS   Saisa-Borreill S, Davidson G, Kleiber T, Thevenot A, Martin E,
            Mondot S, Blottiere H, Helleux A, Mengus G, Plateroti M, Duluc I,
            Davidson I and Freund JN.
  TITLE     General transcription factor TAF4 antagonizes epigenetic silencing
            by Polycomb to maintain intestine stem cell functions
  JOURNAL   Cell Death Differ 30 (3), 839-853 (2023)
   PUBMED   36639541
REFERENCE   2  (bases 1 to 4472)
  AUTHORS   El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh
            S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T and
            Voss AK.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   3  (bases 1 to 4472)
  AUTHORS   Kleiber T, Davidson G, Mengus G, Martianov I and Davidson I.
  TITLE     Single cell transcriptomics reveal trans-differentiation of
            pancreatic beta cells following inactivation of the TFIID subunit
            Taf4
  JOURNAL   Cell Death Dis 12 (8), 790 (2021)
   PUBMED   34385420
  REMARK    GeneRIF: Single cell transcriptomics reveal trans-differentiation
            of pancreatic beta cells following inactivation of the TFIID
            subunit Taf4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4472)
  AUTHORS   Gustafson EA, Seymour KA, Sigrist K, Rooij DGDE and Freiman RN.
  TITLE     ZFP628 Is a TAF4b-Interacting Transcription Factor Required for
            Mouse Spermiogenesis
  JOURNAL   Mol Cell Biol 40 (7), e00228-19 (2020)
   PUBMED   31932482
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4472)
  AUTHORS   Xu Y, Milazzo JP, Somerville TDD, Tarumoto Y, Huang YH, Ostrander
            EL, Wilkinson JE, Challen GA and Vakoc CR.
  TITLE     A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute
            Myeloid Leukemia
  JOURNAL   Cancer Cell 33 (1), 13-28 (2018)
   PUBMED   29316427
  REMARK    GeneRIF: Ectopic expression of the TAF4 histone-fold fragment can
            efficiently squelch TAF12 in cells
REFERENCE   6  (bases 1 to 4472)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4472)
  AUTHORS   Metsis M, Brunkhorst A and Neuman T.
  TITLE     Cell-type-specific expression of the TFIID component TAF(II)135 in
            the nervous system
  JOURNAL   Exp Cell Res 269 (2), 214-221 (2001)
   PUBMED   11570813
REFERENCE   8  (bases 1 to 4472)
  AUTHORS   Freiman RN, Albright SR, Zheng S, Sha WC, Hammer RE and Tjian R.
  TITLE     Requirement of tissue-selective TBP-associated factor TAFII105 in
            ovarian development
  JOURNAL   Science 293 (5537), 2084-2087 (2001)
   PUBMED   11557891
REFERENCE   9  (bases 1 to 4472)
  AUTHORS   Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ,
            Stevenin J, Almouzni G and Tora L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   10 (bases 1 to 4472)
  AUTHORS   Brand M, Yamamoto K, Staub A and Tora L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663067.14.
            
            On Mar 8, 2022 this sequence version replaced NM_001081092.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY038601.1, SRR13862051.954571.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1290              AL663067.14        96287-97576         c
            1291-1451           AL663067.14        60668-60828         c
            1452-1571           AL663067.14        59285-59404         c
            1572-1691           AL663067.14        56766-56885         c
            1692-1814           AL663067.14        55903-56025         c
            1815-1904           AL663067.14        53837-53926         c
            1905-2150           AL663067.14        52854-53099         c
            2151-2298           AL663067.14        50151-50298         c
            2299-2413           AL663067.14        47090-47204         c
            2414-2583           AL663067.14        45291-45460         c
            2584-2714           AL663067.14        44853-44983         c
            2715-2840           AL663067.14        43828-43953         c
            2841-2897           AL663067.14        42785-42841         c
            2898-3017           AL663067.14        42026-42145         c
            3018-4472           AL663067.14        33026-34480         c
FEATURES             Location/Qualifiers
     source          1..4472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.42 cM"
     gene            1..4472
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /note="TATA-box binding protein associated factor 4"
                     /db_xref="GeneID:228980"
                     /db_xref="MGI:MGI:2152346"
     exon            1..1290
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..3185
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase II, C1, 130kd; TAF4A RNA polymerase II,
                     TATA box binding protein (TBP)-associated factor"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 4"
                     /protein_id="NP_001074561.1"
                     /db_xref="CCDS:CCDS38373.1"
                     /db_xref="GeneID:228980"
                     /db_xref="MGI:MGI:2152346"
                     /translation="MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLA
                     PRTPELRAAAAGALGNHVVSGSPAGAAGAGPAASAEGAPAAAPEPPPAGRARPAGGGP
                     RRPGSSSPRRLLVPAGPAPAPAKLRPLPEASAGPCPAAAAAAAATAAAVAGPDPAAAA
                     PPAGPGASKPGPPGPPGPGAAQTLNGSAAPPTAPHAAPAVSPVNNGPAPPPAAGSVIQ
                     AAPAPAAPSPPAAPAPAAPPPPAPPAPVAPARPPGHPAAPAPPVSPAAAAAAAAAAAA
                     AQNGAAPAPAAASGGAAGLGQPGAGAQGAKAEAPKPGPGPGPGPAAAAAAAGVAGGGA
                     AGSVLLGPAMPGALPGPAPGTPAGLAKGAAAATPSLPRTPAATTGAIRATLTPTVLAP
                     RLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAHAQAQPQSTMAPRP
                     ATPTGAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPTTTLQRSPGVQPQL
                     VLGGSAQPASLGTATAVQTGTPQRTVPGASTTSTAATETMENVKKCKSFLSTLIKLAS
                     SGKQSTETAANVKDLVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQ
                     LTPDSAAFIQQSQQQQPPASQATTALTAVVLSSSVQRTAGKTAASVTSALQPPVISLT
                     QPTQVGVGKQAPPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQI
                     QLNQLQPVPVVKPTVLPGTKALSTVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMA
                     GVNLSEESARILATNSELVGTLTRSCKDDTFLLPAPLQRRILEIGKKHGITELHPDVV
                     SYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQR
                     KDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPR
                     KKRKVDCTGPGSGAEGSGPGAAVPGGSGVGTPRQFTRQRITRVNLRDLIFCLENERET
                     SHSLLLYKAFLK"
     exon            1291..1451
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1571
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1691
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1814
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1904
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2150
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2298
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2413
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2583
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2714
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2840
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2897
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3017
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..4472
                     /gene="Taf4"
                     /gene_synonym="135kDa; Taf2c1; Taf4a; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctgccca ggcgcgctcg gccgagcggc ggcggcggcg gcggcgagga ggaaagatgg
       61 cggcgggctc ggatctgctg gacgaggtct tcttcaacag cgaggtggac gagaaagtgg
      121 tgagcgatct ggtgggctcg ctcgagtcgc agctggcggc cagcgcggcc caccaccacc
      181 acctcgcgcc gcgcacgccc gagctgcggg ccgcggccgc cggcgcgctc gggaaccatg
      241 ttgtgagcgg cagcccggcc ggagccgcgg gcgcagggcc ggccgcctcc gccgagggcg
      301 cgcccgcagc ggcgccggag ccgccccccg caggtagagc gcggccggcg ggtgggggcc
      361 cgcggcgccc gggctccagc tcaccgcgcc gcttgcttgt ccccgcaggg cccgcgccgg
      421 cgcccgccaa gctgaggccg ctgcccgagg ccagcgcggg gccctgcccc gccgccgctg
      481 ccgctgccgc cgccaccgcc gccgccgtcg cggggccgga tcccgccgcc gccgccccac
      541 ccgccggccc cggcgcctcc aagcccggcc cgcctggccc gcccggcccc ggcgccgcgc
      601 aaactttgaa tgggagcgcc gcgccgccca ccgcgccgca cgccgcacct gctgtcagcc
      661 cggtcaacaa cgggcccgcg ccgccgcccg ccgccggctc tgtcatccag gcggcccccg
      721 cgcccgccgc gccctcgccg cccgccgcgc ccgcgcccgc cgcgcccccg ccgcccgcgc
      781 ccccagcgcc tgtcgcgcca gcccggccgc ccgggcaccc cgccgcgccc gcgccccccg
      841 tgtcacccgc tgccgctgcc gccgccgccg ccgctgccgc cgccgcgcag aacggggccg
      901 ctcctgcccc cgccgcggcc tccgggggcg ccgcggggtt gggccagccg ggcgcgggcg
      961 cgcagggggc caaggccgag gcgcccaagc ccggaccggg gcccgggccg gggccggcgg
     1021 cggcggcggc ggcggcgggg gtcgcgggcg ggggcgcggc gggcagtgtg ctgctcgggc
     1081 ccgccatgcc gggcgcgctg ccggggcctg cgcccgggac ccccgcgggg ctggcgaagg
     1141 gtgcggccgc ggcgaccccc agcctgcctc ggacgccggc ggccaccacc ggcgctatcc
     1201 gggccacgct gacgcccacc gtgctggccc cgcgcctgcc gcagccgccg cagaacccga
     1261 ccaacatcca gaacttccag ctgcccccag gaatggtcct cgtgcggagt gagaatgggc
     1321 agttgttaat gatccctcag caggccctgg cccagatgca ggcccatgcc caggcccagc
     1381 ctcagagtac catggcaccc cgtcctgcaa cccccacagg tgctccacct gtccagatct
     1441 ccactgtgca ggctccagga acacctatta ttgcacggca ggtgacccca actaccataa
     1501 ttaagcaagt gtctcaggcc cagacgacgg tacagcccac tacaacccta cagcgatctc
     1561 ccggggtaca gcctcagctg gttctgggtg gctccgcaca gccagcctca cttggaacag
     1621 ccacagctgt tcagacaggg acacctcaac gaacagtccc tggggccagc accacctcta
     1681 cagctgccac ggaaactatg gaaaatgtga aaaaatgcaa aagttttcta tctacattaa
     1741 taaaactggc ttcctctggt aaacagtcta cagagacagc ggctaatgtg aaagacttag
     1801 tacaaaactt actggatggg aaaattgaag cagaagattt cactagcagg ttataccgag
     1861 aactgaactc ttcacctcag ccttaccttg tgcctttcct gaagaggagc ttacctgcct
     1921 tgagacagct gaccccagac tccgcggcct ttatccagca gagccagcag cagcagccgc
     1981 ctgcttcgca ggccacgact gcactgacgg ctgtggtgct gagcagctca gtgcagcgta
     2041 cagctgggaa gacagctgcc tcggtgacca gcgccctcca gcccccggtc atcagcctca
     2101 cgcagcccac acaggttggc gttggcaagc aggcgccgcc cacaccactg gtgatccagc
     2161 agcccccgaa gcctggagcc ttgatccggc ccccgcaggt gaccttgacg cagacaccca
     2221 tggtcgcatt gcggcagcct cacaaccgga tcatgctcac cacaccacag cagatccaac
     2281 tgaaccagct gcagccagtc cctgtggtga aacccaccgt gttacctgga accaaagccc
     2341 tgtctactgt atctgcacaa gcagctgctg cccagaaaaa caaactcaag gagccggggg
     2401 gaggctcctt ccgggatgat gatgacatca atgatgttgc gtcaatggct ggagtgaacc
     2461 tgtctgaaga aagtgcaagg atattggcca caaactctga gttggtgggg acgttgaccc
     2521 gatcctgtaa agacgacacc ttcctcctcc ccgcgccttt gcagaggagg atactggaga
     2581 taggtaaaaa gcacggcatc acggaactgc atccagatgt agtgagttac gtgtctcatg
     2641 ccacacagca aaggctgcag aatcttgtag aaaaaatatc tgaaacggct cagcagaaaa
     2701 acttctctta taaggacgac gacagatacg agcaagcgag tgatgtccgg gctcagctca
     2761 aattctttga acaactggat cagattgaaa agcagaggaa agatgagcag gagagggaga
     2821 tcttaatgcg ggcagcgaag tctcgatcca gacaagaaga cccagagcaa ttaaggttga
     2881 agcagaaagc aaaagagatg cagcagcagg agctggcaca gatgcgacaa cgagatgcca
     2941 acctcactgc actggcagcg atcgggccca ggaaaaagag gaaagtggac tgcactgggc
     3001 caggatcagg agcagagggc tcaggcccgg gcgcagcagt cccaggcggc tccggcgtgg
     3061 gaacccccag acagttcaca cggcaaagaa tcacgcgggt caacctcagg gacctcatat
     3121 tttgtttaga aaacgagcgt gagacaagcc attcactgtt gctctacaaa gcattcctta
     3181 agtaacagga tgagccggcg tttctgatgg gatgcttgcg gacgttttta tatatttgca
     3241 gattacgcct ttttgtaaca agcaaatggg atattgttta aaaacagcca cctctttaca
     3301 atggagcagt tttatactcc tgtttataaa tcagctcttc agtgcggcag aaaccgtgtc
     3361 tgcagcagag agaacacaaa ggcctgtggg tgctctcaca ggacagctga cccgagctca
     3421 tcctcggctg agtggccttc ttgccaaaca agccatattt aaagactgat ggaagcgctt
     3481 agcaaataat tagcagttgc tcatcctgtg tgcgttttgg ttcagctcac cctgactccc
     3541 gctaggtgta tgtctacagc cgatgacctc atctcttcct ttctgttgta gcagtcagtt
     3601 ggcgaagcaa gctgactttt tagactattt atcacctcgc ccctgccctg tcctgtccct
     3661 tccctcccgt ctacacgaag ctccccagga acacaagctc caagcagggt cccggtctgc
     3721 agtagaggcc ggggtgcagg ccgggggcag cacctgtaca aacacaattg atttgctgca
     3781 gtttggaagc tgtgaagtgg aaggaagtga gagcctagga agtgagaacc ttttcagcgt
     3841 aaatatattt tacttgcact gtgtttttag ctcagagtga agacttagat gaaataaaat
     3901 cagagttgag aagaatcaac aacagactgt ttctcagtgt ggatcaagtg ttggaaatgg
     3961 ttggtgtatt ttgtcagtaa ttgtacataa tttttggcac ataacataaa atggctatgt
     4021 aaactataat tattttgcta agagactgta tgcaagctgt ggccaacctt acaggcgtcc
     4081 agagcaaagc cccttctttg tacctatttt tttattacaa atatactaat tggttcttta
     4141 tattttcaga ggttattgta ttaaattgtc tattgatagt acttttatga ctgtaaatac
     4201 ttggctttct ccgtgtggat tctcatgtta gacttcaatt cgcacgtgtg aactgaacgc
     4261 tgatcagtat tttttacgac acccaagaac tgttacacct ttcattttat cttttaggaa
     4321 atccctgtct ttccattttt tcatgtaaat tttgcacagt tacttgttaa tatgtaaata
     4381 ttttactttc agaaatgaag tttttaattg ctattgtttt atataggatt gaaagaaaat
     4441 taactccttt attaaaaaca aatttatctg ta
//
