LOCUS       NM_027748               4821 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 3 (Taf3),
            mRNA.
ACCESSION   NM_027748 XM_129997
VERSION     NM_027748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4821)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   2  (bases 1 to 4821)
  AUTHORS   Bardot,P., Vincent,S.D., Fournier,M., Hubaud,A., Joint,M., Tora,L.
            and Pourquie,O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   3  (bases 1 to 4821)
  AUTHORS   Langer,D., Martianov,I., Alpern,D., Rhinn,M., Keime,C., Dolle,P.,
            Mengus,G. and Davidson,I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4821)
  AUTHORS   Stijf-Bultsma,Y., Sommer,L., Tauber,M., Baalbaki,M., Giardoglou,P.,
            Jones,D.R., Gelato,K.A., van Pelt,J., Shah,Z., Rahnamoun,H.,
            Toma,C., Anderson,K.E., Hawkins,P., Lauberth,S.M., Haramis,A.P.,
            Hart,D., Fischle,W. and Divecha,N.
  TITLE     The basal transcription complex component TAF3 transduces changes
            in nuclear phosphoinositides into transcriptional output
  JOURNAL   Mol Cell 58 (3), 453-467 (2015)
   PUBMED   25866244
  REMARK    GeneRIF: Data indicate that TATA box binding protein-associated
            factor TAF3 as a direct target of nuclear phosphoinositides (PI).
REFERENCE   5  (bases 1 to 4821)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   6  (bases 1 to 4821)
  AUTHORS   Bereczki,O., Ujfaludi,Z., Pardi,N., Nagy,Z., Tora,L., Boros,I.M.
            and Balint,E.
  TITLE     TATA binding protein associated factor 3 (TAF3) interacts with p53
            and inhibits its function
  JOURNAL   BMC Mol Biol 9, 57 (2008)
   PUBMED   18549481
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4821)
  AUTHORS   Deato,M.D. and Tjian,R.
  TITLE     Switching of the core transcription machinery during myogenesis
  JOURNAL   Genes Dev 21 (17), 2137-2149 (2007)
   PUBMED   17704303
REFERENCE   8  (bases 1 to 4821)
  AUTHORS   Pointud,J.C., Mengus,G., Brancorsini,S., Monaco,L., Parvinen,M.,
            Sassone-Corsi,P. and Davidson,I.
  TITLE     The intracellular localisation of TAF7L, a paralogue of
            transcription factor TFIID subunit TAF7, is developmentally
            regulated during male germ-cell differentiation
  JOURNAL   J Cell Sci 116 (Pt 9), 1847-1858 (2003)
   PUBMED   12665565
REFERENCE   9  (bases 1 to 4821)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4821)
  AUTHORS   Gangloff,Y.G., Pointud,J.C., Thuault,S., Carre,L., Romier,C.,
            Muratoglu,S., Brand,M., Tora,L., Couderc,J.L. and Davidson,I.
  TITLE     The TFIID components human TAF(II)140 and Drosophila BIP2
            (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47
            containing a histone fold and a PHD finger
  JOURNAL   Mol Cell Biol 21 (15), 5109-5121 (2001)
   PUBMED   11438666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB621106.1, BC137618.1, AK136045.1, CX763644.1 and AW049595.1.
            
            On Oct 30, 2009 this sequence version replaced NM_027748.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137617.1, AK154372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BB621106.1         2-60
            60-3819             BC137618.1         1-3760
            3820-4266           AK136045.1         2478-2924
            4267-4602           CX763644.1         33-368
            4603-4821           AW049595.1         1-219               c
FEATURES             Location/Qualifiers
     source          1..4821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 6.74 cM"
     gene            1..4821
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="TATA-box binding protein associated factor 3"
                     /db_xref="GeneID:209361"
                     /db_xref="MGI:MGI:2388097"
     exon            1..375
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3008
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="TAF3 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 140kDa; RNA polymerase II
                     transcription factor, TFIID subunit; TBP-associated factor
                     3; 140 kDa TATA box-binding protein-associated factor;
                     transcription initiation factor TFIID 140 kDa subunit;
                     TAF(II)140"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 3"
                     /protein_id="NP_082024.2"
                     /db_xref="CCDS:CCDS15675.1"
                     /db_xref="GeneID:209361"
                     /db_xref="MGI:MGI:2388097"
                     /translation="MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQ
                     LGRGCHRYSELYGRTDPILDDVGEAFQLMGVNLHELEDYIHNIEPVTFPHQIPSFPVS
                     KNNVLQFPQPGSKDAEERKDYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEE
                     DDEMEEEEVINDENFLGKRPLDSPEVEEMPSMKRPRLLSTKGDSLDVVLLEAREPLSS
                     INPQKTPPVLSPVRVQDRADLAPPSPQPPMLAPFAKSQLPIAKPLETKSFTPKTKTKA
                     SSPGQKTKSPKAALSPARLGSPIRSPKTIPKEKKSPGRSKSPKSPKSPKIVAHVPQTP
                     VRPETPNRTPSAMVVEKTVKETIPVMKPTQTPPEVVKLNIEMQPKKPVVTDKTIDDSI
                     DAVIARACAEREPDPFEFSSGSESEGDTFTSPKRISGSECATPKASTSSNNFTKSLAT
                     PLPLSSGTSSSDNSWTMDASIDEVVRKAKLGAPSNMPPTFPYISSPSISPPTPEPLHK
                     GYEEKAKLPSSVDVKKKLKKELKTKLKKKEKQRDRERERERNKERSKEKDKMREREKE
                     KEAGKELKYPWRELMKDEDSDPYKFKIKEFEDIDAAKVRLKDGIVRREREKHKDKKKD
                     RERSKREKDKRERERLKEKNREDKIKAPPTQLVLPPKEMALPLFSPSAVRVPAMLPAF
                     SPMLPEKLFEEKEKPKEKERKKDKKEKKKKKEKEKEKEKKEREREKERREREKREKEK
                     EKHKHEKIKVEPVIPAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSLNRPKTP
                     PPAPVPIPVRVSPTPLQPPLLTQAAVCPALMPSPAPALSGIGSAKAPVRSVVTETVST
                     YVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMAAPPEEMQWFCPKC
                     ANKIKKDKKHKKRKHRAH"
     exon            376..618
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            619..2450
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2783
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2890
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..4805
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3735..3740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="hexamer: AATAAA"
     polyA_site      3766
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="hexamer: AGTAAA"
     polyA_site      4067
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="major polyA site"
     regulatory      4781..4786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="hexamer: AATAAA"
     polyA_site      4805
                     /gene="Taf3"
                     /gene_synonym="140kDa; 4933439M23Rik; mTAFII140; TAF140;
                     TAFII-140; TAFII140"
                     /note="major polyA site"
ORIGIN      
        1 agcgggaggc ggagcgagtc caaaatggcg gctctcaggc tggcgcgctc cgtgctgctg
       61 aggctttgag gtggtcgctc cgggtcggag gggggacgat ttccccgccg cggggccccc
      121 agagaatgaa tcgggggctc tgctgaggcg aggcggcagg gctggagagc agtggcagcg
      181 aagggctgcg gtggcgtcca cgcagcggga tgtgcgagag ttactctagg tcgttgttga
      241 gggtctcggt ggcgcagatc tgccaggcgc tgggctggga ctcggtgcag ctcagcgcct
      301 gccacctcct caccgacgtc ctgcagcgct atctgcagca gctgggccgg ggctgccatc
      361 ggtactctga actctatggc cgaacagacc ccattttgga tgatgttggt gaagccttcc
      421 aacttatggg agttaatctg catgaactag aagactatat tcataatatt gaacctgtca
      481 ctttcccaca tcaaattcct tcatttcctg ttagcaagaa caatgtcctt cagtttcctc
      541 agcccggaag taaagatgca gaggaaagaa aagactacat tccggattac cttcccccca
      601 tcgtgtcttc tcaagaagag gaggaagagg aacaggtgcc cactgatggg ggcacctcag
      661 cagaagccat gcaggtgccc ttggaagaag atgatgagat ggaggaggag gaagtcatca
      721 atgatgagaa cttcttgggt aagaggccac tggacagtcc tgaagtggaa gaaatgccct
      781 ccatgaagcg cccacgactc ctgagcacta aaggggactc cctagatgtt gtgttgttag
      841 aagcacgaga acccctcagc tctataaacc cacagaagac cccaccagtg ctctctcctg
      901 tgcgtgtcca ggacagggct gatctggccc ctccatcacc acagcctccc atgctggctc
      961 catttgcaaa gtcacaacta ccaattgcaa agccgttaga aacaaagtcg tttacaccaa
     1021 aaacaaagac taaagctagc tctccaggtc agaaaactaa gtcacccaag gctgccctat
     1081 caccagcaag gcttggaagt cctattcggt caccaaaaac catcccaaaa gaaaagaagt
     1141 cacctggacg ctccaagagc cccaagagtc ctaagagccc caagattgta gctcatgttc
     1201 cccaaacccc tgtcagacct gaaacaccaa ataggacccc ttcagccatg gtggttgaaa
     1261 aaactgttaa agagaccatc ccagtgatga aaccaacaca gactccccca gaagttgtga
     1321 aactgaacat tgaaatgcag ccgaaaaagc ctgtggtgac agacaaaacc atcgatgact
     1381 ccatcgatgc tgtgatcgca cgtgcctgtg cagagcggga gccagaccct ttcgagtttt
     1441 cttccggatc ggaatcggaa ggagacactt ttacaagtcc taagaggatt tcaggctcag
     1501 agtgcgccac tccaaaagcc tccacttcct ccaataactt caccaagtcc ctggccactc
     1561 ctctgcctct ctccagcgga acctcaagtt cagataactc gtggacaatg gatgcctcta
     1621 ttgatgaggt ggtacggaag gcaaagctgg gagccccttc caacatgcct cccaccttcc
     1681 catatatctc ttctccctca atttctcctc ccactcctga gcctctacac aaggggtatg
     1741 aggagaaagc caagctgcct tcgtctgtgg atgtaaagaa aaagttgaaa aaagaactga
     1801 agactaagtt gaaaaagaaa gaaaagcagc gagacagaga gagggagaga gagagaaaca
     1861 aagaaagaag caaagagaaa gataaaatga gagagaggga gaaggagaag gaggctggaa
     1921 aggaacttaa gtacccgtgg agggagctga tgaaagacga agattctgat ccctataagt
     1981 ttaaaatcaa agaatttgaa gacattgatg ctgcgaaagt gcgattgaaa gatgggatcg
     2041 tgaggagaga gcgagagaaa cataaggaca agaagaaaga tcgagaaaga agcaagcggg
     2101 agaaagataa gcgagaaagg gaaaggctta aagaaaaaaa cagagaagac aagataaagg
     2161 cccctccaac acagctggtg ttgcccccaa aagaaatggc actgcctttg ttcagccctt
     2221 cagcagtgag ggtcccggcc atgctgccgg ccttctcacc aatgctccca gaaaaactgt
     2281 ttgaggaaaa agagaagccc aaggagaaag aaaggaaaaa ggacaaaaag gagaagaaga
     2341 agaagaaaga gaaggagaaa gaaaaggaga agaaagagag ggagagggag aaggagagaa
     2401 gggagagaga gaagagagag aaggagaagg agaagcacaa acatgagaag ataaaagtgg
     2461 agcctgtcat ccctgcccca agtccagtta tccccaggtt gactctgcga gttggcgctg
     2521 gccaggacaa gattgttatc agcaaggtgg taccagcccc ggaggctaag cccgctcctt
     2581 ctctgaacag acccaaaacc ccacctccag ccccagtccc tattcctgtg cgagtgagcc
     2641 ctactcccct gcagccacca ctcctcaccc aggctgcagt gtgcccagcc ctgatgccat
     2701 ccccagctcc cgccctctct ggaataggga gtgccaaagc ccccgtgagg agcgtcgtga
     2761 ctgagacggt cagcacttat gtgatccgtg atgagtgggg caatcagatc tggatctgtc
     2821 cagggtgcaa caagcctgat gacgggagcc cgatgattgg ctgtgacgac tgtgacgatt
     2881 ggtaccactg gccctgtgtg ggaatcatgg ctgctcctcc agaagagatg cagtggttct
     2941 gcccgaagtg tgccaacaag ataaagaaag acaagaagca caagaagagg aagcaccgtg
     3001 cgcactgaca tcagcgtggg caggactgct gccctgcgcc gggtcggggc tgggctggtt
     3061 ctgccatcct gtctcccccg ggccctgtgg acttgcagcg catcccagag gagcaaggac
     3121 aagaacatgg cacccctctg gatgctccct ctgaaacaca tgggcctgag ctcccgcagc
     3181 atgttgctga agaaaactcc agtggagggc tggcccgagg gctggcacct ccatctgcct
     3241 attaccagtg acaagtatta ataaagacgc cacacatctg ccctctcgat ttcctttctt
     3301 ctctccagaa cctttcgtca tggtattaga taagaaggta atgtccaaat gccttgactg
     3361 atggaagggc gcatcggtag ctacagttgg caagcccact ccctccacgg ggaggtaatc
     3421 agaaggaaag aacgctccag tcacagcact gggaatattt ttgtgatgag agtatatgaa
     3481 gctccccacc tcacccgact tttattacta acgtgtaaaa tgttcaggct tttgtgagat
     3541 accttatatt ttttaagaaa agggtttcta tcatgtcctg tccacccctg tgcagattgt
     3601 cttcattggc ctattttata ccttggttgc attcccatcc cactgtgtga actgctggag
     3661 tccccctgct gcgtgtgcat cccatcgact tgtataaaac tcttgatact aaggagaatc
     3721 ccctcactgt aaataataaa tatttatgaa gtagttattt ttaaaatttt ttatcgtgtt
     3781 taattctggc tttctctgga atccactgcg atttcagcca tgtctgtaat tgctgctgtg
     3841 cataggcaaa gaagagagac gaggacccag agccatgacc ctgcccaagc gcaccgccca
     3901 cgcaatgggc ggggaggacc ccgcaaccgg aaggaaacag gcaattgaca tctcaagttg
     3961 atggtttgaa actgttttgt ttgttatata ttttctgtaa atttctctca cttttactaa
     4021 aaaggacatg tagtttccac aaaagtaaaa aaagagaaaa tactgtagca tttgtgttta
     4081 tattgtttta tttcacagat ttgttcatgg atattgtgct ttaaggttga aatgaagtat
     4141 attatggatt tttttaagaa aactcatcaa atttcagggt atcacaaaac tttattatat
     4201 tactatactg cccactattt atttatagat atctgaaacg taaaccaaat gttttatttt
     4261 taatgtaaaa aaaaaacatc aaatttaact ttattagcat attttagtga ctttggaata
     4321 actatggact tttacttgat tttgaaataa tcccaatttg ggcatgcgtg aaggctgtct
     4381 tgaatgttag aatgcaggat ttgaacctaa tacaaatata tgaatagaaa tgtgattttt
     4441 tttttactcc caactcaatt gatattagca ttataattac ccctatttta aaacatataa
     4501 tgtggtttca gaaatgcggt tctcggcctt gatgttaaat tgcagaaaag tgggaatgga
     4561 gtcaacctgt gaagagtgtg gaagtcacta ccccccttgt tctagaagcc agattgtccg
     4621 ccatccccac cccacacccc aaaaagtatc tatgttgaga tgtgtctctt ttctttttga
     4681 tttattagag atcatcctga atactttata caatattttc acatgcacaa gtatacccat
     4741 tagtgctttt tggaggagac aaagggtggg ggaagtgcaa aataaagatt attggctgtt
     4801 tcgtaaaaaa aaaaaaaaaa a
//
