LOCUS       NP_065639                586 aa            linear   ROD 27-APR-2025
DEFINITION  TATA box-binding protein-associated factor RNA polymerase I subunit
            B [Mus musculus].
ACCESSION   NP_065639 XP_978206
VERSION     NP_065639.2
DBSOURCE    REFSEQ: accession NM_020614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 586)
  AUTHORS   Tremblay,M.G., Sibai,D.S., Valere,M., Mars,J.C., Lessard,F.,
            Hori,R.T., Khan,M.M., Stefanovsky,V.Y., LeDoux,M.S. and Moss,T.
  TITLE     Ribosomal DNA promoter recognition is determined in vivo by
            cooperation between UBTF1 and SL1 and is compromised in the
            UBTF-E210K neuroregression syndrome
  JOURNAL   PLoS Genet 18 (2), e1009644 (2022)
   PUBMED   35139074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 586)
  AUTHORS   Maga,A.M., Navarro,N., Cunningham,M.L. and Cox,T.C.
  TITLE     Quantitative trait loci affecting the 3D skull shape and size in
            mouse and prioritization of candidate genes in-silico
  JOURNAL   Front Physiol 6, 92 (2015)
   PUBMED   25859222
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 586)
  AUTHORS   Murano,K., Okuwaki,M., Momose,F., Kumakura,M., Ueshima,S.,
            Newbold,R.F. and Nagata,K.
  TITLE     Reconstitution of human rRNA gene transcription in mouse cells by a
            complete SL1 complex
  JOURNAL   J Cell Sci 127 (Pt 15), 3309-3319 (2014)
   PUBMED   24928901
REFERENCE   4  (residues 1 to 586)
  AUTHORS   Adolphe,C., Nieuwenhuis,E., Villani,R., Li,Z.J., Kaur,P., Hui,C.C.
            and Wainwright,B.J.
  TITLE     Patched 1 and patched 2 redundancy has a key role in regulating
            epidermal differentiation
  JOURNAL   J Invest Dermatol 134 (7), 1981-1990 (2014)
   PUBMED   24492243
REFERENCE   5  (residues 1 to 586)
  AUTHORS   Eckey,M., Kraft,F., Kob,R., Escher,N., Asim,M., Fischer,H.,
            Fritsche,M.K., Melle,C. and Baniahmad,A.
  TITLE     The corepressor activity of Alien is controlled by CREB-binding
            protein/p300
  JOURNAL   FEBS J 280 (8), 1861-1868 (2013)
   PUBMED   23441852
REFERENCE   6  (residues 1 to 586)
  AUTHORS   Qiu,H., Nomiyama,R., Moriguchi,K., Fukada,T. and Sugimoto,K.
  TITLE     Identification of novel nuclear protein interactions with the
            N-terminal part of filamin A
  JOURNAL   Biosci Biotechnol Biochem 75 (1), 145-147 (2011)
   PUBMED   21228480
REFERENCE   7  (residues 1 to 586)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (residues 1 to 586)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (residues 1 to 586)
  AUTHORS   Heix,J., Zomerdijk,J.C., Ravanpay,A., Tjian,R. and Grummt,I.
  TITLE     Cloning of murine RNA polymerase I-specific TAF factors: conserved
            interactions between the subunits of the species-specific
            transcription initiation factor TIF-IB/SL1
  JOURNAL   Proc Natl Acad Sci U S A 94 (5), 1733-1738 (1997)
   PUBMED   9050847
REFERENCE   10 (residues 1 to 586)
  AUTHORS   Almendral,J.M., Santaren,J.F., Perera,J., Zerial,M. and Bravo,R.
  TITLE     Expression, cloning and cDNA sequence of a fibroblast
            serum-regulated gene encoding a putative actin-associated protein
            (p27)
  JOURNAL   Exp Cell Res 181 (2), 518-530 (1989)
   PUBMED   2924801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125067.4, AK131963.1 and CK619940.1.
            
            On Aug 28, 2009 this sequence version replaced NP_065639.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057167.1, AK165580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.49 cM"
     Protein         1..586
                     /product="TATA box-binding protein-associated factor RNA
                     polymerase I subunit B"
                     /note="transcription factor TAFI68; TBP-associated factor
                     RNA polymerase I 68; TBP-associated factor 1B; TATA
                     box-binding protein-associated factor 1B; transcription
                     initiation factor SL1/TIF-IB subunit B; RNA polymerase
                     I-specific TBP-associated factor 68 kDa; TATA box binding
                     protein (Tbp)-associated factor, RNA polymerase I, B"
                     /calculated_mol_wt=67823
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q53T94; propagated from
                     UniProtKB/Swiss-Prot (P97358.2)"
     Region          9..37
                     /region_name="zf-RRN7"
                     /note="Zinc-finger of RNA-polymerase I-specific TFIIB,
                     Rrn7; pfam11781"
                     /db_xref="CDD:463348"
     Region          40..68
                     /region_name="B-reader. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97358.2)"
     Region          69..73
                     /region_name="B-linker. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97358.2)"
     Region          74..259
                     /region_name="N-terminal cyclin fold.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97358.2)"
     Region          260..370
                     /region_name="C-terminal cyclin fold.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97358.2)"
     Site            438
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q53T94; propagated from
                     UniProtKB/Swiss-Prot (P97358.2)"
     CDS             1..586
                     /gene="Taf1b"
                     /gene_synonym="4930408G01Rik; A230108M10Rik; p63; TAFI68;
                     Tafi86"
                     /coded_by="NM_020614.2:52..1812"
                     /db_xref="CCDS:CCDS36419.1"
                     /db_xref="GeneID:21340"
                     /db_xref="MGI:MGI:109577"
ORIGIN      
        1 mdveevkafr drcsqcaavs wgltdegkyy ctschnvtdr seevvsaadi pntkinsinr
       61 glrqrskhek gwdwyvcegf qcilyhqaka letlgvspel knevlhnfwk rylqkskqay
      121 cknpvrtsgr kakvledsvq ssdlgsdlel lsdttcples eaefqsdpqi pkpfpvtkgs
      181 pksasvcsgs vdgveyserk ekglvkmtvp rtlalcslsl lwqretitvs dllrfveedh
      241 ipyinafklf peemkvygrd kgifaieswp dyediyknmi elaifldlpr fpditedcyl
      301 hpntlcmkyl levnlpdemh tltcqvvklt gigevdfltf dpiaktkrtv kydvqamavi
      361 vvvlkllfll ddklewsysd laeayneqhr edtpqfdfrk wyqvmkktfd ekrrkweear
      421 aryawktkrp lyrshidksv aykrrkmven lqkqfsalvg sspvvekqap ssfqfnwtee
      481 gtdspcfhgh slqgllimkg qsmitknsly wlstqkfcks yckhvttyee snfslsyqfi
      541 lnifsfllri ktsalheevs llekklfekk yneskkssgs kkgrrh
//
