LOCUS       NM_027427               2052 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 15 (Taf15),
            mRNA.
ACCESSION   NM_027427
VERSION     NM_027427.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Yang,S., Xu,B., Han,Y., Jiang,M., Luo,T., Wu,N., Cao,J., Zheng,Y.,
            Shen,L., Qin,W., Shi,H. and Dong,L.
  TITLE     TAF15 exacerbates nonalcoholic steatohepatitis progression by
            regulating lipid metabolism and inflammation via FASN and p65
            NF-kappaB
  JOURNAL   Liver Int 43 (9), 1920-1936 (2023)
   PUBMED   37183512
  REMARK    GeneRIF: TAF15 exacerbates nonalcoholic steatohepatitis progression
            by regulating lipid metabolism and inflammation via FASN and p65
            NF-kappaB.
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Zhang,L., Sun,P., Zhang,Y., Xu,Y. and Sun,Y.
  TITLE     miR-182-5p inhibits the pathogenic Th17 response in experimental
            autoimmune uveitis mice via suppressing TAF15
  JOURNAL   Biochem Biophys Res Commun 529 (3), 784-792 (2020)
   PUBMED   32736708
  REMARK    GeneRIF: miR-182-5p inhibits the pathogenic Th17 response in
            experimental autoimmune uveitis mice via suppressing TAF15.
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Gasperini,L., Rossi,A., Cornella,N., Peroni,D., Zuccotti,P.,
            Potrich,V., Quattrone,A. and Macchi,P.
  TITLE     The hnRNP RALY regulates PRMT1 expression and interacts with the
            ALS-linked protein FUS: implication for reciprocal cellular
            localization
  JOURNAL   Mol Biol Cell 29 (26), 3067-3081 (2018)
   PUBMED   30354839
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Svetoni,F., De Paola,E., La Rosa,P., Mercatelli,N., Caporossi,D.,
            Sette,C. and Paronetto,M.P.
  TITLE     Post-transcriptional regulation of FUS and EWS protein expression
            by miR-141 during neural differentiation
  JOURNAL   Hum Mol Genet 26 (14), 2732-2746 (2017)
   PUBMED   28453628
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Kapeli,K., Pratt,G.A., Vu,A.Q., Hutt,K.R., Martinez,F.J.,
            Sundararaman,B., Batra,R., Freese,P., Lambert,N.J., Huelga,S.C.,
            Chun,S.J., Liang,T.Y., Chang,J., Donohue,J.P., Shiue,L., Zhang,J.,
            Zhu,H., Cambi,F., Kasarskis,E., Hoon,S., Ares,M. Jr., Burge,C.B.,
            Ravits,J., Rigo,F. and Yeo,G.W.
  TITLE     Distinct and shared functions of ALS-associated proteins TDP-43,
            FUS and TAF15 revealed by multisystem analyses
  JOURNAL   Nat Commun 7, 12143 (2016)
   PUBMED   27378374
  REMARK    GeneRIF: FUS and TAF15 exhibit similar global RNA interaction
            profiles in vivo, but affect a strikingly small subset of common
            genes. Unexpectedly, TAF15 influences a small fraction of
            amyotrophic lateral sclerosis events compared with TDP-43 and FUS
            in the mouse CNS.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Ibrahim,F., Maragkakis,M., Alexiou,P., Maronski,M.A., Dichter,M.A.
            and Mourelatos,Z.
  TITLE     Identification of in vivo, conserved, TAF15 RNA binding sites
            reveals the impact of TAF15 on the neuronal transcriptome
  JOURNAL   Cell Rep 3 (2), 301-308 (2013)
   PUBMED   23416048
  REMARK    GeneRIF: TAF15 is required for a critical alternative splicing
            event of the zeta-1 subunit of the glutamate N-methyl-D-aspartate
            receptor (Grin1) that controls the activity and trafficking of NR1.
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Melot,T., Dauphinot,L., Sevenet,N., Radvanyi,F. and Delattre,O.
  TITLE     Characterization of a new brain-specific isoform of the EWS
            oncoprotein
  JOURNAL   Eur J Biochem 268 (12), 3483-3489 (2001)
   PUBMED   11422378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051568.1 and AL596122.14.
            
            On Jul 3, 2018 this sequence version replaced NM_027427.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051568.1, AK146331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2049              AK051568.1         2-2050
            2050-2052           AL596122.14        18084-18086
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.49 cM"
     gene            1..2052
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /note="TATA-box binding protein associated factor 15"
                     /db_xref="GeneID:70439"
                     /db_xref="MGI:MGI:1917689"
     exon            1..99
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            100..139
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            140..191
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            192..276
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            277..379
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            380..570
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            571..691
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            692..726
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            727..759
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            760..869
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            870..999
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1092
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1174
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1263
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1726
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2052
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /note="hexamer: AATAAA"
     polyA_site      2052
                     /gene="Taf15"
                     /gene_synonym="2610111C21Rik; 68kDa; Taf2n; TAFII68"
                     /note="major polyA site"
ORIGIN      
        1 ctcagagcag ctccagcagc cgcgccgcct ggcttttcgt tttccttgtt ctccgcgggc
       61 cgtggcgggg ctccgcgccg cggctgttag tcatgtcgga ttctggaagt tacagtcagt
      121 ctgggggtga gcagcaaagt tattcttctt atggaaatca aggcagtcaa ggctatggac
      181 aaacaccaca aggttattct ggctatgggc aaacgactga ttcttcgtat ggacaaaact
      241 atggtggtta ctccggttat ggacaaaatc aatcaggtta ttcacagtcg tatggtagtt
      301 atgagaatca aaagcagagt tcatatggcc agcaatcata caataaccag ggacaacaaa
      361 acacggagtc atcaggaggt caaggtggaa gagcaccttc atatggccag tcagactatg
      421 gtcagcaaga ttcttatgac cagcagtcag gttatgatca gcatcaaggc tcatatgatg
      481 agcagtccaa ttatcagcaa catgattcct ataatcaaaa ccaacagtct taccattcac
      541 aaagggaaaa ctacagccac cacacacaag atgaccgtcg tgatgtgagt aggtatggag
      601 aagataatag aggatatggc gggtcacagg gaggaggtag agggcgtggg ggatatgaca
      661 aggatggaag aggtcctatg acaggatcaa gtggtggtga ccgcggtggc ttcaaaaatt
      721 ttggtggtca cagggattat ggacccagac cagatgctga ttcagagtct gataattcag
      781 ataacaacac aatctttgtg caaggacttg gggagggtgt gtctacagat caagtgggag
      841 agttctttaa gcaaatagga attatcaaga ctaacaaaaa gactggaaaa ccaatgataa
      901 atctttacac agacaaagac acaggaaagc caaaagggga agcaacagtg tcatttgatg
      961 accctccatc agctaaggca gccattgatt ggtttgatgg aaaagaattc catggaaaca
     1021 tcataaaagt gtcatttgcc actagaaggc ctgaatttat gagaggtggt ggaagtggag
     1081 gtggacgccg aggccgtgga ggatatagag gccgtggagg ttttcagggg cgaggtggag
     1141 accccaagaa tggggactgg gtttgcccta atccgtcatg tggaaatatg aactttgctc
     1201 gaagaaactc ctgtaatcag tgcaatgagc ctagaccaga ggactcacgt ccctcagggg
     1261 gagatttccg ggggagaggc tatggtggag aaaggggcta cagaggtcgt gggggcagag
     1321 gtggagaccg aggtggctat ggtggagaca gaagtggggg aggttatggt ggagacagga
     1381 gtgggggtgg ctatggtggg gatagaggag gtagctatgg aggagacaga ggtggttatg
     1441 gtggggaccg aggaggcagc tatggaggag accgaggtgg ctacggagga gacagaggtg
     1501 gctatggagg agacagaggt ggctatggag gtgatcgagg aggctatgga ggtgatcgag
     1561 gtggatatgg aggagaccgc agccgggggg cctatggagg agaccgtggt ggtagtggta
     1621 gtggcagtgg aggctacggt ggagacagaa gtggaggcta cggtggagac cgaagtggtg
     1681 gctacggagg agaccgaggt ggctatggag gcaaaatggg aggaagaaac gactacagaa
     1741 atgatcagcg caaccgacca tactgatgac tgtttcagat actcctttgt ctctgacatg
     1801 atccgtgggg aattgtcaga gtgtgcctgc tgctttcctc atggcctctt gggtagtgaa
     1861 attgacattt gggtttttat ttgggtggga gggttggggg cagttttctt tttagaaatg
     1921 tccattaaaa aaatcccctt ttattttccc accttttctt tcctaaccct taaagctaag
     1981 tgcgttgtaa aatattgcca aaatggaaag tgttttgtaa tactgcaata aaagctgctt
     2041 gttttttgtg ga
//
