LOCUS       NM_025579               1353 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TATA-box binding protein associated factor 12 (Taf12),
            mRNA.
ACCESSION   NM_025579 XM_973809
VERSION     NM_025579.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   He,X.D., Phillips,S., Hioki,K., Majhi,P.D., Babbitt,C.,
            Tremblay,K.D., Pobezinsky,L.A. and Mager,J.
  TITLE     TATA-binding associated factors have distinct roles during early
            mammalian development
  JOURNAL   Dev Biol 511, 53-62 (2024)
   PUBMED   38593904
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Sun,F., Sun,T., Kronenberg,M., Tan,X., Huang,C. and Carey,M.F.
  TITLE     The Pol II preinitiation complex (PIC) influences Mediator binding
            but not promoter-enhancer looping
  JOURNAL   Genes Dev 35 (15-16), 1175-1189 (2021)
   PUBMED   34301767
  REMARK    GeneRIF: The Pol II preinitiation complex (PIC) influences Mediator
            binding but not promoter-enhancer looping.
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Bardot,P., Vincent,S.D., Fournier,M., Hubaud,A., Joint,M., Tora,L.
            and Pourquie,O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY069348.1, AK132927.1, AK139748.1 and BE630738.1.
            
            On Apr 22, 2009 this sequence version replaced NM_025579.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.420862.1, AK013133.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               BY069348.1         2-105
            105-867             AK132927.1         106-868
            868-1319            AK139748.1         785-1236
            1320-1353           BE630738.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.09 cM"
     gene            1..1353
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="TATA-box binding protein associated factor 12"
                     /db_xref="GeneID:66464"
                     /db_xref="MGI:MGI:1913714"
     exon            1..113
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /inference="alignment:Splign:2.1.0"
     exon            114..365
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..683
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="TAF12 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 20 kDa; TAFII20; TAFII-20;
                     transcription initiation factor TFIID 20 kDa subunits"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit
                     12"
                     /protein_id="NP_079855.2"
                     /db_xref="CCDS:CCDS18721.1"
                     /db_xref="GeneID:66464"
                     /db_xref="MGI:MGI:1913714"
                     /translation="MNQFGPSALINLSSFSSVKPEPASTPPQGSMANSTTVGKIAGTP
                     GTGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQL
                     ARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTK
                     K"
     exon            366..443
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /inference="alignment:Splign:2.1.0"
     exon            444..558
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /inference="alignment:Splign:2.1.0"
     exon            559..647
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1350
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1093..1098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="hexamer: AATAAA"
     polyA_site      1114
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="major polyA site"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="hexamer: AATAAA"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="hexamer: AACAAG"
     polyA_site      1347
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
     polyA_site      1350
                     /gene="Taf12"
                     /gene_synonym="20kDa; 2810422D08Rik; Taf2J"
                     /note="major polyA site"
ORIGIN      
        1 ggggagcggt gccggaagtg cttggggagg gccgcgcagt cggaccggct gctgagacga
       61 aagcttcact ggggcagtct ccgcatatca tggggagata gacgctgctg cctctgattg
      121 gccttggtcc tcacagctct aaaaagaagc aggatcttga caagctctat gagttgaagt
      181 ctaaagctcg gcagattatg aaccagtttg gcccttcagc gctaatcaac ctctccagtt
      241 tctcatctgt aaaaccagag ccagctagca ccccgccaca aggctccatg gccaatagca
      301 ccaccgtggg gaagatagca ggcactcctg ggacaggtgg tcgtctcagc cctgaaaaca
      361 accaggtatt gaccaagaag aaattacaag acctagtaag agaagtagat cctaatgagc
      421 agctggatga agatgtggaa gagatgctgc tacagatcgc tgatgatttt attgagagtg
      481 tggtgacagc tgcctgccag cttgctcggc accgcaagtc cagcacccta gaggtaaaag
      541 acgtccagct gcatctagag cgccagtgga acatgtggat cccaggcttt ggctctgagg
      601 aaatccgacc ctacaaaaaa gcatgtacca cagaggctca caaacagaga atggcactga
      661 tccggaaaac aaccaagaaa taacacaggg aacggtcagg gaatggacaa cgtgtatttg
      721 gagatacttg agctgagacc tcagccatct catccttgga ttttttttta aatgctttac
      781 agagaagcat atatttttta ttaacagtgc agcaatatct ataatgactg agaagatctg
      841 ccaaaagaat aaagcctcct gcccaccttc tggtcccttt tccctgccgt ctcaaagaga
      901 agcagtgtat ctaccagaga agattttgcc tgtggtttat tatagaagtg attggctgta
      961 ggaagagcat tttggtcgtg ttgggtgaga cagtgttagc aagtttgtag agggtctgtc
     1021 tcctcctccc cccgtccctg tactttgtaa tgtcagtgtt tctatgaata tgaacttgat
     1081 ttgcttttcc agaataaagg agttattaat tgaagacaca gggtgcatag ctgagagcct
     1141 ttgaaatgcc agggtcccag caaggctggg agcgctgcag tcagcaggtg gcagtacagg
     1201 cagtgatcct gttagagaaa ccggcaggga tctcccactg ttttactcca aaggaacaag
     1261 ccagcagtag gagttggagc actttctctg ccaccagaca cagtgacctc tgctaagccc
     1321 caaaataaac aagcattcta gttttgataa aaa
//
