LOCUS       NM_001290729            7266 bp    mRNA    linear   ROD 01-JAN-2023
DEFINITION  Mus musculus TATA-box binding protein associated factor 1 (Taf1),
            transcript variant 1, mRNA.
ACCESSION   NM_001290729 XM_006528049
VERSION     NM_001290729.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7266)
  AUTHORS   Cirnaru MD, Creus-Muncunill J, Nelson S, Lewis TB, Watson J,
            Ellerby LM, Gonzalez-Alegre P and Ehrlich ME.
  TITLE     Striatal Cholinergic Dysregulation after Neonatal Decrease in
            X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms
  JOURNAL   Mov Disord 36 (12), 2780-2794 (2021)
   PUBMED   34403156
  REMARK    GeneRIF: Striatal Cholinergic Dysregulation after Neonatal Decrease
            in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
REFERENCE   2  (bases 1 to 7266)
  AUTHORS   Zhang Q, Hao J and Li G.
  TITLE     Deletion of Prl7d1 causes placental defects at mid-pregnancy in
            mice
  JOURNAL   Mol Reprod Dev 86 (6), 696-713 (2019)
   PUBMED   31012985
REFERENCE   3  (bases 1 to 7266)
  AUTHORS   Bardot P, Vincent SD, Fournier M, Hubaud A, Joint M, Tora L and
            Pourquie O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   4  (bases 1 to 7266)
  AUTHORS   Langer D, Martianov I, Alpern D, Rhinn M, Keime C, Dolle P, Mengus
            G and Davidson I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7266)
  AUTHORS   Quesnel-Vallieres M, Irimia M, Cordes SP and Blencowe BJ.
  TITLE     Essential roles for the splicing regulator nSR100/SRRM4 during
            nervous system development
  JOURNAL   Genes Dev 29 (7), 746-759 (2015)
   PUBMED   25838543
REFERENCE   6  (bases 1 to 7266)
  AUTHORS   Freiman RN, Albright SR, Zheng S, Sha WC, Hammer RE and Tjian R.
  TITLE     Requirement of tissue-selective TBP-associated factor TAFII105 in
            ovarian development
  JOURNAL   Science 293 (5537), 2084-2087 (2001)
   PUBMED   11557891
REFERENCE   7  (bases 1 to 7266)
  AUTHORS   Saadane N, Alpert L and Chalifour LE.
  TITLE     TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal
            rat cardiomyocytes treated with doxorubicin
  JOURNAL   Am J Physiol 276 (3), H803-H814 (1999)
   PUBMED   10070062
REFERENCE   8  (bases 1 to 7266)
  AUTHORS   Weissman JD, Brown JA, Howcroft TK, Hwang J, Chawla A, Roche PA,
            Schiltz L, Nakatani Y and Singer DS.
  TITLE     HIV-1 tat binds TAFII250 and represses TAFII250-dependent
            transcription of major histocompatibility class I genes
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 11601-11606 (1998)
   PUBMED   9751712
REFERENCE   9  (bases 1 to 7266)
  AUTHORS   Stayton CL, Dabovic B, Gulisano M, Gecz J, Broccoli V, Giovanazzi
            S, Bossolasco M, Monaco L, Rastan S, Boncinelli E et al.
  TITLE     Cloning and characterization of a new human Xq13 gene, encoding a
            putative helicase
  JOURNAL   Hum Mol Genet 3 (11), 1957-1964 (1994)
   PUBMED   7874112
REFERENCE   10 (bases 1 to 7266)
  AUTHORS   Borsani G, Tonlorenzi R, Simmler MC, Dandolo L, Arnaud D, Capra V,
            Grompe M, Pizzuti A, Muzny D, Lawrence C, Willard HF, Avner P and
            Ballabio A.
  TITLE     Characterization of a murine gene expressed from the inactive X
            chromosome
  JOURNAL   Nature 351 (6324), 325-329 (1991)
   PUBMED   2034278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831722.8 and AL806534.3.
            
            [WARNING] On Jun 13, 2023 this sequence was replaced by
            NM_001290729.3.
            
            On May 6, 2022 this sequence version replaced NM_001290729.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB299229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AL831722.8         137499-137758
            261-375             AL831722.8         138252-138366
            376-492             AL831722.8         138502-138618
            493-612             AL831722.8         143825-143944
            613-854             AL831722.8         145517-145758
            855-1073            AL831722.8         147221-147439
            1074-1292           AL831722.8         147808-148026
            1293-1500           AL806534.3         2141-2348
            1501-1677           AL806534.3         5152-5328
            1678-1805           AL806534.3         6126-6253
            1806-1913           AL806534.3         6353-6460
            1914-2087           AL806534.3         6556-6729
            2088-2261           AL806534.3         7268-7441
            2262-2366           AL806534.3         7896-8000
            2367-2567           AL806534.3         10542-10742
            2568-2709           AL806534.3         10883-11024
            2710-2840           AL806534.3         11359-11489
            2841-2921           AL806534.3         12796-12876
            2922-3071           AL806534.3         14715-14864
            3072-3191           AL806534.3         15017-15136
            3192-3367           AL806534.3         15368-15543
            3368-3546           AL806534.3         17959-18137
            3547-3760           AL806534.3         20267-20480
            3761-3926           AL806534.3         21007-21172
            3927-4138           AL806534.3         21721-21932
            4139-4247           AL806534.3         25610-25718
            4248-4346           AL806534.3         26652-26750
            4347-4524           AL806534.3         27988-28165
            4525-4592           AL806534.3         33578-33645
            4593-4715           AL806534.3         34774-34896
            4716-4808           AL806534.3         36393-36485
            4809-4893           AL806534.3         36565-36649
            4894-4961           AL806534.3         48141-48208
            4962-5078           AL806534.3         48666-48782
            5079-5084           AL806534.3         48927-48932
            5085-5210           AL806534.3         52133-52258
            5211-5367           AL806534.3         53493-53649
            5368-5545           AL806534.3         54281-54458
            5546-7266           AL806534.3         57502-59222
FEATURES             Location/Qualifiers
     source          1..7266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 44.29 cM"
     gene            1..7266
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /note="TATA-box binding protein associated factor 1"
                     /db_xref="GeneID:270627"
                     /db_xref="MGI:MGI:1336878"
     exon            1..260
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..5762
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /EC_number="2.3.1.48"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription initiation factor TFIID subunit 1; cell
                     cycle, G1 phase defect; cell cycle gene 1 protein;
                     TBP-associated factor 250 kDa; transcription initiation
                     factor TFIID 250 kDa subunit"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 1
                     isoform 1"
                     /protein_id="NP_001277658.1"
                     /db_xref="CCDS:CCDS85793.1"
                     /db_xref="GeneID:270627"
                     /db_xref="MGI:MGI:1336878"
                     /translation="MGPGWAGLLQDKGGGSPSVVMSDTDSDEESAGGGPFSLTGFLFG
                     NINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELSGSDGALVNDEGWIR
                     SREDAVDYSDINEVAEDESRRYQQTMGSLQPLCHTDYDEDDYDADCEDIDCKLMPPPP
                     PPPGPLKKEKDQDDITGVSEDGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQDA
                     AQSESKDGQLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVW
                     RSARRKRKKKHRELIQEGQVQEEECSVELEVNQKSLWNYDYAPPPLPDQCLSDDEITM
                     MAPVESKFSQSTGDTDKVMDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKMKKT
                     EHESTIKCNIMKKLRKLEENSGVDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQ
                     RASLAGWLPSSMTRNAMAYNVQQGFTATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWD
                     AQNMPRILEPPVLTLDPNDENLILEIPDEKEEATSNSPSKENKKESSLKKSRILLGKT
                     GVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFF
                     PTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGE
                     MFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY
                     GETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPESDFLIIRTRQGYFIRELV
                     DIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFP
                     SHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIA
                     AEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVT
                     GVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRK
                     FGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQ
                     RIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQE
                     RKELQRMLLAAGSAAAGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCE
                     TVRKATVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKE
                     KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
                     EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRR
                     VGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVK
                     DYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSM
                     LDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHP
                     VNKKFVPDYYKVIVSPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQY
                     TKTAQEIVNVCHQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQAK
                     PPDLYDNNTSLSVSRDASVYQDESNLSVLDIPSATSEKQLTQEGGDGDGDLADEEEGT
                     VQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFFAIQLSESGSDSDVESGSLRPKQ
                     PRVLQENTRMGMENEESMMSYEGDGGDASRGLEDSNISYGSYEEPDPKSNTQDTSFSS
                     IGGYEVSEEEEDEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDTDLDSDE"
     exon            261..375
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            376..492
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            493..612
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            613..854
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1073
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1292
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1500
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1677
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1805
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1913
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2087
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2261
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2366
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2567
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2709
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2840
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2921
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3071
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3191
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3367
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3546
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3760
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3926
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4138
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4247
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4346
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4524
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4592
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4715
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..4808
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..4893
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..4961
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            4962..5078
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            5079..5084
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            5085..5210
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            5211..5367
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            5368..5545
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
     exon            5546..7266
                     /gene="Taf1"
                     /gene_synonym="B430306D02Rik; Ccg-1; Ccg1; KAT4; N-TAF1;
                     p250; Taf2a; TAFII250"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacttccggt agcctctggt tgggtcaggg agcgctgcaa gtcacccgtg tgcgactgac
       61 gtattttttc tttcccgccc atgggcccgg ggtgggctgg gctgctgcag gacaagggtg
      121 gcggtagccc ttccgtcgtc atgtccgaca cagacagcga cgaagagtcg gctggtggag
      181 gcccattttc tctaactggg ttcctgttcg gcaacatcaa tggagcaggg cagttggaag
      241 gcgaaagcgt cttggatgac gagtgcaaga agcatcttgc gggcttgggg gctttgggtc
      301 ttggcagcct gatcactgaa ctcacagcaa atgaagaatt gtccgggagt gatggtgccc
      361 tggtaaatga tgaaggatgg attaggagta gagaggatgc tgtggactat tctgacatca
      421 acgaggtggc agaagatgaa agtagaagat accagcagac aatgggaagc ttgcaacccc
      481 tttgccacac agattatgat gaagatgact atgatgctga ttgtgaagat attgattgca
      541 aattgatgcc tcctccacct ccacccccag gaccactgaa gaaagagaag gaccaagatg
      601 atattactgg tgtgtctgaa gatggagaag gcatcatctt gccctccatc attgcccctt
      661 cctctttggc ctcagagaaa gtggacttca gtagttcctc tgactcagaa tctgagatgg
      721 gacctcagga cgcagcacag tcagaatcta aggatggaca gctgacccta ccattggctg
      781 ggattatgca gcatgatgcc acgaagctgt tgccaagtgt cacagaactt tttccagaat
      841 ttaggcctgg aaaggtgtta cgctttttac ggctttttgg accggggaag aatgttccat
      901 ctgtttggag gagtgctcgg agaaagagga aaaagaagca ccgtgagctt atacaggaag
      961 ggcaggtcca ggaagaggag tgctcagtgg aattagaagt caaccagaaa tctctgtgga
     1021 actatgacta tgctcctcct ccacttccag accagtgtct ctctgatgat gaaatcacaa
     1081 tgatggctcc tgtggagtcc aagttttccc agtcaactgg agacacagat aaagtaatgg
     1141 ataccaagcc aagagtggcc gaatggcgtt atggacctgc ccggctgtgg tatgatatgc
     1201 taggtgttcc tgaagatggc agtggctttg attatggctt caaaatgaag aagactgaac
     1261 atgaatctac aataaaatgc aacataatga agaaattaag gaaacttgag gaaaacagtg
     1321 gcgtcgatct tctggcagat gaaaacttcc taatggtgac acagctgcat tgggaagatg
     1381 atatcatttg ggatggggag gatgtcaaac acaaaggaac aaaacctcag cgtgcgagtt
     1441 tggcaggctg gcttccttcc agtatgacta ggaatgccat ggcctacaat gtgcagcaag
     1501 gttttacagc tacattggat gatgataaac cttggtactc cattttcccc attgataatg
     1561 aagatctggt atatggacgt tgggaggaca atatcatttg ggatgctcag aacatgccta
     1621 gaattttgga gcctcctgtt ttgacacttg atcccaatga tgagaacttg attttggaga
     1681 tccctgatga gaaggaagaa gctacttcta attctccttc taaggagaat aagaaagaat
     1741 catctctgaa gaagagtcga attctcttag gaaaaacagg agtcatcaag gaagagccac
     1801 agcagaacat gtctcagcca gaagtgaaag atccatggaa tctctccaat gatgagtatt
     1861 actatcccaa gcaacagggc cttcgaggta cttttggagg aaatattatc cagcactcaa
     1921 ttccagctgt agaattacgg cagcccttct ttcctaccca catgggaccc atcaaacttc
     1981 ggcagttcca tcgcccacct ctaaaaaagt actcctttgg ggcactatct cagccaggtc
     2041 cacactcagt tcagcctttg ctgaagcaca tcaaaaagaa ggcaaagatg agagaacaag
     2101 agaggcaagc ctcgggtggt ggagagatgt tttttatgcg cacacctcag gatctcacag
     2161 gcaaagatgg agaccttatt cttgctgaat acagtgagga aaatggacca ttaatgatgc
     2221 aagttggcat ggcaaccaag ataaaaaact actataagcg gaaacctgga aaagatcctg
     2281 gagccccaga ttgcaaatac ggagaaactg tttattgcca tacatcgcct ttcctgggtt
     2341 ctcttcatcc tggccagtta ctgcaggcat ttgagaacaa cctttttcgt gctccaattt
     2401 atcttcataa gatgccagaa tctgacttcc tgatcattcg aacaaggcag ggttacttta
     2461 ttcgagaatt agtggatatt tttgttgttg gccagcagtg tcccttattt gaagttcctg
     2521 gtcctaactc caaaagggcc aatacacaca tccgagattt tcttcaggtt tttatttacc
     2581 ggctcttttg gaagagtaaa gataggccac ggaggatacg gatggaagat ataaagaaag
     2641 cctttccttc acattcagaa agcagcatcc ggaagaggct aaagctctgt gccgacttca
     2701 aacgtacagg gatggattca aactggtggg tgctgaagtc tgattttcgt ttaccaacgg
     2761 aagaggagat ccgagctatg gtatccccag aacagtgctg tgcttattat agcatgatag
     2821 ctgctgaaca gagactaaag gatgctggct atggagagaa gtcctttttt gctcctgagg
     2881 aagaaaatga agaagatttc cagatgaaga ttgatgatga agttcgtact gctccttgga
     2941 atactacaag ggctttcatt gctgccatga agggcaaatg tctcctggag gtgactggag
     3001 tagcagatcc tacaggctgt ggtgaagggt tctcctatgt gaagattcca aacaaaccga
     3061 cacaacagaa ggatgataaa gagcctcagc cagtgaaaaa gacagtcaca ggaacagatg
     3121 cagaccttcg tcgcctgtct ctgaaaaatg ccaagcagct tcttcgtaaa tttggtgtgc
     3181 ctgaggagga gattaaaaag ttgtcccgct gggaagttat tgatgtggta cgtacaatgt
     3241 caacagaaca ggctcgctct ggagaggggc ccatgagtaa atttgctcgt ggatcaaggt
     3301 tttcagtggc tgagcatcaa gaacgttaca aagaggaatg tcagcgcatc tttgacctac
     3361 agaacaaggt tttgtcatca acagaggtct tatcaactga cacagacagc agctcagctg
     3421 aagacagtga ctttgaagaa atgggaaaga atattgagaa tatgctgcag aacaagaaaa
     3481 caagttctca gctgtctcgg gagcgggagg agcaggaacg gaaggaactc cagcggatgc
     3541 tactggcagc aggctcagca gcagcaggaa acaatcacag agatgatgac acagcttcag
     3601 tgaccagcct taactcttct gccactggcc gctgtctcaa gatttatcga acatttcgag
     3661 atgaggaggg gaaggaatat gttcgttgtg agacagtccg aaaagcaact gttattgatg
     3721 cttatgtacg catacggacc acaaaagatg aagagttcat tcgaaaattt gccctttttg
     3781 atgagcaaca ccgagaagag atgagaaaag aacggcggag gattcaagag caattgagga
     3841 gacttaaacg gaaccaggaa aaggaaaagc taaaggggcc tcctgagaaa aagcccaaaa
     3901 aaatgaagga acggcctgac ttaaaattga aatgtggagc atgtggtgcc atcgggcaca
     3961 tgaggacaaa taaattctgc cccctttatt atcaaacaaa tgctccacct tctaaccctg
     4021 ttgctatgac cgaggaacaa gaggaagagc tggaaaagac agtcattcat aatgataatg
     4081 aagaacttat caaggttgaa gggaccaaga tcgttttggg caaacagcta attgagagtg
     4141 cagatgaagt tcgcagaaaa tctctggtcc tgaagttccc taaacaacaa cttcccccca
     4201 agaaaaaacg acgggttgga accactgttc actgtgacta tttgaataga cctcataaat
     4261 ccatccaccg gcgccggaca gacccgatgg tgacactgtc ttctatcttg gagtctatta
     4321 tcaatgacat gagagatctt ccaaatacat accctttcca tactccagtt aatgcaaagg
     4381 ttgtaaagga ttactataaa atcatcactc gaccaatgga tctacagaca ctccgtgaaa
     4441 acgtgcgcaa acgcctttat ccgtctcggg aagaattcag agaacatttg gagctaattg
     4501 tgaaaaacag tgcaacttat aatggaccaa agcactcact gactcagatt tctcaatcca
     4561 tgctggatct ctgcgatgaa aaactcaaag agaaagagga taagttggca cgtttagaga
     4621 aagctatcaa ccccttgctt gacgatgatg atcaagtagc cttttctttt attctggata
     4681 acattgtcac tcagaaaatg atggcagttc cagattcttg gccatttcat cacccagtta
     4741 ataagaaatt tgttccagat tattacaaag tgattgtcag tccaatggat ttggagacta
     4801 tacgtaagaa tatctccaag cacaaatacc agagtcgaga gagctttcta gacgacgtaa
     4861 acctgattct ggccaacagt gttaagtaca atgggcctga gagtcagtat actaagactg
     4921 ctcaggagat tgtgaacgtt tgtcaccaga cattaactga gtatgatgaa catttgactc
     4981 aacttgagaa agatatttgt acagctaaag aagcagctct ggaggaagca gaattagaaa
     5041 gtctggaccc aatgactcca gggccatata cacctcaggc taagcctcct gatttgtatg
     5101 ataacaacac atccctcagt gtttctcgag atgcttctgt atatcaagat gagagcaatc
     5161 tgtctgtctt ggatattccc agtgctactt cagaaaagca gctaacacag gaaggtggag
     5221 atggagatgg tgatcttgca gatgaagagg aaggaactgt acaacagccc caagccagtg
     5281 tcttgtatga ggatttgctt atgtctgaag gcgaagatga tgaggaagat gctgggagtg
     5341 acgaagaagg agataaccct ttctttgcta ttcagctaag tgaaagtgga agtgactctg
     5401 atgtggaatc tggcagttta agacccaaac agccccgtgt gcttcaagag aatacaagga
     5461 tgggcatgga aaatgaagaa agcatgatgt cctatgaggg agatggtggg gacgcttccc
     5521 gtggtttgga ggatagcaac atcagttatg ggagctatga ggagcctgat cccaagtcca
     5581 acacccagga taccagcttc agcagcatcg gtgggtatga ggtatcagag gaggaagaag
     5641 atgaggaaga gcagcgctct gggcccagcg tactaagcca ggtccacctc tcagaggacg
     5701 aggaggacag tgaggatttc cactccattg ccggagacac tgatttggac tctgatgaat
     5761 gaggcttcct ttaagtcttt tcagtcagcc taggtctatt acctttcccc ccagcttgtt
     5821 tctgtgtaca tagtagctga taatgatatc actagattaa caccttagtt ttagtagtaa
     5881 gtaaaatagt aattatttct ctagattgta gagtagcaag ttcttttccc taaccactac
     5941 caaaaggaga gagcagactc actcttcctc attacactcc tttaatggca tttattgctc
     6001 ttgttgtata aacatgccac cattttactt tctaattggc agactggaac aaaggaaaac
     6061 ccctctgctg gattagagaa ttaggtcctg atgagctggc tctgtgccac acttaaaata
     6121 taatcctgtt agacaaactg gttgttcata tattacttac ttggatagac aatgccttgt
     6181 tgctaaatag attacaggga tgtagctata aatctctgaa tgataggtgg tcatgtaaat
     6241 gtcctcttcc cccaccctgg aaaaaattat aggaaaatgg ttagtacctt agggcaaaga
     6301 ctgccttttg gtttttttta tacttaggat atggttttat gcaaagtaac tactcagtag
     6361 atgttcttaa aaatcacaga atcccaacag ataatgttac tgtgtgcctg attcatgtag
     6421 agcactctat cagacctttg cagtgcaaag gttaaataag agcttgccat caagttgggg
     6481 cagtgagact ggaattcaaa caatgttaat taatcagaga actctaagta caattaagaa
     6541 gctagctgta aggtacaaag gaaaaaaatt agaatcatgt gtggaaaagc agagttttct
     6601 agaggctacc tgaatgctga ttgttgagaa gttatagagt accatctcag cagggtgtta
     6661 acatgaaggg aaagttcaca gtctagatgt gacagaatgt gttccttgtt tgtacctgcc
     6721 ttgtttcaga aaaaggatgc tggagtgact agacatgaca ctgaaagacg gacaggaagc
     6781 atatcttcaa gagctttgca tttgagctag gcatggtggc acatgccttt aatcccagca
     6841 cttgagagac agaggcaggc agatttctga gttcgaggcc agcctggtct acagagtgag
     6901 ttccaggaca gccggggcta cacagagaaa ccctgtctca aaaaacaaaa cagaaaaaca
     6961 aagaaatttt cagaatgttg aatgaagata gaaattgagt caagtaataa acatgtatga
     7021 ttcagtttgt ctagaagtca aaaattgggt atatatgata tgcttgtata tacttgtatg
     7081 tgcaaaggaa aagatatgaa agaatgtaca ttaaagtgtt agcagtgata gcctctgagg
     7141 gatgggaatg gagaggaggt ggtttgtttg gtttatgtac agtaggtaag tgttatgctt
     7201 ttatttctgt atcttagttt tataatgtgt attatttttt gtaataaaat gttaatttaa
     7261 cagcaa
//
