LOCUS       NM_001372392            2249 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus transcriptional adaptor 3 (Tada3), transcript variant
            2, mRNA.
ACCESSION   NM_001372392 XM_006505238
VERSION     NM_001372392.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2249)
  AUTHORS   Mohibi,S., Srivastava,S., Bele,A., Mirza,S., Band,H. and Band,V.
  TITLE     Acetylation of Mammalian ADA3 Is Required for Its Functional Roles
            in Histone Acetylation and Cell Proliferation
  JOURNAL   Mol Cell Biol 36 (19), 2487-2502 (2016)
   PUBMED   27402865
  REMARK    GeneRIF: Findings demonstrate that acetylation of ADA3 by its
            associated histone acetyltransferases is essential for its key role
            in histone acetylation and cell cycle progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2249)
  AUTHORS   Mohibi,S., Srivastava,S., Wang-France,J., Mirza,S., Zhao,X.,
            Band,H. and Band,V.
  TITLE     Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle
            Regulator, Associates with the Centromere through CENP-B and
            Regulates Chromosome Segregation
  JOURNAL   J Biol Chem 290 (47), 28299-28310 (2015)
   PUBMED   26429915
  REMARK    GeneRIF: demonstrate a novel ADA3 interaction with
            CENP-B-centromere that may account for its previously known
            function in mitosis
REFERENCE   3  (bases 1 to 2249)
  AUTHORS   Mirza,S., Katafiasz,B.J., Kumar,R., Wang,J., Mohibi,S., Jain,S.,
            Gurumurthy,C.B., Pandita,T.K., Dave,B.J., Band,H. and Band,V.
  TITLE     Alteration/deficiency in activation-3 (Ada3) plays a critical role
            in maintaining genomic stability
  JOURNAL   Cell Cycle 11 (22), 4266-4274 (2012)
   PUBMED   23095635
  REMARK    GeneRIF: The loss of Ada3 led to enhanced chromosomal aberrations,
            such as chromosome breaks, fragments, deletions and translocations,
            which further increased upon DNA damage.
REFERENCE   4  (bases 1 to 2249)
  AUTHORS   Mohibi,S., Gurumurthy,C.B., Nag,A., Wang,J., Mirza,S., Mian,Y.,
            Quinn,M., Katafiasz,B., Eudy,J., Pandey,S., Guda,C., Naramura,M.,
            Band,H. and Band,V.
  TITLE     Mammalian alteration/deficiency in activation 3 (Ada3) is essential
            for embryonic development and cell cycle progression
  JOURNAL   J Biol Chem 287 (35), 29442-29456 (2012)
   PUBMED   22736770
  REMARK    GeneRIF: a critical role of Ada3 in embryogenesis and cell cycle
            progression as an essential component of HAT complex.
REFERENCE   5  (bases 1 to 2249)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   6  (bases 1 to 2249)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 2249)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   8  (bases 1 to 2249)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   9  (bases 1 to 2249)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   10 (bases 1 to 2249)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155287.6.
            
            On Aug 30, 2019 this sequence version replaced XM_006505238.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927938.4421085.1,
                                           SRR7974084.25864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               AC155287.6         210391-210913       c
            524-577             AC155287.6         209967-210020       c
            578-802             AC155287.6         208915-209139       c
            803-1053            AC155287.6         208084-208334       c
            1054-1159           AC155287.6         207854-207959       c
            1160-1301           AC155287.6         205540-205681       c
            1302-1405           AC155287.6         205353-205456       c
            1406-1515           AC155287.6         204014-204123       c
            1516-1701           AC155287.6         203297-203482       c
            1702-2249           AC155287.6         199708-200255       c
FEATURES             Location/Qualifiers
     source          1..2249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.75 cM"
     gene            1..2249
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /note="transcriptional adaptor 3"
                     /db_xref="GeneID:101206"
                     /db_xref="MGI:MGI:1915724"
     exon            1..523
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            524..577
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..1894
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcriptional adapter 3; mADA3; ADA3 homolog; ADA3-like
                     protein"
                     /codon_start=1
                     /product="transcriptional adapter 3 isoform 2"
                     /protein_id="NP_001359321.1"
                     /db_xref="GeneID:101206"
                     /db_xref="MGI:MGI:1915724"
                     /translation="MQGPTSWAMSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDD
                     GIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGA
                     PPKHGKPKKQKLEGKTGHGPGPGPGRPKSKNVQPKIQEYEFTDDPIDVPRIPKNDAPN
                     RFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQK
                     DGARAAAVADKKKGLIGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQAL
                     VEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQG
                     LLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRV
                     RMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG"
     exon            578..802
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1053
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1159
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1301
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1405
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1515
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1701
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2249
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2192
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
     regulatory      2217..2222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /note="hexamer: AACAAA"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /note="hexamer: TATAAA"
     polyA_site      2242
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /note="major polyA site"
     polyA_site      2249
                     /gene="Tada3"
                     /gene_synonym="1110004B19Rik; ADA3; Tada3l"
                     /note="major polyA site"
ORIGIN      
        1 cttccggtgg tgctccccta tcctctccgg gctcctccca tttgcaaccg tagggttcgg
       61 ccgggtagcc agtcccttga gatttgggct ctgggcccca ccccagcccc gggctgcttc
      121 ctagcccggg actcctcagg cctagcattc cacctcccgg agattcgtag gtggccttag
      181 acccccaccc ccaccccggc cctacaggcc accttgggct ggccgtcccc gccctcgcgt
      241 caactgcagg gggcccgccc atagccagtt ccggagcagt tgctccgatc gccctgaact
      301 ccccgccccc tcctgcggcc cagggcctgt aggaggccgc agagaggagg taggagaggc
      361 gggggttgtg ttaggggctc cctagaggac gaggaccctg gaggcgggat cttggggcga
      421 cacacaggtg gagccagcca ttaagcagtc ccacttctgt gccaggcact gaactgggca
      481 cttgacgagc atcacctctt aatcctcaga acattccagg gagattccag acttctgcgg
      541 ttcaaattgc aactaggagg ccggcctaat catgcagggt cccacctcct gggccatgag
      601 cgagctgaag gactgtccac tgcagtttca tgacttcaag tctgtggacc acctgaaggt
      661 ctgtccccgc tacacggcag tgctggcccg ctccgaggac gatggcattg gcattgagga
      721 gctggacacc ctgcagctgg agcttgagac tctgctgtcc tctgcaagcc ggagactgcg
      781 tgtactggaa gctgaaaccc agatccttac tgactggcag gataagaaag gggaccgacg
      841 attcctgaag ctaggtcgcg accacgagct cggtgctccc cccaaacacg gaaagcccaa
      901 gaagcagaaa ctggaaggga agacaggaca tgggccaggc cctggcccgg gacgacccaa
      961 atccaaaaac gtccaaccca agatccagga atatgaattt actgatgacc caatcgacgt
     1021 gcctcggatc cccaagaatg atgctcccaa caggttctgg gcctctgtgg agccctattg
     1081 tgccgacatc accagtgagg aggtacggac actagaggag ctcctgaagc ccccagaaga
     1141 tgaagctgaa cattataaga ttccccccct agggaaacac tactcccagc gctgggccca
     1201 ggaggatctg ctggaggagc agaaggacgg cgctcgggca gcagctgtgg ctgacaagaa
     1261 gaaaggcctc ataggaccac tgacagaact ggacacaaaa gatgtggatg ccctgctgaa
     1321 gaagtctgag gcccagcatg aacagccaga agacgggtgt ccctttggag ccctgacaca
     1381 gcgcctgctg caggccctag tggaggaaaa tattatctcc cctatggagg actcccctat
     1441 tcctgacatg tctgggaaag agtcaggggc agatggagcg agcacctccc cgcgcaatca
     1501 gaacaagcct ttcagtgtgc cacataccaa gtccctggag agccgcatca aggaggagct
     1561 gattgcccag ggcctcctgg agtctgagga ccggcccgcg gaggactcag aggacgaggt
     1621 ccttgctgag ctgcgcaaac ggcaagctga gctgaaagca ctcagtgcac acaaccgcac
     1681 caagaagcat gacctgctga ggctggcaaa ggaggaggtg agccggcagg agctaaggca
     1741 gcgggtccgc atggccgaca acgaagtcat ggatgccttc cggaagatca tggctgcccg
     1801 gcagaagaag cgcaccccta caaagaagga aaaggaccag gcctggaaga ccctgaagga
     1861 gcgggaaagc atcctgaagc tcctagacgg gtagcctgac ctgctgctgg ctatccccct
     1921 ggcctggcag aagtccacaa catcctttga agccttggcc agaggctgcc tatcaaatga
     1981 caacagtctc agggctgaaa cactctcagg ccacccagct gagctttgtg cagccagtat
     2041 gcaaggccct actgcgcctg cctggaccta gcatccgcct gatgccccag atgagcgggc
     2101 ttgttcctca tcccctcccc ccttaccgtc tccacacctc tcctcaggga cttcttcctt
     2161 gaggttttgt aatgtacaaa cttaagaata aagtgactgc tgtgtttcat tttttaaaca
     2221 aaaaaaagtt ataaaaaaac cacccgcaa
//
