LOCUS       NM_172562               2119 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transcriptional adaptor 2A (Tada2a), mRNA.
ACCESSION   NM_172562
VERSION     NM_172562.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Lee,J.Y., Kim,H., Jo,A., Khang,R., Park,C.H., Park,S.J., Kwag,E.
            and Shin,J.H.
  TITLE     alpha-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and
            Blocks Histone H3 Acetylation
  JOURNAL   Int J Mol Sci 22 (10), 5392 (2021)
   PUBMED   34065515
  REMARK    GeneRIF: alpha-Synuclein A53T Binds to Transcriptional Adapter
            2-Alpha and Blocks Histone H3 Acetylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Nagy,Z. and Tora,L.
  TITLE     Distinct GCN5/PCAF-containing complexes function as co-activators
            and are involved in transcription factor and global histone
            acetylation
  JOURNAL   Oncogene 26 (37), 5341-5357 (2007)
   PUBMED   17694077
  REMARK    Review article
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Qian,C., Zhang,Q., Li,S., Zeng,L., Walsh,M.J. and Zhou,M.M.
  TITLE     Structure and chromosomal DNA binding of the SWIRM domain
  JOURNAL   Nat Struct Mol Biol 12 (12), 1078-1085 (2005)
   PUBMED   16299514
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL596447.16
            and AL645615.14.
            
            On May 1, 2007 this sequence version replaced NM_172562.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038821.1, AK157938.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL596447.16        7946-7977           c
            33-140              AL596447.16        5397-5504           c
            141-247             AL645615.14        194303-194409       c
            248-307             AL645615.14        191469-191528       c
            308-399             AL645615.14        183175-183266       c
            400-557             AL645615.14        179410-179567       c
            558-646             AL645615.14        177413-177501       c
            647-719             AL645615.14        176274-176346       c
            720-783             AL645615.14        166805-166868       c
            784-827             AL645615.14        165197-165240       c
            828-938             AL645615.14        163770-163880       c
            939-1010            AL645615.14        160332-160403       c
            1011-1143           AL645615.14        158860-158992       c
            1144-1187           AL645615.14        157935-157978       c
            1188-1261           AL645615.14        155259-155332       c
            1262-2119           AL645615.14        152141-152998       c
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.29 cM"
     gene            1..2119
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /note="transcriptional adaptor 2A"
                     /db_xref="GeneID:217031"
                     /db_xref="MGI:MGI:2144471"
     exon            1..32
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            33..140
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1447
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /note="ADA2-like protein"
                     /codon_start=1
                     /product="transcriptional adapter 2-alpha"
                     /protein_id="NP_766150.1"
                     /db_xref="CCDS:CCDS25183.1"
                     /db_xref="GeneID:217031"
                     /db_xref="MGI:MGI:2144471"
                     /translation="MDRLGSFSNDPSDKPPCRGCSSYLTEPYIKCAECGPPPFFLCLQ
                     CFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQM
                     CTKTKEECEKHYMKHFINNPLFASTLLNLKQAEAAKAADTAIPFHSADDPPRPAFDSL
                     LSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKER
                     QRRKKIIRDHGLVNLRKFRLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALE
                     FELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQ
                     QWLRRQADIDSGLSPSVLMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQVVRLVPG
                     AYLEYKSALLNECHKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKA"
     exon            141..247
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            248..307
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            308..399
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            400..557
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            558..646
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            647..719
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            720..783
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            784..827
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            828..938
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1010
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1143
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1187
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1261
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..2119
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /note="hexamer: ATTAAA"
     polyA_site      2119
                     /gene="Tada2a"
                     /gene_synonym="D030022J10Rik; Tada2l"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcggcg ccgaggtgcg ggacgtggcg aggggatcgt gggattgttt ggcaacgtct
       61 gaagtcttga aactctacat caagggagat caagcagcca tcagtcagct agaggatgga
      121 ccgtttgggt tcctttagca atgacccatc tgataagccg ccctgcagag gctgctcctc
      181 ctacctcacg gaaccttaca ttaaatgtgc tgaatgtggg ccccctcctt tcttcctgtg
      241 tttacagtgt ttcactcgag gatttgagta caagaaacat cagagtgatc acacttacga
      301 aataatgacc tcagacttcc ctgttcttga tcccagctgg acagcacaag aagaaatggc
      361 ccttttagaa gctgtaatgg actgtggctt tggaaattgg caggatgtgg ctaatcaaat
      421 gtgcaccaaa accaaggagg agtgtgagaa gcattacatg aagcatttca tcaataaccc
      481 tctgtttgca tccaccctgc tgaacctgaa gcaagctgag gcggccaaag ctgccgacac
      541 agccattcca tttcactccg cagatgaccc tccccggcct gcctttgact cattgctgtc
      601 tcgggacatg gcaggctaca tgccagcgcg ggcagatttc attgaggagt ttgacaatta
      661 tgcagaatgg gacttaagag acattgattt tgttgaagac gactcagaca tcttacatgc
      721 tctgaagatg gctgtggtgg atatctatca ttccaggtta aaagagaggc aaagaagaaa
      781 aaagattata agagatcacg gattagtcaa ccttaggaag ttccgattaa tggaacggcg
      841 gtatcccaag gaggtccaag acctttatga aacaatgagg agatttgcaa ggattgtggg
      901 acccgtggag cacgacaagt tcattgaaag ccatgcattg gaatttgaac tccgaaggga
      961 aatcaagagg ctccaagaat ataggacagc aggcattacc aatttttgta gtgccaggac
     1021 atatgatcac ctgaagaaga cacgcgagga ggagcgcctt aaacgcacca tgctctcaga
     1081 agttctccag tacatccagg acagcagtgc gtgccagcag tggctccgcc ggcaggctga
     1141 cattgattct gggctgagtc cttctgttct gatggcttct aactcaggaa ggcgaagtgc
     1201 accaccattg aacctcacgg gtctccctgg tacagagaaa ctcaatgaaa aggaaaagga
     1261 gctctgtcag gtggtgaggt tggtacctgg agcctacttg gaatataagt ctgctctatt
     1321 gaacgagtgt cacaagcaag gaggcttgag actggcacaa gcaagggcac tcatcaagat
     1381 agacgtgaac aaaacccgga aaatctatga cttcctcatc cgagaagggt acatcacgaa
     1441 agcctgagac tctgctccat agtgcaggcc agcgtgaagg aatgtgaaca gtcagagggc
     1501 aatgtacaca ttccggagac ttgtgttgga ttcttgctgt gagaagaagg agagacactg
     1561 ggagtctaag gatgatgacc gctttcttct ctgccctctg taaagcgctg cttgctgttg
     1621 tcaggatagt gcgtcagagt gtgtgttcgc caagttatta ttaaacacca gtgggcattt
     1681 gttcctagca gctcttgtaa gtcaaacaag aaccacgggc cctcgcatca tggctttggt
     1741 ggaaggagaa gggacccagg ccacagcatt tcaccccaag aggccagctc agatccatgc
     1801 actagagagt aaagttccca cactcactct gccttcccct cttgcaggca gattttaaat
     1861 gaaagttttt agagcacagg aaagcctttt cttccaagga gtttttcttt ttttatgctg
     1921 acatcttagt ttatgagatg aagaggtgga gctctccccc atgatggtct gtctgaaact
     1981 tcattttaac tgtaatgtct agctttgtac tttgcagtct ggctgtctga tgtgcagtcg
     2041 actcttgagg aggtggcacc ggatataaaa tgtctctgtt atttttagaa ttaatggatt
     2101 aaaatgtttt gctatttaa
//
