LOCUS       NM_020047               1764 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus tumor-associated calcium signal transducer 2
            (Tacstd2), mRNA.
ACCESSION   NM_020047
VERSION     NM_020047.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1764)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39667932
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1764)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1764)
  AUTHORS   Szabo,R., Ward,J.M., Artunc,F. and Bugge,T.H.
  TITLE     EPCAM and TROP2 share a role in claudin stabilization and
            development of intestinal and extraintestinal epithelia in mice
  JOURNAL   Biol Open 11 (7) (2022)
   PUBMED   35730316
REFERENCE   5  (bases 1 to 1764)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1764)
  AUTHORS   Cubas,R., Zhang,S., Li,M., Chen,C. and Yao,Q.
  TITLE     Trop2 expression contributes to tumor pathogenesis by activating
            the ERK MAPK pathway
  JOURNAL   Mol Cancer 9, 253 (2010)
   PUBMED   20858281
  REMARK    GeneRIF: Study also provides the first indication of a molecular
            signaling pathway activated by Trop2 which has important
            implications for cancer cell growth and survival.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1764)
  AUTHORS   Goldstein,A.S., Lawson,D.A., Cheng,D., Sun,W., Garraway,I.P. and
            Witte,O.N.
  TITLE     Trop2 identifies a subpopulation of murine and human prostate basal
            cells with stem cell characteristics
  JOURNAL   Proc Natl Acad Sci U S A 105 (52), 20882-20887 (2008)
   PUBMED   19088204
  REMARK    GeneRIF: Trop2 identifies a subpopulation of murine and human
            prostate basal cells with stem cell characteristics.
REFERENCE   8  (bases 1 to 1764)
  AUTHORS   Lu,J., Izvolsky,K.I., Qian,J. and Cardoso,W.V.
  TITLE     Identification of FGF10 targets in the embryonic lung epithelium
            during bud morphogenesis
  JOURNAL   J Biol Chem 280 (6), 4834-4841 (2005)
   PUBMED   15556938
REFERENCE   9  (bases 1 to 1764)
  AUTHORS   Basak,S., Speicher,D., Eck,S., Wunner,W., Maul,G., Simmons,M.S. and
            Herlyn,D.
  TITLE     Colorectal carcinoma invasion inhibition by CO17-1A/GA733 antigen
            and its murine homologue
  JOURNAL   J Natl Cancer Inst 90 (9), 691-697 (1998)
   PUBMED   9586666
REFERENCE   10 (bases 1 to 1764)
  AUTHORS   El Sewedy,T., Fornaro,M. and Alberti,S.
  TITLE     Cloning of the murine TROP2 gene: conservation of a PIP2-binding
            sequence in the cytoplasmic domain of TROP-2
  JOURNAL   Int J Cancer 75 (2), 324-330 (1998)
   PUBMED   9462726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124758.6.
            
            On Sep 1, 2006 this sequence version replaced NM_020047.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1764              AC124758.6         121606-123369       c
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.88 cM"
     gene            1..1764
                     /gene="Tacstd2"
                     /gene_synonym="EGP-1; GA733-1; Ly97; TROP2"
                     /note="tumor-associated calcium signal transducer 2"
                     /db_xref="GeneID:56753"
                     /db_xref="MGI:MGI:1861606"
     exon            1..1764
                     /gene="Tacstd2"
                     /gene_synonym="EGP-1; GA733-1; Ly97; TROP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1070
                     /gene="Tacstd2"
                     /gene_synonym="EGP-1; GA733-1; Ly97; TROP2"
                     /note="cell surface glycoprotein Trop-2; lymphocyte
                     antigen 97; tunor-associated calcium signal transducer 2"
                     /codon_start=1
                     /product="tumor-associated calcium signal transducer 2
                     precursor"
                     /protein_id="NP_064431.2"
                     /db_xref="CCDS:CCDS20221.1"
                     /db_xref="GeneID:56753"
                     /db_xref="MGI:MGI:1861606"
                     /translation="MARGLDLAPLLLLLLAMATRFCTAQSNCTCPTNKMTVCDTNGPG
                     GVCQCRAMGSQVLVDCSTLTSKCLLLKARMSARKSGRSLVMPSEHAILDNDGLYDPEC
                     DDKGRFKARQCNQTSVCWCVNSVGVRRTDKGDQSLRCDEVVRTHHILIELRHRPTDRA
                     FNHSDLDSELRRLFQERYKLHPSFLSAVHYEEPTIQIELRQNASQKGLRDVDIADAAY
                     YFERDIKGESLFMGRRGLDVQVRGEPLHVERTLIYYLDEKPPQFSMKRLTAGVIAVIA
                     VVSVAVVAGVVVLVVTKRRKSGKYKKVELKELGEMRSEPSL"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tacstd2"
                     /gene_synonym="EGP-1; GA733-1; Ly97; TROP2"
                     /note="hexamer: AATAAA"
     polyA_site      1725
                     /gene="Tacstd2"
                     /gene_synonym="EGP-1; GA733-1; Ly97; TROP2"
                     /note="major polyA site"
     polyA_site      1762
                     /gene="Tacstd2"
                     /gene_synonym="EGP-1; GA733-1; Ly97; TROP2"
                     /note="major polyA site"
ORIGIN      
        1 ataagagctg gagggaaaag cccggcagga gtcgcctgca gtgtcctacc cagcctgatc
       61 cttcagaatc cctgcctctg gtctgtagtt ggaggtccat tctactccac cccaccatgg
      121 cgaggggctt ggatctagca ccgctgctac tgctactgct ggcgatggcg acccgctttt
      181 gcacggctca gagcaactgt acatgcccca ccaacaagat gacggtctgc gacacaaatg
      241 gcccaggcgg ggtctgccaa tgtcgggcaa tgggctcaca ggtattggtc gactgctcca
      301 cgctaacttc caagtgcctg ctgctcaagg cgcgcatgag cgcccggaag agcggccgca
      361 gcctggtgat gccgagcgag cacgcgatac tggacaacga tggcctctac gacccggagt
      421 gtgacgacaa gggccgcttc aaggcgcgcc agtgcaacca gacctcggtg tgctggtgcg
      481 taaactcggt gggcgtgcgc cgcacggaca agggagacca aagcctgcgc tgcgacgaag
      541 tggtgcgaac ccaccacatc ctcattgagt tgcgccaccg cccgaccgac cgagccttca
      601 accactctga cctagactcc gagctgcggc ggctcttcca agaacgctac aagctgcacc
      661 ccagcttcct atccgcggta cactatgagg agcccaccat tcagatagag cttcggcaga
      721 acgcgtcgca gaagggcttg agagacgtgg acatcgctga tgccgcctac tacttcgaaa
      781 gggacattaa aggcgagtca ctgttcatgg gccgccgcgg cctggacgtg caggtgcgtg
      841 gggaacccct gcatgtggag cggacgctca tctactacct ggacgagaag cccccccagt
      901 tctccatgaa gcgcctcacc gccggcgtca ttgccgtcat cgctgtcgtc tcggtagcgg
      961 tagtggctgg tgtggtggtc ttggtggtca ccaaacggag gaagtcgggc aaatacaaaa
     1021 aggtggagct taaggagctg ggggagatga gaagcgaacc tagcttgtag gtttcctgta
     1081 ggatgccccg acttcctcgg cacctcagac cagatgggtt ggcctgttaa ttctcagtca
     1141 ggaggtaatt ttcctcccag ctttgacctc ttccttctct ctccacaaac aagttctcta
     1201 gatgctgagc tcaggtcacc tccctcgccc ttggtttttt aaggacgcat ttctgaaatt
     1261 ccttgtctag tcactggaaa cctgaccggg agagttaagc aaaggctaga tagcttggtt
     1321 aagaagctag tgccaggcag cccacttgtt tcccagcgac ttgaatctac ccaaagactt
     1381 aaacggtttg aaatgggaaa gcggcgattt ggctatccgg gttgttggtg acccattcgc
     1441 tccctgcctc ccaaccttca ggaaaggaag agcagttcac tcactaattg atcctgcgca
     1501 gtgttcatct gccatcgttt gtataagaaa aggcatttcc aacgtctgaa gtcattttca
     1561 atgtctttgt tggactgcat ctatttttct gcttgtcctt gatgtagctg atcctagaga
     1621 gttctctttt gtaaaatgtt tgtacagatg tgtctttgat aatgctgctg ttttttaaaa
     1681 caacaactcg agtttaataa aatatgggaa aggcacacct aaaaagatag gctgtgtgaa
     1741 aaatccctcc agatttatat catt
//
