LOCUS       NM_021382               3764 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tachykinin receptor 3 (Tacr3), mRNA.
ACCESSION   NM_021382
VERSION     NM_021382.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Xu,W., Li,G., Chen,Y., Ye,X. and Song,W.
  TITLE     A novel antidiuretic hormone governs tumour-induced renal
            dysfunction
  JOURNAL   Nature 624 (7991), 425-432 (2023)
   PUBMED   38057665
  REMARK    GeneRIF: A novel antidiuretic hormone governs tumour-induced renal
            dysfunction.
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Guo,F., Fernando,T., Zhu,X. and Shi,Y.
  TITLE     The overexpression of neurokinin B-neurokinin 3 receptor system
            exerts direct effects on the ovary under PCOS-like conditions to
            interfere with mitochondrial function
  JOURNAL   Am J Reprod Immunol 89 (3), e13663 (2023)
   PUBMED   36453600
  REMARK    GeneRIF: The overexpression of neurokinin B-neurokinin 3 receptor
            system exerts direct effects on the ovary under PCOS-like
            conditions to interfere with mitochondrial function.
REFERENCE   4  (bases 1 to 3764)
  AUTHORS   Zhang,W.W., Chen,T., Li,S.Y., Wang,X.Y., Liu,W.B., Wang,Y.Q.,
            Mi,W.L., Mao-Ying,Q.L., Wang,Y.Q. and Chu,Y.X.
  TITLE     Tachykinin receptor 3 in the lateral habenula alleviates pain and
            anxiety comorbidity in mice
  JOURNAL   Front Immunol 14, 1049739 (2023)
   PUBMED   36756128
  REMARK    GeneRIF: Tachykinin receptor 3 in the lateral habenula alleviates
            pain and anxiety comorbidity in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3764)
  AUTHORS   Zhang,L., Fernando,T., Liu,Y., Liu,Y., Zhu,X., Li,M. and Shi,Y.
  TITLE     Neurokinin 3 receptor antagonist-induced adipocyte activation
            improves obesity and metabolism in PCOS-like mice
  JOURNAL   Life Sci 310, 121078 (2022)
   PUBMED   36252700
  REMARK    GeneRIF: Neurokinin 3 receptor antagonist-induced adipocyte
            activation improves obesity and metabolism in PCOS-like mice.
REFERENCE   6  (bases 1 to 3764)
  AUTHORS   Kung,T.T., Crawley,Y., Jones,H., Luo,B., Gilchrest,H.,
            Greenfeder,S., Anthes,J.C., Lira,S., Wiekowski,M., Cook,D.N.,
            Hey,J.A., Egan,R.W. and Chapman,R.W.
  TITLE     Tachykinin NK3-receptor deficiency does not inhibit pulmonary
            eosinophilia in allergic mice
  JOURNAL   Pharmacol Res 50 (6), 611-615 (2004)
   PUBMED   15501700
  REMARK    GeneRIF: NK3-receptors are not involved in the development of lung
            inflammation and inflammatory cell recruitment into airways of
            antigen-challenged mice.
REFERENCE   7  (bases 1 to 3764)
  AUTHORS   Pintado,C.O., Pinto,F.M., Pennefather,J.N., Hidalgo,A.,
            Baamonde,A., Sanchez,T. and Candenas,M.L.
  TITLE     A role for tachykinins in female mouse and rat reproductive
            function
  JOURNAL   Biol Reprod 69 (3), 940-946 (2003)
   PUBMED   12773411
  REMARK    GeneRIF: Tachykinin NK3 receptor genes are expressed in uterine
            cells, oocytes, ovaries and embryos from mice, and may play a role
            in female reproductive function.
REFERENCE   8  (bases 1 to 3764)
  AUTHORS   Sarau,H.M., Feild,J.A., Ames,R.S., Foley,J.J., Nuthulaganti,P.,
            Schmidt,D.B., Buckley,P.T., Elshourbagy,N.A., Brawner,M.E.,
            Luttmann,M.A., Giardina,G.A. and Hay,D.W.
  TITLE     Molecular and pharmacological characterization of the murine
            tachykinin NK(3) receptor
  JOURNAL   Eur J Pharmacol 413 (2-3), 143-150 (2001)
   PUBMED   11226387
REFERENCE   9  (bases 1 to 3764)
  AUTHORS   Cook,G.A., Elliott,D., Metwali,A., Blum,A.M., Sandor,M., Lynch,R.
            and Weinstock,J.V.
  TITLE     Molecular evidence that granuloma T lymphocytes in murine
            schistosomiasis mansoni express an authentic substance P (NK-1)
            receptor
  JOURNAL   J Immunol 152 (4), 1830-1835 (1994)
   PUBMED   8120392
REFERENCE   10 (bases 1 to 3764)
  AUTHORS   Sundelin,J.B., Provvedini,D.M., Wahlestedt,C.R., Laurell,H.,
            Pohl,J.S. and Peterson,P.A.
  TITLE     Molecular cloning of the murine substance K and substance P
            receptor genes
  JOURNAL   Eur J Biochem 203 (3), 625-631 (1992)
   PUBMED   1370937
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK031898.1, AC101889.6 and
            AV336806.1.
            
            On Mar 13, 2010 this sequence version replaced NM_021382.5.
            
            Summary: This gene belongs to a family of genes that function as
            receptors for tachykinins. The receptors belonging to this family
            are characterized by interactions with G proteins and 7 hydrophobic
            transmembrane regions. This gene encodes the receptor for the
            tachykinin neurokinin 3, also referred to as neurokinin B.
            [provided by RefSeq, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031898.1, BC066845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2301              AK031898.1         2-2302
            2302-3516           AC101889.6         82998-84212
            3517-3755           AK031898.1         3517-3755
            3756-3764           AV336806.1         218-226
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.47 cM"
     gene            1..3764
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /note="tachykinin receptor 3"
                     /db_xref="GeneID:21338"
                     /db_xref="MGI:MGI:892968"
     exon            1..775
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1625
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /EC_number="2.7.11.14"
                     /note="Nk3 receptor; neurokinin 3 receptor; neurokinin B
                     receptor; NK-3 receptor; neuromedin K receptor"
                     /codon_start=1
                     /product="neuromedin-K receptor"
                     /protein_id="NP_067357.1"
                     /db_xref="CCDS:CCDS17852.1"
                     /db_xref="GeneID:21338"
                     /db_xref="MGI:MGI:892968"
                     /translation="MASVPTGENWTDGTAGVGSHTGNLSAALGITEWLALQAGNFSSA
                     LGLPVTSQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKR
                     MRTVTNYFLVNLAFSDASVAAFNTLVNFIYGVHSEWYFGANYCRFQNFFPITAVFASI
                     YSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRT
                     LCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHE
                     QLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMS
                     STMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSR
                     MESVTVLYDPSEGDPAKSSRKKRAVPRDPSANGCSHREFKSASTTSSFISSPYTSVDE
                     YS"
     exon            776..964
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1115
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1312
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..3764
                     /gene="Tacr3"
                     /gene_synonym="Nk3r; Nkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctcctgc tgctgcctgg gagctcctcc ctggcaggac ccaagcgagg agtctggttc
       61 tttcctgccc agcaaactcc caggagtgag gctccagctc tgcagccttt gccccacaac
      121 cgcatcccag gggggcggaa ccatccatca ctgccggcta ccaggtagtg ccccaaaaca
      181 acgtgcccag ggagtgaaga acttcaaggg agcgggctcc tgctggcctc cggagtgtga
      241 caggtcccca gctgcagacg ctggccatgg cctcggttcc caccggcgaa aactggacgg
      301 acgggacggc gggcgtgggg tcccatacag ggaatctgag cgctgcgctg gggatcactg
      361 agtggcttgc gctccaggct ggcaacttct cctccgcgct gggcttgcca gtgacatccc
      421 aggcaccttc ccaagtccgg gccaacctga cgaaccagtt cgtgcagccc tcctggcgaa
      481 tcgcgctctg gtcgctggcc tatggcttag tggtggcggt ggcagtcttc ggaaacctca
      541 tcgttatttg gatcatcttg gcccacaagc gcatgaggac cgtcaccaac tatttcctgg
      601 taaacctggc tttctccgac gcctccgtgg ctgccttcaa caccttggtc aatttcatct
      661 atggtgttca cagcgagtgg tactttggcg ccaactactg ccgcttccag aacttctttc
      721 ccatcacagc ggtgtttgcc agcatctact ctatgacagc cattgcagtg gacaggtata
      781 tggccattat cgatcctttg aaacccagac tatctgccac agccactaag attgtcatcg
      841 gaagtatttg gattttggca tttctacttg ccttccctca atgtctttat tccaaaataa
      901 aagtcatgcc aggccgtacc ctttgctatg tgcagtggcc agaaggtccc aagcaacatt
      961 tcacgtacca catcattgtt atcatcctgg tgtactgttt cccattgctc atcatgggtg
     1021 tcacctacac catcgttgga attactctct ggggaggaga gatcccagga gacacctgtg
     1081 acaagtacca tgagcagctt aaggctaaac gaaaggttgt aaaaatgatg attattgtgg
     1141 tggtgacatt tgccatctgc tggctaccct accatgtgta tttcattctc actgcgatct
     1201 accaacagtt aaacaggtgg aaatacatcc agcaggtcta cctggctagc ttctggctgg
     1261 ccatgagctc aaccatgtac aaccccatca tctactgctg tttgaacaaa agatttcgtg
     1321 caggcttcaa gagagcattt cgctggtgtc ctttcatcca agtctccagc tacgatgagc
     1381 tggagctcaa gaccaccagg tttcatccca cacggcagag cagcctgtac accgtgagca
     1441 ggatggagtc agtgaccgtg ctgtatgacc ccagtgaagg ggacccggcc aagtccagcc
     1501 gcaagaagag ggcggtgccc agagacccca gtgccaatgg ctgctcccac agagagttca
     1561 aatctgcctc caccacatca agtttcataa gctcgcccta tacctctgtg gatgaatatt
     1621 cctaaatcca tgtcccaagc taaaggctgt catgaggcca ccatgaggcc aacctaggtc
     1681 cctcattctc ctaaccatgc caggtccttt tctaggtact ttgggaaagc agaagggcag
     1741 tccttaggtg gggatacttc atttgagaaa agtggaatac caacataaca aaaactacca
     1801 acatatcagc cagcacaaag agaactgagt cttcaatcat atgcaaagtg tgaatctgaa
     1861 agatgctcta agtatccggt gtctgtcatt taacaatggc aatgtgtctt tgtgacctcc
     1921 gaacagcaga ggggttttcc aagagaataa ggaggctcta aaatgctatg atgagcaagg
     1981 gaaacatgac ctacataaaa cagaagttct gtgtggctgt gaagtggaga gggcaaatga
     2041 ctgacttccc aaacaagtaa tagaaaactc agcctcaaag agtagggaga tatggtagga
     2101 agaaggcttt tcaagaaaat ttatgtcata aaataaaaac tttcagaaat tccctccaaa
     2161 acacttagca gaaaaggaga gatagtcaaa gcattgccca aacacagcat gtatttctct
     2221 tgattatttt tccaaaggaa ataatttcat ttaattttga ccactaggtg ttttgagtgc
     2281 taaactaagt tgcagtcaaa tttggggctt taaaagacaa agaaaattct taccatcttc
     2341 tttatcttat tattcatgct ttttaaaatt gagtaaaatt gtaaaaacac taaagctatc
     2401 atccaatgga aaaagagaaa tccatatttg cctcggtaac tcacttgctt gatttggata
     2461 acaagttaat agtacttaga cgtcatcaag ccagacacca gcatctccaa gtccctgagc
     2521 cagctgcttc ccactgccat gcaaagaaaa tcaaagtcat gaactttact ggttatatca
     2581 tggcatcctt ctcttctttc ctcactgaga aaaaaacaaa ggccattggg ggagtattac
     2641 aatatatttc aagtgtgagc tgagttgccc caggacaaat tgaaaagtat taatatatgt
     2701 actgataaat cagagaagac ataggcccat aagtagctgg ctagaaaaag aagatgtgta
     2761 ggactctggg gacataagct agagatgagg aagaggacag cacacatgct cccagacaca
     2821 aaacttggtt gtctgtactt agtcaagaga aaatccctct agaaggaaat gtgttggtat
     2881 gtgtgtgtgt ttatgtatct cttcctaaag tttgtttgac tcatctaata gaaattagta
     2941 tttttggtag tctcttttct tacccctata aatgcttccc ttgttaattt atgcttggaa
     3001 tacactgtga gattacttcc tttccagtta ggggaactgc catgtgtagg cacatttaag
     3061 aggcccagaa caaaattaca gacatctaga aatgtagaat gcgtcttcca gactacatcc
     3121 tttacaagtc atctttcctt atgttactac aactgttgat tctgttcata aaatcgcaag
     3181 ccttctggga atgagatttg tcctacaaac ttgtctttcc caacattcaa gtgggtttta
     3241 ttaactatct gtccaaaata cttgcctcta acacgttttt ctttgtatgc tctatcaaca
     3301 taagaatatt tctgaagatc agggcagagg caattgcctg gtagtaaatc atagtggatt
     3361 atcacagcat ttgtctctag tccttttttc tcatttgaag cccaaaccat atataccaga
     3421 ctgttacaca atttcaactc tctaaagtac caaattatat atgcttgggt ttactttaat
     3481 aactccaata aacaaacaga caaccaaata cacatatgag tgtgcagata aacactatca
     3541 aaaatgaatg tgattgcttc aaggattgaa ttcaaaattg aaaccaaaaa ggcagatggt
     3601 cacaacagga ttgccccaaa agccactcag tgatgtctac gaagcattgt gtgcatgttt
     3661 ccccttagca attgtatctc atcatctgaa tatagtgttt gaaaaatgtt tattcttaaa
     3721 ttatgtaagt gcttatcaaa tgtaaaatca tcatgaaaac ctgg
//
