LOCUS       NM_009314               2258 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus tachykinin receptor 2 (Tacr2), mRNA.
ACCESSION   NM_009314 XM_905549
VERSION     NM_009314.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Shen,W., Wang,X., Xiang,H., Shichi,S., Nakamoto,H., Kimura,S.,
            Sugiyama,K., Taketomi,A. and Kitamura,H.
  TITLE     IFN-gamma-STAT1-mediated NK2R expression is involved in the
            induction of antitumor effector CD8+ T cells in vivo
  JOURNAL   Cancer Sci 114 (5), 1816-1829 (2023)
   PUBMED   36715504
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Torres,E., Velasco,I., Franssen,D., Heras,V., Gaytan,F., Leon,S.,
            Navarro,V.M., Pineda,R., Candenas,M.L., Romero-Ruiz,A. and
            Tena-Sempere,M.
  TITLE     Congenital ablation of Tacr2 reveals overlapping and redundant
            roles of NK2R signaling in the control of reproductive axis
  JOURNAL   Am J Physiol Endocrinol Metab 320 (3), E496-E511 (2021)
   PUBMED   33427049
  REMARK    GeneRIF: Congenital ablation of Tacr2 reveals overlapping and
            redundant roles of NK2R signaling in the control of reproductive
            axis.
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Mao,Y.L., Shen,C.L., Zhou,T., Ma,B.T., Tang,L.Y., Wu,W.T.,
            Zhang,H.X., Lu,H.L., Xu,W.X. and Wang,Z.G.
  TITLE     Ablation of Tacr2 in mice leads to gastric emptying disturbance
  JOURNAL   Neurogastroenterol Motil 29 (11) (2017)
   PUBMED   28585346
  REMARK    GeneRIF: Tacr2 negatively regulated the expression of neuronal
            nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide
            (VIP). Its ablation in mice elevated the expression of nNOS and
            VIP, enhanced nitric oxide signaling and changed the Creb and
            NF-kappaB signalings, finally leading to the gastric emptying
            disturbance of Tacr2(-/-) mice.
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Guo,Z., Zhao,C., Huang,M., Huang,T., Fan,M., Xie,Z., Chen,Y.,
            Zhao,X., Xia,G., Geng,J. and Cheng,L.
  TITLE     Tlx1/3 and Ptf1a control the expression of distinct sets of
            transmitter and peptide receptor genes in the developing dorsal
            spinal cord
  JOURNAL   J Neurosci 32 (25), 8509-8520 (2012)
   PUBMED   22723691
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Patak,E., Pinto,F.M., Story,M.E., Pintado,C.O., Fleming,A.,
            Page,N.M., Pennefather,J.N. and Candenas,M.L.
  TITLE     Functional and molecular characterization of tachykinins and
            tachykinin receptors in the mouse uterus
  JOURNAL   Biol Reprod 72 (5), 1125-1133 (2005)
   PUBMED   15647454
REFERENCE   7  (bases 1 to 2258)
  AUTHORS   Scholzen,T.E., Steinhoff,M., Sindrilaru,A., Schwarz,A.,
            Bunnett,N.W., Luger,T.A., Armstrong,C.A. and Ansel,J.C.
  TITLE     Cutaneous allergic contact dermatitis responses are diminished in
            mice deficient in neurokinin 1 receptors and augmented by
            neurokinin 2 receptor blockage
  JOURNAL   FASEB J 18 (9), 1007-1009 (2004)
   PUBMED   15084523
  REMARK    GeneRIF: NK-1R and NK-2R have important but differential roles in
            the regulation of cutaneous inflammatory responses
REFERENCE   8  (bases 1 to 2258)
  AUTHORS   Pintado,C.O., Pinto,F.M., Pennefather,J.N., Hidalgo,A.,
            Baamonde,A., Sanchez,T. and Candenas,M.L.
  TITLE     A role for tachykinins in female mouse and rat reproductive
            function
  JOURNAL   Biol Reprod 69 (3), 940-946 (2003)
   PUBMED   12773411
  REMARK    GeneRIF: Tachykinin NK2 receptor genes are expressed in uterine
            cells, oocytes, ovaries and embryos from mice, and may play a role
            in female reproductive function.
REFERENCE   9  (bases 1 to 2258)
  AUTHORS   Weil,M., Itin,A. and Keshet,E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   10 (bases 1 to 2258)
  AUTHORS   Sundelin,J.B., Provvedini,D.M., Wahlestedt,C.R., Laurell,H.,
            Pohl,J.S. and Peterson,P.A.
  TITLE     Molecular cloning of the murine substance K and substance P
            receptor genes
  JOURNAL   Eur J Biochem 203 (3), 625-631 (1992)
   PUBMED   1370937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127417.3, AK033443.1 and BC106960.2.
            
            On Sep 17, 2009 this sequence version replaced NM_009314.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033443.1, X62933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC127417.3         187605-187922
            319-1018            AK033443.1         2-701
            1019-1021           BC106960.2         1179-1181           c
            1022-1887           AK033443.1         705-1570
            1888-1889           BC106960.2         311-312             c
            1890-2258           AK033443.1         1573-1941
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.37 cM"
     gene            1..2258
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /note="tachykinin receptor 2"
                     /db_xref="GeneID:21337"
                     /db_xref="MGI:MGI:98477"
     exon            1..772
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..1535
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /note="neurokinin A receptor; tachykinin NK-2 receptor; 7
                     transmembrane receptor; NK-2R"
                     /codon_start=1
                     /product="substance-K receptor"
                     /protein_id="NP_033340.3"
                     /db_xref="CCDS:CCDS35919.1"
                     /db_xref="GeneID:21337"
                     /db_xref="MGI:MGI:98477"
                     /translation="MGAHASVTDTNILSGLESNATGVTAFSMPGWQLALWATAYLALV
                     LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFG
                     STFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVAL
                     ALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYS
                     VIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ
                     EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWGTPTEED
                     RLELTHTPSISRRVNRCHTKETLFMTGDMTHSEATNGQVGGPQDGEPAGP"
     exon            773..967
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1121
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1318
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..2258
                     /gene="Tacr2"
                     /gene_synonym="Nk2r; Skr; Tac2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattccgat tctggcttgt caccaacttc ctgaatgccc gttgctggac acatattttc
       61 tctgactctc agccttttga ttttggtgtg aaagatcgga accaaccaac caacgtgtta
      121 tcaggatgcc tcctgctctg agactggaat ttgagttctc catctccacg agatgcttga
      181 acagtctgcc tgggaccttg ctttctgctc agcctgactc atttctgctt gagctgtagg
      241 cgtggtcccc tggctacacg tgtctgcttt ccaatcgtcc tcgcccccgt aaatctacac
      301 acccaagagg atttctcttc tgtggtgatt ctagacggaa ctgcagggcc agaccctgtg
      361 ttccaggccc aggatcagcc atgggggccc acgccagcgt taccgacacc aacatcttgt
      421 ctggccttga gagtaacgca acaggcgtta cagccttctc tatgcctggc tggcagctgg
      481 cgctatgggc cacagcctac ctggccctgg tgctggtggc tgtaacaggc aacgccacag
      541 tcatctggat cattctggcc catgagagaa tgcgcacggt caccaactat ttcatcatca
      601 acctggcctt ggcagacctc tgcatggcgg ccttcaatgc caccttcaac ttcatctatg
      661 ccagtcacaa catctggtac ttcggcagca ccttctgcta cttccagaac ctctttcctg
      721 tcacagccat gttcgtcagc atctactcca tgaccgccat cgccgctgac aggtacatgg
      781 ccattgtcca ccctttccag ccacggctct ccgcccccag caccaaggcg gttattgctg
      841 tcatctggct ggtagccctg gctctcgcct ccccacaatg tttctactcc accatcactg
      901 tggaccaggg ggccaccaag tgtgtggtgg cctggcccaa tgacaacgga ggcaagatgc
      961 tcctactgta tcatctggtg gtgtttgtcc tcatctactt cctgcctcta gtggtgatgt
     1021 ttgcagctta cagtgtcatt ggcctcacac tgtggaaacg cgccgtaccc agacaccagg
     1081 ctcatggagc taacctgcgc catctacagg ccaagaagaa gtttgtgaag gccatggtac
     1141 tggtggtggt gacatttgcc atctgctggc tgccctacca cctctacttc atcctgggga
     1201 ccttccaaga ggacatctac taccgcaagt ttatccagca ggtctacctg gcactcttct
     1261 ggctggccat gagctccacc atgtacaacc ccatcattta ttgctgcctt aaccacaggt
     1321 ttcgctctgg attccggctt gctttccggt gctgcccctg ggggacacca accgaggaag
     1381 acaggctgga gctgacccac actccgtcca tctccaggag agtcaaccgg tgtcacacca
     1441 aggagacttt gttcatgaca ggggatatga cccactctga ggctaccaat gggcaggttg
     1501 ggggccccca ggatggggag cctgctggac cctgaagtct tgagcttgtc tgcagggccc
     1561 aggcttagcc cctttgagaa tcggctgatg gaaaagccct tacataatag cttgtcccac
     1621 accccattct tcaacacacc aacagaaaag aagcaagacg gtgctcagag cgccacaggc
     1681 aatgctgata caaagagctt ggagagcaga cacccatcat aggcattcca gcaaccgagg
     1741 aaggggccag gaagactggg aaccaacatt tggccaatcc aggagctgca aagtgagttg
     1801 tctcccggga gtatagagag gggtggaaaa acgatctcag ggaagacaac tgcagtcata
     1861 atgagaaagg cagctgaagg atggtgacat ggctcagcag cgaggtcgta aagccactct
     1921 ctgctaagcc tcatgaccta agtgcagttc ctgaaaccca cacagaagga aagaaccaac
     1981 gtctgcaagc tgtcccctga cctccccaag tgtgtgtatg cacatgtgtg tgtgcatgta
     2041 tatctgcaca tgtatgcaca cacacacaca cacacacaca tgtacatgtg cctgtgcaca
     2101 tacaatgtta aagagaaaga aggcaaccac tccagtgtta gggtcacagg aaaaggtggg
     2161 gactgtggca gcctgcagag gacaagcacc caaagggaaa ctcagctgct ttgctctgga
     2221 acacagttgc caggttttcc aaataaagcc tgagatct
//
