LOCUS       NM_009313               5036 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus tachykinin receptor 1 (Tacr1), mRNA.
ACCESSION   NM_009313
VERSION     NM_009313.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5036)
  AUTHORS   Cremin,M., Ramirez,V.T., Sanchez,K., Tay,E., Murray,K.,
            Brust-Mascher,I. and Reardon,C.
  TITLE     Substance P receptor signaling contributes to host maladaptive
            responses during enteric bacterial infection
  JOURNAL   Proc Natl Acad Sci U S A 122 (7), e2415287122 (2025)
   PUBMED   39937862
REFERENCE   2  (bases 1 to 5036)
  AUTHORS   Furdui,A., da Silveira Scarpellini,C. and Montandon,G.
  TITLE     Anatomical distribution of micro-opioid receptors, neurokinin-1
            receptors, and vesicular glutamate transporter 2 in the mouse
            brainstem respiratory network
  JOURNAL   J Neurophysiol 132 (1), 108-129 (2024)
   PUBMED   38748514
  REMARK    GeneRIF: Anatomical distribution of micro-opioid receptors,
            neurokinin-1 receptors, and vesicular glutamate transporter 2 in
            the mouse brainstem respiratory network.
REFERENCE   3  (bases 1 to 5036)
  AUTHORS   Cui,K., Xia,Y., Patnaik,A., Salivara,A., Lowenstein,E.D.,
            Isik,E.G., Knorz,A.L., Airaghi,L., Crotti,M., Garratt,A.N.,
            Meng,F., Schmitz,D., Studer,M., Rijli,F.M., Nothwang,H.G.,
            Rost,B.R., Strauss,U. and Hernandez-Miranda,L.R.
  TITLE     Genetic identification of medullary neurons underlying congenital
            hypoventilation
  JOURNAL   Sci Adv 10 (25), eadj0720 (2024)
   PUBMED   38896627
REFERENCE   4  (bases 1 to 5036)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5036)
  AUTHORS   Ruff,C.F., Juarez Anaya,F., Dienel,S.J., Rakymzhan,A.,
            Altamirano-Espinoza,A., Couey,J.J., Fukuda,M., Watson,A.M., Su,A.,
            Fish,K.N., Rubio,M.E., Hooks,B.M., Ross,S.E. and Vazquez,A.L.
  TITLE     Long-range inhibitory neurons mediate cortical neurovascular
            coupling
  JOURNAL   Cell Rep 43 (4), 113970 (2024)
   PUBMED   38512868
REFERENCE   6  (bases 1 to 5036)
  AUTHORS   Bozic,C.R., Lu,B., Hopken,U.E., Gerard,C. and Gerard,N.P.
  TITLE     Neurogenic amplification of immune complex inflammation
  JOURNAL   Science 273 (5282), 1722-1725 (1996)
   PUBMED   8781237
REFERENCE   7  (bases 1 to 5036)
  AUTHORS   Andoh,T., Nagasawa,T. and Kuraishi,Y.
  TITLE     Expression of tachykinin NK1 receptor mRNA in dorsal root ganglia
            of the mouse
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 329-332 (1996)
   PUBMED   8717372
REFERENCE   8  (bases 1 to 5036)
  AUTHORS   Weil,M., Itin,A. and Keshet,E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   9  (bases 1 to 5036)
  AUTHORS   Cook,G.A., Elliott,D., Metwali,A., Blum,A.M., Sandor,M., Lynch,R.
            and Weinstock,J.V.
  TITLE     Molecular evidence that granuloma T lymphocytes in murine
            schistosomiasis mansoni express an authentic substance P (NK-1)
            receptor
  JOURNAL   J Immunol 152 (4), 1830-1835 (1994)
   PUBMED   8120392
REFERENCE   10 (bases 1 to 5036)
  AUTHORS   Sundelin,J.B., Provvedini,D.M., Wahlestedt,C.R., Laurell,H.,
            Pohl,J.S. and Peterson,P.A.
  TITLE     Molecular cloning of the murine substance K and substance P
            receptor genes
  JOURNAL   Eur J Biochem 203 (3), 625-631 (1992)
   PUBMED   1370937
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC075631.1, AC159655.8 and
            BC098332.1.
            
            On Mar 13, 2010 this sequence version replaced NM_009313.4.
            
            Summary: This gene encodes the receptor for the tachykinin,
            substance P, also referred to as neurokinin 1. This gene belongs to
            a gene family of tachykinin receptors which are characterized by
            interactions with G proteins and contain seven hydrophobic
            transmembrane regions. This receptor has been associated with
            nitric oxide formation, and it has been localized to cholinergic
            and nitrergic neurons as well as on smooth muscle cells. [provided
            by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4364              BC075631.1         1-4364
            4365-4365           AC159655.8         103000-103000       c
            4366-5021           BC075631.1         4366-5021
            5022-5036           BC098332.1         4928-4942
FEATURES             Location/Qualifiers
     source          1..5036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..5036
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /note="tachykinin receptor 1"
                     /db_xref="GeneID:21336"
                     /db_xref="MGI:MGI:98475"
     exon            1..108
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            109..1305
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             917..2140
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /note="substance P receptor; Nk1 receptor; neurokinin
                     receptor 1"
                     /codon_start=1
                     /product="substance-P receptor"
                     /protein_id="NP_033339.2"
                     /db_xref="CCDS:CCDS20262.1"
                     /db_xref="GeneID:21336"
                     /db_xref="MGI:MGI:98475"
                     /translation="MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVV
                     TSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGL
                     FYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALL
                     LAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTV
                     VGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD
                     LYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGL
                     EMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNS
                     KTMTESSSFYSNMLA"
     exon            1306..1500
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1651
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1848
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..5026
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5002..5007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /note="hexamer: AATAAA"
     polyA_site      5021
                     /gene="Tacr1"
                     /gene_synonym="Nk1r; Spr; Tac1r"
                     /note="major polyA site"
ORIGIN      
        1 ggaatcagtc caccagggaa cagagctagg tgtctggggg tttctttaac agaaggaaag
       61 ttgacttccg gacttctgaa gcagggtgtg gtcacctgtc acttctaggc caccttgtcg
      121 ccccctcgcg gagtgctgga ttcgtccggc ctgcagaacg cccacagcag gtcacgagca
      181 gcagaaggcg tggtggctgc ggtggtggag cgacacagct gccaacaact ggcgcagctg
      241 ctgcgctgtg cttcgggacc agcgagtaga cagtccaggt acagcccctt ccccgtgacg
      301 tctctgcagc gggttataaa agcctagtag tgctcaccct gccaaggctc tgctaactcc
      361 tgagcacaga aggaccaaga cctggaagct gcgggtggca gtagaggctc taagtgaagc
      421 aacggaaaaa aggagctcac cagttggatg cggacctcag aagccggcca gaggaccaga
      481 acttttacta gctgcgctgc aagcagccct tcttccccat caagctccca cccagcaccc
      541 agctttgcct ttcctgctgc acgcatgtta acgggagttg ctagtagcag caggtgccaa
      601 aaggcgggtt gtcttgcctt ttggaaccgt gtggagtgca gctgcttcaa tgcaaacaag
      661 agcctagcat gaaagtggag gaatttggag agaccaggca aagagctata cagaagcatt
      721 gctcttgtgg acaagtctcc tgctaaccag gactaagttc tgcccaggaa acttcccacc
      781 tcctgagtag caggactcaa gcctcaggca tctgcgacaa ggtcctacag caaggaggtg
      841 tgtgcgtgtg tgtgtacact tctgtgtgta cttgtgagta cctgtagacg ccagggcttt
      901 gctgccttgc cgcaaaatgg ataacgtcct tcctgtggac tctgatctct tccccaacac
      961 ctccaccaac acttctgagt ctaaccagtt tgtgcaacct acctggcaaa ttgtcctttg
     1021 ggcagccgcc tatacggtca tcgtggtgac ttccgtggtg ggcaacgtag tggtgatatg
     1081 gatcattttg gcccacaaga gaatgaggac agtgaccaat tatttcctgg tgaacctggc
     1141 cttcgctgag gcctgcatgg ctgcattcaa tacagtggtg aacttcacct acgcagtcca
     1201 caacgtgtgg tactacggcc tcttttactg caagtttcac aacttcttcc ccattgctgc
     1261 tctcttcgcc agtatctact ccatgacagc tgtggccttt gacagataca tggccatcat
     1321 ccaccctctt cagccccggc tgtcggccac tgctaccaaa gtggtcatct ttgtcatctg
     1381 ggtcctggct ctcctgctgg ccttcccaca gggctactac tccaccacag agaccatgcc
     1441 cagcagagta gtgtgcatga ttgagtggcc agaacatccc aacaggactt acgagaaagc
     1501 gtaccacatc tgtgtgactg tgctgatcta cttcctgcct ctgctggtga ttggctatgc
     1561 atacactgtg gtagggatta cactgtgggc cagtgagatc cccggtgact cctctgaccg
     1621 ttaccatgag caagtctctg ccaagcgcaa ggtggtcaaa atgatgatcg tggttgtgtg
     1681 taccttcgcc atctgctggc tgcccttcca catcttcttc ctcctgccct acatcaaccc
     1741 agatctctac cttaagaagt tcatccagca ggtctacctg gccagcatgt ggctggccat
     1801 gagttctacc atgtacaacc ccatcatcta ctgctgcctc aatgacaggt tccgtctggg
     1861 cttcaagcat gcctttcgct gctgcccttt catcagtgct ggtgattatg aggggctgga
     1921 aatgaaatcc acccgatacc tccagaccca gagcagcgtg tacaaggtca gccgcctgga
     1981 gaccaccatc tccactgtgg tgggagccca tgaagatgag ccagaggaag gtcccaaggc
     2041 cacaccttca tccttggatc tcacctccaa tggctcctct cgaagcaact cgaagaccat
     2101 gacagaaagc tccagcttct actctaacat gctggcctaa gcagcagaca catttccagg
     2161 gcacagccac tagcccatct tgtatcattt attcatggaa gtctttgatt tggaatttgt
     2221 tggaaatacc ctaacactgg agcttttggg gaaaggtcac aatggtttaa ggaaaacatt
     2281 ccatgctgta ttcaatctgg atcccatcct gtctttgcca accatactcc acactggtga
     2341 cccaaggcag attggtgaac ttctaaaaaa tgagaaggct atcctcggtt tcccctgaag
     2401 tttatcccat gattcctgaa acgacttcat ctgcatgcaa ggtgcttatc tggggaggga
     2461 ttctgcaagg cagcagacct atttgcctgg aacatctgtc tttcttcagc gaagtcattc
     2521 tcagccacat gtgcagacta gctcacacca ctccagcctt ccacaggaca gtgtgagcaa
     2581 aagaagacgc cacctaaatc ctaaggaaag ctctatcccc acctaagcac acatgaatgg
     2641 aggacactta gcattgtgac atcttgatgt ctcagttcat ttaaacatca tgggattgac
     2701 aatattggat tcttctgcat tgtgtcccca gtacaaccaa ctctgactga atatgtctac
     2761 acaagccagc tgatgttcga accaagagtc aggagatcca cgccaggctt aacctatctg
     2821 agactctttt ccttctttgt aaagcagcag agctgaacca aatactctaa gtgtttcttt
     2881 gagtgtctgt gtttcctggt ttaatgatgt atatacttca ttctctctct ctctctctct
     2941 ctctctctct ctctctctct ctctctctct ctctctctct ttctctctct tttgtacaca
     3001 cacacacaca cacgctcaca cactcacaca cactcacaca cacacattct ctctctctct
     3061 ctctctctct ctctctctct cacacacaca cacacacaca cacacacaca cacacacaca
     3121 cacacacaca cacacaaaat ataaagaaaa gcaatgacag catcaaaaat accagggctg
     3181 tcagtcccta gagatgggtg tgtgtaaata ttctcccatt gatccaaaag cccttctcca
     3241 caaattcctt ctccaggaaa gttttcctct ttgacagagc agaggacttc tcaggaaatc
     3301 tcggatatct ccagcaggct acaacccagt tctgagaaca gcattgagag ggacaagtgt
     3361 gtggacttcc tgctctgacc aatcgagtct ttgtcttcat gttttgctac acatggtgta
     3421 gaggagggag gctgccctct gcagctacat tcctggaaag aggagccttg cctcttctct
     3481 tcagactctg aacctttccc tcctgctcca ctttgccaac ctctgtctat aagagtttga
     3541 aggatccacc aatccaaaag gacacttagt ctgccaagag ccaagaactg aaagtgtcac
     3601 atcctgaaac ggcttcagga tccccagcaa gggagcatgc tctttctttc tgtctctcag
     3661 atgtggctgg aagccaaagc ttcatgtgac atccatgaat atcctcatgg ttcgggtaac
     3721 tggatgcaca aaagctctat ccagcatgtg gaggagaaca agaccactca tcagcaggat
     3781 ttataacttc taccagcctt gttgggtcta accctttgag ggcatcagca tacctggaga
     3841 aggcaagcgt tatatagaaa taatataagc taggggcagg ggaagaaatg agaagcatac
     3901 tctgcagaga attatgggaa attttaatga actaagcaaa ggccactgaa tgacaaccta
     3961 tgagttgaaa atagtgtaag aacaacaaaa gccaatgccc aagttgtata ttacacttcc
     4021 aagaaggaat cttgctatat agggatggaa aaaaatgtgg ctatgaaaag tacctaagaa
     4081 gaaaacaccc agcatggaaa ggcatctcat ctacagaaga gatggttaag gtaaagttgg
     4141 caaggattta tggagtgcct gctgtggact ttgcccaaac tgaggacaca cagctccttc
     4201 caccctgagg agattcttgt ccctgctatt cctgatgatg ccagcctgct tcaccaggca
     4261 tggaggcatt gagaagcaga ttcctcctaa gattttaaaa actaactttc aacttgggga
     4321 ctccagccaa ggggtggggc tttcagagag cttctaaaat ggcaggtctc tgaggtaact
     4381 atgaagggag ccaccagtca gccctgggaa cctataactg atatgagaaa tttcactcca
     4441 tgtgtagtat gagcgaagat gaggtggacc gggcttcatg gatatgccga agcatccctc
     4501 agagaggacc agcaagcttc ccattgcccc tgctccaaag accatttaac ttgtaaaaat
     4561 gtcgtcaatt cctgtttgtg agaacactgt gatttgtgct ctgtgcatgg gtctcttatt
     4621 gaaatgtgtc accctgtgtt tatctcctgt gttttcttga tgtaccctcc agtatcgaca
     4681 ggctgggagc catcctggag ccatccttcc tgcattccct ccaacctgtg ggatcccagt
     4741 gccatcgctc ttgttgggcc aggcctcctc ctgccactgt tcttgcttag agaggagctc
     4801 tgaagtctgc cccatattca atgaaactgg aggctgtgga aggaccttgg tgggaggaac
     4861 atcctgagcc cttcagcaga ttgctgagac aaagggctga gtggaattct gggaaaggag
     4921 aggacacagg cctggagaaa agaatggccg tagaaagggg tcattcctga agcatctgta
     4981 tttggggcct gggatcctgg aaataaagta tgctttggct atctcaaaaa aaaaaa
//
