LOCUS       NM_027346               1787 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus translational activator of mitochondrially encoded
            cytochrome c oxidase I (Taco1), mRNA.
ACCESSION   NM_027346 XM_193639
VERSION     NM_027346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1787)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1787)
  AUTHORS   Ferreira,N., Andoniou,C.E., Perks,K.L., Ermer,J.A., Rudler,D.L.,
            Rossetti,G., Periyakaruppiah,A., Wong,J.K.Y., Rackham,O.,
            Noakes,P.G., Degli-Esposti,M.A. and Filipovska,A.
  TITLE     Murine cytomegalovirus infection exacerbates complex IV deficiency
            in a model of mitochondrial disease
  JOURNAL   PLoS Genet 16 (3), e1008604 (2020)
   PUBMED   32130224
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1787)
  AUTHORS   Richman,T.R., Spahr,H., Ermer,J.A., Davies,S.M., Viola,H.M.,
            Bates,K.A., Papadimitriou,J., Hool,L.C., Rodger,J., Larsson,N.G.,
            Rackham,O. and Filipovska,A.
  TITLE     Loss of the RNA-binding protein TACO1 causes late-onset
            mitochondrial dysfunction in mice
  JOURNAL   Nat Commun 7, 11884 (2016)
   PUBMED   27319982
  REMARK    GeneRIF: The Taco1 mutant mice develop a late-onset visual
            impairment, motor dysfunction and cardiac hypertrophy and thus
            provide a useful model for future treatment trials for
            mitochondrial disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1787)
  AUTHORS   Clark,A.G., Glanowski,S., Nielsen,R., Thomas,P.D., Kejariwal,A.,
            Todd,M.A., Tanenbaum,D.M., Civello,D., Lu,F., Murphy,B.,
            Ferriera,S., Wang,G., Zheng,X., White,T.J., Sninsky,J.J.,
            Adams,M.D. and Cargill,M.
  TITLE     Inferring nonneutral evolution from human-chimp-mouse orthologous
            gene trios
  JOURNAL   Science 302 (5652), 1960-1963 (2003)
   PUBMED   14671302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047078.1 and AW491435.1.
            
            On Jul 3, 2018 this sequence version replaced NM_027346.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.231302.1,
                                           SRR1660815.128749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1336              AK047078.1         5-1340
            1337-1787           AW491435.1         1-451               c
FEATURES             Location/Qualifiers
     source          1..1787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..1787
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /note="translational activator of mitochondrially encoded
                     cytochrome c oxidase I"
                     /db_xref="GeneID:70207"
                     /db_xref="MGI:MGI:1917457"
     exon            1..428
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1042
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /note="translational activator of mitochondrially-encoded
                     cytochrome c oxidase 1; coiled-coil domain-containing
                     protein 44"
                     /codon_start=1
                     /product="translational activator of cytochrome c oxidase
                     1"
                     /protein_id="NP_081622.1"
                     /db_xref="CCDS:CCDS25547.1"
                     /db_xref="GeneID:70207"
                     /db_xref="MGI:MGI:1917457"
                     /translation="MMSWAAASLRMTAVPCFRVRCLGFRVGPWGASQHANPGCGAAPH
                     RTLHVSATASAGHNKWSKVRHIKGPKDMERSRIFSKLTLSIRLAVKEGGPNPENNSSL
                     ANILELCRSKNMPKSTIESALKTEKNKGIYLLYEGRGPGGSSLLIEALSNSGPKCHLD
                     IKYILNKNGGMMAEGARHFFDKKGVVVVGVEDREKKAVNLERALELAIEAGAEDVKEA
                     EDEEEKNLFKFICDASSLHQVRKKLDSLGLCPVSCSMEFIPHSKVQLAEPELEQAAHL
                     IQALNNYEDVIHVYDNIE"
     exon            429..535
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /inference="alignment:Splign:2.1.0"
     exon            536..663
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /inference="alignment:Splign:2.1.0"
     exon            664..841
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1776
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1313..1318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /note="hexamer: AATAAT"
     polyA_site      1335
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
                     /note="major polyA site"
     polyA_site      1448
                     /gene="Taco1"
                     /gene_synonym="2310066I18Rik; Ccdc44"
ORIGIN      
        1 actcaaggca gtgcagcgtc aggaagagcc gaacctctga gtttctggag agctgtagca
       61 gcggtctgaa cgtccagacc gggttgttcc ggggccggac tagacgggct gattttagct
      121 gctcatcttt gcaccgcgca gccccttgtc gaagcagatg atgtcttggg ctgccgccag
      181 cctgagaatg accgctgtcc cgtgctttcg tgtgcgatgc ctcgggttcc gcgtgggtcc
      241 ttggggcgcc tcccagcatg caaaccccgg ctgtggtgca gcgccacaca ggacgctgca
      301 tgtcagcgcg acggcctcgg cgggacacaa taagtggtct aaagtccggc acatcaaggg
      361 ccccaaggac atggaaagga gtcgaatctt ctctaaactc actctcagta tccgcctggc
      421 ggttaaagag ggaggcccta accctgagaa caacagcagc ctggccaaca tcttagagtt
      481 gtgtcgcagc aagaatatgc ccaagtcaac catcgagtca gcactgaaga cagagaaaaa
      541 caagggcatt tatttgctat atgagggtcg tggccctgga ggctcttctc tgctcattga
      601 ggcgttatca aacagtggtc ccaagtgcca tctggacatt aaatatatcc tgaacaagaa
      661 tgggggaatg atggctgaag gagcacgcca cttttttgac aaaaaaggag tggttgttgt
      721 tggagtggag gacagagaga agaaagctgt gaacctagag cgtgccctag aactggccat
      781 cgaagcagga gccgaggatg tgaaggaagc cgaagacgaa gaagaaaaga acctttttaa
      841 attcatttgt gatgcttctt cactacatca agtgaggaaa aaactggact cgctgggcct
      901 gtgtcctgtg tcctgttcaa tggagttcat ccctcactcc aaggtgcagc tggctgagcc
      961 ggagctggag caggctgctc acctcatcca ggcgcttaac aactatgagg atgtgattca
     1021 cgtttatgac aatattgaat aagcggcctc gactagactt ggctccggct ctttcctagg
     1081 ccgcacaagc ttctgcagca atctcagaga ctgaaacagc tgagagccta ttagagacct
     1141 gctgcaatgg ctgtcagcct tgggaaaggg ggactcttag ctctgttggt atcaccgggc
     1201 catctggaat gcaaggtgag actggccagc cggtctgact ctgatcccag gtgactggct
     1261 cttgtgaaga gtcttaagtg tcctgtggta ccgtagagtg gaaatgatct tcaataataa
     1321 cagtagtgac ttttggatgc tttgttgctg gtatgactct tgaggtgtcc tgatttgtgt
     1381 ccagtttttg aacctctgga ctaactgaca ttcaagccca catgcttact tctctacttt
     1441 catactaaga ttgtcttttt ccttttcttt ctgttgtgga atagagacgt ggctgttctt
     1501 gtggttgggt gctggtataa cgacctagcc ttctcacttg ttcatgcagc tagtgtctct
     1561 tgaacacctt acttacaggg attgtgcttt tctagggaga aggcagttca gttggtgctt
     1621 atgtcctgct ctaagatgtg agacctcaaa gggaagacac agggatgtac ccatggcact
     1681 gctccagggt atcatggatt acgttcatta tctttgttct ctttttgtgg tttctgttcc
     1741 ccgtttgaga gcttaagttt tagtgccaat agaaaaaaaa aaaaaaa
//
