LOCUS       NM_001310541            2209 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus transforming, acidic coiled-coil containing protein 3
            (Tacc3), transcript variant 1, mRNA.
ACCESSION   NM_001310541 XM_006503831
VERSION     NM_001310541.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2209)
  AUTHORS   Simerly,C., Robertson,E., Harrison,C., Ward,S., George,C.,
            Deleon,J., Hartnett,C. and Schatten,G.
  TITLE     Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG
            differently from female meiotic or somatic mitotic spindles in mice
  JOURNAL   Sci Rep 14 (1), 4808 (2024)
   PUBMED   38413710
  REMARK    GeneRIF: Male meiotic spindle poles are stabilized by TACC3 and
            cKAP5/chTOG differently from female meiotic or somatic mitotic
            spindles in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2209)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2209)
  AUTHORS   Blengini,C.S., Ibrahimian,P., Vaskovicova,M., Drutovic,D., Solc,P.
            and Schindler,K.
  TITLE     Aurora kinase A is essential for meiosis in mouse oocytes
  JOURNAL   PLoS Genet 17 (4), e1009327 (2021)
   PUBMED   33901174
  REMARK    GeneRIF: Aurora kinase A is essential for meiosis in mouse oocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2209)
  AUTHORS   Fujita,R., Jamet,S., Lean,G., Cheng,H.C.M., Hebert,S.,
            Kleinman,C.L. and Crist,C.
  TITLE     Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3
            translation
  JOURNAL   Development 148 (2) (2021)
   PUBMED   33318147
  REMARK    GeneRIF: Satellite cell expansion is mediated by
            P-eIF2alpha-dependent Tacc3 translation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2209)
  AUTHORS   Yao,R., Oyanagi,J., Natsume,Y., Kusama,D., Kato,Y., Nagayama,S. and
            Noda,T.
  TITLE     Suppression of intestinal tumors by targeting the mitotic spindle
            of intestinal stem cells
  JOURNAL   Oncogene 35 (47), 6109-6119 (2016)
   PUBMED   27157623
  REMARK    GeneRIF: Tacc3 is required for the proper mitosis of Apc-deficient
            ISCs, and its disruption significantly attenuated the expansion of
            the crypt domain. In vivo analysis of corresponding mutant mice
            demonstrated that Tacc3 disruption led to a significant decrease in
            tumor number and prolonged survival.
REFERENCE   6  (bases 1 to 2209)
  AUTHORS   Piekorz,R.P., Hoffmeyer,A., Duntsch,C.D., McKay,C., Nakajima,H.,
            Sexl,V., Snyder,L., Rehg,J. and Ihle,J.N.
  TITLE     The centrosomal protein TACC3 is essential for hematopoietic stem
            cell function and genetically interfaces with p53-regulated
            apoptosis
  JOURNAL   EMBO J 21 (4), 653-664 (2002)
   PUBMED   11847113
  REMARK    GeneRIF: role in hematopoietic stem cell function and interface
            with p53-regulated apoptosis
REFERENCE   7  (bases 1 to 2209)
  AUTHORS   McKeveney,P.J., Hodges,V.M., Mullan,R.N., Maxwell,P., Simpson,D.,
            Thompson,A., Winter,P.C., Lappin,T.R. and Maxwell,A.P.
  TITLE     Characterization and localization of expression of an
            erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid
            precursor cells
  JOURNAL   Br J Haematol 112 (4), 1016-1024 (2001)
   PUBMED   11298601
REFERENCE   8  (bases 1 to 2209)
  AUTHORS   Sadek,C.M., Jalaguier,S., Feeney,E.P., Aitola,M.,
            Damdimopoulos,A.E., Pelto-Huikko,M. and Gustafsson,J.A.
  TITLE     Isolation and characterization of AINT: a novel ARNT interacting
            protein expressed during murine embryonic development
  JOURNAL   Mech Dev 97 (1-2), 13-26 (2000)
   PUBMED   11025203
REFERENCE   9  (bases 1 to 2209)
  AUTHORS   Stebbins-Boaz,B., Cao,Q., de Moor,C.H., Mendez,R. and Richter,J.D.
  TITLE     Maskin is a CPEB-associated factor that transiently interacts with
            elF-4E
  JOURNAL   Mol Cell 4 (6), 1017-1027 (1999)
   PUBMED   10635326
  REMARK    Erratum:[Mol Cell 2000 Apr;5(4):following 766]
REFERENCE   10 (bases 1 to 2209)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     The third member of the transforming acidic coiled coil-containing
            gene family, TACC3, maps in 4p16, close to translocation
            breakpoints in multiple myeloma, and is upregulated in various
            cancer cell lines
  JOURNAL   Genomics 58 (2), 165-170 (1999)
   PUBMED   10366448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162898.10.
            
            On Apr 22, 2022 this sequence version replaced NM_001310541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003252.1, SRR17253011.9565772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC162898.10        34926-35068
            144-306             AC162898.10        37563-37725
            307-431             AC162898.10        37862-37986
            432-513             AC162898.10        40162-40243
            514-1102            AC162898.10        40608-41196
            1103-1155           AC162898.10        43034-43086
            1156-1280           AC162898.10        43384-43508
            1281-1371           AC162898.10        44304-44394
            1372-1473           AC162898.10        44475-44576
            1474-1550           AC162898.10        45003-45079
            1551-1594           AC162898.10        45159-45202
            1595-1764           AC162898.10        45819-45988
            1765-1871           AC162898.10        47745-47851
            1872-1992           AC162898.10        48006-48126
            1993-2209           AC162898.10        48323-48539
FEATURES             Location/Qualifiers
     source          1..2209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..2209
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /note="transforming, acidic coiled-coil containing protein
                     3"
                     /db_xref="GeneID:21335"
                     /db_xref="MGI:MGI:1341163"
     exon            1..143
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..306
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2058
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ARNT-interacting protein"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 3 isoform 1"
                     /protein_id="NP_001297470.1"
                     /db_xref="CCDS:CCDS80258.1"
                     /db_xref="GeneID:21335"
                     /db_xref="MGI:MGI:1341163"
                     /translation="MSLHVLNDENVPNEKSSQCRDFQFLPPELTGRSSVLCLSQKENV
                     PPQSQAKATNVTFQTPPRDPQTHRILSPNMTNKREAPFGLQNDHCVFLQKENQRPLAP
                     VDDAPVVQMAAEILRAEGELQEGILTSSSLSASTSLLDSELVTPPIEPVLEPSHQGLE
                     PVLESELVTPPVEPVLEPSHQELEPVLESELVTPPIEPVLEPSHQGLEPVLDSELVTP
                     PIEPVLEPSHQGLEPVLESELVTPPIEPVLEPSHQGLEPVLDSELVTPPIEPVLEPSH
                     QGLEPVLDSELVTPPIEPLLEPSHQGLEPVVDLKEESFRDPSEVLGTGAEVDYLEQFG
                     TSSSHLSNSQFKESAWRKQSLYVKFDPLLKDSPLRPMPVAPITNSTQDTEEESGSGKP
                     TEAELVNLDFLGDLDVPVSAPPLCVLEPRGLLPAEPIVDVLKYSQKDLDAVVNVMQQE
                     NLELKSKYEDLNTKYLEMGKSVDEFEKIAYKSLEEAEKQRELKEIAEDKIQKVLKERD
                     QLNADLNSMEKSFSDLFKRFEKRKEVIEGYQKNEESLKKYVGECIVKIEKEGQRYQAL
                     KIHAEEKLRLANEEIAQVHSKAQAEVLALQASLRKAQMQNHSLEMTLEQKTKEIDELT
                     RICDDLISKMEKI"
     exon            307..431
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..513
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1102
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1155
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1280
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1371
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1473
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1550
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1594
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1764
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1871
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1992
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2209
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /note="hexamer: ACTAAA"
     polyA_site      2209
                     /gene="Tacc3"
                     /gene_synonym="Aint; Eric1"
                     /note="major polyA site"
ORIGIN      
        1 gttccgggac tgcgagagcg gaccttgttg gggttccttc ggctgggttt ctcctgctcc
       61 gttttcttag cgcgaagcgg gcacggcgct cctcccttgc ggtgggcgtc cgcgcgggcc
      121 cagggcttgg caaccgtagt cagaatgagt ctgcatgtct taaatgacga aaacgtgccc
      181 aatgaaaaga gttcacagtg ccgtgatttc cagtttttgc caccagaact taccggcaga
      241 tcatctgttc tttgtctgtc acagaaagaa aatgtaccac cccagagcca ggctaaggcc
      301 acaaatgtga cgttccagac accacctcgg gatccacaga cacacaggat cttaagtcct
      361 aacatgacca ataagcgtga ggctcctttt ggattacaaa atgaccactg tgtcttctta
      421 cagaaagaaa accagcggcc tttagcccca gtggatgatg cacctgtggt tcaaatggca
      481 gctgagatcc taagagcaga aggcgagtta caggagggaa tcttgacttc ctcaagcctt
      541 tcagcttcca caagtcttct ggacagtgag ctggtgaccc ctcctatcga gccagtgctg
      601 gagccttccc atcagggact agaacctgtc ttggaaagtg agctggtgac ccctcctgtt
      661 gagccagtgc tggagccttc ccatcaggaa ctagaacctg tcttggaaag tgagctggtg
      721 acccctccta ttgagccagt gctggagcct tcccatcagg gactagaacc tgtcttggac
      781 agtgagctgg tgacccctcc tattgagcca gtgctggagc cttcccatca gggactagaa
      841 cctgtcttag aaagtgagct ggtgacccct cctattgagc cagtgctgga gccttcccat
      901 cagggactag aacctgtctt ggacagtgag ctggtgaccc ctcctattga gccagtgctg
      961 gagccttccc atcagggact agaacctgtc ttggacagtg agctggtgac ccctcctatc
     1021 gagcctttgc tggagccttc ccatcaggga ctagaacctg tcgtggatct aaaggaagag
     1081 agcttcagag acccatcaga agtcctaggt actggtgctg aagtggatta tctggagcag
     1141 tttggaactt cctcgtccca tctctccaac tctcagttta aggagtcggc ctggaggaag
     1201 cagtctttgt acgtgaaatt tgaccctctt ctgaaagaca gccctttgcg gccaatgccg
     1261 gtggccccaa taacaaatag tacacaggat acagaggagg agtctggttc tggaaagccg
     1321 acagaagctg agcttgtcaa cttagatttc ttgggagatt tggatgttcc ggtatctgcc
     1381 ccacccctgt gtgtccttga gcctcgaggt ctccttcctg ctgagcctat tgtggatgtg
     1441 ctgaagtaca gccagaaaga cctggatgca gtggtgaatg tgatgcagca ggagaacttg
     1501 gagctgaaaa gcaagtatga ggacctcaac acaaaatatt tggagatggg gaagtccgtt
     1561 gatgagtttg agaagatcgc gtacaaatca ttggaggagg ctgagaaaca gagggaacta
     1621 aaggaaatag ctgaagacaa aatccaaaag gttttaaaag agagagacca acttaatgca
     1681 gacctgaact ccatggaaaa gtccttttct gaccttttca aacggtttga gaagcggaag
     1741 gaagtgattg aaggctacca gaagaatgaa gagtcactga agaagtatgt tggggaatgc
     1801 atagtgaaaa ttgaaaaaga aggccagagg taccaggcgc tgaagatcca tgcagaagaa
     1861 aagctcaggc tggcaaatga ggagatcgcc caggtacaca gcaaggccca agcagaggta
     1921 ctggctttgc aggcaagcct gaggaaggca caaatgcaga accactcgct ggagatgact
     1981 ctggagcaga agacaaaaga aattgatgag ctgacccgga tctgtgatga cctcatctct
     2041 aagatggaga agatctgagc acagccagct ataaccagcg ctcttctgtc tgtctaccca
     2101 tttatttcct tatctgtctg atttatctct tacgtgtggt ttatttaacc tctgttcatt
     2161 tctaaattac tttattttga aaagactaaa gtttaatctc aaactcaaa
//
