LOCUS       NM_001004468            9253 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus transforming, acidic coiled-coil containing protein 2
            (Tacc2), transcript variant 3, mRNA.
ACCESSION   NM_001004468
VERSION     NM_001004468.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9253)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9253)
  AUTHORS   Mallampalli,R.K., Li,X., Jang,J.H., Kaminski,T., Hoji,A., Coon,T.,
            Chandra,D., Welty,S., Teng,Y., Sembrat,J., Rojas,M., Zhao,Y.,
            Lafyatis,R., Zou,C., Sciurba,F., Sundd,P., Lan,L. and Nyunoya,T.
  TITLE     Cigarette smoke exposure enhances transforming acidic
            coiled-coil-containing protein 2 turnover and thereby promotes
            emphysema
  JOURNAL   JCI Insight 5 (2), 125895 (2020)
   PUBMED   31996486
  REMARK    GeneRIF: Cigarette smoke exposure enhances transforming acidic
            coiled-coil-containing protein 2 turnover and thereby promotes
            emphysema.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9253)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   4  (bases 1 to 9253)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9253)
  AUTHORS   Tei,S., Saitoh,N., Funahara,T., Iida,S., Nakatsu,Y., Kinoshita,K.,
            Kinoshita,Y., Saya,H. and Nakao,M.
  TITLE     Simian virus 40 large T antigen targets the microtubule-stabilizing
            protein TACC2
  JOURNAL   J Cell Sci 122 (Pt 17), 3190-3198 (2009)
   PUBMED   19671663
REFERENCE   6  (bases 1 to 9253)
  AUTHORS   Schuendeln,M.M., Piekorz,R.P., Wichmann,C., Lee,Y., McKinnon,P.J.,
            Boyd,K., Takahashi,Y. and Ihle,J.N.
  TITLE     The centrosomal, putative tumor suppressor protein TACC2 is
            dispensable for normal development, and deficiency does not lead to
            cancer
  JOURNAL   Mol Cell Biol 24 (14), 6403-6409 (2004)
   PUBMED   15226440
  REMARK    GeneRIF: Results suggest that TACC2 is not required for mouse
            development and normal cell proliferation and is not a tumor
            suppressor protein.
REFERENCE   7  (bases 1 to 9253)
  AUTHORS   Still,I.H., Vettaikkorumakankauv,A.K., DiMatteo,A. and Liang,P.
  TITLE     Structure-function evolution of the transforming acidic coiled coil
            genes revealed by analysis of phylogenetically diverse organisms
  JOURNAL   BMC Evol Biol 4, 16 (2004)
   PUBMED   15207008
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 9253)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 9253)
  AUTHORS   Piekorz,R.P., Hoffmeyer,A., Duntsch,C.D., McKay,C., Nakajima,H.,
            Sexl,V., Snyder,L., Rehg,J. and Ihle,J.N.
  TITLE     The centrosomal protein TACC3 is essential for hematopoietic stem
            cell function and genetically interfaces with p53-regulated
            apoptosis
  JOURNAL   EMBO J 21 (4), 653-664 (2002)
   PUBMED   11847113
REFERENCE   10 (bases 1 to 9253)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Ivan Still. The reference sequence was derived
            from AC175034.1 and AC145294.4.
            
            On Feb 22, 2019 this sequence version replaced NM_001004468.2.
            
            Summary: This gene encodes a member of the transforming, acidic
            coiled-coil (TACC) family of proteins. Members of this family are
            centrosomal proteins that interact with microtubules and tubulin.
            TACC proteins are thought to be involved in centrosome/mitotic
            spindle dynamics and gene regulation. Alternative splicing of this
            gene results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164133,
                              SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC175034.1         10589-10667         c
            80-180              AC145294.4         33489-33589
            181-5301            AC145294.4         53373-58493
            5302-5427           AC145294.4         94668-94793
            5428-5565           AC145294.4         106254-106391
            5566-5702           AC145294.4         148355-148491
            5703-7008           AC145294.4         160175-161480
            7009-7044           AC145294.4         163183-163218
            7045-7105           AC145294.4         165158-165218
            7106-7385           AC145294.4         166601-166880
            7386-7447           AC145294.4         171464-171525
            7448-7563           AC145294.4         172492-172607
            7564-7735           AC145294.4         173782-173953
            7736-7876           AC145294.4         175196-175336
            7877-7966           AC145294.4         176179-176268
            7967-8110           AC145294.4         182842-182985
            8111-8187           AC145294.4         183486-183562
            8188-8231           AC145294.4         185270-185313
            8232-8392           AC145294.4         190817-190977
            8393-8499           AC145294.4         191186-191292
            8500-8620           AC145294.4         191567-191687
            8621-9253           AC145294.4         195906-196538
FEATURES             Location/Qualifiers
     source          1..9253
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.19 cM"
     gene            1..9253
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /note="transforming, acidic coiled-coil containing protein
                     2"
                     /db_xref="GeneID:57752"
                     /db_xref="MGI:MGI:1928899"
     exon            1..79
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..8686
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /note="isoform c is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 2 isoform c"
                     /protein_id="NP_001004468.1"
                     /db_xref="CCDS:CCDS21903.1"
                     /db_xref="GeneID:57752"
                     /db_xref="MGI:MGI:1928899"
                     /translation="MGNENSTSDHQRTSSVQSPRSLQPPGKSQSLQKQQGDLPGSCAG
                     STGLGGSCSASESVASLDPCTVSPEVAEQGEHPQEARGPEGSPLPRSSLPWEQPCPSA
                     SMPFTEGPSEGCLASSEAEAPEDSTLTNHLRMEPSPNIPGNILPTSTPEVDGPTQHSM
                     AARTPSAEGDKELKEEGPNSSSNRTGQLPGISLVPLQEPRTELLSGEGTGPRDFEFQR
                     KEDMDDCPSPESATKAPAATQPGMQNSADLESPPKLETMVPQDSVLRSSDRERDGVEV
                     LPTCSAKNLEFLEGCHPSKSNSRAIPGSGTSTASQESCQQKVEMHLPYAELPSGPPGL
                     TTAPANSGSWKETLDTSDAQRQPQTGTSGTELQQVVCVAAASQLNGSFLLSAEAPLFT
                     RTEETSSSASSPTAHAAAWNSVASEESTETVSETKMSVSADLAATEQMDTGVAERKPT
                     SDLRKTQEQPEGSLQQVPAPFLQGQNDTVQQGLLLPTFSHGISNESSVEPTDGPKAPK
                     NTQNRVVAREESRSHGDNLEGQQEATRALAGAEPGNHDEEKSQAFHSKPHLETKKGEV
                     SKAHSNTENKIVPSSDSTQPLRQEVAGHRDGSHSGSAEVVGQVVAESHVTDTATSLHK
                     LHEEDPILSSASDGTGEHFLPQEAIWESSRSQTKSPVMLQDRGGLEAIESLPALESEK
                     GDFLPATAAEEVPKAGEMEDILEVKKSHSPFHPPFSCDGEGLLMSPGQPCGVEKVEPG
                     QEVHADASSPRNGKDSTIGHGLAVLSLEQDCQRKLSCPEDSLPPSPKNRLQPSQLDPE
                     ASISAILCDKNQPPTNGQKACQSDPGLKKQSTDPSSILVPEERKPWADVSLSTQGGNE
                     QGSELPSKGSPCNTPSSSPKDKVLEGAPPSEMSELSTPLGQESPALGGNEQEGTGSSS
                     QLSEIPPPAAATALTENLGGKDSLSTGQGLSKSQQELDDALQIGSLREEARCGDSGLS
                     EAGDVLPPPLGLDKTETASRNRVEALPCPPDSVALLDTAHYSPDPVPTNPRVTLTQDA
                     LESEACDEGQKESAPQLEMEQPAPLGTEAQSPLGSFQKAEERDGKGGSAEVNVDASEG
                     DPGMQQASEAPEPALSSGFLQADQSLASTLSEPRQLVQLEPSCGDALLPAGETDGMPR
                     SSVDVLTQHTVSGPQSLLPAEPPDTPYLHINSAARKDAEDGSTRGAVSSEDPGAPHES
                     PVKEPPPALENDTLEKTPAVSFTTVLQPGTADGDISAAGDGNSIGIPQAGTTEGHVSF
                     MPYLDRMPLPVRDEQMAREMHVAAAPEANARPSEIAACPASEDAAGEREGNRERPVEL
                     TPDLRVVASGSEGASSKQTSIIAGLPDFREHITKIFEQSVLGALAADRPHSKKSGVPR
                     NVLFEGPDVSLNSEKLLDGAQGVAAALLPVPPAGLQVEKKQESAVEAESSHQVPQDPA
                     SEKMMGLVGTALEESRPGASVEGERTGEPVQGTQAHSQQARSRQELTVGLPSSAAVQG
                     LPAERAPDFPVAPQSHADVDEASAQGDKSHSIKEHLETLPSNGQQREDGTWDPTHTKG
                     LTNLSGSPCALNGSSHGSVLNVPEPISEPLIPSTLEGDRQIEAAVSTANMQNMLGNQD
                     APKMLAGGVLTTPLDPSKMARAAEEAEGDVTPSRAETWACASGDLLETGTTRMLPGVA
                     GNSAHPGSFQDSGCSNRAQVMEEDAATLQGDSQVEDQQAKQQLGPQLPTPVGHGKPSI
                     SSPPEPDESKDEKLHLVAPEELLSDSIPGTDDVIQPAAPVDPGHPPLADSSHHGDAVS
                     SVSTHLTVQSASPSAARASPAPLAPEHTASAPSAAGPGVEVTPTASPQHLAKNEPRSS
                     DSEEAFETPESTTPVKAPPAPPPPPPEVTPEPEVIDPPAPEEPGCISEPPVVVPDGPR
                     SSESVEGSPFRPSHSSSAVFDEDKPIASSGTYNLDFDSIELVDNFQSLEPCSADSKGQ
                     ECKVSTRRKSTESVPPSKSTLSRSLSLQASDFDGASCPGSPEAGTLTTDACGTGSNSA
                     SSTLKRTKKTRPPSLKKKQATKKPTETPPVKETQQEPGEESPVPSEEHLAPETKTESA
                     TPEGAGCTLSDDTPLESPAVPTATCPLTLESAEDVSPLVSGGGRVQNSPPVGRKSVPL
                     TTASEAVEVTLSDSGGQEDLPAKGLSVRLEFDYSEDKGSWESQQENAPPTKKIGKKPV
                     AKMPLRRPKMKKTPEKLDNTPASPPRSPTEPSDTPIAKGTYTFDIDKWDDPNFNPFSS
                     TSKMQESPKLSQQSYNFDPDACEESLDPFKASSKTPSSPSKSPASFEIPASTTEADGD
                     GLNKPAKKKKTPLKTMVEDVMSVCSLFDTFRVKKSPKRSPLSDPPSQDPTPAATPEAP
                     SAISTVVHATDEEKLAVTSQKWTCMTVDLDADKQDFPQPSDLSNFVNETKFNSPSEGK
                     QLGGQPDPHLALENTVPRGQRARKELDYRNSYEIEYMEKLGSSLPQDDDTPKKQALYL
                     MFDTPQESPVKSPPVRMSDSPTPCSGSSFEDTEALVNAATKLQHPVARGLPSSQEPLL
                     QVPEKPSQKELEAMALGTPAEAIEITAPEGAFASADTLLSRLAHPASLCGALGYLEPD
                     LAEKNPPVFAQKLQEELEFAVMRIEALKLARQIALASRSRQDTKREAAHPPDVSISKT
                     ALYSRIGSTEVEKPPGLLFQQPDLDSALQVARAEVIAKEREVSEWRDKYEESRREVVE
                     MRKIVAEYEKTIAQMIEDEQREKSISHQTVQQLVLEKEQALADLNSVEKSLADLFRRY
                     EKMKEVLEGFRKNEEVLKKCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRG
                     KAQQEQAAYQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS"
     exon            80..180
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            181..5301
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            5302..5427
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..5565
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            5566..5702
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            5703..7008
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7009..7044
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7045..7105
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7106..7385
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7386..7447
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7448..7563
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7564..7735
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7736..7876
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7877..7966
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            7967..8110
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            8111..8187
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            8188..8231
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            8232..8392
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            8393..8499
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            8500..8620
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     exon            8621..9253
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9125..9130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /note="hexamer: AATAAA"
     polyA_site      9152
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /note="major polyA site"
     regulatory      9203..9208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
                     /note="hexamer: ATTAAA"
     polyA_site      9224
                     /gene="Tacc2"
                     /gene_synonym="mKIAA4180"
ORIGIN      
        1 tcactctgac caacattgcg agggacgctg ggcaccctga gtcaccatgg gcaacgagaa
       61 cagcacctcg gaccaccaga ggacttcttc agttcagagt ccaaggtcac tgcagccacc
      121 tgggaagagt caatctctac agaagcaaca aggagacttg cctggatcgt gtgctggaag
      181 cactgggcta ggaggctcct gctctgcttc tgaaagtgtt gccagcctgg acccgtgcac
      241 tgtgtctcca gaggtggctg agcaagggga gcacccccag gaagccagag gcccagaagg
      301 ttctccactg cccagatcat ctctgccctg ggaacagccg tgcccctcag cctccatgcc
      361 cttcacagag ggcccctcag aaggttgctt ggccagctca gaagcagaag ctcctgaaga
      421 cagcaccctg acaaatcacc ttaggatgga accctccccc aacatcccag ggaacatctt
      481 accgacatcc actcctgaag tagatggccc cacacagcac tcaatggctg ccagaacccc
      541 tagtgctgaa ggagacaaag agctgaagga agagggacca aattcatcct ccaatcgcac
      601 tggccaattg ccaggaattt ccctagttcc tctccaggag ccaaggacag agctgctgtc
      661 tggagagggc actgggcctc gtgactttga gttccaaagg aaagaggata tggatgactg
      721 tccctcccca gagtcagcaa ccaaagcccc tgctgccact cagccaggga tgcaaaactc
      781 agctgacctt gagtctcccc caaaacttga gactatggtc ccacaagatt cagtcctaag
      841 atcatcagac agagaaagag atggagtgga ggtgctacct acgtgttcag ccaagaattt
      901 ggaatttctc gaaggctgcc atccctctaa aagcaactcc agagctatcc ctggatcagg
      961 gacaagcact gcctcccagg aaagctgcca gcagaaagtg gaaatgcatc tgccatatgc
     1021 agaactgccc tcaggcccac caggtcttac cacagcacca gcaaacagtg gctcctggaa
     1081 agagactctg gacaccagcg atgctcagag gcaaccacag acagggacat cgggaactga
     1141 gctccagcaa gttgtctgtg tggcagcagc cagccagctg aatgggagct tccttctgag
     1201 tgctgaggct cctctcttca ctagaacaga ggaaacttca agctcagctt caagtcccac
     1261 tgcacacgca gctgcttgga attcggttgc ctcagaagaa tccacagaga ctgtttctga
     1321 gacaaagatg tcagtttctg cagatctggc tgccacagaa cagatggata caggggtggc
     1381 agaacggaag ccaacatcag atcttagaaa aacgcaagaa caaccagaag gtagcctcca
     1441 gcaggttcct gcacctttct tgcaggggca aaatgataca gtccaacaag ggctgttgct
     1501 gccaactttc tcccatggca tttcaaatga aagttcagtg gaaccaactg atggtcccaa
     1561 ggcccccaag aatactcaaa atagagttgt ggctagagag gaaagcagat cacatggaga
     1621 caaccttgag ggacagcaag aagccaccag agcccttgct ggtgcagagc ctgggaacca
     1681 tgatgaagag aagtctcaag cctttcacag caagccccat ctggagacca agaaaggtga
     1741 ggtttcaaag gcacacagta atacagagaa caaaatcgtt cccagctcag actcaacaca
     1801 gccacttaga caggaggttg ctggccacag ggatgggtcc cactctggat cagcagaggt
     1861 agtggggcag gtggttgctg aatcccatgt gactgacaca gctacctcac tgcacaaact
     1921 ccatgaggag gaccccatcc tgtcctcagc atcagatggc actggtgagc actttcttcc
     1981 ccaagaagcc atctgggaaa gttcaagatc tcagaccaaa agcccagtca tgcttcagga
     2041 caggggagga ttggaagcaa tagagtcact tcctgcttta gaatctgaga aaggagattt
     2101 cctgcctgct acagctgcgg aggaggtacc caaagctggg gagatggagg atatattgga
     2161 agtaaagaag agccactcac cctttcatcc gcctttcagc tgtgatgggg aaggcttgct
     2221 gatgtcccca ggccaacctt gtggggtgga gaaggttgaa cctggacagg aagtccatgc
     2281 tgatgcgtca tctccccgca atgggaaaga ctcaacaata ggccatggac ttgctgtgct
     2341 cagtctggaa caagactgtc agagaaaact gtcttgccca gaggacagtc tcccaccatc
     2401 tccaaagaac cgtctccagc catctcaact agacccagaa gcgtccatct ctgctattct
     2461 ctgtgacaag aaccaaccac ctacaaatgg gcaaaaggct tgtcaaagtg acccaggtct
     2521 gaagaagcag agtacagatc cttcctcaat cctggtacct gaggaaagga agccttgggc
     2581 agatgtgagc ttgtccactc aaggaggaaa cgagcagggg tcagagcttc cctccaaagg
     2641 cagcccatgc aatactccaa gttcatcacc caaggataaa gttctggaag gagcaccacc
     2701 gtcagagatg tcagaactgt caaccccact gggacaagag tcgcctgcac tagggggaaa
     2761 tgagcaagag ggcacaggca gcagtagtca gctctcagag atcccgcctc ctgcagcagc
     2821 caccgctctt acagaaaact tgggtgggaa ggatagtctc tctactgggc aggggctgag
     2881 caagtcccaa caggagctgg atgatgcttt gcaaataggc agcctgcgtg aagaagcacg
     2941 ttgtggggac tcgggccttt ctgaagccgg tgacgtactg cctccgcctc tgggcttgga
     3001 taagacagag acagcaagta gaaacagagt ggaggccctg ccctgtccac ctgactcagt
     3061 agctctcctg gatacagcac actactctcc agacccagtg cctaccaatc ccagagtcac
     3121 actcacccag gatgccctag agagcgaggc ctgtgatgag ggccagaaag agtcggcccc
     3181 acagctggaa atggagcagc cggccccctt gggtacagaa gcacagagtc ctcttggaag
     3241 tttccagaaa gcagaggaac gagatggtaa aggtggatct gccgaagtga acgtcgatgc
     3301 cagtgaagga gaccccggga tgcagcaggc ttcagaggca ccagaacctg ctctgagtag
     3361 tggcttcctt caggctgacc agagcctcgc ctccaccctg agtgagccac gccaacttgt
     3421 gcagcttgag cccagctgcg gggatgcctt gctgccagct ggagaaacag acgggatgcc
     3481 cagaagttct gtggacgttc tgacacagca cactgtttca ggcccacaga gccttctgcc
     3541 ggctgaacca cctgacaccc cttacctgca tatcaatagt gctgccagga aggatgcaga
     3601 agatggaagc acgagaggag ccgtttcctc tgaggacccc ggagcacctc atgaaagtcc
     3661 tgtaaaggag cctccacctg ctttggaaaa tgacaccctt gaaaagacac ctgctgtctc
     3721 cttcaccaca gtcttgcaac caggaactgc agatggggac atctctgcag cgggggatgg
     3781 taatagtatc ggtatccccc aagctggaac cactgagggg cacgtgagtt tcatgcccta
     3841 cctggacagg atgcctctcc cggtcagaga cgagcagatg gcaagggaga tgcatgtggc
     3901 tgctgctcca gaagcaaatg ccaggccctc tgagatcgca gcatgccctg ccagtgagga
     3961 tgcagcagga gagagagagg ggaacaggga gaggccagta gaacttaccc cagatctgag
     4021 ggttgttgca tcaggtagcg agggtgcaag ctccaagcag accagcataa tagcggggct
     4081 tcctgatttt agggagcata tcaccaagat ctttgagcag tctgtgcttg gagccctggc
     4141 tgctgaccgg ccccatagta aaaagtcagg agttccaagg aatgtgctgt ttgagggtcc
     4201 tgatgtctca ctgaactcag agaagcttct agatggggca caaggagtgg ctgctgccct
     4261 tctccctgta cctcctgcag gactccaggt tgagaagaag caagagtcag ctgttgaggc
     4321 tgagagttct catcaagtac cccaggatcc agcatcagag aagatgatgg gtctggtggg
     4381 gacagccttg gaggagagca ggccaggtgc cagtgttgaa ggagagagga ctggagagcc
     4441 tgttcaggga actcaggctc actcacagca ggcaagaagc aggcaggaat taacagtggg
     4501 ccttccctct tctgcagctg ttcaggggct accagcagaa agagcccctg acttccctgt
     4561 ggctccccag agccatgcag atgtagatga ggcttctgct caaggtgaca aaagccattc
     4621 cataaaagag cacctggaaa cattgcccag caacggtcaa caaagagaag atggtacctg
     4681 ggaccctact cacaccaagg gtctaactaa tctatcagga tccccctgtg ccctgaatgg
     4741 ctcttctcat ggaagtgttt tgaatgtgcc tgaacctatc agtgagccct tgatcccttc
     4801 cacacttgag ggtgacagac agattgaagc tgctgtcagt actgcaaaca tgcaaaatat
     4861 gctgggcaac caggatgccc ccaaaatgct ggctggagga gtgttgacta ctcccctgga
     4921 tcccagcaaa atggcaagag ctgctgagga agcagaaggt gatgtcacac caagcagggc
     4981 tgagacgtgg gcatgtgcgt ctggtgacct ccttgaaaca ggtactacaa ggatgcttcc
     5041 cggtgtggca ggtaactcag cacatcctgg gagctttcag gactcaggat gttctaacag
     5101 ggctcaggtg atggaggagg atgcagccac ccttcaaggg gacagccagg ttgaagacca
     5161 gcaagccaag caacagctgg gccctcagct ccctactcct gtagggcatg ggaagccgag
     5221 tatctcttct cctccagagc ctgatgagag caaagatgaa aagctgcacc tggtggctcc
     5281 agaagaactc ctcagtgaca gtatccctgg aactgatgat gtcatccagc cagctgctcc
     5341 tgttgacccg ggacacccac ccttagctga ctcgtcccac catggtgacg ctgtcagctc
     5401 agtctctaca catctgacag tccagagcgc ctccccatct gctgcccgtg caagtcctgc
     5461 tcctttggcc ccagaacata cagcctcggc tccctccgca gccggtcctg gagtagaagt
     5521 cacccccact gcctcccccc aacacctggc caagaacgaa cccaggagtt ccgactctga
     5581 ggaagccttt gagacccccg agtcaacgac ccctgtcaaa gctccaccag cccctccccc
     5641 tccaccccct gaagtcaccc cagagcctga ggtcatcgat ccaccagccc cagaagaacc
     5701 aggatgcatt tctgagccac cggttgtggt tcccgatggc cctcgcagca gcgagtccgt
     5761 ggaaggaagc cctttccgtc cttcccactc ctcctcggcg gtgttcgatg aagacaagcc
     5821 gatagccagc agcgggactt acaacttaga cttcgacagc atcgagctgg tggataactt
     5881 ccagagcttg gagccgtgct ctgccgactc taagggtcag gagtgtaagg tgagcacgcg
     5941 gaggaaatcc accgagtccg tgccaccctc caagtccacg ctgtcccgtt cgcttagcct
     6001 acaagccagt gactttgacg gtgcttcttg ccccggcagc cctgaagctg ggacccttac
     6061 cacagatgca tgtggcacag gatccaacag tgcttccagc acccttaagc gaactaaaaa
     6121 aacacggcca ccttccttga aaaagaagca agccaccaag aaacccacag aaaccccccc
     6181 agtgaaggag acccaacagg aaccaggtga agagagtcca gtccccagtg aggaacactt
     6241 agcaccagag acaaagacgg agtcggccac acctgagggc gctggttgca ccttgtcaga
     6301 cgatacaccc ctggagtccc ctgctgtccc cacagccacc tgtcctctga ctttggagag
     6361 tgcagaagac gttagccccc tggtttctgg aggtggcaga gtgcagaact cacccccagt
     6421 tgggaggaaa tcagtgcctc ttaccacagc ctctgaggcg gtggaggtga ccctgtcgga
     6481 cagtgggggg caagaggact tgcctgccaa ggggttgtca gtgaggctgg agtttgacta
     6541 ttctgaggac aagggaagtt gggagagtca gcaggaaaac gcccctccca ccaaaaagat
     6601 aggcaagaag ccagttgcca aaatgcccct aaggaggcca aagatgaaaa agacccccga
     6661 gaaacttgac aacactcctg cctcacctcc aaggtcccct actgaaccca gtgacacccc
     6721 tattgctaaa ggtacctaca cctttgatat agacaagtgg gatgacccca attttaaccc
     6781 tttttcctcc acctcaaaaa tgcaagagtc tcccaaactg tcccaacaat cgtacaactt
     6841 tgaccctgac gcctgtgaag agtcccttga cccctttaag gcatcctcta agacccccag
     6901 ctcaccttct aagtccccag cctcttttga gatcccagcc agcaccacgg aagcggatgg
     6961 ggatgggttg aataaacctg ccaagaagaa gaagactcca ctaaagacga tggttgaaga
     7021 tgtgatgtct gtgtgttctc tgtttgacac gtttagggtg aagaagtctc caaagcggtc
     7081 tcctctgtct gacccgcctt ctcaggaccc cactccagct gccacgccgg aagcaccctc
     7141 agccatctct acagtggtcc acgccacaga tgaggagaag ctggcagtca ctagccagaa
     7201 gtggacgtgt atgacggtgg acttggatgc tgacaaacag gacttccctc agccctcgga
     7261 cctgtctaac tttgtaaatg agaccaaatt caattcaccc tcagagggta agcaactcgg
     7321 tggccagcca gacccacacc ttgccttgga gaatactgtc cctagggggc aaagagccag
     7381 aaaagagctg gactacagaa actcctatga aattgaatac atggaaaagc ttggctcctc
     7441 cttacctcag gacgatgaca ctccgaagaa gcaggccttg taccttatgt ttgacactcc
     7501 tcaggagagc cccgtcaagt ctcctccagt ccggatgtca gattccccaa ctccatgttc
     7561 agggtcgagt tttgaggaca ccgaagccct tgtgaatgca gcaacaaagc tccagcatcc
     7621 agtcgcaaga ggtctgccct ccagtcagga gcctctcttg caggtgcctg agaagccctc
     7681 ccagaaggag ctggaggcca tggccttggg caccccagca gaagcaattg aaatcacagc
     7741 tcccgagggt gcctttgctt ctgcagatac cctcctcagc aggctggccc atcccgcctc
     7801 tctctgtggt gcacttggct atctggagcc tgacttagca gaaaagaacc ccccagtatt
     7861 tgcccagaaa cttcaggagg agttagagtt tgctgtcatg cggatagaag ccctgaagct
     7921 ggccaggcag atcgccctgg cttcccgcag ccgccaggac accaagaggg aagctgctca
     7981 cccaccagat gtctccatct ccaaaactgc cttgtactcc cgcatcgggt ccaccgaggt
     8041 ggagaaaccc ccaggccttc tgttccagca gccagacctg gactctgcac tccaggttgc
     8101 cagagcagag gtcatcgcca aggagagaga agtctcagag tggagggata aatatgaaga
     8161 aagccgacgg gaagtggtgg aaatgaggaa aattgtggcc gaatatgaga agaccattgc
     8221 acagatgatc gaggacgaac agagagaaaa atccatctcc caccaaactg tacagcagct
     8281 ggtcctggag aaggagcaag ccctggctga cctgaactct gtggaaaagt ctctggctga
     8341 cctcttcagg agatacgaaa agatgaagga ggtcctggaa ggttttcgaa agaatgaaga
     8401 ggtgttgaag aaatgtgcgc aggagtacct atcccgagtg aagaaagagg aacagaggta
     8461 ccaggccctg aaggtgcacg ccgaagagaa actggacaga gccaatgcag agattgccca
     8521 ggttcgcggc aaggcccagc aagagcaagc agcctaccag gctagcctgc ggaaggagca
     8581 gcttcgagtg gatgctctgg aaagaacgct ggagcagaag aataaagaga tagaagaact
     8641 caccaagatt tgtgacgagc tgatcgccaa gatgggaaaa agctaactct gggccaagtg
     8701 cgtggacttg gccgttgcgt gcaatacgag cgtcggctca actgtttgtc cttccgattc
     8761 cgtgaacagc gtctcctttc acttccgtat gcactactgt gtcctctttc taaataaggt
     8821 tggtttgacc gtatgcagtg ccgagaccta ccaggattcc ttgctatccg tttgcatttt
     8881 ctagtataat tcatagcaag ttgacctcgg agttcctgta tcagggagac tgtcagattc
     8941 tctaatagac tacaaattgc tggccttggc cttggccttt ggcgagcagc atctgatggg
     9001 acgtgaacat atgcatcggg actcttgcct taaggagtgt acaattgatc cacatttgct
     9061 ggtttggttt tttaggaaaa aaaaaaaaaa agaatgcatg tttcaaataa aattctctat
     9121 tgtaaataaa gttttttctt tgagtcttgg cagcgagtgt ggctgtgagt tattttctgg
     9181 gaatggctga gtcctttcct tcattaaatc atatcaggtt ttggtctctg cctcttttgc
     9241 ttattgattt aaa
//
