LOCUS       NM_053093               1262 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus tachykinin 4 (Tac4), mRNA.
ACCESSION   NM_053093
VERSION     NM_053093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Nethander,M., Moverare-Skrtic,S., Kampe,A., Coward,E., Reimann,E.,
            Grahnemo,L., Borbely,E., Helyes,Z., Funck-Brentano,T.,
            Cohen-Solal,M., Tuukkanen,J., Koskela,A., Wu,J., Li,L., Lu,T.,
            Gabrielsen,M.E., Magi,R., Hoff,M., Lerner,U.H., Henning,P.,
            Ullum,H., Erikstrup,C., Brunak,S., Langhammer,A., Tuomi,T.,
            Oddsson,A., Stefansson,K., Pettersson-Kymmer,U., Ostrowski,S.R.,
            Pedersen,O.B.V., Styrkarsdottir,U., Makitie,O., Hveem,K.,
            Richards,J.B. and Ohlsson,C.
  CONSRTM   Estonian Biobank Research Team; DBDS Genomic Consortium
  TITLE     An atlas of genetic determinants of forearm fracture
  JOURNAL   Nat Genet 55 (11), 1820-1830 (2023)
   PUBMED   37919453
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Morelli,A.E., Sumpter,T.L., Rojas-Canales,D.M., Bandyopadhyay,M.,
            Chen,Z., Tkacheva,O., Shufesky,W.J., Wallace,C.T., Watkins,S.C.,
            Berger,A., Paige,C.J., Falo,L.D. Jr. and Larregina,A.T.
  TITLE     Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux
            in T-Cell-Receptor-Activated T Cells
  JOURNAL   Cell Rep 30 (10), 3448-3465 (2020)
   PUBMED   32160549
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Borbely,E., Hajna,Z., Nabi,L., Scheich,B., Tekus,V., Laszlo,K.,
            Ollmann,T., Kormos,V., Gaszner,B., Karadi,Z., Lenard,L.,
            Paige,C.J., Quinn,J.P., Szolcsanyi,J., Pinter,E., Keeble,J.,
            Berger,A. and Helyes,Z.
  TITLE     Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in
            mice
  JOURNAL   Brain Behav Immun 59, 219-232 (2017)
   PUBMED   27621226
  REMARK    GeneRIF: Our results provide the first evidence for an anxiolytic
            and anti-depressant-like actions of HK-1 through a presently
            unknown target-mediated mechanism
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Hajna,Z., Borbely,E., Kemeny,A., Botz,B., Kereskai,L.,
            Szolcsanyi,J., Pinter,E., Paige,C.J., Berger,A. and Helyes,Z.
  TITLE     Hemokinin-1 is an important mediator of endotoxin-induced acute
            airway inflammation in the mouse
  JOURNAL   Peptides 64, 1-7 (2015)
   PUBMED   25541043
  REMARK    GeneRIF: hemokinin-1 plays a crucial pro-inflammatory role in the
            lung by increasing inflammatory cell activities, and might also be
            a specific regulator of lymphocyte functions.
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Borbely,E., Hajna,Z., Sandor,K., Kereskai,L., Toth,I., Pinter,E.,
            Nagy,P., Szolcsanyi,J., Quinn,J., Zimmer,A., Stewart,J., Paige,C.,
            Berger,A. and Helyes,Z.
  TITLE     Role of tachykinin 1 and 4 gene-derived neuropeptides and the
            neurokinin 1 receptor in adjuvant-induced chronic arthritis of the
            mouse
  JOURNAL   PLoS One 8 (4), e61684 (2013)
   PUBMED   23626716
  REMARK    GeneRIF: Hemokinin-1, but not substance P increases inflammation
            and hyperalgesia in the late phase of adjuvant-induced arthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Zhang,Y. and Paige,C.J.
  TITLE     T-cell developmental blockage by tachykinin antagonists and the
            role of hemokinin 1 in T lymphopoiesis
  JOURNAL   Blood 102 (6), 2165-2172 (2003)
   PUBMED   12791665
  REMARK    GeneRIF: HK-1 influences T-cell development, enhancing the
            proliferation of T-cell precursors and increased the number of
            thymocytes in fetal thymus organ cultures
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Pintado,C.O., Pinto,F.M., Pennefather,J.N., Hidalgo,A.,
            Baamonde,A., Sanchez,T. and Candenas,M.L.
  TITLE     A role for tachykinins in female mouse and rat reproductive
            function
  JOURNAL   Biol Reprod 69 (3), 940-946 (2003)
   PUBMED   12773411
  REMARK    GeneRIF: Preprotachykinin (PPT)-C genes are expressed in uterine
            cells, oocytes, ovaries and embryos from mice, and may play a role
            in female reproductive function.
REFERENCE   8  (bases 1 to 1262)
  AUTHORS   Page,N.M., Bell,N.J., Gardiner,S.M., Manyonda,I.T., Brayley,K.J.,
            Strange,P.G. and Lowry,P.J.
  TITLE     Characterization of the endokinins: human tachykinins with
            cardiovascular activity
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6245-6250 (2003)
   PUBMED   12716968
REFERENCE   9  (bases 1 to 1262)
  AUTHORS   Kurtz,M.M., Wang,R., Clements,M.K., Cascieri,M.A., Austin,C.P.,
            Cunningham,B.R., Chicchi,G.G. and Liu,Q.
  TITLE     Identification, localization and receptor characterization of novel
            mammalian substance P-like peptides
  JOURNAL   Gene 296 (1-2), 205-212 (2002)
   PUBMED   12383518
REFERENCE   10 (bases 1 to 1262)
  AUTHORS   Zhang,Y., Lu,L., Furlonger,C., Wu,G.E. and Paige,C.J.
  TITLE     Hemokinin is a hematopoietic-specific tachykinin that regulates B
            lymphopoiesis
  JOURNAL   Nat Immunol 1 (5), 392-397 (2000)
   PUBMED   11062498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF235035.1 and AW489379.1.
            
            On Jul 4, 2018 this sequence version replaced NM_053093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF235035.1, BC119426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1248              AF235035.1         1-1248
            1249-1262           AW489379.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..1262
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /note="tachykinin 4"
                     /db_xref="GeneID:93670"
                     /db_xref="MGI:MGI:1931130"
     exon            1..291
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..558
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /note="preprotachykinin-C; hemokinin I (HK-1)"
                     /codon_start=1
                     /product="tachykinin-4 preproprotein"
                     /protein_id="NP_444323.1"
                     /db_xref="CCDS:CCDS25274.1"
                     /db_xref="GeneID:93670"
                     /db_xref="MGI:MGI:1931130"
                     /translation="MLPLLALLLLIGPSVCTTAGDREELAFGAEAESWVTVNLKGIPV
                     PSIELKLQELKRSRTRQFYGLMGKRVGGYQLGRIVQDLLGTRGLSIEGTCRQAASQQR
                     ARPGAVTRESLQSREEDEAPLTTSNV"
     exon            292..385
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /inference="alignment:Splign:2.1.0"
     exon            386..445
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /inference="alignment:Splign:2.1.0"
     exon            446..1251
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1228..1233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /note="hexamer: AATAAA"
     polyA_site      1251
                     /gene="Tac4"
                     /gene_synonym="PPT-C"
                     /note="major polyA site"
ORIGIN      
        1 gagaggctgt cccatgaagc agtgcaaagg tggggtgagg cataggaagg aagcagagag
       61 tctaggacac atctcagcca catacaagtg gccccgtggg gaccggagcc tgctggagga
      121 ggtggcatca ggctgagtgg ggctccctgg acagagaggc acctgctcac catgttgcct
      181 ctccttgccc tgcttctcct gatcgggcca tcagtgtgca ctacagcagg agacagagag
      241 gaactggctt ttggtgcaga ggcagagtcc tgggtgaccg tgaacctgaa gggaatcccc
      301 gtccccagca ttgaacttaa gcttcaggag ttgaagagaa gcaggactcg ccagttctat
      361 ggtctgatgg ggaagcgggt gggagggtat cagctgggac gtatagtgca ggatctcctt
      421 ggcacgagag gtttgtccat agaagggacc tgcagacagg cggcgagtca acagagggca
      481 cgacccggag cagtgaccag agaaagcctc cagagtcgag aggaagatga ggctccccta
      541 accaccagca acgtgtagca ctctgccacc catctctccc cagaacatca cagctgagga
      601 gcctcagcca acagtcctgt cttttgtcct caacttgggt atttcctgcc aggccctcgt
      661 cacactctgc attttctccc aggactcact cttggcatct ggtagcaacg acacacaaag
      721 cacggctgcc tcctcacaag ctggactgac ccagctctcc cttgtcccta cagcaaagct
      781 tcacactctg tatcccaggc ctagcacaca gtagggctca atcaacgacg agttagcagt
      841 aataggtagc ttcctcagcc atgcagggta gagggtggga tgtcagaaaa gcagagacca
      901 acattacaca gcccaggtct aatgtctaat ccttgggtgg gaagagagct tggggcctgg
      961 ctaaaacggc aatagaaaca agaaaaagac cctggtggag aagacgctgc atgtattgta
     1021 tttgggggcg gggtcaggag ccttcttccc tttagattcc tgatgttgct accaacagac
     1081 atctccctct gtgctgaggc tatggctcag tgggctaagg cgattgtggc caagcctgac
     1141 aacttgagtt caatccccag gacccacaaa gtggaagaaa aaaattgtcc ttttacctct
     1201 gcatgtgtca tggcatatgt tacacaaaat aaaaagacag tttggaaaag aaaaaaaaaa
     1261 aa
//
