LOCUS       NM_009312                698 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus tachykinin 2 (Tac2), transcript variant 1, mRNA.
ACCESSION   NM_009312
VERSION     NM_009312.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 698)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   2  (bases 1 to 698)
  AUTHORS   Liu,Y., Wang,Y., Zhao,Z.D., Xie,G., Zhang,C., Chen,R. and Zhang,Y.
  TITLE     A subset of dopamine receptor-expressing neurons in the nucleus
            accumbens controls feeding and energy homeostasis
  JOURNAL   Nat Metab 6 (8), 1616-1631 (2024)
   PUBMED   39147933
REFERENCE   3  (bases 1 to 698)
  AUTHORS   Florido,A., Velasco,E.R., Romero,L.R., Acharya,N., Marin
            Blasco,I.J., Nabas,J.F., Perez-Caballero,L., Rivero,G.,
            Olabarrieta,E., Nunez-delMoral,A., Gonzalez-Parra,J.A.,
            Porta-Casteras,D., Cano,M., Steward,T., Antony,M.S., Cardoner,N.,
            Torrubia,R., Jackson,A.C., Fullana,M.A. and Andero,R.
  TITLE     Sex differences in neural projections of fear memory processing in
            mice and humans
  JOURNAL   Sci Adv 10 (28), eadk3365 (2024)
   PUBMED   38985873
REFERENCE   4  (bases 1 to 698)
  AUTHORS   Dai,D., Zhao,T., Li,Z., Li,W., Chen,A., Tang,Y., Gao,X.F. and
            Xiong,L.
  TITLE     The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons
            contributes to mechanical hyperknesis during chronic itch
  JOURNAL   Theranostics 14 (1), 363-378 (2024)
   PUBMED   38164144
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 698)
  AUTHORS   Lee,H., Weinberg-Wolf,H., Lee,H.L., Lee,T., Conte,J.,
            Godoy-Parejo,C., Demb,J.B., Rudenko,A. and Kim,I.J.
  TITLE     Brn3b regulates the formation of fear-related midbrain circuits and
            defensive responses to visual threat
  JOURNAL   PLoS Biol 21 (11), e3002386 (2023)
   PUBMED   37983249
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 698)
  AUTHORS   Duarte,C.R., Schutz,B. and Zimmer,A.
  TITLE     Incongruent pattern of neurokinin B expression in rat and mouse
            brains
  JOURNAL   Cell Tissue Res 323 (1), 43-51 (2006)
   PUBMED   16160861
  REMARK    GeneRIF: Incongruent pattern of neurokinin B expression in rat and
            mouse brains.
REFERENCE   7  (bases 1 to 698)
  AUTHORS   Krieger,K.E., Abbott,M.A., Joksimovic,M., Lueth,P.A., Sonea,I.M.,
            Jeannotte,L. and Tuggle,C.K.
  TITLE     Transgenic mice ectopically expressing HOXA5 in the dorsal spinal
            cord show structural defects of the cervical spinal cord along with
            sensory and motor defects of the forelimb
  JOURNAL   Brain Res Dev Brain Res 150 (2), 125-139 (2004)
   PUBMED   15158076
REFERENCE   8  (bases 1 to 698)
  AUTHORS   Pintado,C.O., Pinto,F.M., Pennefather,J.N., Hidalgo,A.,
            Baamonde,A., Sanchez,T. and Candenas,M.L.
  TITLE     A role for tachykinins in female mouse and rat reproductive
            function
  JOURNAL   Biol Reprod 69 (3), 940-946 (2003)
   PUBMED   12773411
  REMARK    GeneRIF: Preprotachykinin (PPT)-B genes are expressed in uterine
            cells, oocytes, ovaries and embryos from mice, and may play a role
            in female reproductive function.
REFERENCE   9  (bases 1 to 698)
  AUTHORS   Shearman,L.P. and Weaver,D.R.
  TITLE     Haloperidol regulates neurotensin gene expression in striatum of
            c-fos-deficient mice
  JOURNAL   Brain Res Mol Brain Res 47 (1-2), 275-285 (1997)
   PUBMED   9221926
REFERENCE   10 (bases 1 to 698)
  AUTHORS   Andoh,T., Nagasawa,T. and Kuraishi,Y.
  TITLE     Expression of tachykinin NK1 receptor mRNA in dorsal root ganglia
            of the mouse
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 329-332 (1996)
   PUBMED   8717372
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160970.7 and BC031348.1.
            
            On Jan 31, 2008 this sequence version replaced NM_009312.1.
            
            Summary: This gene encodes a member of the tachykinin family of
            signaling peptides that is widely expressed in the central nervous
            system and plays a role in diverse processes such as water
            homeostasis, pulmonary inflammation, cognition, fear memory
            consolidation and preeclampsia. The encoded protein is
            enzymatically processed to generate the mature neuropeptide.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ175657.1, BC031348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC160970.7         186432-186434
            4-698               BC031348.1         1-695
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.81 cM"
     gene            1..698
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="tachykinin 2"
                     /db_xref="GeneID:21334"
                     /db_xref="MGI:MGI:98476"
     exon            1..74
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            75..197
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..443
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="tachykinin-3; preprotachykinin-B; neurokinin B-like
                     protein Zneurok1; substance K; neurokinin 2; neurokinin A;
                     neuropeptide K; neuromedin L; neurokinin alpha"
                     /codon_start=1
                     /product="tachykinin-3 preproprotein"
                     /protein_id="NP_033338.2"
                     /db_xref="CCDS:CCDS24248.1"
                     /db_xref="GeneID:21334"
                     /db_xref="MGI:MGI:98476"
                     /translation="MRSAMLFAAVLALSLAWTFGAVCEEPQGQGGRLSKDSDLYQLPP
                     SLLRRLYDSRPVSLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPT
                     DVVEENTPSFGILK"
     exon            198..303
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            304..333
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            334..387
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..461
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            462..681
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      660..665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="hexamer: AATAAA"
     polyA_site      681
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="major polyA site"
ORIGIN      
        1 ccctgcactc ttgtctctgt ctctgcagca gcatcagcca gctccctgat cctgtcagct
       61 atccagctcc acagctttgt ccttcaggca ccatgaggag cgccatgctg tttgcggctg
      121 tcctcgccct cagcttggct tggaccttcg gggctgtgtg tgaggagcca caggggcagg
      181 gagggaggct cagtaaggac tctgatctct atcagctgcc tccgtccctg cttcggagac
      241 tctacgacag ccgccctgtc tctctggaag gattgctgaa agtgctgagc aaggctagcg
      301 tgggaccaaa ggagacatca cttccacaga aacgtgacat gcacgacttc tttgtgggac
      361 ttatgggcaa gaggaacagc caaccagaca ctcccaccga cgtggttgaa gagaacaccc
      421 ccagctttgg catcctcaaa taatccccca gtacagaaaa gcactctacc cctggacccc
      481 ggattgcatc ataaagcagt gcctgctcct gcttcctctt ctcctcccct gcctgtaagg
      541 tcctcctgtt ggctcccttc cctactctgc atagaagctg catatgaaca gcctcaaccc
      601 catagcaatt atggtttctg tagtgtcctg cattaaaaat gctatctctc ttcgtcaaca
      661 ataaagggtt tttacaaagg aaaaaaaaaa aaaaaaaa
//
