LOCUS       NM_001199971             870 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus tachykinin 2 (Tac2), transcript variant 2, mRNA.
ACCESSION   NM_001199971
VERSION     NM_001199971.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Liu,Y., Wang,Y., Zhao,Z.D., Xie,G., Zhang,C., Chen,R. and Zhang,Y.
  TITLE     A subset of dopamine receptor-expressing neurons in the nucleus
            accumbens controls feeding and energy homeostasis
  JOURNAL   Nat Metab 6 (8), 1616-1631 (2024)
   PUBMED   39147933
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Florido,A., Velasco,E.R., Romero,L.R., Acharya,N., Marin
            Blasco,I.J., Nabas,J.F., Perez-Caballero,L., Rivero,G.,
            Olabarrieta,E., Nunez-delMoral,A., Gonzalez-Parra,J.A.,
            Porta-Casteras,D., Cano,M., Steward,T., Antony,M.S., Cardoner,N.,
            Torrubia,R., Jackson,A.C., Fullana,M.A. and Andero,R.
  TITLE     Sex differences in neural projections of fear memory processing in
            mice and humans
  JOURNAL   Sci Adv 10 (28), eadk3365 (2024)
   PUBMED   38985873
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Dai,D., Zhao,T., Li,Z., Li,W., Chen,A., Tang,Y., Gao,X.F. and
            Xiong,L.
  TITLE     The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons
            contributes to mechanical hyperknesis during chronic itch
  JOURNAL   Theranostics 14 (1), 363-378 (2024)
   PUBMED   38164144
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Lee,H., Weinberg-Wolf,H., Lee,H.L., Lee,T., Conte,J.,
            Godoy-Parejo,C., Demb,J.B., Rudenko,A. and Kim,I.J.
  TITLE     Brn3b regulates the formation of fear-related midbrain circuits and
            defensive responses to visual threat
  JOURNAL   PLoS Biol 21 (11), e3002386 (2023)
   PUBMED   37983249
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Duarte,C.R., Schutz,B. and Zimmer,A.
  TITLE     Incongruent pattern of neurokinin B expression in rat and mouse
            brains
  JOURNAL   Cell Tissue Res 323 (1), 43-51 (2006)
   PUBMED   16160861
  REMARK    GeneRIF: Incongruent pattern of neurokinin B expression in rat and
            mouse brains.
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Krieger,K.E., Abbott,M.A., Joksimovic,M., Lueth,P.A., Sonea,I.M.,
            Jeannotte,L. and Tuggle,C.K.
  TITLE     Transgenic mice ectopically expressing HOXA5 in the dorsal spinal
            cord show structural defects of the cervical spinal cord along with
            sensory and motor defects of the forelimb
  JOURNAL   Brain Res Dev Brain Res 150 (2), 125-139 (2004)
   PUBMED   15158076
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Pintado,C.O., Pinto,F.M., Pennefather,J.N., Hidalgo,A.,
            Baamonde,A., Sanchez,T. and Candenas,M.L.
  TITLE     A role for tachykinins in female mouse and rat reproductive
            function
  JOURNAL   Biol Reprod 69 (3), 940-946 (2003)
   PUBMED   12773411
  REMARK    GeneRIF: Preprotachykinin (PPT)-B genes are expressed in uterine
            cells, oocytes, ovaries and embryos from mice, and may play a role
            in female reproductive function.
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Shearman,L.P. and Weaver,D.R.
  TITLE     Haloperidol regulates neurotensin gene expression in striatum of
            c-fos-deficient mice
  JOURNAL   Brain Res Mol Brain Res 47 (1-2), 275-285 (1997)
   PUBMED   9221926
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Andoh,T., Nagasawa,T. and Kuraishi,Y.
  TITLE     Expression of tachykinin NK1 receptor mRNA in dorsal root ganglia
            of the mouse
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 329-332 (1996)
   PUBMED   8717372
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160970.7 and BC031348.1.
            
            Summary: This gene encodes a member of the tachykinin family of
            signaling peptides that is widely expressed in the central nervous
            system and plays a role in diverse processes such as water
            homeostasis, pulmonary inflammation, cognition, fear memory
            consolidation and preeclampsia. The encoded protein is
            enzymatically processed to generate the mature neuropeptide.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14423.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC160970.7         185518-185720
            204-870             BC031348.1         29-695
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.81 cM"
     gene            1..870
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="tachykinin 2"
                     /db_xref="GeneID:21334"
                     /db_xref="MGI:MGI:98476"
     exon            1..203
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..246
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            247..369
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..615
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="tachykinin-3; preprotachykinin-B; neurokinin B-like
                     protein Zneurok1; substance K; neurokinin 2; neurokinin A;
                     neuropeptide K; neuromedin L; neurokinin alpha"
                     /codon_start=1
                     /product="tachykinin-3 preproprotein"
                     /protein_id="NP_001186900.1"
                     /db_xref="CCDS:CCDS24248.1"
                     /db_xref="GeneID:21334"
                     /db_xref="MGI:MGI:98476"
                     /translation="MRSAMLFAAVLALSLAWTFGAVCEEPQGQGGRLSKDSDLYQLPP
                     SLLRRLYDSRPVSLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPT
                     DVVEENTPSFGILK"
     exon            370..475
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            476..505
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..559
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..633
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..853
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="hexamer: AATAAA"
     polyA_site      853
                     /gene="Tac2"
                     /gene_synonym="PPT-B; Tac3"
                     /note="major polyA site"
ORIGIN      
        1 tgactggccc tctctgagtt ccaattcgga tgctggctct ttctccttcc ttcagtctct
       61 ctctctctcc tgggctaaga aacctggaga aagccccttc atctgtgtgg gatgtaaagg
      121 agggctggaa gggtcaaaaa agatgcccga gctttgaggg gaaaaggaag caatcaagag
      181 acgaggttgc aaagcagagc aagcatcagc cagctccctg atcctgtcag ctatccagct
      241 ccacagcttt gtccttcagg caccatgagg agcgccatgc tgtttgcggc tgtcctcgcc
      301 ctcagcttgg cttggacctt cggggctgtg tgtgaggagc cacaggggca gggagggagg
      361 ctcagtaagg actctgatct ctatcagctg cctccgtccc tgcttcggag actctacgac
      421 agccgccctg tctctctgga aggattgctg aaagtgctga gcaaggctag cgtgggacca
      481 aaggagacat cacttccaca gaaacgtgac atgcacgact tctttgtggg acttatgggc
      541 aagaggaaca gccaaccaga cactcccacc gacgtggttg aagagaacac ccccagcttt
      601 ggcatcctca aataatcccc cagtacagaa aagcactcta cccctggacc ccggattgca
      661 tcataaagca gtgcctgctc ctgcttcctc ttctcctccc ctgcctgtaa ggtcctcctg
      721 ttggctccct tccctactct gcatagaagc tgcatatgaa cagcctcaac cccatagcaa
      781 ttatggtttc tgtagtgtcc tgcattaaaa atgctatctc tcttcgtcaa caataaaggg
      841 tttttacaaa ggaaaaaaaa aaaaaaaaaa
//
