LOCUS       NM_009311               1049 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus tachykinin 1 (Tac1), transcript variant 1, mRNA.
ACCESSION   NM_009311 XM_984642 XM_984673 XM_984706
VERSION     NM_009311.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   Zhu,Y., Meerschaert,K.A., Galvan-Pena,S., Bin,N.R., Yang,D.,
            Basu,H., Kawamoto,R., Shalaby,A., Liberles,S.D., Mathis,D.,
            Benoist,C. and Chiu,I.M.
  TITLE     A chemogenetic screen reveals that Trpv1-expressing neurons control
            regulatory T cells in the gut
  JOURNAL   Science 385 (6708), eadk1679 (2024)
   PUBMED   39088603
REFERENCE   6  (bases 1 to 1049)
  AUTHORS   Buma,P., Verschuren,C., Versleyen,D., Van der Kraan,P. and
            Oestreicher,A.B.
  TITLE     Calcitonin gene-related peptide, substance P and GAP-43/B-50
            immunoreactivity in the normal and arthrotic knee joint of the
            mouse
  JOURNAL   Histochemistry 98 (5), 327-339 (1992)
   PUBMED   1283163
REFERENCE   7  (bases 1 to 1049)
  AUTHORS   Shimamura,K., Takahashi,T. and Takeichi,M.
  TITLE     E-cadherin expression in a particular subset of sensory neurons
  JOURNAL   Dev Biol 152 (2), 242-254 (1992)
   PUBMED   1644219
REFERENCE   8  (bases 1 to 1049)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   9  (bases 1 to 1049)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   10 (bases 1 to 1049)
  AUTHORS   Chiwakata,C., Brackmann,B., Hunt,N., Davidoff,M., Schulze,W. and
            Ivell,R.
  TITLE     Tachykinin (substance-P) gene expression in Leydig cells of the
            human and mouse testis
  JOURNAL   Endocrinology 128 (5), 2441-2448 (1991)
   PUBMED   1708336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132117.3.
            
            On Mar 19, 2018 this sequence version replaced NM_009311.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17584.1, SRR5189673.75183.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC132117.3         101859-101959
            102-233             AC132117.3         102403-102534
            234-330             AC132117.3         103482-103578
            331-375             AC132117.3         104014-104058
            376-399             AC132117.3         104518-104541
            400-453             AC132117.3         105897-105950
            454-1049            AC132117.3         109181-109776
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 3.31 cM"
     gene            1..1049
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="tachykinin 1"
                     /db_xref="GeneID:21333"
                     /db_xref="MGI:MGI:98474"
     exon            1..101
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            102..233
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..503
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protachykinin-1; substance P; neurokinin 1;
                     preprotachykinin A; neurokinin A"
                     /codon_start=1
                     /product="protachykinin-1 isoform 1 precursor"
                     /protein_id="NP_033337.1"
                     /db_xref="CCDS:CCDS19906.1"
                     /db_xref="GeneID:21333"
                     /db_xref="MGI:MGI:98474"
                     /translation="MKILVAVAVFFLVSTQLFAEEIDANDDLNYWSDWSDSDQIKEAM
                     PEPFEHLLQRIARRPKPQQFFGLMGKRDADSSVEKQVALLKALYGHGQISHKRHKTDS
                     FVGLMGKRALNSVAYERSAMQNYERRRK"
     exon            234..330
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            331..375
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            376..399
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            400..453
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            454..1049
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="hexamer: AATAAA"
     polyA_site      1049
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcact cggacctgct ccgctcctgc accgcggcca aggagagcaa agagcgccca
       61 gcaagtgcgc acctgcggag catccccgcg gtctgaccgc aaaatcgaac atgaaaatcc
      121 tcgtggccgt ggcggtcttt tttctcgttt ccactcaact gtttgcagag gaaatcgatg
      181 ccaacgatga tctaaattat tggtccgact ggtccgacag tgaccagatc aaggaggcaa
      241 tgccggagcc ctttgagcat cttctgcaga gaatcgcccg aagacccaag cctcagcagt
      301 tctttggatt aatgggcaag cgggatgctg attcctcagt tgaaaaacaa gtggccctgt
      361 taaaggctct ttatggacat ggccagatct ctcacaaaag gcataaaaca gattcctttg
      421 ttggactaat gggcaaaaga gctttaaatt ctgtggctta tgaaagaagc gcgatgcaga
      481 actacgaaag aagacgtaaa taaacccctg aacgcactat ctattcatct tcatctgtgt
      541 cagtgagcag tgaacggtaa aataaaatgt gcgctatgag gaatgattat ttatttaata
      601 acacatgttg ttgtgagtga aaaactcaaa aaagaagtgt ttattttttc atattgtgcc
      661 aataagcctt gtaattctaa tgtggtgacc tccccagaag tagaaattag ttgtaatttc
      721 agcaaagcac agtgatgaag gagctgtcca agcttggcag tgacgcagtc tccaaagaaa
      781 ggacccttct gtgagccagc gcaggcagct gctgctggaa gcagagactc ctgtgcgtct
      841 ctctcacgct acccctggtt ctgctttcat gctgataatg tactgagact tcggtatttg
      901 actctatttg tatcctagca gcatgtttcc tgtttcgtga ctatatagag atgttttgaa
      961 aaagtttcaa tgtaattctc tggtcttcag tcattgtatg atgtgttgtg atagctacca
     1021 ttttaaataa aagaatgtat cttcaggaa
//
