LOCUS       NM_001311060            1019 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus tachykinin 1 (Tac1), transcript variant 2, mRNA.
ACCESSION   NM_001311060 XM_006505028
VERSION     NM_001311060.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   2  (bases 1 to 1019)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1019)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   4  (bases 1 to 1019)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1019)
  AUTHORS   Zhu,Y., Meerschaert,K.A., Galvan-Pena,S., Bin,N.R., Yang,D.,
            Basu,H., Kawamoto,R., Shalaby,A., Liberles,S.D., Mathis,D.,
            Benoist,C. and Chiu,I.M.
  TITLE     A chemogenetic screen reveals that Trpv1-expressing neurons control
            regulatory T cells in the gut
  JOURNAL   Science 385 (6708), eadk1679 (2024)
   PUBMED   39088603
REFERENCE   6  (bases 1 to 1019)
  AUTHORS   Buma,P., Verschuren,C., Versleyen,D., Van der Kraan,P. and
            Oestreicher,A.B.
  TITLE     Calcitonin gene-related peptide, substance P and GAP-43/B-50
            immunoreactivity in the normal and arthrotic knee joint of the
            mouse
  JOURNAL   Histochemistry 98 (5), 327-339 (1992)
   PUBMED   1283163
REFERENCE   7  (bases 1 to 1019)
  AUTHORS   Shimamura,K., Takahashi,T. and Takeichi,M.
  TITLE     E-cadherin expression in a particular subset of sensory neurons
  JOURNAL   Dev Biol 152 (2), 242-254 (1992)
   PUBMED   1644219
REFERENCE   8  (bases 1 to 1019)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   9  (bases 1 to 1019)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   10 (bases 1 to 1019)
  AUTHORS   Chiwakata,C., Brackmann,B., Hunt,N., Davidoff,M., Schulze,W. and
            Ivell,R.
  TITLE     Tachykinin (substance-P) gene expression in Leydig cells of the
            human and mouse testis
  JOURNAL   Endocrinology 128 (5), 2441-2448 (1991)
   PUBMED   1708336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ059943.1, CX238160.1, AI835507.1 and AI837972.1.
            
            On Mar 28, 2018 this sequence version replaced NM_001311060.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1. It
            encodes isoform 2, which lacks an internal segment and is shorter,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX241407.1, BQ219049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               CJ059943.1         2-469
            469-717             CX238160.1         451-699
            718-1000            AI835507.1         17-299              c
            1001-1019           AI837972.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 3.31 cM"
     gene            1..1019
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="tachykinin 1"
                     /db_xref="GeneID:21333"
                     /db_xref="MGI:MGI:98474"
     exon            1..101
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            102..233
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..458
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protachykinin-1; substance P; neurokinin 1;
                     preprotachykinin A; neurokinin A"
                     /codon_start=1
                     /product="protachykinin-1 isoform 2 precursor"
                     /protein_id="NP_001297989.1"
                     /db_xref="CCDS:CCDS80486.1"
                     /db_xref="GeneID:21333"
                     /db_xref="MGI:MGI:98474"
                     /translation="MKILVAVAVFFLVSTQLFAEEIDANDDLNYWSDWSDSDQIKEAM
                     PEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSVAY
                     ERSAMQNYERRRK"
     exon            234..330
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            331..354
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            355..408
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            409..1004
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      981..986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="hexamer: AATAAA"
     polyA_site      1004
                     /gene="Tac1"
                     /gene_synonym="4930528L02Rik; NK-1; NK1; Nkna; PPT-A;
                     PPTA; SP"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcact cggacctgct ccgctcctgc accgcggcca aggagagcaa agagcgccca
       61 gcaagtgcgc acctgcggag catccccgcg gtctgaccgc aaaatcgaac atgaaaatcc
      121 tcgtggccgt ggcggtcttt tttctcgttt ccactcaact gtttgcagag gaaatcgatg
      181 ccaacgatga tctaaattat tggtccgact ggtccgacag tgaccagatc aaggaggcaa
      241 tgccggagcc ctttgagcat cttctgcaga gaatcgcccg aagacccaag cctcagcagt
      301 tctttggatt aatgggcaag cgggatgctg gacatggcca gatctctcac aaaaggcata
      361 aaacagattc ctttgttgga ctaatgggca aaagagcttt aaattctgtg gcttatgaaa
      421 gaagcgcgat gcagaactac gaaagaagac gtaaataaac ccctgaacgc actatctatt
      481 catcttcatc tgtgtcagtg agcagtgaac ggtaaaataa aatgtgcgct atgaggaatg
      541 attatttatt taataacaca tgttgttgtg agtgaaaaac tcaaaaaaga agtgtttatt
      601 ttttcatatt gtgccaataa gccttgtaat tctaatgtgg tgacctcccc agaagtagaa
      661 attagttgta atttcagcaa agcacagtga tgaaggagct gtccaagctt ggcagtgacg
      721 cagtctccaa agaaaggacc cttctgtgag ccagcgcagg cagctgctgc tggaagcaga
      781 gactcctgtg cgtctctctc acgctacccc tggttctgct ttcatgctga taatgtactg
      841 agacttcggt atttgactct atttgtatcc tagcagcatg tttcctgttt cgtgactata
      901 tagagatgtt ttgaaaaagt ttcaatgtaa ttctctggtc ttcagtcatt gtatgatgtg
      961 ttgtgatagc taccatttta aataaaagaa tgtatcttca ggaaaaaaaa aaaaaaaaa
//
