LOCUS       NM_001358447            6641 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus TGF-beta activated kinase 1/MAP3K7 binding protein 3
            (Tab3), transcript variant 2, mRNA.
ACCESSION   NM_001358447 XM_017318604
VERSION     NM_001358447.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6641)
  AUTHORS   Ali,T., Nguyen,H.M., Abbas,N., Takeuchi,O., Akira,S., Suzuki,T.,
            Matsuzaki,G. and Takaesu,G.
  TITLE     TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for
            TLR-induced cytokine production in macrophages
  JOURNAL   Int Immunol 36 (9), 439-450 (2024)
   PUBMED   38567483
REFERENCE   2  (bases 1 to 6641)
  AUTHORS   Sun,L., Zhang,H., Zhang,H., Lou,X., Wang,Z., Wu,Y., Yang,X.,
            Chen,D., Guo,B., Zhang,A. and Qian,F.
  TITLE     Staphylococcal virulence factor HlgB targets the
            endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote
            pneumonia
  JOURNAL   Nat Microbiol 8 (1), 107-120 (2023)
   PUBMED   36593296
REFERENCE   3  (bases 1 to 6641)
  AUTHORS   Lei,C.Q., Wu,X., Zhong,X., Jiang,L., Zhong,B. and Shu,H.B.
  TITLE     USP19 Inhibits TNF-alpha- and IL-1beta-Triggered NF-kappaB
            Activation by Deubiquitinating TAK1
  JOURNAL   J Immunol 203 (1), 259-268 (2019)
   PUBMED   31127032
REFERENCE   4  (bases 1 to 6641)
  AUTHORS   Sheng,Y., Xu,C. and Zeng,W.
  TITLE     TAB3 defect induces augmented cardioprotection loss from ischemic
            injury
  JOURNAL   Cell Biol Int 41 (7), 787-797 (2017)
   PUBMED   28462515
  REMARK    GeneRIF: Findings indicate that the absence of TAB3 plays a harmful
            role in ischemic heart disease
REFERENCE   5  (bases 1 to 6641)
  AUTHORS   Panda,S., Nilsson,J.A. and Gekara,N.O.
  TITLE     Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation
            of TRAF3 and TRAF6 Complexes
  JOURNAL   Immunity 43 (4), 647-659 (2015)
   PUBMED   26474655
REFERENCE   6  (bases 1 to 6641)
  AUTHORS   Shi,M., Deng,W., Bi,E., Mao,K., Ji,Y., Lin,G., Wu,X., Tao,Z.,
            Li,Z., Cai,X., Sun,S., Xiang,C. and Sun,B.
  TITLE     TRIM30 alpha negatively regulates TLR-mediated NF-kappa B
            activation by targeting TAB2 and TAB3 for degradation
  JOURNAL   Nat Immunol 9 (4), 369-377 (2008)
   PUBMED   18345001
REFERENCE   7  (bases 1 to 6641)
  AUTHORS   Seth,R.B. and Chen,Z.J.
  TITLE     Smads keep TABs on inflammation
  JOURNAL   Nat Immunol 8 (5), 477-478 (2007)
   PUBMED   17440456
REFERENCE   8  (bases 1 to 6641)
  AUTHORS   Olesen,C., Nyeng,P., Kalisz,M., Jensen,T.H., Moller,M., Tommerup,N.
            and Byskov,A.G.
  TITLE     Global gene expression analysis in fetal mouse ovaries with and
            without meiosis and comparison of selected genes with meiosis in
            the testis
  JOURNAL   Cell Tissue Res 328 (1), 207-221 (2007)
   PUBMED   17431699
REFERENCE   9  (bases 1 to 6641)
  AUTHORS   Lu,J., Qian,J., Izvolsky,K.I. and Cardoso,W.V.
  TITLE     Global analysis of genes differentially expressed in branching and
            non-branching regions of the mouse embryonic lung
  JOURNAL   Dev Biol 273 (2), 418-435 (2004)
   PUBMED   15328023
REFERENCE   10 (bases 1 to 6641)
  AUTHORS   Cheung,P.C., Nebreda,A.R. and Cohen,P.
  TITLE     TAB3, a new binding partner of the protein kinase TAK1
  JOURNAL   Biochem J 378 (Pt 1), 27-34 (2004)
   PUBMED   14670075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645586.9, AL645567.7 and BC090666.1.
            
            On Dec 1, 2017 this sequence version replaced XM_017318604.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.271151.1,
                                           SRR14995048.650260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AL645586.9         173170-173470
            302-362             AL645586.9         174698-174758
            363-465             AL645586.9         192800-192902
            466-660             AL645567.7         8038-8232
            661-2119            AL645567.7         12619-14077
            2120-2280           AL645567.7         15022-15182
            2281-2374           AL645567.7         20202-20295
            2375-2458           AL645567.7         22990-23073
            2459-2560           AL645567.7         26808-26909
            2561-6623           AL645567.7         29054-33116
            6624-6641           BC090666.1         3613-3630
FEATURES             Location/Qualifiers
     source          1..6641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 39.32 cM"
     gene            1..6641
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /note="TGF-beta activated kinase 1/MAP3K7 binding protein
                     3"
                     /db_xref="GeneID:66724"
                     /db_xref="MGI:MGI:1913974"
     exon            1..301
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            302..362
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            363..465
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            466..660
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     CDS             559..2709
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /note="TAK1-binding protein 3; TGF-beta-activated kinase
                     1-binding protein 3; mitogen-activated protein kinase
                     kinase kinase 7-interacting protein 3"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 3"
                     /protein_id="NP_001345376.1"
                     /db_xref="CCDS:CCDS41049.1"
                     /db_xref="GeneID:66724"
                     /db_xref="MGI:MGI:1913974"
                     /translation="MAQNSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCR
                     ALSQESSKYLYMEYHSPEDNRMNRNRLLHINLGIHSPSSYHPGDGAHLNGGRTLVHSS
                     SDGHIDPQHTAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQP
                     SSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQ
                     IPSNLYGSPGSIFIRQTSQSSSGRQTPQNAPWQSSPQGPVPHYSQRPLPVYPHQQNYQ
                     PSQYSPKQQQIPQSVYHSPPPSQCPSPFSSPQHQVQPPQLGHPSSHVFMPPSPSTTPP
                     HLYQQGPPSYQKPGSHSVAYLPYTASSLPKGSMKKIEITVEPSQRPGTAITRSPSPIS
                     NQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCAPSPSPR
                     VIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGNHKYQRS
                     SSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKAEVNSMEHDLMQRRLRRV
                     SCTTAIPTPEEMTRLRSTNRQLQINVDCTLKEVDLLQSRGNFDPKAINNFYDHIEPGP
                     VVPPKPSKKDSSDSCAIERKARRISVTSKAPVDIHDAQAAAADEHLSICKQSARTQPR
                     DEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT"
     exon            661..2119
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2280
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2374
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2458
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2560
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..6624
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6429..6434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /note="hexamer: ATTAAA"
     polyA_site      6454
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /note="major polyA site"
     regulatory      6595..6600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /note="hexamer: AATAAA"
     polyA_site      6624
                     /gene="Tab3"
                     /gene_synonym="4921526G09Rik; Map3k7ip3; mKIAA4135"
                     /note="major polyA site"
ORIGIN      
        1 gcggctcaca ccggatctgc cctcggcacg gcgcgcagtc aagggggttc ggccggggaa
       61 gccgtgcccg cccggacccc ccgtgggagc ctgcggacgg accgagggcc gggcggagga
      121 gcccggagcg gccgcggggg ctcggtgagt ggtggcgggg aggcccggca cctgcccgag
      181 gctaggactt cggaggtgcc ctggggtcgt cctagtgacc ccgcgaccac gacgttgggc
      241 gtgggcgaga ctgcgggtgt cggcggggct cgtcccggcc tctggctctc agccggcccg
      301 ggcaaccctg tgcagtttgt gttggagcaa agtgagctga gtatctgcag tcactggact
      361 tggacagtgg tgccagcatt ttcttcaagt tattcaccct gaattatagt gtgtctaact
      421 ttgcaatgtg tcttagctga agtattagca attgagacgt tgacgaagaa aatgacagag
      481 tgtttggaag attattactt ttggaagtcc tgctaatatc catttcctaa gagatagttg
      541 accaacattg actctggcat ggcgcaaaac agtccacagc ttgatattca ggttctccat
      601 gatcttcgac aacgttttcc tgaaattcca gagggtgtgg tatcccagtg catgttacag
      661 aataacaaca atctagaagc ctgttgtcga gccctttccc aggagagcag caaatacttg
      721 tatatggaat accatagtcc agaagacaat agaatgaata gaaatcgcct tttgcatatt
      781 aatttgggta ttcattctcc tagtagctac cacccaggag atggagctca ccttaatggt
      841 ggtcggacac tggtacatag ctcaagtgat ggacatattg atcctcagca tacagcaggc
      901 aaacagctga tatgtttagt tcaggaacca cactcagctc cagctgttgt ggctgctact
      961 cccaactata atccgttttt tatgaatgag cagaacagaa gtgcagctac cccgccttca
     1021 cagccacctc agcagccatc ttccatgcaa acaggaatga atccatctgc tatgcaaggt
     1081 ccttcaccac caccaccacc tccgtcctac atgcacatac ctcggtatag tacaaatcca
     1141 attactgtta cagtgtccca aaaccttcct tctggacaga ctgtgccaag agctttacag
     1201 attcttccac aaattccaag caatctctat ggatctcctg ggtctatttt tattagacag
     1261 acatctcaga gttcatcagg aagacagact cctcagaatg ctccatggca gtcctcacca
     1321 caaggcccag tgcctcatta cagccagcgt cctttacctg tttatccaca tcaacagaac
     1381 tatcaacctt ctcagtattc tcccaaacaa cagcagattc ctcagtcagt ttaccattca
     1441 ccacctcctt ctcagtgtcc ttcccccttt agctctccac agcatcaagt acaaccaccc
     1501 cagctgggtc acccaagctc tcatgtgttt atgccaccca gtccttcaac tactccaccc
     1561 cacctatatc aacaaggacc tcctagttat cagaaaccag gaagtcattc ggtagcctat
     1621 ctcccttaca cagcatctag cttacccaaa ggttccatga agaagataga aattacagtt
     1681 gaaccttctc aaagacctgg gacagcaata actagaagtc cgtcacctat cagtaatcaa
     1741 ccatctccaa ggaaccagca ttcactgtac acagccacca caccaccttc aagttcccct
     1801 tcaagaggga tctctagtca accaaaacct ccatttagtg ttaatcctgt gtatattacg
     1861 tatacacagc caactggacc ttcatgtgct ccatcaccat ctcctcgggt gataccaaat
     1921 ccaactacag tttttaaaat tactgtaggc cgagcaacaa ctgaaaacct tttaaattta
     1981 gtggaccaag aagaacgctc tgcagcacca gaacctattc agcccatttc agtgatacca
     2041 ggctctgggg gagaaaaggg aaaccacaag tatcaaagga gctctagttc tggatcagat
     2101 gactatgcct atacccaagc cttgctgtta catcagcgag caagaatgga gaggttagca
     2161 aagcaattga aacttgaaaa agaggagcta gagcggttga aagctgaagt taacagtatg
     2221 gagcatgacc tgatgcagag acggcttaga agagtcagct gcaccactgc aattcccacg
     2281 cctgaggaaa tgacaagatt gagaagcacg aacagacaac tccagataaa tgttgactgt
     2341 acactgaaag aagttgacct ccttcaatct agaggaaact ttgatccaaa agccatcaat
     2401 aatttttatg accacataga acctggccca gttgtaccac cgaagccatc taaaaaagac
     2461 tcctcagact cctgtgcaat tgagagaaaa gcccgaagaa ttagtgtgac ttccaaagcg
     2521 ccagtagata tccatgacgc ccaggcagca gctgcagatg aacatttaag tatctgcaaa
     2581 cagagtgctc ggacacaacc ccgagatgag gattatgaag gggctccgtg gaattgtgac
     2641 agctgtacct ttctcaacca ccctgcactg aatcgctgtg agcagtgtga gatgccacgg
     2701 tacacttgaa ttcagaagag ttgacaccag gttgagagtg aaactttgag cactcaccaa
     2761 aagaaaagga aactttggga ttgtgttcat ctgcccagcc ttttcatttc ttgattgcac
     2821 agggggaggt gggggaatgg tgccctggct caggaaagga aaagtgggga ggtctttctt
     2881 ttttcctttc ttaactcatt acagagtgag aggtagaagg ggatacttga attcactcct
     2941 gtaagaatgt acacagagat gttaagggct cttctatgga atccaaattg ttacagttac
     3001 tgctgagtgg ctcttcattt ctaaaggtga actttggatt atggtaggac atgttacagt
     3061 ttatgcagac aaactgtgaa ttccagagca gacttacttg gtcacagctc tctggaaacc
     3121 aaggctccct gtgcctcttc ctgctgcttc ctgtgaagag atggacagga aaaagcaccc
     3181 aggatatgct ttattttctt ttgtgcaaaa taatgagttt atttgtaatt gctgcttttt
     3241 tcaggggtaa tttcaaacac acattcatac gcagacagga tacttttaaa atgtgatttg
     3301 tagtagtcag gaattaggca tattgtgccc tttgtgagga agtacaatca gaggtagtat
     3361 tatctctttt gcttgaacaa tggttcatca agctgcattg acactggtaa ctaagaccta
     3421 cttataccac ataaattatt gtatattttc ttaggttatt gattttgaaa gtaatgaagt
     3481 atggttttat aaaatgccat tctcataaaa ctgtgctttg ccagtagcac actgaatgta
     3541 tgccaaatgc aagtccattc caaaaccatt ggaaattcta agctcagttg tggttcttaa
     3601 gaaatgcttg cagtatacag ggccccctac ttctggtttg taatgaatac atgatgttta
     3661 cagcacagaa aatactttgt gccgtagtcc taatttagct gaaaaaaaat caatatgagc
     3721 tatttatttg cacatttgtt aactagccaa tgagagggaa agcgaagttg gccaacatca
     3781 taaagttgca ttaatgaagg agtgagacga gactactcaa gaaataccat tgggctgggg
     3841 atatatagct cagtggaagc acggtagcct ggcattaaca aggtgctata ggtggaaaag
     3901 aaaaaaacta ctgtcaaaag aatgatgtat acagggagtt tgaatttttt tttttagttg
     3961 aatagacaga tcatactgaa tttcaacagt tcagggaata ctaaagcact acttatgaaa
     4021 caatgcaggt gtggatacac tgaaaaagat aacaaatcag gccacttgct gtgatgtata
     4081 atgagaaaat taatgatagt atatttaagt aggttctttg ccttaaattt ccttcttggt
     4141 tcagaattga attttggaat ttttccccat tccagtgaac atagacagca ataaaattgc
     4201 taggtttctc catcctgaag aatttcacct gaggttataa ccttaggaat actaggtctg
     4261 tccccaactc ctgtatacac aaccactttg tactgtcact gtattctcat taagcagaaa
     4321 tcgctgccag acctggaaaa agaagctgca ctcaatagca tattgaaacc aaaggcatag
     4381 ctcattgtag ttttctatca gtcataatct tctacatcgc atctagcctt catatgtgga
     4441 tacactgaaa aagataacaa taatcatgtc tcaagaagag catgattatg taactatctc
     4501 tcacacaact gcgacaaaac tgtgaaaatc gtaatggtgg gaaaacaggc gcaaacccat
     4561 ggacttggaa agggtgaaag gcttgtaagg tgggtttcct gtcgatcccc agaagcagtc
     4621 tagcagtcct actgttctta aaggtgccct tgcctttgtg tagtttttgt ctcccttaga
     4681 gatggacaac tccacttgct attatgagac aagttaggag gaacatatac actacttgac
     4741 atatctgact aaaggtgtcc cagtgttcgt aataagatgc tgaaataccg acagcatgac
     4801 acttgtcagt tgaccatgaa agaagcatgt gtgaaaagtc tgatgcttta ttaaaactat
     4861 tgcatgaaaa ctcaccaagg tcaataagct gttaacatac agtagatgca tggttcaggc
     4921 cttcgatgat gtatctagtc actcatggct ttcatctgcc aggaaaaagg aggccccagt
     4981 tcatttgctt gctatggaag ttaggtatga gacatcaggg gccattaaga aagctttgga
     5041 cgtggtaagg tttgaatgcc cacatacatt ttattcagtt cctaaaaaca atcaaaacaa
     5101 cttgacactg atgaacttga tacatttgac tgtatcatat atagacccat atatagactg
     5161 ctccttatct atgaccactt tgaataagaa ttcattgagc cgtccaggtg gttttgtttc
     5221 ttttttccag aatgttctcc tgctcagatt ggcatccata agcaggtggc atatggtgga
     5281 tactactatg gaagttgctg gatactgatg tggaggtgtc catgcccttt gggtcagtta
     5341 gtgtacgctt atgttcgtgt gagaggcttg ctttcttaaa ctgctagttt gatgtactga
     5401 taaggcagac ctgactctac attttacatt tctttttgta aactgggtct ttagaaagca
     5461 tgttagccat tgtgttaaaa gaacattgtt cccgtaaaat ttagaggtct taaagtttaa
     5521 aatggaaaga aaggagccac aaacttctaa ggattgtaaa atgtttggat tgattctgat
     5581 ctagtttggg aaacagtgga ggcaggggat attaaagaaa caaaagaaat gcattgtaca
     5641 aatatgtagt tttagtgcag gttaatgatg gtggaggaaa gtgttgctaa tttgtttatt
     5701 tcccaggatg gaatgggaag tgtgatatgc agtttaattt ttaaggagct ggtctcaatt
     5761 ttagtactct ctaattataa aagaaatcaa tgtttcgtta aattttgtca ttggtttgtc
     5821 acaattatct aggggttcat atccaactct ctgtggcaac tcaattttat ataatctttt
     5881 aattgtttat gtatttctga cagtatgaag agaaagcata tgaggcatag aactgtcttt
     5941 tagaaatatg gatgatgtat cctggaatgt gaaggtgtcc ctctaagatg aaaaatggaa
     6001 ttattttact gttgtaccat tgttagacct tgaatgaatc catgttgcag tgtgtgtctg
     6061 tatatttgta gagaaaggga aatgacaatt gaaaggttac tttaaaattt tcaaattggg
     6121 cactgcctgt gttgcagcac tactgtatct ttgttgagcg acctaacagt atttccctgt
     6181 tgtgaaagtt aattctgatg atgtttcaca ttcaccagct ttttttctgt actatttgca
     6241 tccccaaata cttagtacaa gtagaattgt gcatggcttg ggcattcaaa gataagcgag
     6301 cgatgagtca gtctgagttt ctaaagccat gaaaacttgc tttgagactg aatagttctg
     6361 agttatttac aacagcacca attgtccaag tttctttccc tactgtaaaa gaattgatca
     6421 gtttcttcat taaagcagca agaaattaat taaatttgta cataccatgt ctcttagatt
     6481 tctgtgtatg ttgtgaagga cattattttg agaagaaatg tacaaaggca tattacaagg
     6541 ctatgcatgc accgtccaag cagtacatat tcagaaagtc aaagattcct gcaaaataaa
     6601 ttaataaact aaaaacaagc tctaaaaaaa aaaaaaaaaa a
//
