LOCUS       NM_138667               4278 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus TGF-beta activated kinase 1/MAP3K7 binding protein 2
            (Tab2), transcript variant 1, mRNA.
ACCESSION   NM_138667
VERSION     NM_138667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4278)
  AUTHORS   Li,N., Yun,B., Zeng,L., Lv,Y., Zhou,Y., Fang,M., Li,S., Chen,Y.,
            Huang,E., Zhang,L., Jiang,Y., Zhang,H., Li,J. and Yuan,X.
  TITLE     The antisense lncRNA of TAB2 that prevents oxidative stress to
            enhance the follicular growth in mammals
  JOURNAL   Commun Biol 7 (1), 1246 (2024)
   PUBMED   39358475
  REMARK    GeneRIF: The antisense lncRNA of TAB2 that prevents oxidative
            stress to enhance the follicular growth in mammals.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4278)
  AUTHORS   Ali,T., Nguyen,H.M., Abbas,N., Takeuchi,O., Akira,S., Suzuki,T.,
            Matsuzaki,G. and Takaesu,G.
  TITLE     TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for
            TLR-induced cytokine production in macrophages
  JOURNAL   Int Immunol 36 (9), 439-450 (2024)
   PUBMED   38567483
REFERENCE   3  (bases 1 to 4278)
  AUTHORS   Yao,X., Dong,R., Hu,S., Liu,Z., Cui,J., Hu,F., Cheng,X., Wang,X.,
            Ma,T., Tian,S., Zhang,X.J., Hu,Y., Bai,L., Li,H. and Zhang,P.
  TITLE     Tripartite motif 38 alleviates the pathological process of
            NAFLD-NASH by promoting TAB2 degradation
  JOURNAL   J Lipid Res 64 (7), 100382 (2023)
   PUBMED   37116711
  REMARK    GeneRIF: Tripartite motif 38 alleviates the pathological process of
            NAFLD-NASH by promoting TAB2 degradation.
REFERENCE   4  (bases 1 to 4278)
  AUTHORS   Zhang,J., Cao,L., Gao,A., Ren,R., Yu,L., Li,Q., Liu,Y., Qi,W.,
            Hou,Y., Sui,W., Su,G., Zhang,Y., Zhang,C. and Zhang,M.
  TITLE     E3 ligase RNF99 negatively regulates TLR-mediated inflammatory
            immune response via K48-linked ubiquitination of TAB2
  JOURNAL   Cell Death Differ 30 (4), 966-978 (2023)
   PUBMED   36681779
REFERENCE   5  (bases 1 to 4278)
  AUTHORS   Yin,H., Guo,X., Chen,Y., Zeng,Y., Mo,X., Hong,S., He,H., Li,J.,
            Steinmetz,R. and Liu,Q.
  TITLE     TAB2 deficiency induces dilated cardiomyopathy by promoting
            RIPK1-dependent apoptosis and necroptosis
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34990405
  REMARK    GeneRIF: TAB2 deficiency induces dilated cardiomyopathy by
            promoting RIPK1-dependent apoptosis and necroptosis.
REFERENCE   6  (bases 1 to 4278)
  AUTHORS   Orelio,C. and Dzierzak,E.
  TITLE     Identification of 2 novel genes developmentally regulated in the
            mouse aorta-gonad-mesonephros region
  JOURNAL   Blood 101 (6), 2246-2249 (2003)
   PUBMED   12433684
  REMARK    GeneRIF: the expression of mouse TAB2 in the E11 dorsal aorta
            endothelium suggests a role for mTAB2 in hematopoietic stem cell
            emergence and/or regulation
REFERENCE   7  (bases 1 to 4278)
  AUTHORS   Sanjo,H., Takeda,K., Tsujimura,T., Ninomiya-Tsuji,J., Matsumoto,K.
            and Akira,S.
  TITLE     TAB2 is essential for prevention of apoptosis in fetal liver but
            not for interleukin-1 signaling
  JOURNAL   Mol Cell Biol 23 (4), 1231-1238 (2003)
   PUBMED   12556483
  REMARK    GeneRIF: TAB2 is essential for embryonic development through
            prevention of liver apoptosis but not for the IL-1
            receptor-mediated signaling pathway.
REFERENCE   8  (bases 1 to 4278)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   9  (bases 1 to 4278)
  AUTHORS   Baek,S.H., Ohgi,K.A., Rose,D.W., Koo,E.H., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     Exchange of N-CoR corepressor and Tip60 coactivator complexes links
            gene expression by NF-kappaB and beta-amyloid precursor protein
  JOURNAL   Cell 110 (1), 55-67 (2002)
   PUBMED   12150997
REFERENCE   10 (bases 1 to 4278)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092856.26, CK391470.1, AY093701.1, BF468714.1, BG078791.2,
            AK003993.1 and BY429748.1.
            
            On Apr 7, 2009 this sequence version replaced NM_138667.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.202650.1,
                                           SRR11927938.4397555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC092856.26        172185-172507       c
            324-340             CK391470.1         190-206
            341-2689            AY093701.1         1-2349
            2690-3119           BF468714.1         1-430               c
            3120-3654           BG078791.2         63-597
            3655-4271           AK003993.1         243-859
            4272-4278           BY429748.1         406-412
FEATURES             Location/Qualifiers
     source          1..4278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.56 cM"
     gene            1..4278
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /note="TGF-beta activated kinase 1/MAP3K7 binding protein
                     2"
                     /db_xref="GeneID:68652"
                     /db_xref="MGI:MGI:1915902"
     exon            1..323
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     exon            324..511
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2491
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /note="TGF-beta-activated kinase 1-binding protein 2;
                     mitogen-activated protein kinase kinase kinase
                     7-interacting protein 2; Tak1 binding protein 2"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 2"
                     /protein_id="NP_619608.1"
                     /db_xref="CCDS:CCDS23691.1"
                     /db_xref="GeneID:68652"
                     /db_xref="MGI:MGI:1915902"
                     /translation="MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCA
                     VLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRT
                     LTHSVSDGQLHGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLG
                     SKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPY
                     ITTPSGTARQTQQHSGWVSQFNPMNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQ
                     GHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQ
                     RNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPNTDEMISRSQPKVYISAN
                     ATAGDEQGMRNQPTLFISTNSGPSAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSATS
                     PRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTD
                     PALAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVN
                     EMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFN
                     PSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDAEDEEGAQWNCTACTFLNHPALI
                     RCEQCEMPRHF"
     exon            512..2012
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2173
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2267
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2348
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..4278
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /note="hexamer: AATAAA"
     polyA_site      4181
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
     regulatory      4252..4257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /note="hexamer: ATTAAA"
     polyA_site      4273
                     /gene="Tab2"
                     /gene_synonym="1110030N06Rik; A530078N03Rik; Map3k7ip2;
                     mKIAA0733"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgagccg gagccgagca gcgggccgcg gcgacgccgc cccggccatc gctttgatcc
       61 gcggcaggcg ccggcggcgg ggcgccccag gccgaccccc tcccctcccc ctcagccgcg
      121 agcggcggcg gcggccggag ggagttggcg gcggccgggc ggagggggcc gagcggggag
      181 ggagggaggg ctgaggtgtc ccccctgccg ggtggaatcg gcgctggcgg cggccgcggt
      241 gacgacgggg gagacggctg cccaagtggg agaggcggcg gcggcggacg aggaggaggg
      301 ggaagccgcg gcggcggcga aggaaaatgc ttggccagaa gagatgagta ctaattccac
      361 tcaggcctag aattgcctat tgagatagac ctgagcaggc gacatacgaa tggcccaagg
      421 aagccaccaa attgattttc aggttttaca tgacctgcga caaaaattcc cagaagtgcc
      481 tgaagttgtt gtatccaggt gcatgttaca gaacaataat aacctggatg cctgctgcgc
      541 tgttctctct caggagagta caaggtatct ttatggtgaa ggagacctga atttttcaga
      601 tgagtctgga atttctggtc tacgcaatca catgacttct ctcaacttgg acttgcagtc
      661 acagaatgtt taccaccatg gaagagaagg aagtcgagtg aatggaagca ggactttaac
      721 acacagcgtt agtgatggac agcttcacgg tgggcagtcc aataacgaac tgtttcagca
      781 agagccacag acagcaccag ctcaagttcc tcaaggcttt aatgtttttg gaatgcccag
      841 tacatctggt gcttcaaact caacaccgca tcttggattt cacctaggca gcaaagggac
      901 atcaaacctt tctcaacaga ctcccaggtt caatcctatt atggtaactt tagccccaaa
      961 catacagact ggccgtagta ctcctacatc tttgcacata catggtgtac ctccgcctgt
     1021 actgaacagt ccacagggaa attctatcta tattaggcct tatattacaa ctcctagtgg
     1081 tacagctcgg cagacacaac aacattctgg ctgggtgtct cagtttaatc ccatgaaccc
     1141 tcagcaagcc tatcaacctt cacagcctgg accttggact acttatcctg catccaatcc
     1201 tttgccacat acctcaaccc agcagccgaa tcagcagggc catcagacct ctcatgtcta
     1261 catgcctatc agttcgccaa ctactccaca accgccaacc attcactcat ctgggagctc
     1321 tcagtcttct gcccatagcc aatataacat tcagaatatt tcaacaggac ctcgaaagaa
     1381 ccagatagaa atcaaacttg aacccccaca aagaaacagt tcttcaaaat tacgttcttc
     1441 tggacctcga actgccagca cttcctcatt ggtcaacagc cagaccttaa atagaaatca
     1501 gcccactgtt tacatagctg ccagtcctcc aaatactgat gagatgatct cccgtagtca
     1561 acccaaggtc tatatttcag ccaatgccac cgcaggagat gagcaaggca tgcggaatca
     1621 accgacactc ttcatatcta caaactctgg gccatctgca gcctccagga acatgtctgg
     1681 gcaagtgagc atgggtcctg cctttatcca tcaccatcca cccaaaagcc gagtgttagg
     1741 tggtaactct gcaacgtctc ctcgagtggt ggtcactcaa cccaacacaa aatatacttt
     1801 caaaattaca gtttccccca ataagccccc tgctgtttcc ccgggggtgg tctccccaac
     1861 ctttgaactt acaaatcttc taaatcatcc tgaccattat gtagaaacag agaacattca
     1921 gcatctcaca gacccggctc tagcacatgt ggatagaata agcgaagccc ggaaactgag
     1981 tatgggatct gatgatgctg cctacacaca agctctgctg gtgcaccaga aggccaggat
     2041 ggaacggctt caaagagagc tcgagatgca aaagaaaaag ctggataaac tcaaatctga
     2101 ggtcaatgag atggaaaata atctaactcg aaggcgcctg aagagatcaa attccatttc
     2161 ccagataccg tcactcgaag aaatgcagca gttgagaagt tgtaatagac aactccagat
     2221 tgacattgac tgcttaacca aagaaattga tctttttcaa gcccgaggac cacattttaa
     2281 ccccagcgct attcataact tttatgacaa tattggattt gtaggccctg tgccaccaaa
     2341 acccaaagat caaaggtcca ccatcaaagc accaaagacc caagacgcag aggatgagga
     2401 aggtgctcag tggaattgca ctgcctgtac gtttctgaat cacccggcct taatccgctg
     2461 tgaacagtgt gagatgcctc ggcatttctg agccaaaggc cccgccttcc tctgaaacca
     2521 catctaaagt tcaagaaggt cgcctgtcat cgggaaagtg tttcaccgcc acaggagtta
     2581 gtccagttga aggtgtgacg agacagtggt gtgctgtgtt gagtgtcagc ccacagagct
     2641 aatgatacct caatctaatg tcatgggcag tgagattcat cacctgaaag gcctgagaga
     2701 ccgggctgcc tgctgcctga ccatgtccag tgtcacgtgt cagtgcctag gtgttcccag
     2761 gactcctccc ctcttgtcac cactgatcct gacgggagga agggagagac aggatgattg
     2821 ctttttgtgt tgttagagct tttggtgaaa cactacatac acaaagagaa ggaacaaggt
     2881 ttgactgaga actctgctgc cacatagtgc cagtagatgt gggaaacgcc acaaatctgg
     2941 ggtacttttg gccctgtcct ctgtcttctg aggacatctc tgtgaagcca gcatttaggt
     3001 gtgagataaa aggaaagctg tgtctgtctg tacatccaca gtgcgctccc caagcctctc
     3061 ctactgtaca gatgtctcac gtctgctttg atttctccat tatcttctta tatttctata
     3121 tgtatagtgt aatagacttg tgttaactag tgtccttttc ccttttagta agcacgatca
     3181 tgctcctttt aagccttacc tgagaaaagc aatgccataa ggtagaaagc attaatgaaa
     3241 tgaaactgtg cacaacataa ctccctctcc ccttcctcct cctgtccttt gtcccttggt
     3301 gccaatgctc tgagaagaca tgcaggtgct gcatgtgagt cactgcaaga aacactgcag
     3361 ccatcggacg gtcgaggtca cgctgtacac tgacttgagc agtgggtgac caaacatgtc
     3421 gttttgtctt ctccagcagc ttaaagcaga aagtatttaa acccactgcc atcttgcccc
     3481 atctgtgtgg tatcccatag aactccatgg gaggctcttg ttgggaaaat gcagttttaa
     3541 gaagcagcct cagcagccgt tcccgcagcc tcttcttccc gggaagaagt gtggctgtcg
     3601 gactgttggc acagtcatgt gtatttataa agcatagtca tctttaggac aactgaagaa
     3661 aagctggaaa aaagaaagaa aacaagcaga cttgaacact gaagcaacct cagacatctc
     3721 tttattttga tgatatattt ttgtaaggaa aataaatatt catatgatca ggaatgtata
     3781 taactaaatg aaatcaagaa aaaataacca tatgcatttt aaaagaatta tgaaattatc
     3841 agtgcttgga atggggctaa gggaagtgct gaaatataag aaaaaaatag gaaataatgt
     3901 agattgtccc actgtaaatg ttcacaagtg gctatgtttt aaataaacag gattattatg
     3961 aatgagcgtt aagaaggtca gagcctggcc ttccgggctt tgcactgtga gtatggaaag
     4021 agatacggca accataggtc actaggcaac agaccccaaa actcgtacat ttgatgcatt
     4081 gtgttttaaa agtaggcctt gtttttcagc ttcctctgca gttctatgtg aagattgata
     4141 aatcagtttt tacttgtttt attaataaaa cgtaatttgg atatcttgag ttgatggttt
     4201 tgtgatttag ctgggtaaac tatctttgta acagataagt tatttataaa aattaaaaaa
     4261 acttatattc taatgtgg
//
