LOCUS       NM_025609               2960 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus TGF-beta activated kinase 1/MAP3K7 binding protein 1
            (Tab1), mRNA.
ACCESSION   NM_025609
VERSION     NM_025609.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Zhang,J., Cao,L., Gao,A., Ren,R., Yu,L., Li,Q., Liu,Y., Qi,W.,
            Hou,Y., Sui,W., Su,G., Zhang,Y., Zhang,C. and Zhang,M.
  TITLE     E3 ligase RNF99 negatively regulates TLR-mediated inflammatory
            immune response via K48-linked ubiquitination of TAB2
  JOURNAL   Cell Death Differ 30 (4), 966-978 (2023)
   PUBMED   36681779
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Yuan,L., Bu,S., Du,M., Wang,Y., Ju,C., Huang,D., Xu,W., Tan,X.,
            Liang,M., Deng,S., Yang,L. and Huang,K.
  TITLE     RNF207 exacerbates pathological cardiac hypertrophy via
            post-translational modification of TAB1
  JOURNAL   Cardiovasc Res 119 (1), 183-194 (2023)
   PUBMED   35352799
  REMARK    GeneRIF: RNF207 exacerbates pathological cardiac hypertrophy via
            post-translational modification of TAB1.
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Li,J., Tan,J., Song,Q., Yang,X., Zhang,X., Qin,H., Huang,G., Su,X.
            and Li,J.
  TITLE     Exosomal miR-767 from senescent endothelial-derived accelerating
            skin fibroblasts aging via inhibiting TAB1
  JOURNAL   J Mol Histol 54 (1), 13-24 (2023)
   PUBMED   36409439
  REMARK    GeneRIF: Exosomal miR-767 from senescent endothelial-derived
            accelerating skin fibroblasts aging via inhibiting TAB1.
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Zeng,H., Qi,X., Xu,X. and Wu,Y.
  TITLE     TAB1 regulates glycolysis and activation of macrophages in diabetic
            nephropathy
  JOURNAL   Inflamm Res 69 (12), 1215-1234 (2020)
   PUBMED   33044562
  REMARK    GeneRIF: TAB1 regulates glycolysis and activation of macrophages in
            diabetic nephropathy.
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Makeeva,N., Roomans,G.M., Myers,J.W. and Welsh,N.
  TITLE     Transforming growth factor-beta-activated protein kinase 1-binding
            protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced
            p38 mitogen-activated protein kinase phosphorylation and cell death
            in insulin-producing cells
  JOURNAL   Endocrinology 149 (1), 302-309 (2008)
   PUBMED   17932218
  REMARK    GeneRIF: TAB1alpha, but not TAB1beta, plays an important role in
            the activation of p38 in insulin-producing cells and therefore also
            in cytokine-induced beta-cell death.
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   Blanco,S., Santos,C. and Lazo,P.A.
  TITLE     Vaccinia-related kinase 2 modulates the stress response to hypoxia
            mediated by TAK1
  JOURNAL   Mol Cell Biol 27 (20), 7273-7283 (2007)
   PUBMED   17709393
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Makeeva,N., Roomans,G.M. and Welsh,N.
  TITLE     Role of TAB1 in nitric oxide-induced p38 activation in
            insulin-producing cells
  JOURNAL   Int J Biol Sci 3 (2), 71-76 (2006)
   PUBMED   17205106
  REMARK    GeneRIF: We propose that TAB1 promotes nitric oxide-induced p38
            autophosphorylation. In addition, nitric oxide-induced p38
            activation seems to promote JNK inhibition and ERK activation, but
            this effect appears to not require TAB1.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Shim,J.H., Xiao,C., Paschal,A.E., Bailey,S.T., Rao,P., Hayden,M.S.,
            Lee,K.Y., Bussey,C., Steckel,M., Tanaka,N., Yamada,G., Akira,S.,
            Matsumoto,K. and Ghosh,S.
  TITLE     TAK1, but not TAB1 or TAB2, plays an essential role in multiple
            signaling pathways in vivo
  JOURNAL   Genes Dev 19 (22), 2668-2681 (2005)
   PUBMED   16260493
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Komatsu,Y., Shibuya,H., Takeda,N., Ninomiya-Tsuji,J., Yasui,T.,
            Miyado,K., Sekimoto,T., Ueno,N., Matsumoto,K. and Yamada,G.
  TITLE     Targeted disruption of the Tab1 gene causes embryonic lethality and
            defects in cardiovascular and lung morphogenesis
  JOURNAL   Mech Dev 119 (2), 239-249 (2002)
   PUBMED   12464436
  REMARK    GeneRIF: TAB1 plays an important role in mammalian embryogenesis
            and is required for TAK1 activation in TGF-beta signaling
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY262560.1, BC054369.1 and BQ176587.1.
            
            On Jul 12, 2018 this sequence version replaced NM_025609.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027054.1, BC054369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY262560.1         20-27
            9-2940              BC054369.1         1-2932
            2941-2960           BQ176587.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..2960
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /note="TGF-beta activated kinase 1/MAP3K7 binding protein
                     1"
                     /db_xref="GeneID:66513"
                     /db_xref="MGI:MGI:1913763"
     exon            1..43
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1519
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /note="mitogen-activated protein kinase kinase kinase
                     7-interacting protein 1; Tak1-binding protein 1"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 1"
                     /protein_id="NP_079885.2"
                     /db_xref="CCDS:CCDS27659.1"
                     /db_xref="GeneID:66513"
                     /db_xref="MGI:MGI:1913763"
                     /translation="MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGT
                     ESHPPEDNWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTEADV
                     RRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKALER
                     EISGGAMAVVAVLLNSKLYVANVGTNRALLCKSTVDGLQVTQLNMDHTTENEDELFRL
                     SQLGLDAGKIKQMGVICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQ
                     PLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRV
                     KRIHSDTFASGGERAKFCPRHEDMTLLVRNFGYPLGEMSQPTPTPAPGGRVYPVSVPY
                     SSAQSTSKTSVTLSLVMPSQGQMVNGSHSASTLDEATPTLTNQSPTLTLQSTNTHTQS
                     SSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVMTAP"
     exon            44..180
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..334
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..421
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..560
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..674
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..786
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..931
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1154
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1311
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..2945
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2918..2923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /note="hexamer: AATAGA"
     polyA_site      2945
                     /gene="Tab1"
                     /gene_synonym="2310012M03Rik; b2b449Clo; Map3k7ip1"
                     /note="major polyA site"
ORIGIN      
        1 gtcctccaag atggcggcgc agaggaggag cctgctccag agtgagcagc agccaagctg
       61 gacagatgac ctgccactct gtcacctctc tggagttggt tcagcgtcca accgcagcta
      121 ctctgctgat ggcaagggca ctgagagcca ccctccggag gacaactggc ttaagttcag
      181 aagtgaaaat aactgcttcc tgtacggggt cttcaatggc tatgatggca accgcgtgac
      241 caactttgtg gcgcagaggc tttctgcaga gctcctgctg ggccagctca acactgagca
      301 cactgaggct gatgtgcgac gggtcctgct gcaggccttt gatgtggtgg agaggagctt
      361 cctggagtct atcgatgatg ccttagctga gaaagcaagc ctccagtccc agctgccgga
      421 gggtgtgccc cagcaccagc tgccacctca gtaccagaag atccttgaga gactcaaggc
      481 actggagagg gagatttcgg gaggagccat ggctgtcgtg gcagtccttc tcaacagcaa
      541 gctctacgtt gccaatgtcg gtacgaacag ggcccttctg tgcaaatcta cagtggatgg
      601 gttacaggtt acacagctaa acatggacca caccaccgag aacgaggacg agctctttcg
      661 gctttcgcaa ctgggtttag acgcagggaa gatcaagcag atgggcgtca tctgtggaca
      721 ggagagcacc aggcggattg gggattacaa ggtcaaatat ggctacaccg acattgacct
      781 gctcagcgct gccaagtcca aacccatcat cgcagagccg gaaattcatg gcgcacagcc
      841 tctggatggc gtgacgggct tcctggtgct gatgtcagag gggctgtaca aggccctgga
      901 ggcagcccat gggcctgggc aggccaacca ggagattgcc gcgatgattg acaccgagtt
      961 tgccaagcag acctccctgg atgcggttgc ccaggctgtg gtagaccgtg taaagcggat
     1021 ccacagtgac acctttgcca gtggtgggga gcgtgccaag ttctgcccac ggcatgaaga
     1081 catgaccctg ctggtgagga actttggcta tccattgggt gaaatgagcc agcctacacc
     1141 gacccctgcc ccagggggcc gtgtgtaccc tgtttctgtg ccctactcaa gtgcccagag
     1201 caccagcaag actagtgtga ctctgtccct cgtcatgcct tctcagggcc agatggtcaa
     1261 cggctctcac agtgcctcca ctctggacga agccactccc acactcacta accagagccc
     1321 cactctgacc ctgcagtcca ccaacacgca cacccagagc agcagctcca gctctgacgg
     1381 gggcctcttc cgctccagac cggctcactc acttccaccc ggagaggatg gccgtgtgga
     1441 gccctatgtg gactttgctg agttctaccg actctggagc gtggaccacg gcgagcagag
     1501 cgtgatgacg gcaccttagt ctagcctcag agtgcagcct gggcacaact ttgtgtagac
     1561 acagagggcc agtgccaaag caagacaagc ttcctgacct ttgcgggggc catggaaccc
     1621 tcgggcagtg agtcatgacg tgctgcaggt tcaaccacag ccctgggctg tggcctgagt
     1681 acagactgca ttgctgctgg tccacacagg aggctggagt ccagaccaca ggcatcctaa
     1741 gacagggcca agcgggaaag ctgcaggtag cttacaaacc atcacgagtg cctcctgaca
     1801 cgtttaaaga ctagcaagat gccgtcctgt ggaccccagc taccaaaggc cagacagaca
     1861 ctgctccctc aagactcctc cacctgcttc agcttccccc ggaagagctg tggcctctgc
     1921 gagtgcccgt tacctctggg tggctatccc ctttccacct ttcagcccaa actcctagat
     1981 ccagagtagc gaataacagg agtgggtgcc tgtcactgga tgtcactgga aaagtccagg
     2041 gaagcagagg ggttattaac agccacagag gagcaagaca aggaagtacc agagagagct
     2101 ggccaaggaa tgctagtcct gggctgcagg tcagccagct ggcagctgag ctaactcaga
     2161 gagctggctt cccaatgggg tgcagttagt aggccaggcc caccaggcag ctgcagttct
     2221 gcttctgcta gatcctgccc tggggtgagg caggccaagt cagaagccag tgccttcctc
     2281 ccagcgggtc ctgggaagcc agtgataggg ggtgctgagg caacagacct cacgctgatg
     2341 aggaggctgc ttggttccgg gctctgccga aagaggagtg ggatacggct gtgagagggc
     2401 cgaggttgag tcttgctcac ccagaagacc aaggacatca ggtgcagtga tgcggacgtg
     2461 cagggaaaag actctgctgg tcaggccctg actgggacct gttcacacag aatctctccc
     2521 ttcagacagg agggttacca cagctgcctg cagtgtggcc acccctgtgc tcagaggaga
     2581 aaggctgggt gctcctctta cctgagccct tccatcagga ttaaatctgc agccctttcc
     2641 ccactgtgtg cagctactgg gcagggtgcc cagtgtggcc tggtggcaaa ggccaattca
     2701 gagcacttct cagactccat ttccctaaag cgaggctgct ggctccatgc tgaggagaag
     2761 ccctggggtg atgggaagaa gaagccttcc tgctctccac taggaagtca cctctgccct
     2821 gcaggtgccc tgcaggtgag cagctctcag ctggtgcaca aggacatggg acaaaggagg
     2881 tcctccccaa ggaatgtggt gctgtttggt ctctagaaat agaaccatgt tcttcatgca
     2941 gtaaaaaaaa aaaaaaaaaa
//
