LOCUS       NM_053205                999 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus trace amine-associated receptor 1 (Taar1), mRNA.
ACCESSION   NM_053205
VERSION     NM_053205.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Sun,M., Zhang,Y., Zhang,X.Q., Zhang,Y., Wang,X.D., Li,J.T., Si,T.M.
            and Su,Y.A.
  TITLE     Dopamine D1 receptor in medial prefrontal cortex mediates the
            effects of TAAR1 activation on chronic stress-induced cognitive and
            social deficits
  JOURNAL   Neuropsychopharmacology 49 (8), 1341-1351 (2024)
   PUBMED   38658737
  REMARK    GeneRIF: Dopamine D1 receptor in medial prefrontal cortex mediates
            the effects of TAAR1 activation on chronic stress-induced cognitive
            and social deficits.
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Zhang,Y., Zhang,X.Q., Niu,W.P., Sun,M., Zhang,Y., Li,J.T., Si,T.M.
            and Su,Y.A.
  TITLE     TAAR1 in dentate gyrus is involved in chronic stress-induced
            impairments in hippocampal plasticity and cognitive function
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 132, 110995 (2024)
   PUBMED   38514038
  REMARK    GeneRIF: TAAR1 in dentate gyrus is involved in chronic
            stress-induced impairments in hippocampal plasticity and cognitive
            function.
REFERENCE   3  (bases 1 to 999)
  AUTHORS   Xu,Z., Guo,L., Yu,J., Shen,S., Wu,C., Zhang,W., Zhao,C., Deng,Y.,
            Tian,X., Feng,Y., Hou,H., Su,L., Wang,H., Guo,S., Wang,H., Wang,K.,
            Chen,P., Zhao,J., Zhang,X., Yong,X., Cheng,L., Liu,L., Yang,S.,
            Yang,F., Wang,X., Yu,X., Xu,Y., Sun,J.P., Yan,W. and Shao,Z.
  TITLE     Ligand recognition and G-protein coupling of trace amine receptor
            TAAR1
  JOURNAL   Nature 624 (7992), 672-681 (2023)
   PUBMED   37935376
  REMARK    GeneRIF: Ligand recognition and G-protein coupling of trace amine
            receptor TAAR1.
REFERENCE   4  (bases 1 to 999)
  AUTHORS   Shang,P., Rong,N., Jiang,J.J., Cheng,J., Zhang,M.H., Kang,D.,
            Qi,L., Guo,L., Yang,G.M., Liu,Q., Zhou,Z., Li,X.B., Zhu,K.K.,
            Meng,Q.B., Han,X., Yan,W., Kong,Y., Yang,L., Wang,X., Lei,D.,
            Feng,X., Liu,X., Yu,X., Wang,Y., Li,Q., Shao,Z.H., Yang,F. and
            Sun,J.P.
  TITLE     Structural and signaling mechanisms of TAAR1 enabled preferential
            agonist design
  JOURNAL   Cell 186 (24), 5347-5362 (2023)
   PUBMED   37963465
REFERENCE   5  (bases 1 to 999)
  AUTHORS   Zhai,L., Xiao,H., Lin,C., Wong,H.L.X., Lam,Y.Y., Gong,M., Wu,G.,
            Ning,Z., Huang,C., Zhang,Y., Yang,C., Luo,J., Zhang,L., Zhao,L.,
            Zhang,C., Lau,J.Y., Lu,A., Lau,L.T., Jia,W., Zhao,L. and Bian,Z.X.
  TITLE     Gut microbiota-derived tryptamine and phenethylamine impair insulin
            sensitivity in metabolic syndrome and irritable bowel syndrome
  JOURNAL   Nat Commun 14 (1), 4986 (2023)
   PUBMED   37591886
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 999)
  AUTHORS   Wolinsky,T.D., Swanson,C.J., Smith,K.E., Zhong,H., Borowsky,B.,
            Seeman,P., Branchek,T. and Gerald,C.P.
  TITLE     The Trace Amine 1 receptor knockout mouse: an animal model with
            relevance to schizophrenia
  JOURNAL   Genes Brain Behav 6 (7), 628-639 (2007)
   PUBMED   17212650
REFERENCE   7  (bases 1 to 999)
  AUTHORS   Reese,E.A., Bunzow,J.R., Arttamangkul,S., Sonders,M.S. and
            Grandy,D.K.
  TITLE     Trace amine-associated receptor 1 displays species-dependent
            stereoselectivity for isomers of methamphetamine, amphetamine, and
            para-hydroxyamphetamine
  JOURNAL   J Pharmacol Exp Ther 321 (1), 178-186 (2007)
   PUBMED   17218486
REFERENCE   8  (bases 1 to 999)
  AUTHORS   Liberles,S.D. and Buck,L.B.
  TITLE     A second class of chemosensory receptors in the olfactory
            epithelium
  JOURNAL   Nature 442 (7103), 645-650 (2006)
   PUBMED   16878137
  REMARK    GeneRIF: Previous studies reported TAAR expression in brain. This
            paper found TAAR expression only in olfactory epithelial cells and
            that each TAAR detects a unique set of amine ligands. TAARs seem to
            function as a family of chemosensory receptors for amines.
REFERENCE   9  (bases 1 to 999)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   10 (bases 1 to 999)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380187.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/SvJ"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 11.39 cM"
     gene            1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="trace amine-associated receptor 1"
                     /db_xref="GeneID:111174"
                     /db_xref="MGI:MGI:2148258"
     CDS             1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /codon_start=1
                     /product="trace amine-associated receptor 1"
                     /protein_id="NP_444435.1"
                     /db_xref="CCDS:CCDS23735.1"
                     /db_xref="GeneID:111174"
                     /db_xref="MGI:MGI:2148258"
                     /translation="MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVI
                     ISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTD
                     IMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFL
                     ELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKG
                     QARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGY
                     VIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL"
     exon            1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcatcttt gccacgctat cacaaacatt tcccacagaa acagcgactg gtcaagagaa
       61 gtccaagctt ccctgtacag cttaatgtca ctcataatcc tggccactct ggttggcaac
      121 ttaatagtaa taatttccat atcccatttc aagcaacttc atacacccac caactggctc
      181 cttcactcca tggccattgt cgactttctg ctgggctgtc tgataatgcc ctgcagcatg
      241 gtgagaactg ttgagcgctg ttggtatttt ggggaaatcc tctgtaaagt tcacaccagc
      301 accgatatca tgctgagctc cgcctccatt ttccacttag ctttcatttc cattgaccgc
      361 tactgtgctg tgtgtgaccc tttgagatac aaagccaaga tcaatatctc cactattctt
      421 gtgatgatcc tcgttagttg gagccttcct gctgtttatg catttgggat gatcttcctg
      481 gaactgaact taaaaggagt ggaagagctg tatcgcagtc aggtcagcga cctgggcggc
      541 tgttctccct tctttagtaa agtatctggg gtactggcgt tcatgacttc cttctatata
      601 cctggatctg ttatgttatt tgtttactat aggatatatt tcatagctaa aggacaagca
      661 aggtcaatca atcgtacgaa tgttcaagtt ggattggaag ggaaaagcca agcaccacaa
      721 agcaaggaaa caaaagccgc gaagacctta gggatcatgg tgggcgtttt cctcgtatgc
      781 tggtgcccgt tctttctctg cacggtcctg gaccctttcc tgggctatgt tatcccaccc
      841 tctctgaatg acgcactgta ttggtttggg tacttgaatt ctgccctcaa tccgatggtt
      901 tatgcctttt tctatccctg gttcagaaga gccttgaaga tggttctcct tggtaaaatt
      961 ttccaaaaag attcatctag gtctaagcta tttttgtaa
//
