LOCUS       NM_009309               2046 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus brachyury, T-box transcription factor T (T), mRNA.
ACCESSION   NM_009309
VERSION     NM_009309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Lehr,S., Bruckner,D.B., Minchington,T.G., Greunz-Schindler,M.,
            Merrin,J., Hannezo,E. and Kicheva,A.
  TITLE     Self-organized pattern formation in the developing mouse neural
            tube by a temporal relay of BMP signaling
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39603235
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Chen,S., Hayoun-Neeman,D., Nagar,M., Pinyan,S., Hadad,L.,
            Yaacobov,L., Alon,L., Shachar,L.E., Swissa,T., Kryukov,O.,
            Gershoni-Yahalom,O., Rosental,B., Cohen,S. and Lichtenstein,R.G.
  TITLE     Terminal alpha1,2-fucosylation of glycosphingolipids by FUT1 is a
            key regulator in early cell-fate decisions
  JOURNAL   EMBO Rep 25 (10), 4433-4464 (2024)
   PUBMED   39256596
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Li,M., Jin,H., Zhao,Y., Zhu,G., Liu,Y., Long,H. and Shen,X.
  TITLE     PHD2 safeguards modest mesendoderm development
  JOURNAL   Commun Biol 7 (1), 1100 (2024)
   PUBMED   39244636
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Kralova,J. and Lengerova,A.
  TITLE     H-Y antigen: genetic control of the expression as detected by
            host-versus-graft popliteal lymph node enlargement assay maps
            between the T and H-2 complexes
  JOURNAL   J Immunogenet 6 (6), 429-438 (1979)
   PUBMED   521667
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Silver,L.M., Artzt,K. and Bennett,D.
  TITLE     A major testicular cell protein specified by a mouse T/t complex
            gene
  JOURNAL   Cell 17 (2), 275-284 (1979)
   PUBMED   455464
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Demant,P., Ivanyi,D. and van Nie,R.
  TITLE     The map position of the rds gene on the 17th chromosome of the
            mouse
  JOURNAL   Tissue Antigens 13 (1), 53-55 (1979)
   PUBMED   419532
REFERENCE   9  (bases 1 to 2046)
  AUTHORS   Cheers,C. and McKenzie,I.F.
  TITLE     Resistance and susceptibility of mice to bacterial infection:
            genetics of listeriosis
  JOURNAL   Infect Immun 19 (3), 755-762 (1978)
   PUBMED   305895
REFERENCE   10 (bases 1 to 2046)
  AUTHORS   Klein,J. and Hammerberg,C.
  TITLE     The control of differentiation by the T complex
  JOURNAL   Immunol Rev 33, 70-104 (1977)
   PUBMED   321329
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154579.3.
            
            On Nov 17, 2006 this sequence version replaced NM_009309.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51683.1, BC120807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC154579.3         50929-51242
            315-579             AC154579.3         51697-51961
            580-714             AC154579.3         52617-52751
            715-776             AC154579.3         53484-53545
            777-838             AC154579.3         53656-53717
            839-1012            AC154579.3         55122-55295
            1013-1142           AC154579.3         56416-56545
            1143-2046           AC154579.3         58099-59002
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.92 cM"
     gene            1..2046
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /note="brachyury, T-box transcription factor T"
                     /db_xref="GeneID:20997"
                     /db_xref="MGI:MGI:98472"
     exon            1..314
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1419
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /note="brachyury protein; protein T; low ratio;
                     brachyury-like 2; brachyury-like 3"
                     /codon_start=1
                     /product="T-box transcription factor T"
                     /protein_id="NP_033335.1"
                     /db_xref="CCDS:CCDS28383.1"
                     /db_xref="GeneID:20997"
                     /db_xref="MGI:MGI:98472"
                     /translation="MSSPGTESAGKSLQYRVDHLLSAVESELQAGSEKGDPTERELRV
                     GLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVTADNHRW
                     KYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIML
                     NSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFL
                     DAKERNDHKDVMEEPGDCQQPGYSQWGWLVPGAGTLCPPASSHPQFGGSLSLPSTHGC
                     ERYPALRNHRSSPYPSPYAHRNSSPTYADNSSACLSMLQSHDNWSSLGVPGHTSMLPV
                     SHNASPPTGSSQYPSLWSVSNGTITPGSQTAGVSNGLGAQFFRGSPAHYTPLTHTVSA
                     ATSSSSGSPMYEGAATVTDISDSQYDTAQSLLIASWTPVSPPSM"
     exon            315..579
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..714
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..776
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..838
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1012
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1142
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..2046
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="T"
                     /gene_synonym="Bra; cou; D17Mit170; Low; Lr; me75; T1;
                     Tbxt; Tl2; Tl3"
                     /note="major polyA site"
ORIGIN      
        1 ggctccgcag agtgaccctt tttcttggaa aagcggtggc gagagaagtg aaggtggctg
       61 ttgggtaggg agtcaagact cctggaaggt ggagagggtg gcgggaggat gagctcgccg
      121 ggcacagaga gcgcagggaa gagcctgcag taccgagtgg accacctgct cagcgccgtg
      181 gagagcgagc tgcaggcggg cagcgagaag ggagacccca ccgaacgcga actgcgagtg
      241 ggcctggagg agagcgagct gtggctgcgc ttcaaggagc taactaacga gatgattgtg
      301 accaagaacg gcaggaggat gttcccggtg ctgaaggtaa atgtgtcagg cctggacccc
      361 aatgccatgt actctttctt gctggacttc gtgacggctg acaaccaccg ctggaaatat
      421 gtgaacgggg agtgggtacc tgggggcaaa ccagagcctc aggcgcccag ctgcgtctac
      481 atccacccag actcgcccaa ttttggggcc cactggatga aggcgcctgt gtctttcagc
      541 aaagtcaaac tcaccaacaa gctcaatgga gggggacaga tcatgttaaa ctccttgcat
      601 aagtatgaac ctcggattca catcgtgaga gttgggggcc cgcaacgcat gatcaccagc
      661 cactgctttc ccgagaccca gttcatagct gtgactgcct accagaatga ggagattaca
      721 gcccttaaaa ttaaatacaa cccatttgct aaagccttcc ttgatgccaa agaaagaaac
      781 gaccacaaag atgtaatgga ggaaccgggg gactgccagc agccggggta ttcccaatgg
      841 gggtggcttg ttcctggtgc tggcaccctc tgcccgcctg ccagctccca ccctcagttt
      901 ggaggctcgc tctctctccc ctccacacac ggctgtgaga ggtacccagc tctaaggaac
      961 caccggtcat cgccctaccc cagcccctat gctcatcgga acagctctcc aacctatgcg
     1021 gacaattcat ctgcttgtct gtccatgctg cagtcccatg ataactggtc tagcctcgga
     1081 gtgcctggcc acaccagcat gctgcctgtg agtcataacg ccagcccacc tactggctct
     1141 agccagtatc ccagtctctg gtctgtgagc aatggtacca tcaccccagg ctcccagaca
     1201 gctggggtgt ccaacgggct gggagctcag ttctttcgag gctcccctgc acattacaca
     1261 ccactgacgc acacggtctc agctgccacg tcctcgtctt ctggttctcc gatgtatgaa
     1321 ggggctgcta cagtcacaga catttctgac agccagtatg acacggccca aagcctcctc
     1381 atagcctcgt ggacacctgt gtcaccccca tctatgtgaa ttgaactttc ctccatgtgc
     1441 tgagacttgt aacaaccggt gtcaactgga tcttctaggc tcaaagtggc aggctcttgg
     1501 gacaagggaa aaataaataa ataaaagcta gatactaaca actccatttt caaataagag
     1561 caataataca tgtcctataa tcatgttcta cagcctcttg tttgatacct acagtagtga
     1621 tatgtgtcct acattatgaa gccaaggaca gagagacggc tgtggtccag ttttttgtga
     1681 ctggcagtta atcagagtcc tttgctaggt agggtcctat atcttgtgtt tctctacaac
     1741 atatatgtga ctttgaaatc ctggaattcg tccaccccct gtcctacttt agtgagacac
     1801 aaggtacacc tctaatgtcc tcccttgttg ccttagagta gttaactttg aggacagaaa
     1861 aaagcatagc cagaagattg taactgaacc gtcaactgtt ctgcccttgg aacatgccta
     1921 ctttaagcac acgtagcttt ttgtgttggg aagtcaactg tatggatact tttctgttga
     1981 caaagtagcc aaagacaatc tgcagaaagt gttttctgca caataaaggc aatatatagc
     2041 acctgg
//
