LOCUS       NP_937813               3431 aa            linear   ROD 09-FEB-2025
DEFINITION  KICSTOR complex protein SZT2 [Mus musculus].
ACCESSION   NP_937813 XP_001477707 XP_001481325
VERSION     NP_937813.3
DBSOURCE    REFSEQ: accession NM_198170.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 3431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 3431)
  AUTHORS   Yin,N., Jin,G., Ma,Y., Zhao,H., Zhang,G., Li,M.O. and Peng,M.
  TITLE     SZT2 maintains hematopoietic stem cell homeostasis via
            nutrient-mediated mTORC1 regulation
  JOURNAL   J Clin Invest 132 (20), e146272 (2022)
   PUBMED   36250465
  REMARK    GeneRIF: SZT2 maintains hematopoietic stem cell homeostasis via
            nutrient-mediated mTORC1 regulation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 3431)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 3431)
  AUTHORS   Peng,M., Yin,N. and Li,M.O.
  TITLE     SZT2 dictates GATOR control of mTORC1 signalling
  JOURNAL   Nature 543 (7645), 433-437 (2017)
   PUBMED   28199315
  REMARK    GeneRIF: SZT2 has a central role in dictating GATOR-dependent
            nutrient sensing by promoting lysosomal localization of
            SZT2-orchestrated GATOR complex, and reveal an unexpected function
            of lysosome-located GATOR2 in suppressing mTORC1 signalling through
            SESN recruitment
            Erratum:[Nature. 2018 Jun;558(7710):E2. doi:
            10.1038/s41586-018-0114-2.. PMID: 29769712]
REFERENCE   5  (residues 1 to 3431)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
  REMARK    GeneRIF: in mice that lack SZT2, mTORC1 signalling is increased in
            several tissues, including in neurons in the brain
REFERENCE   6  (residues 1 to 3431)
  AUTHORS   Toutzaris,D., Lewerenz,J., Albrecht,P., Jensen,L.T., Letz,J.,
            Geerts,A., Golz,S. and Methner,A.
  TITLE     A novel giant peroxisomal superoxide dismutase motif-containing
            protein
  JOURNAL   Free Radic Biol Med 48 (6), 811-820 (2010)
   PUBMED   20045724
REFERENCE   7  (residues 1 to 3431)
  AUTHORS   Frankel,W.N., Yang,Y., Mahaffey,C.L., Beyer,B.J. and O'Brien,T.P.
  TITLE     Szt2, a novel gene for seizure threshold in mice
  JOURNAL   Genes Brain Behav 8 (5), 568-576 (2009)
   PUBMED   19624305
  REMARK    GeneRIF: While the biological function of Szt2 remains unknown, its
            high conservation, unique structure and effect on seizure threshold
            suggest that it serves an important role in the central nervous
            system.
REFERENCE   8  (residues 1 to 3431)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   9  (residues 1 to 3431)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 3431)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FJ998170.1 and CJ191816.1.
            
            On or before Jul 10, 2009 this sequence version replaced
            XP_001481325.1, XP_001477707.1, NP_937813.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ998170.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.61 cM"
     Protein         1..3431
                     /product="KICSTOR complex protein SZT2"
                     /note="Seizure threshold 2 protein; Transcript increased
                     in glutamate resistance; seaizure threshold 2"
                     /calculated_mol_wt=377498
     Region          699..731
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1067..1101
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1082..1188
                     /region_name="Mediates interaction with the GATOR1
                     complex. /evidence=ECO:0000250|UniProtKB:Q5T011"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1162..1231
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Site            1275
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T011; propagated from
                     UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1356..1378
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Site            1415
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T011; propagated from
                     UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1512..1534
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1629..1678
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Site            1640
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5T011; propagated from
                     UniProtKB/Swiss-Prot (A2A9C3.1)"
     Site            1650
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T011; propagated from
                     UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          1806..1883
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          2113..2148
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          2450..2512
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          2735..2756
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     Region          2866..2899
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9C3.1)"
     CDS             1..3431
                     /gene="Szt2"
                     /gene_synonym="6430407N22; TIGR"
                     /coded_by="NM_198170.4:75..10370"
                     /db_xref="CCDS:CCDS51283.1"
                     /db_xref="GeneID:230676"
                     /db_xref="MGI:MGI:3033336"
ORIGIN      
        1 maserpepev eeagqvfllm kkdyrisrnv rlawflnhlh qtvqatpqel llqseqelev
       61 lsvlppgwqp depvvprpfl lvpstrvtfl awqyrfviel dlspstgivd dstgeilfde
      121 vfhalsrclg gllrpfrvpg scinfqpeiy vtiqayssii glqshqvlvq gclldpsqre
      181 aflqqvyeql clfedkvatm lqqqyepqgq aedqspesge slgrkvgvsm vtadlglvsm
      241 irqgilalql lpsnssagii vitdgvtsvp dvavcetlln qlrsgtvacs fvqvggvysy
      301 dcsfghvpnv elmkfiamat fgsylstcpe tepgnlgltv yhrafllysf lrsgealnpe
      361 yycgsqhrlf nehlvsassn palalrrkkh tekevpadlv stvsvrlreg ysvrevtlak
      421 ggsqlevklv llwkhnmrie yvavapwple pegprgtrve vtmeggydil hdvscalrqp
      481 irslyrthvi rrfwntlqsi nqtdqmlahl qsfssvpehf tlpdstksgv plfyippgss
      541 tpvlslqhsg sdsshaqfaa ywkpvlsmda nswqrwlhmh rlvlilehdt plpkhlhtpg
      601 sngrystiqc rishssltsl lrdwssfvlv egysyvklls sapdqppssf ymvriisktp
      661 cmvlrlgfpi gtpaqarhki vsglkeeilr lrfphrvqsk eptpkvkrkg lggvggssps
      721 kspptlgpqq alsdrpclvv lhkpldklli ryeklpldyr apflltlepp gplplvsgrs
      781 assslaslsr ylyhrrwlws vpsglaptlp lsataqllsv ltevrlsegf hfacsgegii
      841 nmvlelpvqn eplgqaaaee khtcvvqyil fpphststkd sfstdddndv evealegdse
      901 lnlvtevwve pqygrvgpgp enwkhlqdlt yseipqalhp rdaacigsll tfeyliqlcq
      961 skewgplppe prlsdgldqr gdtcvheipf hfdllgllpq cqqlqmffll lsrepegvpl
     1021 aegpcptndm vlcllhsclg qelsdreipl tpadqaafln evlrrslrdp gpegppvggh
     1081 avakdragns tqasgdstlp sqsvvipgvl rssisaqppq whcyarllgp qhvfltflpa
     1141 tfsdvqhlta yglessfqee tkpklgdwsg apslkdpgat gtkatesqvp tlsvtlasds
     1201 aqdsgepstp scqdlaansg rqapqtegad gprtrcpvyi yscslealre qmvglqppqa
     1261 prdlifraqd ldhpssssaw meprckeaat hcallqehaq rcfvrglfrs lqqaqsvtcq
     1321 dlltavdace ellqeidits fllalcghtw glphappspg plspgpfsss ieegpeprer
     1381 ailvsessie tedlsepefq ssrvsgnldp gpeisltdvc qlrgeahdal hsliqekfle
     1441 isrlhfrtvp snphyffycp pssrredegp rdtvdrkisd lefseaelvg eegdtsaccv
     1501 vtesdpelev eyresrepdl gpagldsasl sdadtvnpde dsfsilggds ptgpdslmhd
     1561 lpplflhltc svrlrgqhss vpvcslptcl gqvlsslegp piggrvplrd lsitldvfvl
     1621 tlplevelpp asdpqhhrst sessasfprs pgqpsslrsd dglgpplppp eeerhpglss
     1681 lamphrlaie stmneirwll edemvgalrr ggipqspalh raaahihsss grptclrqap
     1741 plsfvfgper sltqfkeefr rlhlpghvll edpdsgfffv aagqqpgvlh geppsaawaw
     1801 hnhedraeda egevltaspq vpgsledseg tplislpsls qggsqpgpsr glslmssqgs
     1861 vdsdhlgydg gssgsdsegp getlgekalf tlrtppgpap pqpslpvlpg pslpdfwliv
     1921 rilqdrvevy aharslsred ggpgaecrhl qqflvrrvge icrevnqrll lqdlhdshvc
     1981 nsllvaesee dlwrsetpfh srqravlpsd dfaadescap rgylaatmqf vpghfscdvv
     2041 wgtvirvhsr lkmgpsmgvs raiqalrsvl nafsvvnrkn mfvyqeratk avyylrllet
     2101 scsdrpwegd tlppslalsr sqepisseds vaprspldma ssrssdavrp vgqvdrhiql
     2161 lvhgvgqagp eitdelvrvl rrrldeatld iitvmlvrnc kltpadvefi qppgslpsev
     2221 lhlvlppscr pclpalawyl rqnlltflhs pkytdsnsrn hfqhplpaqg glpdldiyly
     2281 nkpggqgtgg kgvacitlaf veeggtpisl aswppsspgp pdplreeefe qltqvircpn
     2341 tldscsaqdg sprlrldvwe kgnisivqle eklraaarqa ladaimelrl lpaslctedi
     2401 ppgslksgpl dtkspacran tfpctpvsge pvtppskagr rsfwdmlskt eagdlgspkt
     2461 tddivldrpe dtrgrrrhkt envrtpggse rapgpdsgaq rqrrrttqle egevgtlhpv
     2521 farviqrwmg fmvqigcasv srssthmvsr fllpsilsef ttlvismagd tsvrvfeqhl
     2581 gsepdvfspc spgqlgpapr paaqrhllll grnfaqwrrp tqqaakavqr fesggdgspg
     2641 rsaprqrlll levtdkklql ltynwapdlg aalgralirl vqwqnarahl iscllsqklg
     2701 lfhhcgqldf pmrdgkepnp fllptmevet lirnasppls reqgrlsgss rgggplsldt
     2761 fpfdealrdi taarpsstgg paprppdpvt yhgqqfleik mterkelerq mkmenlfvtw
     2821 qqrsapasmp isageletlk qssrlvhyca tallfdpaaw lhgppetcap segqrrpcpe
     2881 sgsgsrevpt scesldvppp gareepwlke lslaflqqyv qylqsigfvl vplrppspar
     2941 stsrlramai lgtegrgsfs cpkakaegsp kststpvtty hlqralpggi ilmeltfqgc
     3001 yfcvkqfale csripmgqav nsqlsllfte ecdkvrdlmh vhsfsydfhl rlvhqhvlga
     3061 hlalrhgyhl ttflqhflah hpdgphfgrn hiyqgtlelp tpliaahqly nyvadhassy
     3121 hmkplrmarp ggpehneyal vsawhssgsy ldseglrhqd dfdvsllvch saapfeeqge
     3181 aerhvlrlqf fvvltsqrel fprltadmrr frkpsrlple petpgslvgs preasgmmla
     3241 pgpaplfppl aaevgmarar laqlvrlagg hcrrdtlwkr lflleppgpd rlrlggrlal
     3301 aeleelleav haksiadidp qldcflsmtv swyqslikvl lsrfpqscrh fqspdlgtqy
     3361 lvvlnqkftd cfvlvfldsh lgktsltvvf repfpvqpqd sesppaqlvs tyhhlesvin
     3421 tacftlwtrl l
//
