LOCUS       NM_028769               3470 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synovial apoptosis inhibitor 1, synoviolin (Syvn1),
            transcript variant 1, mRNA.
ACCESSION   NM_028769
VERSION     NM_028769.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Song,Z., Thepsuwan,P., Hur,W.S., Torres,M., Wu,S.A., Wei,X.,
            Tushi,N.J., Wei,J., Ferraresso,F., Paton,A.W., Paton,J.C.,
            Zheng,Z., Zhang,K., Fang,D., Kastrup,C.J., Jaiman,S., Flick,M.J.
            and Sun,S.
  TITLE     Regulation of hepatic inclusions and fibrinogen biogenesis by
            SEL1L-HRD1 ERAD
  JOURNAL   Nat Commun 15 (1), 9244 (2024)
   PUBMED   39455574
  REMARK    GeneRIF: Regulation of hepatic inclusions and fibrinogen biogenesis
            by SEL1L-HRD1 ERAD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3470)
  AUTHORS   Wang,Y., Chen,Y., Xiao,X., Deng,S., Kuang,J. and Li,Y.
  TITLE     HRD1-mediated ubiquitination of HDAC2 regulates PPARalpha-mediated
            autophagy and alleviates metabolic-associated fatty liver disease
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119765 (2024)
   PUBMED   38815686
  REMARK    GeneRIF: HRD1-mediated ubiquitination of HDAC2 regulates
            PPARalpha-mediated autophagy and alleviates metabolic-associated
            fatty liver disease.
REFERENCE   3  (bases 1 to 3470)
  AUTHORS   Gu,C., Liu,Y., An,X., Yin,G. and Sun,C.
  TITLE     Dysregulated SYVN1 promotes CAV1 protein ubiquitination and
            accentuates ischemic stroke
  JOURNAL   J Stroke Cerebrovasc Dis 33 (5), 107668 (2024)
   PUBMED   38423151
  REMARK    GeneRIF: Dysregulated SYVN1 promotes CAV1 protein ubiquitination
            and accentuates ischemic stroke.
REFERENCE   4  (bases 1 to 3470)
  AUTHORS   Zhao,X., Liu,D., Zhao,Y., Wang,Z., Wang,Y., Chen,Z., Ning,S.,
            Wang,G., Meng,L., Yao,J. and Tian,X.
  TITLE     HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated
            apoptosis through a non-canonical pathway in intestinal
            ischemia/reperfusion
  JOURNAL   Cell Death Dis 15 (2), 154 (2024)
   PUBMED   38378757
  REMARK    GeneRIF: HRD1-induced TMEM2 ubiquitination promotes ER
            stress-mediated apoptosis through a non-canonical pathway in
            intestinal ischemia/reperfusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3470)
  AUTHORS   Lin,L.L., Wang,H.H., Pederson,B., Wei,X., Torres,M., Lu,Y.,
            Li,Z.J., Liu,X., Mao,H., Wang,H., Zhou,L.E., Zhao,Z., Sun,S. and
            Qi,L.
  TITLE     SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD
            complex
  JOURNAL   Nat Commun 15 (1), 1440 (2024)
   PUBMED   38365914
  REMARK    GeneRIF: SEL1L-HRD1 interaction is required to form a functional
            HRD1 ERAD complex.
            Erratum:[Nat Commun. 2024 Apr 15;15(1):3241. doi:
            10.1038/s41467-024-47251-2.. PMID: 38622165]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3470)
  AUTHORS   Omura,T., Kaneko,M., Okuma,Y., Orba,Y., Nagashima,K., Takahashi,R.,
            Fujitani,N., Matsumura,S., Hata,A., Kubota,K., Murahashi,K.,
            Uehara,T. and Nomura,Y.
  TITLE     A ubiquitin ligase HRD1 promotes the degradation of Pael receptor,
            a substrate of Parkin
  JOURNAL   J Neurochem 99 (6), 1456-1469 (2006)
   PUBMED   17059562
REFERENCE   7  (bases 1 to 3470)
  AUTHORS   Tsuchimochi,K., Yagishita,N., Yamasaki,S., Amano,T., Kato,Y.,
            Kawahara,K., Aratani,S., Fujita,H., Ji,F., Sugiura,A., Izumi,T.,
            Sugamiya,A., Maruyama,I., Fukamizu,A., Komiya,S., Nishioka,K. and
            Nakajima,T.
  TITLE     Identification of a crucial site for synoviolin expression
  JOURNAL   Mol Cell Biol 25 (16), 7344-7356 (2005)
   PUBMED   16055742
  REMARK    GeneRIF: transcriptional regulation of synoviolin via EBS-1 (ETS
            binding site) plays an important role in cellular homeostasis
REFERENCE   8  (bases 1 to 3470)
  AUTHORS   Yagishita,N., Ohneda,K., Amano,T., Yamasaki,S., Sugiura,A.,
            Tsuchimochi,K., Shin,H., Kawahara,K., Ohneda,O., Ohta,T.,
            Tanaka,S., Yamamoto,M., Maruyama,I., Nishioka,K., Fukamizu,A. and
            Nakajima,T.
  TITLE     Essential role of synoviolin in embryogenesis
  JOURNAL   J Biol Chem 280 (9), 7909-7916 (2005)
   PUBMED   15611074
  REMARK    GeneRIF: Synoviolin has an indispensable role in embryogenesis
REFERENCE   9  (bases 1 to 3470)
  AUTHORS   Qi,X., Okuma,Y., Hosoi,T., Kaneko,M. and Nomura,Y.
  TITLE     Induction of murine HRD1 in experimental cerebral ischemia
  JOURNAL   Brain Res Mol Brain Res 130 (1-2), 30-38 (2004)
   PUBMED   15519674
REFERENCE   10 (bases 1 to 3470)
  AUTHORS   Amano,T., Yamasaki,S., Yagishita,N., Tsuchimochi,K., Shin,H.,
            Kawahara,K., Aratani,S., Fujita,H., Zhang,L., Ikeda,R., Fujii,R.,
            Miura,N., Komiya,S., Nishioka,K., Maruyama,I., Fukamizu,A. and
            Nakajima,T.
  TITLE     Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic
            factor for arthropathy
  JOURNAL   Genes Dev 17 (19), 2436-2449 (2003)
   PUBMED   12975321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD349490.1, AK004688.2 and BB676375.1.
            
            On Sep 15, 2009 this sequence version replaced NM_028769.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057917.1, AK143720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CD349490.1         1-21
            22-513              CD349490.1         23-514
            514-3459            AK004688.2         1-2946
            3460-3470           BB676375.1         409-419
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..3470
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /note="synovial apoptosis inhibitor 1, synoviolin"
                     /db_xref="GeneID:74126"
                     /db_xref="MGI:MGI:1921376"
     exon            1..553
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..702
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..2409
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /EC_number="2.3.2.27"
                     /note="synoviolin 1; RING-type E3 ubiquitin transferase
                     synoviolin"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase synoviolin"
                     /protein_id="NP_083045.4"
                     /db_xref="CCDS:CCDS29487.1"
                     /db_xref="GeneID:74126"
                     /db_xref="MGI:MGI:1921376"
                     /translation="MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMA
                     VLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPR
                     FVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAY
                     HSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELF
                     TGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLY
                     PDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVL
                     RASLPAQSPPPPEPADQGPPPAPHPQPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFP
                     PVPPPPSSGEAAAPPPTSTAVSRPSGAATTTAAGTSTSAPAPGSVPGPEAGPAPGFPF
                     PPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLL
                     DAAMLQINQYLTVLASLGPPRPATSVNPTEETASTVVSAAPSTSAPSSEAPTPSPGAS
                     PPIPEAEKPPAPESVGIVEELPEDGEPDAAELRRRRLQKLESPVAH"
     exon            703..795
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..948
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..997
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1101
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1228
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1328
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1394
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1511
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1675
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1804
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1960
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2147
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2299
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..3470
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3444..3449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /note="hexamer: AATAAA"
     polyA_site      3464
                     /gene="Syvn1"
                     /gene_synonym="1200010C09Rik; D530017H19Rik; Hrd1"
                     /note="major polyA site"
ORIGIN      
        1 tgcgttgggg ggaggtaacc tgggaagacc tatatctgtt ttctgcaccg ctattttttt
       61 ccgagaagca cttaacttct taccgtgtcg tagctatccc tggaatgagg cgcttacaca
      121 ttttatttct ttcatgcctg acataaagtc tggcccttgc tcgctcctgc cccccgtcca
      181 aatggctcgg cccgcggaac gccccatctt ccaggcacat tgagagccgg agtcttggag
      241 gagtttaggg tggtgattct acaacggcga ctagcaagtg gcgggcttca gccctttccc
      301 gctgctctcc tggtcgcgac cacacgtcac agctctcgct cgttccggtt gctcgcgcac
      361 gggccccaga agcgcaggcg agatcggagc gcgcaaagag aacttggtac ggtccactcc
      421 gccgcgcccc gcgccgccgg aagtgaggtg tcttaccccc gaagttccgg ttcgcagggg
      481 gtggggagtg ttgttaaccg gagcggctgc cgcagtcgcg gtgattgagc gtgctcgcgg
      541 cgctgggctc ctggtctctg ggccagggcg atgttccgca ccgcagtgat gatggcggcc
      601 agcctggcgc taaccggggc agtggtggct catgcctact acctcaaaca ccagttctac
      661 cccactgtag tgtatttgac caagtccagc cccagcatgg cagtcctgta catccaggcc
      721 tttgtccttg tcttcctctt gggcaaggtg atgggcaagg tgttcttcgg gcagctgagg
      781 gcagcagaga tggagcacct tctggaacgg tcctggtacg ctgttactga gacttgtttg
      841 gccttcaccg tttttcggga tgacttcagc cctcgctttg tggcgctctt tacgctgctc
      901 ctcttcctca aatgtttcca ttggttggct gaagaccgtg tggactttat ggaacgcagc
      961 cccaacatct cctggctctt ccactgccgc atcgtctctc tcatgtttct cctgggtatc
     1021 ctggacttcc tcttcgtcag ccacgcttat cacagcatcc tgacccgtgg ggcttctgtg
     1081 cagctggtat ttggctttga gtacgccatt ctgatgacca tggtgcttac catcttcatc
     1141 aagtatgtgc tgcactccgt ggacctccag agcgagaacc cctgggacaa caaggctgta
     1201 tacatgctct acacggagct gtttacaggc ttcatcaagg tcctgctgta catggccttc
     1261 atgaccatca tgatcaaggt gcacacattc ccactctttg ccattaggcc catgtacctg
     1321 gccatgaggc agttcaagaa agctgtgaca gatgccatca tgtctcgccg agccatccgc
     1381 aacatgaaca cactgtaccc agatgccacc cccgaggagc tccaggcaat ggataatgtc
     1441 tgcatcatct gcagagaaga aatggtgact ggtgctaaga gattgccttg caaccacatc
     1501 tttcacacga gctgcctgcg ctcctggttc cagagacagc agacctgccc gacatgccgc
     1561 atggatgtcc tgcgggcatc gttgccagcc cagtcaccac cacctcctga gcctgctgac
     1621 caaggaccac cccccgcccc tcatccccaa ccgctgctgc cacagccccc taatttcccc
     1681 cagggcctcc tgcctccttt tcctccaggc atgttcccac tgtggccccc aatgggtccc
     1741 tttccacctg tcccgcctcc cccaagctca ggagaggctg cggcccctcc acccaccagt
     1801 acagccgttt ctcggcctag tggagcagcc accaccacag ctgctggcac cagtacttct
     1861 gccccagcac ctgggtctgt acctggccca gaggctggtc ctgcccccgg cttccctttc
     1921 cctcctcctt ggatgggtat gcctctgcct ccaccttttg ccttcccccc aatgcctgtg
     1981 ccccctgcgg gctttgctgg cctaacccca gaggagctgc gagcactaga gggccatgag
     2041 cggcagcacc tggaggcccg gctgcagagt ctgcgcaaca tacacacact actggatgct
     2101 gccatgcttc aaatcaacca gtacctcact gtgctggctt ccctggggcc ccccaggcca
     2161 gctacttcag tgaaccccac tgaagagact gcctctacag tggtatctgc tgccccttcc
     2221 accagcgccc ccagctctga ggctcctacc ccgtctccgg gagcttcccc accaattcct
     2281 gaagcagaaa agcctcctgc tcctgagtca gtgggcattg tagaggagct tcccgaggat
     2341 ggagagcctg atgctgcaga actccgccgg cgtcgcctgc agaagctgga gtcccctgtt
     2401 gcccactgac actgcccaga cctggccctg ttctcttgag tggccctcac tggaacacgt
     2461 cctgccatca agtgccagct ccctctctgc ttgcaccagg gagtaatagc cccagttgag
     2521 aaagacttgg caggatctct gaggatcaag gagaagtgtc tgggcttcca gtcgatccat
     2581 ccccagtgcc cctggcagcc atggagatac tggtcagctc taacctccct ccacttctgc
     2641 catgttcaac tggggccttc aaagtagaag ctgaatctct ggtaagcctt ctcttccatg
     2701 ctttctggga gaaggtgaag cccctccaag ccctgcttgt gagtatggga ccatgctgca
     2761 gtgccgaaca gtattagctt ctgttcccaa ctgtggaaac ccagaggggc tgaagacaga
     2821 ccaggacctt gccccaccct cctgccaaga ctggtaccag tctctttcct ctagcccagt
     2881 cttcccagaa cccctttgtg atggtggctg tgccccccga agccctgtgg catttccatg
     2941 tcttactggc aaccacacaa ctcagggaaa ggagtgcctg ggggtggggc acaggcgggc
     3001 agcaccgagg gaccctgccc tgcccctccc cagctctttc cccatatcac ccagcagcca
     3061 ctgcctggtg ggcctggcta agggtgtgtg ctgctcctta aaccactgct ccccagaacc
     3121 caaggcaggc cacctccaac ctgtgggatg tcgtcaggat tggaactatt ctgtacctac
     3181 tggctttggg cttaaatttt gtcttctgaa tttgaatgct tgaccccagg aaggaggagc
     3241 aggtgtgggg ctaggtacct ggacttcgca gtttagaaca agctctgggc cgggccgggc
     3301 caggccaggc ctagggagcc aaggcctagc tgctgcttcc ttcttttggt tttgtgttac
     3361 aggagtttct ggagagtttc agatgattat ttaatttgta aatattgtat aaattttaat
     3421 agcttaaatt gtatatacag ctcaataaaa acttgcatta atgattggta
//
