LOCUS       NM_177704               6623 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus synaptotagmin-like 5 (Sytl5), transcript variant 1,
            mRNA.
ACCESSION   NM_177704
VERSION     NM_177704.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6623)
  AUTHORS   Scavuzzo,M.A., Chmielowiec,J., Yang,D., Wamble,K., Chaboub,L.S.,
            Duraine,L., Tepe,B., Glasgow,S.M., Arenkiel,B.R., Brou,C.,
            Deneen,B. and Borowiak,M.
  TITLE     Pancreatic Cell Fate Determination Relies on Notch Ligand
            Trafficking by NFIA
  JOURNAL   Cell Rep 25 (13), 3811-3827 (2018)
   PUBMED   30590051
REFERENCE   3  (bases 1 to 6623)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   4  (bases 1 to 6623)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   5  (bases 1 to 6623)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   6  (bases 1 to 6623)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 5: a novel Rab27A effector with
            C-terminal tandem C2 domains
  JOURNAL   Biochem Biophys Res Commun 293 (3), 899-906 (2002)
   PUBMED   12051743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672031.10 and BX547929.3.
            
            On Mar 19, 2014 this sequence version replaced NM_177704.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150480.1, AB098160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL672031.10        74829-74987
            160-369             AL672031.10        94726-94935
            370-485             AL672031.10        103111-103226
            486-594             AL672031.10        104714-104822
            595-729             AL672031.10        121941-122075
            730-871             AL672031.10        132248-132389
            872-1001            AL672031.10        138020-138149
            1002-1108           AL672031.10        140786-140892
            1109-1198           AL672031.10        145567-145656
            1199-1264           AL672031.10        146392-146457
            1265-1443           AL672031.10        149222-149400
            1444-1543           AL672031.10        150941-151040
            1544-1705           AL672031.10        152799-152960
            1706-1814           AL672031.10        176004-176112
            1815-1950           AL672031.10        177759-177894
            1951-2159           AL672031.10        182097-182305
            2160-2379           AL672031.10        183609-183828
            2380-6623           BX547929.3         2001-6244
FEATURES             Location/Qualifiers
     source          1..6623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.62 cM"
     gene            1..6623
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="synaptotagmin-like 5"
                     /db_xref="GeneID:236643"
                     /db_xref="MGI:MGI:2668451"
     exon            1..159
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2302
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptotagmin-like protein 5"
                     /codon_start=1
                     /product="synaptotagmin-like protein 5 isoform 1"
                     /protein_id="NP_808372.1"
                     /db_xref="CCDS:CCDS40860.1"
                     /db_xref="GeneID:236643"
                     /db_xref="MGI:MGI:2668451"
                     /translation="MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKN
                     ELLEAKRRSGKTHQEASRVCVHCHKTLGLIFDRGDPCQACSLRVCSECRVTGLDGSWK
                     CTVCAKVAQLRIISGEWFLEEKAKRFKQVNVLGTDVVRQSILRRSPGSEETQNQEQAQ
                     QCVDKSDTLSSVRQKTTHDGPKKKGFLLSKFRSATRGEIRTPKPESGRSYSLDLDSQN
                     LQSFKSASGSDRGSTTSSDLIDQEAGRRTSKSSYSNGGIPVTQRSPVPSAHSVTSINS
                     REHGFENSMALATIENTCEELTKSHRRNTSGTPSIAVSGTSLSSERSRSEVDLSESFA
                     EDLEDTSSIRSRSVPGALDKDLNSLEDTEDGVDLVSSRFSANTHSLASGLSTNSQAGS
                     DRKRSYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVTGEILLHISYCYKTGGLYIFV
                     KSCRNLATGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHTQ
                     LETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNFENPCDEWFVLQPKVELAPDISLQY
                     KGELTIVLRYIPPEENLIFPAGQRQEKKIFKRGKKKESSSISGGILEVFIKKAKNLTA
                     VKSGGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPEWNHTFIFSGLYPQDIKNACLE
                     LTIWDKEAFSSNVFLGGVRLNSGSGMSYGKTVDWMDSHGEEQRLWQKMADNPGTSVEG
                     VLMLRSSMAKCRL"
     exon            160..369
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            370..485
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            486..594
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            595..729
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            730..871
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1001
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1108
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1198
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1264
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1443
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1543
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1705
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1814
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1950
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2159
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..6623
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5180..5185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="hexamer: AATAAA"
     polyA_site      5213
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="major polyA site"
     regulatory      6320..6325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="hexamer: AATAAA"
     regulatory      6336..6341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="hexamer: AATAAA"
     polyA_site      6341
                     /gene="Sytl5"
                     /gene_synonym="slp5"
                     /note="major polyA site"
     polyA_site      6361
                     /gene="Sytl5"
                     /gene_synonym="slp5"
ORIGIN      
        1 agattcaacc actgctacac agagctgctg ctgaagtacc atgtctaaga actcggagtt
       61 catcaatctg tcatttttat tagatcatga gaaggaaatg atactgggag tcctaaagag
      121 agatgaatat ttgaaaaagg tggaagacaa gaggataagg aagctgaaaa atgaactctt
      181 agaagcaaag cgtaggagtg ggaagactca ccaagaggcc agtagagtct gcgttcactg
      241 tcacaaaacc cttggcctca tctttgaccg gggagatcca tgccaagcct gctcactcag
      301 ggtatgcagt gagtgtcgag tcaccggact tgatggcagc tggaagtgca ctgtctgtgc
      361 caaagtcgcg cagctaagga ttataagtgg agaatggttc ttggaagaaa aggcaaagcg
      421 tttcaagcaa gtcaatgttc tgggcactga tgtcgttcga cagtccatct taagaagaag
      481 tccagggtct gaagaaacac aaaaccaaga gcaagcacaa caatgtgtag acaagtcaga
      541 tactttgtct tctgtcaggc agaagacaac tcatgatggc ccaaagaaga agggttttct
      601 tcttagcaag ttcagatcag caaccagagg agaaatcaga actccaaaac ctgaaagcgg
      661 aaggagctat agcttggact tagacagtca aaatcttcag agtttcaagt cagcctctgg
      721 ttcagacagg ggaagtacca cttcatcaga tctcattgac caggaggctg gacgaagaac
      781 atcaaaaagc agctacagca acggtggaat cccagttact cagaggtcac cagtcccaag
      841 tgctcatagt gtgacctcca tcaacagcag agaacatggt tttgaaaatt ccatggcttt
      901 ggctaccatt gaaaacacct gtgaagagct cacaaagagt caccgcagaa acacatccgg
      961 tacaccctcc atagcggtgt ctggcacctc actctcctca gagcggagtc gatctgaggt
     1021 agatttgagt gagtcatttg cggaagactt agaggacact tcaagcataa gaagcagatc
     1081 tgtccctggg gctttagaca aagacttgaa ctccttagaa gacactgaag acggtgttga
     1141 cttagtgtcc tccaggtttt ctgcaaatac ccacagtctg gcaagtggat tgtcaactaa
     1201 ctcccaagca ggatctgata ggaagaggag ctacctaaat gtgcctgatg ccgattcaga
     1261 cactactagc cttaacagca tgatgagtgt ttacagtgaa acgggagact atggcaacgt
     1321 gaaagtcacc ggtgagatcc ttctccacat cagctactgc tacaaaaccg gcgggctata
     1381 catttttgtc aagagctgca gaaacctggc cacaggagat gaaaagaaac agaggacaga
     1441 tgcttatgtc aagtcatacc ttcttccaga caagtcccga aacaacaagc gtaagaccaa
     1501 aatcagaacg ggtaccaatc cagaattcaa cgaaacatta aagtatacca tcagccacac
     1561 ccagctggaa acaagaactc tgcagctctc agtctggcac tatgatcggt ttggacgcaa
     1621 cagtttcctg ggagaggtgg agattgcttt tgactcatgg aactttgaaa atccatgtga
     1681 tgagtggttt gtgcttcagc cgaaggtgga gttggctcct gatattagcc ttcaatacaa
     1741 aggagagcta accattgttt tgcgttatat tcctccagag gagaacctaa tattcccagc
     1801 aggacagcgt caagaaaaga agatctttaa aaggggaaag aagaaagagt catcttccat
     1861 ttctggggga atacttgaag tgttcatcaa aaaagcaaag aatctgacag cagtaaaatc
     1921 aggaggcact tctgacagct tcgtcaaggg ctacctgctt cctgatgata acaaagccac
     1981 caagcacaaa actgctgttg taaaaaagag tgtcaatcct gagtggaacc atacgttcat
     2041 attcagtggc ctgtatcctc aggatataaa gaatgcttgc ctagaactca ccatctggga
     2101 caaagaggcc ttttccagca acgtctttct aggaggtgtt cgtttaaatt ctggaagtgg
     2161 tatgagctac ggtaaaactg tggactggat ggactctcat ggggaagagc aacgcctttg
     2221 gcaaaagatg gctgacaacc ctgggacatc tgtagagggg gttctcatgc tacgttccag
     2281 catggcgaaa tgtaggctct gaggcgacca gttctcccca aactacatct ctggttgcca
     2341 gctgtttcct ctcagtgaaa ggactaggac tgtgaattca ccaaagagta ttaggccata
     2401 attggaaaca catcagtgct gtgaaaaaac aaatctgatt tttttgctga ttgtcaaagc
     2461 aaacaaaaaa aaaccaaacc catatctttt tatatgttca cctacgcagg cttcccttat
     2521 tagtcagtag gaagtatacc acaccatctt tccaacaatc aaaccatgct aagactcata
     2581 ggcttcatat tgatagaaac attacaagct tattagaaaa tactgtgttt agattggggc
     2641 tccccatgct ttctccaact gagttactta aggtttattg agtttgagaa gagaagggaa
     2701 cattaagaag gtagagtgct tgatgaataa caaagaaaga tacaggcctc ctttttttta
     2761 tcctaggatg acctgtgatg taaagatggc atgctgggga tggtttgaag gatagggtag
     2821 aatgctgtta tagtggcaag cttcggaatg gagatgggat tatttcagga catactggtt
     2881 ggattatggt aactacagaa ttcatcatga aattcagcct ccttttcaag gtaaagagag
     2941 ctaaatggtt acatgtgatc tctctgtctc tctctttcta atacatacac acacacacac
     3001 acacacacac acacacacac acacacacac acacacacat gaaaaccaca gataccagta
     3061 tgtgtgtaga aaaactggaa tatagggtta caggttacct tgatgattat ctagcaattt
     3121 taaggagttt gttataagaa aatacaaaat atatattttg tcaaatattt taagctattc
     3181 agtaaatgga aataataaat aagggccagt caactcatat ctctacattt tgttaacttg
     3241 taaggctagt taagtgaaaa gggagatact gtgctgtcct gcgctgctgt aggagagtca
     3301 ggaagtctat gttctctctt tcactttcac ttttcccaag ttattatttt cttctgctat
     3361 gataacagca agtaacaaac caccccaaaa gtcaatgact ttaaatgaaa actaattttc
     3421 tcatgcctat gaaatttgcc taggaaagct ctgcttccta cttacaagcc tgggcatcta
     3481 agatctaaac cagctgcttc tctcttctcc tcattggacc agaagaatag tctgagggtg
     3541 gtggtaacag aagtataatt ggataggtct cgctgctcaa gcacctaagt gtggtatgct
     3601 tcattggtca aaaggaagcc atattgctaa gtccaaagtt taagaaggaa atgtgccttg
     3661 ccaatagtga tgccatgaca cgaatgaggg tggtagaaag gatgctgaaa cagaggccag
     3721 taatgaaccc attttgcgcc ctggcacttt gatgccaaac ataaactacc aaatttagat
     3781 acaaagtcag ttaaagccag aagggatgcc aagtctggtt gtccattttg tgagttccaa
     3841 ccctgtggtc caaagagctg aggtgacttg tccaaggtca tatagtggct ctgactgaat
     3901 ctggacttaa tccatagata attttgacat gactatgctt atcaagaaag taggtcagag
     3961 tcttattatt ttctttctga aatttgaaaa ctgatttaag aatgcattta atgttcttca
     4021 tagtaaggga atacataaac caatctaact gggtatttct ataaaacaaa acccacatag
     4081 acaaaagaca tacttttaaa tttttactct agttcttcat gtaaataaaa ggtaaacatt
     4141 ttcagttcac tatcttttcc taaatgccag tgcaaaatac aagtacactg tgttagtata
     4201 taaccagaac cttgcattta ggagactaat tccagaggac cacaagttca gcatcagcct
     4261 aaactataat gagactcact ggcaaaagta aaatagtgta tgaagattat agaattcaag
     4321 cgcttaaaga ctatggagtt gctttgccca ccacttccac gtgaaagtat acttactgtc
     4381 agtgttagcc ttttctatgc ctataggtta ttaccttata gaaatccact gaatatgttc
     4441 agtcagtgtt atcagatgcc acaggaaata tggctaagcc atctatgctt aatagcttct
     4501 ctcaatagac ttttcttttt aatgatatat aggaaggtct gggaatatat atgtatttta
     4561 tttgatatag atatcaatca cccagccatc cagttacatg taactacttt atagaagtag
     4621 atatgtatat gaggaatgag cacatagatg cctgtatttc tgaaagatca gaaacaaagc
     4681 aaaatcaatg aaaagaagtg tgaaattcac acactccaga ctttttctgt ttttctgttt
     4741 ctagttattg cttgctcctt cttttctaac tctgataatt ctcagcagaa ctgttaacat
     4801 ctactctttg gagctctttc tccttgattc tatactactt tcatgataat atatgcttac
     4861 aacttcaaac ttgcatatcc agtgaagatt tacttctcag ccctagacac tgagaaaatc
     4921 tatcaaccca gtataagtta ttcctgtcac tgcgtaggat aaagctgaaa aatcacgggg
     4981 aataacatgt aggtcacaga tatctgttct gtaggatgcc ttgcaagcct tatgcaacca
     5041 aaagacccac tatgacttta agacaaaatt taaacagcag ttgatgctaa tcaccaatcc
     5101 aagcttgcaa acttctaaaa gacactatct gacatatgag cttgcttcca aaatgatctg
     5161 tgttaatacc tctttcctca ataaaacacc aatattttcg tttgttctct ggacacatca
     5221 gagactgctc agtctggtgt atctgattac atattcagtc tgctatcatt ctatctttcc
     5281 actctttttc atgtagggtt tcctttctca aggatttatt tctataattt tatttagtga
     5341 tgacaacgtg aatcgaactg ccagtatgac atctcagtcg gggtacttta tttgaaactc
     5401 tattcaaact aagcattctg ttatcattct tgttctggag tcttgttcta ggccattcta
     5461 cctcagcact tagagcgttc gtcctctctc aagtgacagc aaacaggctg attgctgagt
     5521 tttatctctt gcttttcctt catcctgagg caaagtcaat caaagattcc taagtctact
     5581 taagtgtcct tatccccacg ataccaacca agtccaaact aacattactc cttttcatga
     5641 ctagttcagc aagtctccta acattaatca tttaagtatt tttattcatt gtgtgcatat
     5701 atgatgtgtg tgttacatgc acatgtcagc cagggaaaag ttctgtggag tcagttctct
     5761 ctttccactt tacagggact ctggggattg aacctaggca attggtgttg tgctgaaagt
     5821 atgttgctaa aatgagatat cactctggct gttattttta cagcccttct tgttctgtat
     5881 cattccaata tccaccatat aagattcatc tcaaaatagt atcttaaatg tccaaatata
     5941 cagaaaaatt gaaagaactt tataggaaat actattgtat ccatgaccta gcattagcac
     6001 atgactgtac ttgcctgtca ttatagaggt tatatctgac catcctgagt gatctataca
     6061 actttccatg ggctttcaac tgaaatgaaa acaaaacaca aagtattgta tatggcccag
     6121 cctaagaagg ccactgcctt ttccccaggc tgtgcccccc ctccctgtcc tcccttcctc
     6181 tttagtcccc ttgtgtactc ttctggtctt catctccata aataatccca gtcttgaatg
     6241 ctacttcctc aggaaaacct tcttgatcct gttctgaagc tggcctttat ttcccctcca
     6301 ctgcacctat cacaattaca ataaattatt catgcaataa atctgatgcc tatgtctgct
     6361 accttcccgt tatgtaagat tcatgtaaga ttcatgaggg ctggagcaac acatgttcgt
     6421 aagtctatcc ccagtgctta gctgaaagta gctgatccaa acttttgtta aataaataaa
     6481 aagagaacaa atataacatc acaaaacctt acattagcaa acacattttt cttttctgtt
     6541 aattaattta tttacttact ttacatccca atcacatttt tttaaaccac catttcaaag
     6601 tgagtgtggg aaggagcaaa cgg
//
