LOCUS       NM_013757               3770 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus synaptotagmin-like 4 (Sytl4), transcript variant 1,
            mRNA.
ACCESSION   NM_013757
VERSION     NM_013757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Zhao,K., Matsunaga,K., Mizuno,K., Wang,H., Okunishi,K. and Izumi,T.
  TITLE     Functional hierarchy among different Rab27 effectors involved in
            secretory granule exocytosis
  JOURNAL   Elife 12, e82821 (2023)
   PUBMED   36803984
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Scavuzzo,M.A., Hill,M.C., Chmielowiec,J., Yang,D., Teaw,J.,
            Sheng,K., Kong,Y., Bettini,M., Zong,C., Martin,J.F. and Borowiak,M.
  TITLE     Endocrine lineage biases arise in temporally distinct endocrine
            progenitors during pancreatic morphogenesis
  JOURNAL   Nat Commun 9 (1), 3356 (2018)
   PUBMED   30135482
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Zhang,Q., Huang,R., Ye,Y., Guo,X., Lu,J., Zhu,F., Gong,X.,
            Zhang,Q., Yan,J., Luo,L., Zhuang,S., Chen,Y., Zhao,X., Evans,S.M.,
            Jiang,C., Liang,X. and Sun,Y.
  TITLE     Temporal requirements for ISL1 in sympathetic neuron proliferation,
            differentiation, and diversification
  JOURNAL   Cell Death Dis 9 (2), 247 (2018)
   PUBMED   29445148
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Abdellatif,A.M., Oishi,H., Itagaki,T., Jung,Y., Shawki,H.H.,
            Okita,Y., Hasegawa,Y., Suzuki,H., El-Morsy,S.E., El-Sayed,M.A.,
            Shoaib,M.B., Sugiyama,F. and Takahashi,S.
  TITLE     beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine
            Cell Development
  JOURNAL   PLoS One 11 (2), e0150010 (2016)
   PUBMED   26901059
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3770)
  AUTHORS   Zhao,S., Torii,S., Yokota-Hashimoto,H., Takeuchi,T. and Izumi,T.
  TITLE     Involvement of Rab27b in the regulated secretion of pituitary
            hormones
  JOURNAL   Endocrinology 143 (5), 1817-1824 (2002)
   PUBMED   11956164
REFERENCE   7  (bases 1 to 3770)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains
            an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD
            of Slp4 specifically and directly binds the GTP-bound form of
            Rab3A, Rab8, and Rab27A.
REFERENCE   8  (bases 1 to 3770)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem Biophys Res Commun 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   9  (bases 1 to 3770)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
REFERENCE   10 (bases 1 to 3770)
  AUTHORS   Wang,J., Takeuchi,T., Yokota,H. and Izumi,T.
  TITLE     Novel rabphilin-3-like protein associates with insulin-containing
            granules in pancreatic beta cells
  JOURNAL   J Biol Chem 274 (40), 28542-28548 (1999)
   PUBMED   10497219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX510358.4 and AB025258.1.
            
            On Mar 19, 2014 this sequence version replaced NM_013757.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025258.1, SRR17253014.643832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BX510358.4         4072-4100           c
            30-3770             AB025258.1         1-3741
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.47 cM"
     gene            1..3770
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /note="synaptotagmin-like 4"
                     /db_xref="GeneID:27359"
                     /db_xref="MGI:MGI:1351606"
     exon            1..151
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            152..324
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2236
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptotagmin-like protein 4; exophilin-2; granuphilin-a;
                     granuphilin-b"
                     /codon_start=1
                     /product="synaptotagmin-like protein 4 isoform 1"
                     /protein_id="NP_038785.1"
                     /db_xref="CCDS:CCDS30388.1"
                     /db_xref="GeneID:27359"
                     /db_xref="MGI:MGI:1351606"
                     /translation="MSEILDLSFLSEMERDLILGVLQRDEELRKADEKRIRRLKNELL
                     EIKRKGAKRGSQHYSDRTCARCQEGLGRLIPKSSTCVGCNHLVCRECRVLESNGSWRC
                     KVCSKEIELKKATGDWFYDQKVNRFDYRTGSEIIRMSLRQKPAVNKRETAGQSLLQQT
                     QMGDIWPGRRIIQEQQQREQSVLFEVPKTRSGKSALEAESESLDSYTADSDSTSRRDS
                     LDKSGLFPEWKKMSAPKSQVEKEIPPGNQNAVCGDEGDMVFKKNTKKVLRPSEYTKSV
                     IDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEEDIDHLVKLHRQKLARGSMQSG
                     SSMSTLGSIMSIYSEAGDFGNISVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAK
                     KRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWH
                     HGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYI
                     PASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASK
                     RKTPVMKKTLSPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGT
                     GISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMVKQKLGV"
     exon            325..540
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..650
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            651..756
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            757..858
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            859..934
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1025
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1129
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1225
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1404
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1507
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1669
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1778
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1878
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2087
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..3753
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3720..3725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /note="hexamer: AATAAA"
     polyA_site      3748
                     /gene="Sytl4"
                     /gene_synonym="Gph; Slp4"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagttg cagctttttc cgcctcctgg gagggttgag tagggccggc cgcctgggtt
       61 gctggtctaa gtctttttgg agctagagac ccttccaacc attcggcacc cggacctttg
      121 gtcacctagt agcacctgtt gcaggtgaca gacacatctg gtcactcttc ttgcccaggt
      181 tgctttgaag gaagaggagg agcctaaagc caccatgtcg gagatactag acctctcttt
      241 tctgtccgag atggaaaggg atttgatcct cggtgttctg cagagagatg aagaactcag
      301 aaaagcagat gagaaaagga ttcggcgact gaagaatgag ctcctggaga tcaaaagaaa
      361 aggggccaaa aggggcagcc aacactatag tgatcgaacc tgtgccaggt gccaggaggg
      421 cctgggccgc ttaattccca aaagcagcac ttgtgtgggc tgcaatcatt tagtgtgccg
      481 agaatgccga gttctggaaa gcaatggctc ttggaggtgc aaggtgtgct cgaaggagat
      541 agagctgaag aaagcaactg gagattggtt ttatgaccag aaagtaaatc gctttgatta
      601 ccgaacaggc agcgagataa tcaggatgtc cctgcgccag aagcctgcag tgaataaaag
      661 agagacagcg gggcagtccc tccttcagca gacacagatg ggtgatatct ggccaggaag
      721 aaggatcatt caagaacaac aacagaggga acaaagtgtg ctgtttgaag tgccaaagac
      781 cagaagtgga aagagtgcac tggaggctga gagcgagagt ctggatagct acactgctga
      841 ctcagacagc acctccagga gagattctct ggataaatct ggactcttcc cagaatggaa
      901 gaagatgtcc gctcccaaat ctcaagttga aaaggaaatt ccaccaggga accaaaatgc
      961 agtctgtggt gatgagggtg acatggtatt caagaagaac accaaaaaag tcctgaggcc
     1021 ttcagaatac actaagtctg tgatagacct tcgcccagaa gatgtggccc aagaaagtgg
     1081 catcttggga gacagaagca aatctgtacc aggcctcagt gtggatatgg aagaagagga
     1141 ggaggaggaa gaggacattg accacctggt gaagttgcac cgccagaaac tggccagagg
     1201 cagcatgcag agtggctcct ccatgagtac ccttggcagc attatgagta tctatagcga
     1261 agctggtgat tttgggaaca tctctgtgac gggcaagatt gccttttcac tgaagtttga
     1321 gcagaaaaca cagactttgg tcatccatgt caaggagtgc caccagctgg cctatgctga
     1381 tgaagccaag aagcgttcta acccatatgt gaagacttat cttctgcctg acaagtcccg
     1441 ccaaggaaaa agaaaaacca gcatcaagcg ggacaccatc aatccactat atgatgagac
     1501 ctttcggtac gagatttcgg aatctcttct ggctcagagg actttgcagt tttccgtttg
     1561 gcatcatggt cgttttggca gaaacacttt ccttggagag gcggaggtcc acatggactc
     1621 ttggaagctg gataagaagc tggatcactg cctcccttta catggaaaga tcagtactga
     1681 gtcctcgcct ggtttgccag cacacaaagg cgagttggtg gtttcattga aatacatccc
     1741 agcctccaaa ctccctgttg gaggtgaccg gaaaaagagt aaaggtgggg aagggggaga
     1801 actccaggtg tggatcaaag aagccaagaa cctgacggct gccaaatcag gagggacttc
     1861 agacagcttt gtcaagggat acctccttcc catgaggaac aaggccagta agcgtaaaac
     1921 tcctgtgatg aagaagactc tgagtcccca ctacaaccat acatttgtct acaatggtgt
     1981 gaggctggaa gatctacaac acatgtgcct ggaactgact gtatgggacc gggagcccct
     2041 ggccagcaat gacttcctgg gaggggtcag actgggtgtt ggcactggga tcagtaatgg
     2101 cgaagtggtg gactggatgg attcgactgg tgaagaagta agcttgtggc agaagatgcg
     2161 acagtaccca gggtcttggg cagaaggaac tctgcagctc cgttcttcaa tggtcaagca
     2221 gaagctgggt gtatgagttc ctatcctcat ctgcaggtgc agccctggtc agtccaagtc
     2281 aaaagaaagc aaagcaacca caagaaaaga tttctaattt aatgtgtgtg tgtgtgcatg
     2341 tgtgtgtgta tgtgtgtgtg tgtaaacatg tatttctaca gatcttattt tgctagcaag
     2401 tgtggcacag gcttgctcct tcttttaaag cagcccaaga ataagggccc tttcaaatgg
     2461 tttttattta tatataatct agtatagttt ttgagtacat agttggcttt ttctgtggtt
     2521 taattaagtt taaaaaccat attacaacaa ctctctactt tctatcttgc tatctttgct
     2581 cacactttcg ctggaagtgt ggctgctttt ggcacgagtt ctagttcatg ggtctaagtg
     2641 tgcctgatca aaggccagag ctcttggaag caaggtttgg ttgttcaaga tattattaga
     2701 ctatgggaga agggtgaacg agcagtcctt cctctctaat ttgtatttta tctcatcatc
     2761 taccttgata cccttctaga acttgccttt taacttttcc cgttttaagc agtttccacc
     2821 ttgcttgagt atagtgtttt tctttgaaat gcaatgaaaa attccccagc tccttctgag
     2881 gcctttgggg agtccttata atggagtcac tgtagaaaaa tcactttaat tagataatgg
     2941 ccttttcact gagacattaa catgtcccat gagacctact agctgatccc acaaggtcca
     3001 agtgactctg aatgaagttt ttcaaagcct gtgctgagtt ctctgtttta aactgttaca
     3061 gcacttgttg gacagagata tccttatctc cctcatggaa gatgaggcat gttcactctc
     3121 atgtattatc gctttctcta agtttgtgtc tgggtgtgct gctacataga acatagtctg
     3181 tatacctctg tttcatctgc aagggccaaa gaccgtctaa aatgacaccg tgctccccca
     3241 ggttgggtac tagtaccatg ccatgaaaat gtggatggaa ttccccagcc attctaactt
     3301 ttcacccaat atactttcag ttcctgtctt tggttgtttc ctaaacttga cctgggtgta
     3361 acatgggagt agtgtgtgtt gagacttaaa agaggttcta gtgggctttc atttcctgct
     3421 actcattctt ccgaactgaa cttttcattc ataagcagtc tgtctataga aaggtgtatg
     3481 tggaaggtgt ctggagcaga gaagaaatgc ctgtcagtga catccagctg caagttgaca
     3541 ttcctgtaag gtcactggat tgcaggcagc taaagtgatt aagattatgg gtgtaaactg
     3601 catagaatgt ttttcaaaga ttcccttcaa tatggattga tcctgtaatg gaaacatacc
     3661 tgagagccca ggctcagact tgttctttga tattctactt taatatgcat gtgtgtttca
     3721 ataaagcttt ctcacccgag tgtttacatt tgaaaaaaaa aaaaaaaaaa
//
